Polyhydramnios Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A placenta disease that is characterized by an excess of amniotic fluid in the amniotic sac. (Human Disease Ontology, DOID_8488)
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Genes

379 genes co-occuring with the disease Polyhydramnios in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 2.974
CLCNKB chloride channel, voltage-sensitive Kb 2.926
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 2.906
BSND barttin CLCNK-type chloride channel accessory beta subunit 2.902
MAGED2 melanoma antigen family D2 2.723
OXT oxytocin/neurophysin I prepropeptide 2.535
CLCNKA chloride channel, voltage-sensitive Ka 2.53
SLC26A3 solute carrier family 26 (anion exchanger), member 3 2.431
AFP alpha-fetoprotein 2.357
RTL1 retrotransposon-like 1 2.302
INS insulin 2.28
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 2.255
TSEN54 TSEN54 tRNA splicing endonuclease subunit 2.248
SHOC2 soc-2 suppressor of clear homolog (C. elegans) 2.152
REN renin 2.115
SOS1 son of sevenless homolog 1 (Drosophila) 2.114
WDR20 WD repeat domain 20 2.114
PAPPA pregnancy-associated plasma protein A, pappalysin 1 2.109
DIS3L2 DIS3 like 3'-5' exoribonuclease 2 2.103
STRADA STE20-related kinase adaptor alpha 2.094
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 2.085
PTPN11 protein tyrosine phosphatase, non-receptor type 11 2.055
MTM1 myotubularin 1 2.055
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 2.032
KLHL40 kelch-like family member 40 2.011
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 1.993
CASR calcium-sensing receptor 1.978
TSEN34 TSEN34 tRNA splicing endonuclease subunit 1.952
CSH2 chorionic somatomammotropin hormone 2 1.926
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 1.926
DLK1 delta-like 1 homolog (Drosophila) 1.916
DMPK dystrophia myotonica-protein kinase 1.904
LZTR1 leucine-zipper-like transcription regulator 1 1.882
LMOD3 leiomodin 3 (fetal) 1.878
AQP9 aquaporin 9 1.877
TSEN2 TSEN2 tRNA splicing endonuclease subunit 1.853
IGF2 insulin-like growth factor 2 1.851
AQP8 aquaporin 8 1.849
GBE1 glucan (1,4-alpha-), branching enzyme 1 1.83
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 1.813
AQP2 aquaporin 2 (collecting duct) 1.81
MAGEL2 melanoma antigen family L2 1.809
HRAS Harvey rat sarcoma viral oncogene homolog 1.807
CHD7 chromodomain helicase DNA binding protein 7 1.804
MAP2K2 mitogen-activated protein kinase kinase 2 1.776
UROD uroporphyrinogen decarboxylase 1.76
CNTNAP1 contactin associated protein 1 1.744
MAP2K1 mitogen-activated protein kinase kinase 1 1.721
RYR1 ryanodine receptor 1 (skeletal) 1.713
MYO5B myosin VB 1.712
ALB albumin 1.68
SCN4A sodium channel, voltage gated, type IV alpha subunit 1.678
DEPDC5 DEP domain containing 5 1.676
GPC3 glypican 3 1.67
FGR FGR proto-oncogene, Src family tyrosine kinase 1.663
TNNT3 troponin T type 3 (skeletal, fast) 1.659
AQP7 aquaporin 7 1.655
GLDN gliomedin 1.655
AQP3 aquaporin 3 (Gill blood group) 1.653
ERAS ES cell expressed Ras 1.648
PIGV phosphatidylinositol glycan anchor biosynthesis, class V 1.644
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 1.638
FGFR3 fibroblast growth factor receptor 3 1.632
VRK1 vaccinia related kinase 1 1.629
PIGW phosphatidylinositol glycan anchor biosynthesis, class W 1.626
GUCY2C guanylate cyclase 2C 1.624
PRL prolactin 1.621
MUSK muscle, skeletal, receptor tyrosine kinase 1.619
AVPR2 arginine vasopressin receptor 2 1.614
TPM2 tropomyosin 2 (beta) 1.604
TTC7A tetratricopeptide repeat domain 7A 1.592
KLHL41 kelch-like family member 41 1.591
SOS2 son of sevenless homolog 2 (Drosophila) 1.583
