Poliomyelitis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A viral infectious disease that results_in destruction located_in motor neurons, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom vomiting, has_symptom fatigue, has_symptom neck stiffness, has_symptom muscle spasms, and has_symptom acute flaccid paralysis. (Human Disease Ontology, DOID_4953)
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Genes

238 genes co-occuring with the disease Poliomyelitis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
PVR poliovirus receptor 3.066
CD4 CD4 molecule 2.264
PI4KB phosphatidylinositol 4-kinase, catalytic, beta 2.239
CD8A CD8a molecule 2.225
IFNG interferon, gamma 2.12
ACE2 angiotensin I converting enzyme 2 2.077
ACBD3 acyl-CoA binding domain containing 3 2.031
IFNA1 interferon, alpha 1 2.02
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 2.0
TNF tumor necrosis factor 1.992
IFNB1 interferon, beta 1, fibroblast 1.96
IL6 interleukin 6 1.959
ERVW-1 endogenous retrovirus group W, member 1 1.928
TLR3 toll-like receptor 3 1.927
IL10 interleukin 10 1.894
IL2 interleukin 2 1.883
IFIH1 interferon induced with helicase C domain 1 1.879
IL1B interleukin 1, beta 1.855
ALB albumin 1.819
CRP C-reactive protein, pentraxin-related 1.786
IL4 interleukin 4 1.783
IRF3 interferon regulatory factor 3 1.763
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.755
CKB creatine kinase, brain 1.755
CKMT1B creatine kinase, mitochondrial 1B 1.754
CKM creatine kinase, muscle 1.754
MAVS mitochondrial antiviral signaling protein 1.749
PCBP2 poly(rC) binding protein 2 1.733
OTOL1 otolin 1 1.711
SELPLG selectin P ligand 1.709
TLR7 toll-like receptor 7 1.707
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 1.701
MFSD6 major facilitator superfamily domain containing 6 1.694
IFNAR1 interferon (alpha, beta and omega) receptor 1 1.69
OSBP oxysterol binding protein 1.67
NECTIN1 nectin cell adhesion molecule 1 1.66
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 1.658
CXCL10 chemokine (C-X-C motif) ligand 10 1.64
ERVFRD-1 endogenous retrovirus group FRD, member 1 1.63
ERV3-1 endogenous retrovirus group 3, member 1 1.63
MOG myelin oligodendrocyte glycoprotein 1.626
OC90 otoconin 90 1.625
TLR9 toll-like receptor 9 1.619
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 1.617
CXADR coxsackie virus and adenovirus receptor 1.607
C4A complement component 4A (Rodgers blood group) 1.6
IRF7 interferon regulatory factor 7 1.598
IFNA2 interferon, alpha 2 1.592
SH2D3A SH2 domain containing 3A 1.585
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 1.582
TLR4 toll-like receptor 4 1.58
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 1.566
PRSS57 protease, serine, 57 1.563
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 1.563
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.561
IL17A interleukin 17A 1.554
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 1.552
FIMP1 fertilization-influencing membrane protein 1 1.546
TMPRSS2 transmembrane protease, serine 2 1.534
TLR8 toll-like receptor 8 1.532
BMP8A bone morphogenetic protein 8a 1.525
CCL2 chemokine (C-C motif) ligand 2 1.518
ICAM5 intercellular adhesion molecule 5, telencephalin 1.493
IFNA4 interferon, alpha 4 1.488
ICAM1 intercellular adhesion molecule 1 1.483
IFNA14 interferon, alpha 14 1.475
IFNA6 interferon, alpha 6 1.475
IFNA5 interferon, alpha 5 1.474
IL5 interleukin 5 1.469
IFNA16 interferon, alpha 16 1.467
IFNA8 interferon, alpha 8 1.466
IFNA7 interferon, alpha 7 1.466
IFNA17 interferon, alpha 17 1.465
IFNA13 interferon, alpha 13 1.463
SH2D3C SH2 domain containing 3C 1.462
EIF4A2 eukaryotic translation initiation factor 4A2 1.461
