Plicamycin_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Plicamycin perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Plicamycin_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ZNF395 zinc finger protein 395 0.0615139
PRELID2 PRELI domain containing 2 0.0580335
NAV2 neuron navigator 2 0.0554421
ERRFI1 ERBB receptor feedback inhibitor 1 0.0528217
PTK2 protein tyrosine kinase 2 0.0477271
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0461683
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.044753
EGFR epidermal growth factor receptor 0.0427278
METTL15 methyltransferase like 15 0.0424971
SDK1 sidekick cell adhesion molecule 1 0.0404989
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0397342
MYH9 myosin, heavy chain 9, non-muscle 0.0395492
RNF145 ring finger protein 145 0.0371605
TPM3 tropomyosin 3 0.0366468
FAM13A family with sequence similarity 13, member A 0.0365739
CALR calreticulin 0.0364206
DENND4C DENN/MADD domain containing 4C 0.0363911
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0354773
TTC3 tetratricopeptide repeat domain 3 0.0353319
PGK1 phosphoglycerate kinase 1 0.0348303
TNIP1 TNFAIP3 interacting protein 1 0.0343692
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0323421
FNDC3B fibronectin type III domain containing 3B 0.0319968
SKAP2 src kinase associated phosphoprotein 2 0.0314816
KDM6A lysine (K)-specific demethylase 6A 0.0310277
EXOC4 exocyst complex component 4 0.0307009
CUL3 cullin 3 0.0296883
MSN moesin 0.0293954
COL11A1 collagen, type XI, alpha 1 0.029241
ZMYND8 zinc finger, MYND-type containing 8 0.0287697
RPS18 ribosomal protein S18 0.0287613
HMGA1 high mobility group AT-hook 1 0.0287211
RPL3 ribosomal protein L3 0.0286667
BBX bobby sox homolog (Drosophila) 0.0282105
CYLD cylindromatosis (turban tumor syndrome) 0.0281261
BIRC3 baculoviral IAP repeat containing 3 0.028045
MCL1 myeloid cell leukemia 1 0.0279741
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0273267
ZMYM2 zinc finger, MYM-type 2 0.0267567
COL7A1 collagen, type VII, alpha 1 0.0267435
ANKRD11 ankyrin repeat domain 11 0.0263946
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0259986
PCBP2 poly(rC) binding protein 2 0.0256893
KDM4C lysine (K)-specific demethylase 4C 0.0252666
ADAM17 ADAM metallopeptidase domain 17 0.025092
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0249858
NCOA3 nuclear receptor coactivator 3 0.0248095
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0247302
TRIO trio Rho guanine nucleotide exchange factor 0.0247221
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0244356
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0244154
MYO10 myosin X 0.0241961
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0241635
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0241173
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0239179
RBM27 RNA binding motif protein 27 0.0237836
RSF1 remodeling and spacing factor 1 0.0233246
HYOU1 hypoxia up-regulated 1 0.023288
ZMIZ1 zinc finger, MIZ-type containing 1 0.0231944
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0231337
VEGFA vascular endothelial growth factor A 0.0221526
GOLGA2 golgin A2 0.0219741
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0217901
EEF2 eukaryotic translation elongation factor 2 0.0217424
AVL9 AVL9 homolog (S. cerevisiase) 0.0214365
CEMIP cell migration inducing protein, hyaluronan binding 0.0212908
JARID2 jumonji, AT rich interactive domain 2 0.0212679
RBM25 RNA binding motif protein 25 0.0211468
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0210012
SRPK2 SRSF protein kinase 2 0.0209874
NRXN3 neurexin 3 0.0208716
FRMD5 FERM domain containing 5 0.0208228
THOC2 THO complex 2 0.0208207
RPL21 ribosomal protein L21 0.0207608
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0206541
ICE2 interactor of little elongation complex ELL subunit 2 0.0206535
RASA3 RAS p21 protein activator 3 0.0205942
TENT2 terminal nucleotidyltransferase 2 0.02056
EFNA5 ephrin-A5 0.020484
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0203965
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.0202082
FAM219A family with sequence similarity 219, member A 0.0200781
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0200576
AMPD3 adenosine monophosphate deaminase 3 0.0200424
SMYD3 SET and MYND domain containing 3 0.0200101
SCAF8 SR-related CTD-associated factor 8 0.0198808
WDR41 WD repeat domain 41 0.019835
MYLK myosin light chain kinase 0.0197742
GPR107 G protein-coupled receptor 107 0.0196714
STC2 stanniocalcin 2 0.0196409
SRSF5 serine/arginine-rich splicing factor 5 0.0195394
PTBP2 polypyrimidine tract binding protein 2 0.0195112
SEPTIN9 septin 9 0.019388
JMJD1C jumonji domain containing 1C 0.0193185
ZBTB20 zinc finger and BTB domain containing 20 0.0192136
ATXN1 ataxin 1 0.0190637
FRMD6 FERM domain containing 6 0.0190125
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0189329