SPINT2 serine peptidase inhibitor, Kunitz type, 2 1.578
CKM creatine kinase, muscle 1.577
PTH parathyroid hormone 1.568
RTL5 retrotransposon Gag like 5 1.568
ACTA1 actin, alpha 1, skeletal muscle 1.565
NEB nebulin 1.564
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.562
CKMT1B creatine kinase, mitochondrial 1B 1.561
RARS2 arginyl-tRNA synthetase 2, mitochondrial 1.56
CKB creatine kinase, brain 1.558
PIGL phosphatidylinositol glycan anchor biosynthesis, class L 1.556
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 1.549
PLAGL1 pleiomorphic adenoma gene-like 1 1.545
DOK7 docking protein 7 1.542
SCNN1G sodium channel, non voltage gated 1 gamma subunit 1.541
NSD1 nuclear receptor binding SET domain protein 1 1.541
EXOSC3 exosome component 3 1.533
A2ML1 alpha-2-macroglobulin-like 1 1.527
DIO3 deiodinase, iodothyronine, type III 1.524
CLDN16 claudin 16 1.521
TGM1 transglutaminase 1 1.521
OXTR oxytocin receptor 1.518
CHMP1A charged multivesicular body protein 1A 1.513
SMN2 survival of motor neuron 2, centromeric 1.509
AQP1 aquaporin 1 (Colton blood group) 1.508
COL2A1 collagen, type II, alpha 1 1.503
CLDN19 claudin 19 1.5
OOEP oocyte expressed protein 1.496
PGF placental growth factor 1.482
STX3 syntaxin 3 1.48
SMN1 survival of motor neuron 1, telomeric 1.477
CHRND cholinergic receptor, nicotinic, delta (muscle) 1.475
TBX1 T-box 1 1.475
KBTBD13 kelch repeat and BTB (POZ) domain containing 13 1.473
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 1.472
TTN titin 1.469
PIGO phosphatidylinositol glycan anchor biosynthesis, class O 1.469
WDR25 WD repeat domain 25 1.468
BRAF B-Raf proto-oncogene, serine/threonine kinase 1.468
RAPSN receptor-associated protein of the synapse 1.467
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 1.463
AVP arginine vasopressin 1.458
SNRPN small nuclear ribonucleoprotein polypeptide N 1.454
PIGT phosphatidylinositol glycan anchor biosynthesis, class T 1.44
KMT2D lysine (K)-specific methyltransferase 2D 1.44
POMC proopiomelanocortin 1.438
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 1.438
TRPM6 transient receptor potential cation channel, subfamily M, member 6 1.433
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.429
KRAS Kirsten rat sarcoma viral oncogene homolog 1.424
ZMPSTE24 zinc metallopeptidase STE24 1.423
NLRP2 NLR family, pyrin domain containing 2 1.422
AQP11 aquaporin 11 1.418
PIGY phosphatidylinositol glycan anchor biosynthesis, class Y 1.418
PHOX2B paired-like homeobox 2b 1.416
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 1.411
ZBTB42 zinc finger and BTB domain containing 42 1.41
TLE6 transducin-like enhancer of split 6 1.409
ZFP57 ZFP57 zinc finger protein 1.409
BICD2 bicaudal D homolog 2 (Drosophila) 1.405
GLE1 GLE1 RNA export mediator 1.405
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 1.398
CRP C-reactive protein, pentraxin-related 1.397
PIGN phosphatidylinositol glycan anchor biosynthesis, class N 1.394
EFTUD2 elongation factor Tu GTP binding domain containing 2 1.39
SHH sonic hedgehog 1.385
TNNT1 troponin T type 1 (skeletal, slow) 1.383
SLC36A3 solute carrier family 36, member 3 1.383
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 1.38
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.375
IGF1 insulin-like growth factor 1 (somatomedin C) 1.369
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 1.368
SMAD9 SMAD family member 9 1.368
DNM2 dynamin 2 1.361
KHDC3L KH domain containing 3-like, subcortical maternal complex member 1.359
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 1.353