IFNA21 interferon, alpha 21 1.457
IFNA10 interferon, alpha 10 1.457
CXCL8 chemokine (C-X-C motif) ligand 8 1.452
SCARB2 scavenger receptor class B, member 2 1.45
CD19 CD19 molecule 1.448
EIF4A1 eukaryotic translation initiation factor 4A1 1.445
TARDBP TAR DNA binding protein 1.444
NTSR1 neurotensin receptor 1 (high affinity) 1.444
IL1A interleukin 1, alpha 1.442
FURIN furin (paired basic amino acid cleaving enzyme) 1.441
CCL5 chemokine (C-C motif) ligand 5 1.439
C9ORF72 chromosome 9 open reading frame 72 1.429
CD209 CD209 molecule 1.428
IL13 interleukin 13 1.408
BMP8B bone morphogenetic protein 8b 1.406
NUP153 nucleoporin 153kDa 1.405
NKRF NFKB repressing factor 1.402
CD40 CD40 molecule, TNF receptor superfamily member 5 1.402
GOLPH3 golgi phosphoprotein 3 (coat-protein) 1.401
INS insulin 1.395
CD46 CD46 molecule, complement regulatory protein 1.393
DYNLT1 dynein, light chain, Tctex-type 1 1.391
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa 1.39
MBP myelin basic protein 1.386
CCL3 chemokine (C-C motif) ligand 3 1.384
ARF1 ADP-ribosylation factor 1 1.381
NUP62 nucleoporin 62kDa 1.373
CSDE1 cold shock domain containing E1, RNA-binding 1.37
ACE angiotensin I converting enzyme 1.367
STAT1 signal transducer and activator of transcription 1, 91kDa 1.367
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 1.347
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 1.342
PABPC1 poly(A) binding protein, cytoplasmic 1 1.341
TBK1 TANK-binding kinase 1 1.336
TLR5 toll-like receptor 5 1.322
GYPC glycophorin C (Gerbich blood group) 1.317
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 1.316
CD40LG CD40 ligand 1.316
IL15 interleukin 15 1.311
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 1.308
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.307
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 1.307
PXDNL peroxidasin-like 1.306
PXDN peroxidasin 1.298
TLR2 toll-like receptor 2 1.294
CD80 CD80 molecule 1.291
ANXA2 annexin A2 1.29
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 1.282
FCGRT Fc fragment of IgG, receptor, transporter, alpha 1.276
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha 1.271
MYD88 myeloid differentiation primary response 88 1.267
TSPAN4 tetraspanin 4 1.266
IRF9 interferon regulatory factor 9 1.263
IL7 interleukin 7 1.253
MAP1LC3B2 microtubule-associated protein 1 light chain 3 beta 2 1.251
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.245
BTK Bruton agammaglobulinemia tyrosine kinase 1.244
SOD1 superoxide dismutase 1, soluble 1.24
MYOM2 myomesin 2 1.238
IL18 interleukin 18 1.237
EIF4B eukaryotic translation initiation factor 4B 1.235
SMN1 survival of motor neuron 1, telomeric 1.232
TK2 thymidine kinase 2, mitochondrial 1.228
PAM peptidylglycine alpha-amidating monooxygenase 1.227
CA13 carbonic anhydrase XIII 1.225
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 1.218
SMN2 survival of motor neuron 2, centromeric 1.217
ACTB actin, beta 1.211
PCBP1 poly(rC) binding protein 1 1.21
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 1.21
CARD16 caspase recruitment domain family, member 16 1.201
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.198
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.198
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 1.19
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 1.189
SRSF3 serine/arginine-rich splicing factor 3 1.188
MX1 MX dynamin-like GTPase 1 1.187
TGFB1 transforming growth factor, beta 1 1.179
CA10 carbonic anhydrase X 1.17
JUN jun proto-oncogene 1.167
CD86 CD86 molecule 1.164
TP53 tumor protein p53 1.162
IFNK interferon, kappa 1.162
