| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | An aromatic amine that is thalidomide substituted at position 4 on the isoindole ring system by an amino group. Used for the treatment of multiple myeloma in patients who failed to respond to previous therapies. (Chemical Entities of Biological Interest Ontology, CHEBI_72690) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/134780 |
| Similar Terms | |
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199 proteins with high or low expression in Pomalidomide relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KIAA0825 | KIAA0825 | 1.2 |
| CKM | creatine kinase, muscle | 0.99 |
| RNF4 | ring finger protein 4 | 0.86 |
| LMBRD1 | LMBR1 domain containing 1 | 0.82 |
| ZNF263 | zinc finger protein 263 | 0.73 |
| ADCY10 | adenylate cyclase 10 (soluble) | 0.71 |
| ITGAM | integrin, alpha M (complement component 3 receptor 3 subunit) | 0.67 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.66 |
| BCOR | BCL6 corepressor | 0.61 |
| SPCS1 | signal peptidase complex subunit 1 homolog (S. cerevisiae) | 0.61 |
| TPST2 | tyrosylprotein sulfotransferase 2 | 0.58 |
| WDR20 | WD repeat domain 20 | 0.57 |
| RGN | regucalcin | 0.56 |
| TM7SF2 | transmembrane 7 superfamily member 2 | 0.55 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | 0.48 |
| LMOD1 | leiomodin 1 (smooth muscle) | 0.47 |
| ZHX1 | zinc fingers and homeoboxes 1 | 0.46 |
| FAM8A1 | family with sequence similarity 8, member A1 | 0.45 |
| BTBD11 | BTB (POZ) domain containing 11 | 0.42 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.41 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.41 |
| DNAJC22 | DnaJ (Hsp40) homolog, subfamily C, member 22 | 0.4 |
| ONECUT3 | one cut homeobox 3 | 0.4 |
| METTL22 | methyltransferase like 22 | 0.4 |
| PRR36 | proline rich 36 | 0.39 |
| C6ORF136 | chromosome 6 open reading frame 136 | 0.38 |
| TPM1 | tropomyosin 1 (alpha) | 0.38 |
| THAP11 | THAP domain containing 11 | 0.38 |
| SEMA6B | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B | 0.37 |
| TIGD5 | tigger transposable element derived 5 | 0.37 |
| TMEM160 | transmembrane protein 160 | 0.36 |
| MDM4 | MDM4, p53 regulator | 0.35 |
| DOP1A | DOP1 leucine zipper like protein A | 0.35 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) | 0.34 |
| CLN3 | ceroid-lipofuscinosis, neuronal 3 | 0.34 |
| XBP1 | X-box binding protein 1 | 0.34 |
| ZG16B | zymogen granule protein 16B | 0.33 |
| NMNAT3 | nicotinamide nucleotide adenylyltransferase 3 | 0.33 |
| LPIN3 | lipin 3 | 0.33 |
| SPTBN5 | spectrin, beta, non-erythrocytic 5 | 0.33 |
| MSX1 | msh homeobox 1 | 0.33 |
| CCDC170 | coiled-coil domain containing 170 | 0.32 |
| ATXN2 | ataxin 2 | 0.32 |
| TMEM51 | transmembrane protein 51 | 0.32 |
| C8ORF76 | chromosome 8 open reading frame 76 | 0.31 |
| KLK6 | kallikrein-related peptidase 6 | 0.3 |
| ZNF799 | zinc finger protein 799 | 0.3 |
| SEPHS1 | selenophosphate synthetase 1 | 0.29 |
| TNFAIP1 | tumor necrosis factor, alpha-induced protein 1 (endothelial) | 0.29 |
| CCDC77 | coiled-coil domain containing 77 | 0.29 |
| RPS21 | ribosomal protein S21 | 0.29 |
| MYH4 | myosin, heavy chain 4, skeletal muscle | 0.28 |
| COA5 | cytochrome c oxidase assembly factor 5 | 0.28 |
| SET | SET nuclear proto-oncogene | 0.27 |
| ZNF224 | zinc finger protein 224 | 0.27 |
| COMMD2 | COMM domain containing 2 | 0.26 |
| MED19 | mediator complex subunit 19 | 0.26 |
| TENT4B | terminal nucleotidyltransferase 4B | 0.26 |
| RPL26 | ribosomal protein L26 | 0.26 |
| ARHGAP44 | Rho GTPase activating protein 44 | 0.25 |
| ZFP64 | ZFP64 zinc finger protein | 0.25 |
| KCTD12 | potassium channel tetramerization domain containing 12 | 0.25 |