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 1.348
TSC2 tuberous sclerosis 2 1.345
RTL6 retrotransposon Gag like 6 1.34
NLRP7 NLR family, pyrin domain containing 7 1.34
NPPA natriuretic peptide A 1.339
TMEM11 transmembrane protein 11 1.339
CNBP CCHC-type zinc finger, nucleic acid binding protein 1.338
ALG12 ALG12, alpha-1,6-mannosyltransferase 1.329
FAM131C family with sequence similarity 131, member C 1.325
NLRP5 NLR family, pyrin domain containing 5 1.321
MEST mesoderm specific transcript 1.317
PGAP2 post-GPI attachment to proteins 2 1.304
POMT2 protein-O-mannosyltransferase 2 1.304
MYBPC1 myosin binding protein C, slow type 1.304
OCRL oculocerebrorenal syndrome of Lowe 1.304
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 1.303
LEP leptin 1.302
IGHMBP2 immunoglobulin mu binding protein 2 1.299
TPM3 tropomyosin 3 1.298
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 1.295
PGAP3 post-GPI attachment to proteins 3 1.294
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 1.292
ASCC1 activating signal cointegrator 1 complex subunit 1 1.289
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic 1.289
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q 1.288
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 1.284
RRAS related RAS viral (r-ras) oncogene homolog 1.278
PAGR1 PAXIP1 associated glutamate-rich protein 1 1.275
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 1.27
RTL9 retrotransposon Gag like 9 1.267
SELENON selenoprotein N 1.265
FOXF1 forkhead box F1 1.262
TMEM94 transmembrane protein 94 1.26
LHCGR luteinizing hormone/choriogonadotropin receptor 1.26
POF1B premature ovarian failure, 1B 1.259
BRWD3 bromodomain and WD repeat domain containing 3 1.258
PSG6 pregnancy specific beta-1-glycoprotein 6 1.257
ADGRG6 adhesion G protein-coupled receptor G6 1.257
DNAH8 dynein, axonemal, heavy chain 8 1.253
IL6 interleukin 6 1.248
CBLL2 Cbl proto-oncogene like 2 1.247
ACE angiotensin I converting enzyme 1.246
MRAS muscle RAS oncogene homolog 1.242
MKRN3 makorin ring finger protein 3 1.24
PIGM phosphatidylinositol glycan anchor biosynthesis, class M 1.239
PIGA phosphatidylinositol glycan anchor biosynthesis, class A 1.238
L1CAM L1 cell adhesion molecule 1.236
NDN necdin, melanoma antigen (MAGE) family member 1.235
NPAP1 nuclear pore associated protein 1 1.234
SYNGAP1 synaptic Ras GTPase activating protein 1 1.232
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 1.232
IFT80 intraflagellar transport 80 1.23
TRIP4 thyroid hormone receptor interactor 4 1.228
PSG3 pregnancy specific beta-1-glycoprotein 3 1.228
CLCN5 chloride channel, voltage-sensitive 5 1.227
FRAS1 Fraser extracellular matrix complex subunit 1 1.224
STXBP2 syntaxin binding protein 2 1.224
IGF2R insulin-like growth factor 2 receptor 1.221
RASA1 RAS p21 protein activator (GTPase activating protein) 1 1.216
TBX22 T-box 22 1.215
ZNF597 zinc finger protein 597 1.213
SLC26A2 solute carrier family 26 (anion exchanger), member 2 1.212
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16 1.208
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 1.206
ZDHHC15 zinc finger, DHHC-type containing 15 1.206
ZDBF2 zinc finger, DBF-type containing 2 1.206
HIRA histone cell cycle regulator 1.201
NFASC neurofascin 1.2
ACTG2 actin, gamma 2, smooth muscle, enteric 1.2
SHOX short stature homeobox 1.197
FLNA filamin A, alpha 1.195
COL1A2 collagen, type I, alpha 2 1.192
PMM2 phosphomannomutase 2 1.192
ACHE acetylcholinesterase (Yt blood group) 1.191
TCOF1 Treacher Collins-Franceschetti syndrome 1 1.191
TNF tumor necrosis factor 1.19
EPO erythropoietin 1.186
INSR insulin receptor 1.183
