Plicamycin_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Plicamycin perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Plicamycin_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.0840518
NAMPT nicotinamide phosphoribosyltransferase 0.0742732
ZNF292 zinc finger protein 292 0.069605
PDE4D phosphodiesterase 4D, cAMP-specific 0.0689196
ERRFI1 ERBB receptor feedback inhibitor 1 0.0588907
RBM39 RNA binding motif protein 39 0.0553685
HOOK2 hook microtubule-tethering protein 2 0.0545777
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0537003
FAM13A family with sequence similarity 13, member A 0.0507643
RB1CC1 RB1-inducible coiled-coil 1 0.0496813
KMT2C lysine (K)-specific methyltransferase 2C 0.0461254
PGK1 phosphoglycerate kinase 1 0.0426733
KDM3A lysine (K)-specific demethylase 3A 0.0423403
JARID2 jumonji, AT rich interactive domain 2 0.0421226
EGFR epidermal growth factor receptor 0.0420187
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0412566
TRIO trio Rho guanine nucleotide exchange factor 0.0409922
RNF145 ring finger protein 145 0.0408798
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0401769
PDLIM5 PDZ and LIM domain 5 0.0385022
MYH9 myosin, heavy chain 9, non-muscle 0.0369663
GOLGA4 golgin A4 0.0361625
ELL2 elongation factor, RNA polymerase II, 2 0.0353035
ANKRD12 ankyrin repeat domain 12 0.0350895
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0343875
HELZ helicase with zinc finger 0.033516
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.033143
ASPH aspartate beta-hydroxylase 0.0330991
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0328679
ESYT2 extended synaptotagmin-like protein 2 0.0326599
MCL1 myeloid cell leukemia 1 0.0322515
DTNA dystrobrevin, alpha 0.0316779
CDC73 cell division cycle 73 0.0313931
RYBP RING1 and YY1 binding protein 0.0313533
ADAM17 ADAM metallopeptidase domain 17 0.0303447
ZMYM2 zinc finger, MYM-type 2 0.0302623
TIMP3 TIMP metallopeptidase inhibitor 3 0.0297994
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0295347
DSCAM Down syndrome cell adhesion molecule 0.029385
KMT2E lysine (K)-specific methyltransferase 2E 0.0290524
AKAP13 A kinase (PRKA) anchor protein 13 0.0285203
CADM1 cell adhesion molecule 1 0.0281286
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.028123
FN1 fibronectin 1 0.0280836
IQGAP1 IQ motif containing GTPase activating protein 1 0.0279188
PUM2 pumilio RNA-binding family member 2 0.0278287
ZEB1 zinc finger E-box binding homeobox 1 0.0278194
TPD52 tumor protein D52 0.0276149
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.02745
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0273542
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0264487
UBA6 ubiquitin-like modifier activating enzyme 6 0.0260026
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0256069
RSRC2 arginine/serine-rich coiled-coil 2 0.0253406
IPO7 importin 7 0.0253154
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0252394
TNS3 tensin 3 0.0248828
BRWD3 bromodomain and WD repeat domain containing 3 0.0248737
INSIG2 insulin induced gene 2 0.0247946
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0247524
RBM33 RNA binding motif protein 33 0.0247097
TRA2A transformer 2 alpha homolog (Drosophila) 0.0245459
APP amyloid beta (A4) precursor protein 0.024484
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.024271
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0242245
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0241177
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0240135
IRS2 insulin receptor substrate 2 0.0238911
RTN4 reticulon 4 0.0238398
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0238241
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0237239
CSDE1 cold shock domain containing E1, RNA-binding 0.0235402
ACTN4 actinin, alpha 4 0.023494
RAD51B RAD51 paralog B 0.0233867
TXNIP thioredoxin interacting protein 0.0232717
CCNY cyclin Y 0.0232366
NPEPPS aminopeptidase puromycin sensitive 0.0230635
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0227636
RBM25 RNA binding motif protein 25 0.0224289
USP9X ubiquitin specific peptidase 9, X-linked 0.0223484
USP53 ubiquitin specific peptidase 53 0.0222521
BTG1 B-cell translocation gene 1, anti-proliferative 0.0221874
SETD5 SET domain containing 5 0.0219729
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0219605
AFF4 AF4/FMR2 family, member 4 0.0213139
PRRC2C proline-rich coiled-coil 2C 0.0208676
EEF2 eukaryotic translation elongation factor 2 0.0207009
GLS2 glutaminase 2 (liver, mitochondrial) 0.0204882
PHF21A PHD finger protein 21A 0.0204458
PRRC1 proline-rich coiled-coil 1 0.0203905
TENT2 terminal nucleotidyltransferase 2 0.0202518
MATR3 matrin 3 0.0201861
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0201149
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0201135
USP3 ubiquitin specific peptidase 3 0.0200778