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial 0.0189317
BPTF bromodomain PHD finger transcription factor 0.0188421

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.379403
HLA-B major histocompatibility complex, class I, B -0.139478
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.133022
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.119073
IGFBP3 insulin-like growth factor binding protein 3 -0.100705
TMSB10 thymosin beta 10 -0.0820424
LOC112694756 uncharaterized LOC112694756 -0.0792138
B2M beta-2-microglobulin -0.0790669
COL1A1 collagen, type I, alpha 1 -0.0781772
FTL ferritin, light polypeptide -0.0760985
STC1 stanniocalcin 1 -0.075827
COL6A3 collagen, type VI, alpha 3 -0.0705346
COL6A2 collagen, type VI, alpha 2 -0.0702038
VIM vimentin -0.0658726
CAVIN1 caveolae associated protein 1 -0.0645088
COL1A2 collagen, type I, alpha 2 -0.0640422
LOX lysyl oxidase -0.0636858
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0633772
CCNI cyclin I -0.0617804
MT2A metallothionein 2A -0.0580141
HDLBP high density lipoprotein binding protein -0.0578226
ANXA2 annexin A2 -0.0550124
MAP1B microtubule-associated protein 1B -0.0533959
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0532666
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0530447
EIF1 eukaryotic translation initiation factor 1 -0.0523322
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0519055
SDC4 syndecan 4 -0.0503784
CALU calumenin -0.0502848
FUS FUS RNA binding protein -0.0502395
S100A10 S100 calcium binding protein A10 -0.0490719
PRSS23 protease, serine, 23 -0.0486765
UBC ubiquitin C -0.0456645
LOXL2 lysyl oxidase-like 2 -0.0453147
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0452658
SEC31A SEC31 homolog A (S. cerevisiae) -0.0448367
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0441967
HLA-A major histocompatibility complex, class I, A -0.0440694
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0439608
HLA-C major histocompatibility complex, class I, C -0.0438461
MT1X metallothionein 1X -0.043073
MYOF myoferlin -0.0430618
OGA O-GlcNAcase -0.0428835
PRRC1 proline-rich coiled-coil 1 -0.041955
PDE4D phosphodiesterase 4D, cAMP-specific -0.0417279
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0416895
PDIA3 protein disulfide isomerase family A, member 3 -0.041674
RTN4 reticulon 4 -0.0414291
CD44 CD44 molecule (Indian blood group) -0.041171
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0400661
LMAN1 lectin, mannose-binding, 1 -0.0396131
HM13 histocompatibility (minor) 13 -0.0394185
FTH1 ferritin, heavy polypeptide 1 -0.039082
TGFBI transforming growth factor, beta-induced, 68kDa -0.0386614
COG5 component of oligomeric golgi complex 5 -0.0384958
AHNAK AHNAK nucleoprotein -0.0383207
LIMS1 LIM and senescent cell antigen-like domains 1 -0.037774
DKK3 dickkopf WNT signaling pathway inhibitor 3 -0.0377357
PTMA prothymosin, alpha -0.0368771
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0368752
RLF rearranged L-myc fusion -0.0366001
RPL28 ribosomal protein L28 -0.0365164
MTPN myotrophin -0.0359981
RPLP1 ribosomal protein, large, P1 -0.0358221
MORF4L2 mortality factor 4 like 2 -0.035472
ARF1 ADP-ribosylation factor 1 -0.0352834
SLC38A2 solute carrier family 38, member 2 -0.0346008
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0344616
ANKRD17 ankyrin repeat domain 17 -0.0343427
KLHDC10 kelch domain containing 10 -0.0340239
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0338248
GLIS3 GLIS family zinc finger 3 -0.0337069
ZNF207 zinc finger protein 207 -0.03366
DPYD dihydropyrimidine dehydrogenase -0.0335349
TXNIP thioredoxin interacting protein -0.0335149
NALF1 NALCN channel auxiliary factor 1 -0.0330765
SAR1A secretion associated, Ras related GTPase 1A -0.0328667
DDIT4 DNA-damage-inducible transcript 4 -0.0324973
IGFBP7 insulin-like growth factor binding protein 7 -0.0324858
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0324797
CAV1 caveolin 1, caveolae protein, 22kDa -0.0321738
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0321368
RHEB Ras homolog enriched in brain -0.0318928
CD99 CD99 molecule -0.0314097
ELL2 elongation factor, RNA polymerase II, 2 -0.0307695
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0304773
THY1 Thy-1 cell surface antigen -0.0304602
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0299882
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0299414
ITM2B integral membrane protein 2B -0.0298822
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.029759
RND3 Rho family GTPase 3 -0.0295037
RAB10 RAB10, member RAS oncogene family -0.0293516
AHR aryl hydrocarbon receptor -0.0289507
SOD2 superoxide dismutase 2, mitochondrial -0.0289329
AKAP13 A kinase (PRKA) anchor protein 13 -0.0289292
NABP1 nucleic acid binding protein 1 -0.0286734
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0285845
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0284648
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0278529