PSG4 pregnancy specific beta-1-glycoprotein 4 1.18
NF1 neurofibromin 1 1.18
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 1.177
PIEZO1 piezo-type mechanosensitive ion channel component 1 1.175
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1 1.174
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) 1.173
FREM2 FRAS1 related extracellular matrix protein 2 1.172
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.172
GP1BB glycoprotein Ib (platelet), beta polypeptide 1.171
HNF1B HNF1 homeobox B 1.17
CRTAP cartilage associated protein 1.169
PSG11 pregnancy specific beta-1-glycoprotein 11 1.168
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 1.165
MYBPC2 myosin binding protein C, fast type 1.165
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 1.164
FN1 fibronectin 1 1.163
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 1.163
MTMR14 myotubularin related protein 14 1.163
AGRN agrin 1.162
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 1.162
FKRP fukutin related protein 1.161
ALPL alkaline phosphatase, liver/bone/kidney 1.157
NEXMIF neurite extension and migration factor 1.156
RHD Rh blood group, D antigen 1.151
ATAD3C ATPase family, AAA domain containing 3C 1.149
F2 coagulation factor II (thrombin) 1.146
FLT1 fms-related tyrosine kinase 1 1.146
CXCL8 chemokine (C-X-C motif) ligand 8 1.145
ANKRD11 ankyrin repeat domain 11 1.14
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 1.136
SNAP29 synaptosomal-associated protein, 29kDa 1.136
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.135
NIPBL Nipped-B homolog (Drosophila) 1.135
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma 1.135
CLCN1 chloride channel, voltage-sensitive 1 1.133
SPRED1 sprouty-related, EVH1 domain containing 1 1.132
PSG8 pregnancy specific beta-1-glycoprotein 8 1.131
PSG9 pregnancy specific beta-1-glycoprotein 9 1.13
ECEL1 endothelin converting enzyme-like 1 1.13
CD34 CD34 molecule 1.129
FLNB filamin B, beta 1.128
FGF8 fibroblast growth factor 8 (androgen-induced) 1.128
TRIP11 thyroid hormone receptor interactor 11 1.127
PIGP phosphatidylinositol glycan anchor biosynthesis, class P 1.126
TOE1 target of EGR1, member 1 (nuclear) 1.126
PSG7 pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene) 1.125
CAB39 calcium binding protein 39 1.124
FREM1 FRAS1 related extracellular matrix 1 1.123
GJA1 gap junction protein, alpha 1, 43kDa 1.12
ITGB4 integrin, beta 4 1.119
MYPN myopalladin 1.119
SLC26A4 solute carrier family 26 (anion exchanger), member 4 1.119
EYA1 EYA transcriptional coactivator and phosphatase 1 1.119
PLEC plectin 1.116
ARSL arylsulfatase L 1.116
SCARF2 scavenger receptor class F, member 2 1.115
TSEN15 TSEN15 tRNA splicing endonuclease subunit 1.114
AKT3 v-akt murine thymoma viral oncogene homolog 3 1.111
KCNJ18 potassium channel, inwardly rectifying subfamily J, member 18 1.108
THOC6 THO complex 6 1.107
PADI6 peptidyl arginine deiminase, type VI 1.106
GCG glucagon 1.104
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha 1.102
F3 coagulation factor III (thromboplastin, tissue factor) 1.099
IGFBP1 insulin-like growth factor binding protein 1 1.097
UBE3A ubiquitin protein ligase E3A 1.097
LGALS1 lectin, galactoside-binding, soluble, 1 1.096
SRY sex determining region Y 1.095
UNC45A unc-45 homolog A (C. elegans) 1.095
LGALS13 lectin, galactoside-binding, soluble, 13 1.093
WT1 Wilms tumor 1 1.093
TUBGCP5 tubulin, gamma complex associated protein 5 1.093
GPC4 glypican 4 1.092
ENO2 enolase 2 (gamma, neuronal) 1.091
CTCF CCCTC-binding factor (zinc finger protein) 1.09
SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like 1.09