FOXP3 forkhead box P3 1.159
CCL4 chemokine (C-C motif) ligand 4 1.157
OTOP1 otopetrin 1 1.157
CSF3 colony stimulating factor 3 (granulocyte) 1.157
LTF lactotransferrin 1.155
HNRNPK heterogeneous nuclear ribonucleoprotein K 1.154
TAC1 tachykinin, precursor 1 1.152
EIF4E eukaryotic translation initiation factor 4E 1.152
ARMH3 armadillo like helical domain containing 3 1.147
POMC proopiomelanocortin 1.142
MAP6 microtubule-associated protein 6 1.138
MMP11 matrix metallopeptidase 11 1.136
NUP98 nucleoporin 98kDa 1.129
FUT2 fucosyltransferase 2 (secretor status included) 1.129
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 1.127
RAG1 recombination activating gene 1 1.122
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 1.117
IGF1 insulin-like growth factor 1 (somatomedin C) 1.116
EXOSC4 exosome component 4 1.116
BDNF brain-derived neurotrophic factor 1.115
CTRL chymotrypsin-like 1.111
PF4 platelet factor 4 1.111
CD27 CD27 molecule 1.109
FUS FUS RNA binding protein 1.106
IL22 interleukin 22 1.105
ALS2 amyotrophic lateral sclerosis 2 (juvenile) 1.102
DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 1.099
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 1.098
SLAMF1 signaling lymphocytic activation molecule family member 1 1.098
PRF1 perforin 1 (pore forming protein) 1.097
KREMEN1 kringle containing transmembrane protein 1 1.097
DMD dystrophin 1.088
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.088
IFNL1 interferon, lambda 1 1.086
KLK6 kallikrein-related peptidase 6 1.085
ILF3 interleukin enhancer binding factor 3, 90kDa 1.08
CXCL9 chemokine (C-X-C motif) ligand 9 1.076
COCH cochlin 1.075
PNMA2 paraneoplastic Ma antigen 2 1.073
PITPNB phosphatidylinositol transfer protein, beta 1.072
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 1.065
PIGR polymeric immunoglobulin receptor 1.064
OTOGL otogelin-like 1.057
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 1.055
ACHE acetylcholinesterase (Yt blood group) 1.055
SNAP29 synaptosomal-associated protein, 29kDa 1.052
TIA1 TIA1 cytotoxic granule-associated RNA binding protein 1.052
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 1.051
NOD2 nucleotide-binding oligomerization domain containing 2 1.048
NGF nerve growth factor (beta polypeptide) 1.046
NUCLEOLIN nucleolin multifunctional protein 1.042
BCHE butyrylcholinesterase 1.041
CCR7 chemokine (C-C motif) receptor 7 1.036
MUSK muscle, skeletal, receptor tyrosine kinase 1.036
NLRP3 NLR family, pyrin domain containing 3 1.036
RSAD2 radical S-adenosyl methionine domain containing 2 1.034
HCRT hypocretin (orexin) neuropeptide precursor 1.034
STAT2 signal transducer and activator of transcription 2, 113kDa 1.03
CDHR3 cadherin-related family member 3 1.028
CA6 carbonic anhydrase VI 1.026
VCP valosin containing protein 1.026
ATG4A autophagy related 4A, cysteine peptidase 1.022
CXCR3 chemokine (C-X-C motif) receptor 3 1.018
SETD3 SET domain containing 3 1.017
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.014
ENPEP glutamyl aminopeptidase (aminopeptidase A) 1.014
PLAAT3 phospholipase A and acyltransferase 3 1.012
CTSL cathepsin L 1.011
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 1.011
PTPRC protein tyrosine phosphatase, receptor type, C 1.009
RABIF RAB interacting factor 1.009
ATAD1 ATPase family, AAA domain containing 1 1.007
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 1.005
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.004
EPYC epiphycan 1.003
CD69 CD69 molecule 1.003
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 1.002
CLEC4M C-type lectin domain family 4, member M 1.0
CA5A carbonic anhydrase VA, mitochondrial 1.0