ANKRD17 ankyrin repeat domain 17 0.0199413
NAV2 neuron navigator 2 0.0196089
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 0.0195973
GRB10 growth factor receptor-bound protein 10 0.0194493
ANKRD11 ankyrin repeat domain 11 0.0193268

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.143196
MUC16 mucin 16, cell surface associated -0.0797142
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced -0.077614
TMSB10 thymosin beta 10 -0.0700366
TPT1 tumor protein, translationally-controlled 1 -0.0694195
POTEF POTE ankyrin domain family, member F -0.066289
AKAP12 A kinase (PRKA) anchor protein 12 -0.064856
SLC38A1 solute carrier family 38, member 1 -0.0600691
RPS16 ribosomal protein S16 -0.0586018
KRT17 keratin 17, type I -0.0537613
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0533089
FTL ferritin, light polypeptide -0.0528544
MT2A metallothionein 2A -0.0527763
RPLP0 ribosomal protein, large, P0 -0.0518252
IGFBP3 insulin-like growth factor binding protein 3 -0.0508328
S100A9 S100 calcium binding protein A9 -0.0506798
LMO7 LIM domain 7 -0.0501821
RPL35A ribosomal protein L35a -0.0499261
TPM4 tropomyosin 4 -0.0496742
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0490943
RPL37A ribosomal protein L37a -0.0486656
RPL15 ribosomal protein L15 -0.0485293
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0478342
RPS20 ribosomal protein S20 -0.0477367
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0471393
S100A6 S100 calcium binding protein A6 -0.0470826
RPL31 ribosomal protein L31 -0.0468272
ACTG1 actin gamma 1 -0.0462735
RPS12 ribosomal protein S12 -0.0448603
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0439385
RPS6 ribosomal protein S6 -0.0434116
RPS25 ribosomal protein S25 -0.043003
SVIL supervillin -0.0429496
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0415703
RPL12 ribosomal protein L12 -0.0409034
RPS19 ribosomal protein S19 -0.0402435
RPL28 ribosomal protein L28 -0.0394227
KATNBL1 katanin p80 subunit B-like 1 -0.0379543
ABHD17C abhydrolase domain containing 17C -0.0376549
CAPN2 calpain 2, (m/II) large subunit -0.0365425
STC1 stanniocalcin 1 -0.0365127
RAB7A RAB7A, member RAS oncogene family -0.0365012
RPS27A ribosomal protein S27a -0.0363344
DLG1 discs, large homolog 1 (Drosophila) -0.0359695
MYO1E myosin IE -0.0353763
RPS3 ribosomal protein S3 -0.0352589
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0351913
TM4SF1 transmembrane 4 L six family member 1 -0.0348495
RPL19 ribosomal protein L19 -0.0341773
BACE2 beta-site APP-cleaving enzyme 2 -0.0341634
TJP1 tight junction protein 1 -0.0341426
RBM47 RNA binding motif protein 47 -0.033233
IGF2 insulin-like growth factor 2 -0.0331883
RPL37 ribosomal protein L37 -0.0329975
ANXA2 annexin A2 -0.0322205
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0309624
CEMIP cell migration inducing protein, hyaluronan binding -0.0309162
CLIP1 CAP-GLY domain containing linker protein 1 -0.0306667
BCAR3 breast cancer anti-estrogen resistance 3 -0.030537
NABP1 nucleic acid binding protein 1 -0.0300771
NACA nascent polypeptide-associated complex alpha subunit -0.0300729
ERBIN erbb2 interacting protein -0.029765
RPL26 ribosomal protein L26 -0.0297292
RPS14 ribosomal protein S14 -0.0290069
RPS29 ribosomal protein S29 -0.0287204
DOCK4 dedicator of cytokinesis 4 -0.0286559
ATOSA atos homolog A -0.0285657
RPL23 ribosomal protein L23 -0.0285264
RPS8 ribosomal protein S8 -0.0284639
RPL36 ribosomal protein L36 -0.028423
CSTB cystatin B (stefin B) -0.0279055
HLA-B major histocompatibility complex, class I, B -0.0273387
LAMC2 laminin, gamma 2 -0.0271634
RPS5 ribosomal protein S5 -0.0269132
RPS24 ribosomal protein S24 -0.0265844
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0261073
TBC1D15 TBC1 domain family, member 15 -0.0259794
TMOD3 tropomodulin 3 (ubiquitous) -0.0254558
RPL11 ribosomal protein L11 -0.0246493
JMJD1C jumonji domain containing 1C -0.0241568
RPLP1 ribosomal protein, large, P1 -0.0237467
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0236614
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0235279
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0234959
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0234766
RPS17 ribosomal protein S17 -0.0232836
ANXA1 annexin A1 -0.0230043
RPLP2 ribosomal protein, large, P2 -0.0227879
MBD5 methyl-CpG binding domain protein 5 -0.0227819
ECE1 endothelin converting enzyme 1 -0.0225874
HDAC9 histone deacetylase 9 -0.0224764
EZR ezrin -0.0224387
WNK1 WNK lysine deficient protein kinase 1 -0.0219148
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0218374
RPS23 ribosomal protein S23 -0.0217727
RPS11 ribosomal protein S11 -0.0212746
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0208689
RPS13 ribosomal protein S13 -0.0203938
RACK1 receptor for activated C kinase 1 -0.0202107
RPS27 ribosomal protein S27 -0.0201096