IGFBP3 insulin-like growth factor binding protein 3 1.089
STAC3 SH3 and cysteine rich domain 3 1.088
PAX6 paired box 6 1.087
MIP major intrinsic protein of lens fiber 1.087
EVC2 Ellis van Creveld syndrome 2 1.087
NIPA2 non imprinted in Prader-Willi/Angelman syndrome 2 1.087
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 1.086
PSG2 pregnancy specific beta-1-glycoprotein 2 1.086
COL1A1 collagen, type I, alpha 1 1.084
PLEK2 pleckstrin 2 1.083
POMT1 protein-O-mannosyltransferase 1 1.083
GNAS GNAS complex locus 1.083
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 1.082
RRAS2 related RAS viral (r-ras) oncogene homolog 2 1.081
TRIM8 tripartite motif containing 8 1.08
TBC1D32 TBC1 domain family, member 32 1.078
STK24 serine/threonine kinase 24 1.078
PSG1 pregnancy specific beta-1-glycoprotein 1 1.078
DGCR6L DiGeorge syndrome critical region gene 6-like 1.077
MYH14 myosin, heavy chain 14, non-muscle 1.075
PLEK pleckstrin 1.075
NEK9 NIMA-related kinase 9 1.074
TNNI2 troponin I type 2 (skeletal, fast) 1.07
P3H1 prolyl 3-hydroxylase 1 1.068
FBXL4 F-box and leucine-rich repeat protein 4 1.068
SRD5A3 steroid 5 alpha-reductase 3 1.067
ZNF711 zinc finger protein 711 1.067
PKD1 polycystic kidney disease 1 (autosomal dominant) 1.065
RTL4 retrotransposon Gag like 4 1.064
KDM6A lysine (K)-specific demethylase 6A 1.063
RELN reelin 1.062
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 1.06
PIGC phosphatidylinositol glycan anchor biosynthesis, class C 1.059
IL1B interleukin 1, beta 1.058
AMH anti-Mullerian hormone 1.058
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.057
DUOXA2 dual oxidase maturation factor 2 1.052
WNK3 WNK lysine deficient protein kinase 3 1.049
CAPN11 calpain 11 1.046
NUB1 negative regulator of ubiquitin-like proteins 1 1.046
AP2S1 adaptor-related protein complex 2, sigma 1 subunit 1.043
DMD dystrophin 1.042
PIEZO2 piezo-type mechanosensitive ion channel component 2 1.04
ZNF699 zinc finger protein 699 1.039
KAT6B K(lysine) acetyltransferase 6B 1.038
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 1.038
PIGG phosphatidylinositol glycan anchor biosynthesis, class G 1.038
ZPR1 ZPR1 zinc finger 1.037
FKTN fukutin 1.036
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 1.035
CHST14 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 1.033
CRH corticotropin releasing hormone 1.032
YIPF7 Yip1 domain family, member 7 1.028
FOXC2 forkhead box C2 1.027
ADIPOQ adiponectin, C1Q and collagen domain containing 1.023
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae) 1.021
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter) 1.02
SCNN1A sodium channel, non voltage gated 1 alpha subunit 1.018
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 1.018
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 1.013
WDR81 WD repeat domain 81 1.011
KCNT1 potassium channel, sodium activated subfamily T, member 1 1.011
ALG3 ALG3, alpha-1,3- mannosyltransferase 1.011
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 1.01
KCNK2 potassium channel, two pore domain subfamily K, member 2 1.008
ZIC3 Zic family member 3 1.007
FBN1 fibrillin 1 1.007
MECP2 methyl CpG binding protein 2 1.006
SMC1A structural maintenance of chromosomes 1A 1.004
PKD1L1 polycystic kidney disease 1 like 1 1.003
PHKG1 phosphorylase kinase, gamma 1 (muscle) 1.002
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.002
TRPV5 transient receptor potential cation channel, subfamily V, member 5 1.002
ZAR1 zygote arrest 1 1.0
BEGAIN brain-enriched guanylate kinase-associated 1.0
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.0