| MTFR2 | mitochondrial fission regulator 2 | 0.25 |
| METRN | meteorin, glial cell differentiation regulator | 0.25 |
| TNS2 | tensin 2 | 0.25 |
| BAHCC1 | BAH domain and coiled-coil containing 1 | 0.25 |
| EVI5L | ecotropic viral integration site 5-like | 0.24 |
| MRC2 | mannose receptor, C type 2 | 0.24 |
| ZDHHC3 | zinc finger, DHHC-type containing 3 | 0.24 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.24 |
| HSPA12B | heat shock 70kD protein 12B | 0.24 |
| FKBP1A | FK506 binding protein 1A, 12kDa | 0.24 |
| BTBD7 | BTB (POZ) domain containing 7 | 0.24 |
| RXRA | retinoid X receptor, alpha | 0.24 |
| EHF | ets homologous factor | 0.24 |
| CA2 | carbonic anhydrase II | 0.24 |
| MROH6 | maestro heat-like repeat family member 6 | 0.24 |
| IFFO1 | intermediate filament family orphan 1 | 0.24 |
| NDUFAF6 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 | 0.23 |
| CDC20 | cell division cycle 20 | 0.23 |
| GMIP | GEM interacting protein | 0.23 |
| HIKESHI | heat shock protein nuclear import factor hikeshi | 0.23 |
| TMEM106C | transmembrane protein 106C | 0.23 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.23 |
| SBNO2 | strawberry notch homolog 2 (Drosophila) | 0.23 |
| CYBRD1 | cytochrome b reductase 1 | 0.23 |
| NES | nestin | 0.23 |
| DONSON | downstream neighbor of SON | 0.23 |
| ZNF286A | zinc finger protein 286A | 0.23 |
| ASPHD2 | aspartate beta-hydroxylase domain containing 2 | 0.23 |
| GIN1 | gypsy retrotransposon integrase 1 | 0.23 |
| TMEM102 | transmembrane protein 102 | 0.23 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | 0.22 |
| CCN3 | cellular communication network factor 3 | 0.22 |
| FAM171B | family with sequence similarity 171, member B | 0.22 |
| HMGB2 | high mobility group box 2 | 0.22 |
| OTUD5 | OTU deubiquitinase 5 | 0.22 |
| COBL | cordon-bleu WH2 repeat protein | 0.22 |
| BRCC3 | BRCA1/BRCA2-containing complex, subunit 3 | 0.22 |
| ARSK | arylsulfatase family, member K | 0.22 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZNF692 | zinc finger protein 692 | -1.77 |
| ZNF827 | zinc finger protein 827 | -1.64 |
| ZFP91 | ZFP91 zinc finger protein | -1.55 |
| DTWD1 | DTW domain containing 1 | -1.48 |
| PIP | prolactin-induced protein | -1.43 |
| RNF166 | ring finger protein 166 | -1.2 |
| SACK1F | scaffolding CK1 anchoring protein F | -1.19 |
| ATP6V0A1 | ATPase, H+ transporting, lysosomal V0 subunit a1 | -1.15 |
| MIIP | migration and invasion inhibitory protein | -0.66 |
| TK2 | thymidine kinase 2, mitochondrial | -0.57 |
| RTN1 | reticulon 1 | -0.54 |
| ARPIN | actin-related protein 2/3 complex inhibitor | -0.53 |
| FN1 | fibronectin 1 | -0.52 |
| MAP3K12 | mitogen-activated protein kinase kinase kinase 12 | -0.52 |
| LMTK2 | lemur tyrosine kinase 2 | -0.52 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.5 |
| MCRIP2 | MAPK regulated corepressor interacting protein 2 | -0.47 |
| ZNF92 | zinc finger protein 92 | -0.46 |
| GRHL1 | grainyhead-like 1 (Drosophila) | -0.45 |
| NBPF20 | neuroblastoma breakpoint family, member 20 | -0.44 |
| RAB28 | RAB28, member RAS oncogene family | -0.44 |
| TICAM1 | toll-like receptor adaptor molecule 1 | -0.43 |
| CELSR2 | cadherin, EGF LAG seven-pass G-type receptor 2 | -0.41 |
| DAP | death-associated protein | -0.4 |
| OAF | OAF homolog (Drosophila) | -0.4 |
| COL14A1 | collagen, type XIV, alpha 1 | -0.4 |
| C2CD3 | C2 calcium-dependent domain containing 3 | -0.4 |
| KRT222 | keratin 222, type II | -0.4 |
| C4BPA | complement component 4 binding protein, alpha | -0.39 |
| RBX1 | ring-box 1, E3 ubiquitin protein ligase | -0.39 |
| AMACR | alpha-methylacyl-CoA racemase | -0.39 |
| SMAD1 | SMAD family member 1 | -0.39 |
| KDELR2 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | -0.39 |
| ZRSR2 | zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 | -0.39 |
| C1ORF43 | chromosome 1 open reading frame 43 | -0.38 |
| CCSER2 | coiled-coil serine-rich protein 2 | -0.38 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.38 |
| IER5 | immediate early response 5 | -0.38 |
| BRK1 | BRICK1, SCAR/WAVE actin-nucleating complex subunit | -0.37 |
| PREX1 | phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 | -0.36 |
| TMEM189 | transmembrane protein 189 | -0.35 |
| USP45 | ubiquitin specific peptidase 45 | -0.35 |
| IRX4 | iroquois homeobox 4 | -0.35 |
| GLI4 | GLI family zinc finger 4 | -0.35 |
| MIS12 | MIS12 kinetochore complex component | -0.35 |
| SYTL4 | synaptotagmin-like 4 | -0.35 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | -0.35 |
| BRD3 | bromodomain containing 3 | -0.35 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.35 |
| PFKFB1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | -0.34 |
| RWDD2A | RWD domain containing 2A | -0.34 |
| MVP | major vault protein | -0.34 |
| CD58 | CD58 molecule | -0.34 |
| PRSS8 | protease, serine, 8 | -0.34 |
| PWWP2B | PWWP domain containing 2B | -0.34 |
| NAIF1 | nuclear apoptosis inducing factor 1 | -0.34 |
| NHSL1 | NHS-like 1 | -0.33 |
| ISOC2 | isochorismatase domain containing 2 | -0.33 |
| ZNF865 | zinc finger protein 865 | -0.33 |
| ITGA1 | integrin, alpha 1 | -0.33 |
| FANCC | Fanconi anemia, complementation group C | -0.33 |
| SLC38A7 | solute carrier family 38, member 7 | -0.32 |
| NFIX | nuclear factor I/X (CCAAT-binding transcription factor) | -0.32 |
| HBA1 | hemoglobin, alpha 1 | -0.32 |
| SLC25A44 | solute carrier family 25, member 44 | -0.32 |
| ARG2 | arginase 2 | -0.31 |
| ZNF362 | zinc finger protein 362 | -0.31 |
| FGFBP1 | fibroblast growth factor binding protein 1 | -0.31 |
| PPP1R14C | protein phosphatase 1, regulatory (inhibitor) subunit 14C | -0.31 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.31 |
| FIG4 | FIG4 phosphoinositide 5-phosphatase | -0.31 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.31 |
| NDUFA11 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa | -0.31 |
| C6ORF141 | chromosome 6 open reading frame 141 | -0.31 |
| CSPG4 | chondroitin sulfate proteoglycan 4 | -0.31 |
| TFAP2C | transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) | -0.3 |
| ABHD6 | abhydrolase domain containing 6 | -0.3 |
| SERINC5 | serine incorporator 5 | -0.3 |
| ABCD1 | ATP-binding cassette, sub-family D (ALD), member 1 | -0.3 |
| SLC25A23 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23 | -0.29 |
| FAM124A | family with sequence similarity 124A | -0.29 |
| DCTN2 | dynactin 2 (p50) | -0.29 |
| KLF4 | Kruppel-like factor 4 (gut) | -0.29 |
| MERTK | MER proto-oncogene, tyrosine kinase | -0.29 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | -0.29 |
| HELB | helicase (DNA) B | -0.29 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.29 |
| SERAC1 | serine active site containing 1 | -0.28 |
| CHRD | chordin | -0.28 |
| ADIRF | adipogenesis regulatory factor | -0.28 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.28 |
| AP4S1 | adaptor-related protein complex 4, sigma 1 subunit | -0.28 |
| CCDC158 | coiled-coil domain containing 158 | -0.28 |
| UBQLN2 | ubiquilin 2 | -0.28 |
| S100A11 | S100 calcium binding protein A11 | -0.28 |
| TIMM8A | translocase of inner mitochondrial membrane 8 homolog A (yeast) | -0.28 |
| PEMT | phosphatidylethanolamine N-methyltransferase | -0.27 |
| MCFD2 | multiple coagulation factor deficiency 2 | -0.27 |
| CBR1 | carbonyl reductase 1 | -0.27 |
