| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ponatinib perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ponatinib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.292302 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.171755 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.143915 |
| SQSTM1 | sequestosome 1 | 0.0968991 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0918203 |
| LDHA | lactate dehydrogenase A | 0.0744932 |
| NDRG1 | N-myc downstream regulated 1 | 0.0739282 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.066103 |
| UBC | ubiquitin C | 0.0652832 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0600802 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.0551454 |
| GOLGA4 | golgin A4 | 0.0521735 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0516978 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0509223 |
| B2M | beta-2-microglobulin | 0.0506528 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0497107 |
| PRELID2 | PRELI domain containing 2 | 0.0486445 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0484667 |
| SEPTIN9 | septin 9 | 0.0472223 |
| OPTN | optineurin | 0.0465171 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0454708 |
| NFIX | nuclear factor I/X (CCAAT-binding transcription factor) | 0.0441226 |
| ZNF292 | zinc finger protein 292 | 0.04332 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0428001 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0415188 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0415002 |
| LOXL2 | lysyl oxidase-like 2 | 0.0414592 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0413461 |
| HLA-B | major histocompatibility complex, class I, B | 0.0411544 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0408059 |
| ADM | adrenomedullin | 0.0407887 |
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) | 0.0406896 |
| FLNA | filamin A, alpha | 0.038648 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0375723 |
| HELZ | helicase with zinc finger | 0.0365707 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0364728 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0362745 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0361676 |
| COL3A1 | collagen, type III, alpha 1 | 0.0359993 |
| SMYD3 | SET and MYND domain containing 3 | 0.0354523 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0345483 |
| CD109 | CD109 molecule | 0.0344382 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0344086 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0339765 |
| LMNA | lamin A/C | 0.033623 |
| CALR | calreticulin | 0.0333409 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0329855 |
| RTN4 | reticulon 4 | 0.0326877 |
| OGA | O-GlcNAcase | 0.0324256 |
| FNIP1 | folliculin interacting protein 1 | 0.0313175 |
| C1D | C1D nuclear receptor corepressor | 0.0308832 |
| ANK2 | ankyrin 2, neuronal | 0.0307691 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0307047 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0303579 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0300351 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0298532 |
| WDFY1 | WD repeat and FYVE domain containing 1 | 0.0296619 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0284453 |
| SBF2 | SET binding factor 2 | 0.0284103 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0283006 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0277704 |
| NEFL | neurofilament, light polypeptide | 0.0276586 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0271754 |
| SETD5 | SET domain containing 5 | 0.0270469 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0269877 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0269072 |
| GSE1 | Gse1 coiled-coil protein | 0.0268657 |
| PCBP2 | poly(rC) binding protein 2 | 0.0264403 |
| FAM162A | family with sequence similarity 162, member A | 0.0263747 |
| ENO1 | enolase 1, (alpha) | 0.026344 |
| ANXA4 | annexin A4 | 0.0262775 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0258998 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0258401 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | 0.0257433 |
| TMSB10 | thymosin beta 10 | 0.025448 |
| ARRDC3 | arrestin domain containing 3 | 0.0254363 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | 0.0253785 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | 0.0252815 |
| FLNB | filamin B, beta | 0.0252682 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | 0.0250999 |
| FTL | ferritin, light polypeptide | 0.0250917 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0248872 |
| FBN1 | fibrillin 1 | 0.024863 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.024845 |
| KIF13A | kinesin family member 13A | 0.0246315 |
| FAM13A | family with sequence similarity 13, member A | 0.0243494 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0242018 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0239203 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0238516 |
| CD99 | CD99 molecule | 0.0237791 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0236917 |
| CLU | clusterin | 0.023591 |
| ZNF148 | zinc finger protein 148 | 0.0235658 |
| TPM3 | tropomyosin 3 | 0.0234433 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0232683 |
| AUTS2 | autism susceptibility candidate 2 | 0.0232072 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0231142 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0230532 |
| ADAR | adenosine deaminase, RNA-specific | 0.0230121 |
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 | 0.0229651 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.205571 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.186526 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.13503 |
| PLAT | plasminogen activator, tissue | -0.129843 |
| NAV1 | neuron navigator 1 | -0.126459 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.119401 |
| LOX | lysyl oxidase | -0.112131 |
| PODXL | podocalyxin-like | -0.103219 |
| CDH13 | cadherin 13 | -0.102914 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.10008 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.081647 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0720078 |
| MAP1B | microtubule-associated protein 1B | -0.0694918 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0673713 |
| GLIS3 | GLIS family zinc finger 3 | -0.0658875 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0648507 |
| RIGI | RNA sensor RIG-I | -0.0585018 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0575899 |
| SUCNR1 | succinate receptor 1 | -0.0562762 |
| PRSS23 | protease, serine, 23 | -0.0549728 |
| EFNA5 | ephrin-A5 | -0.0537724 |
| FN1 | fibronectin 1 | -0.0515611 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0503446 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0479121 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0468001 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0448879 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0444998 |
| FRMD4A | FERM domain containing 4A | -0.0438104 |
| MX2 | MX dynamin-like GTPase 2 | -0.0410072 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0394334 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0392208 |
| VEGFC | vascular endothelial growth factor C | -0.0384121 |
| RASAL2 | RAS protein activator like 2 | -0.0354881 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0343443 |
| CCND1 | cyclin D1 | -0.0340026 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0335639 |
| AHNAK | AHNAK nucleoprotein | -0.0330715 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0324655 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0318454 |
| MEIS2 | Meis homeobox 2 | -0.0317521 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0315287 |
| EHBP1 | EH domain binding protein 1 | -0.0314222 |
| CAVIN1 | caveolae associated protein 1 | -0.0302938 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0291724 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0289062 |
| ZNF217 | zinc finger protein 217 | -0.028481 |
| PLXNA2 | plexin A2 | -0.0280566 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0279839 |
| CDK6 | cyclin-dependent kinase 6 | -0.0273606 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0272769 |
| HS3ST3A1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 | -0.0272114 |
| COL5A1 | collagen, type V, alpha 1 | -0.0266897 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0264488 |
| VCL | vinculin | -0.0254476 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 | -0.025314 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | -0.0244855 |
| DGKG | diacylglycerol kinase, gamma 90kDa | -0.0242948 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0240991 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0240759 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.023981 |
| FLT1 | fms-related tyrosine kinase 1 | -0.0239762 |
| RAI14 | retinoic acid induced 14 | -0.0238012 |
| CYTH3 | cytohesin 3 | -0.0233897 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0228582 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0225025 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0223777 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0221674 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0221496 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | -0.0219681 |
| IL7R | interleukin 7 receptor | -0.0219187 |
| RRBP1 | ribosome binding protein 1 | -0.0212541 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0209986 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.020794 |
| ASPH | aspartate beta-hydroxylase | -0.0207573 |
| FSTL1 | follistatin-like 1 | -0.0206345 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.020186 |
| JAZF1 | JAZF zinc finger 1 | -0.0198723 |
| SP100 | SP100 nuclear antigen | -0.0198522 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0197727 |
| COL1A2 | collagen, type I, alpha 2 | -0.0196276 |
| SAMD9L | sterile alpha motif domain containing 9-like | -0.0195596 |
| INTS6 | integrator complex subunit 6 | -0.0194513 |
| CDK14 | cyclin-dependent kinase 14 | -0.0191405 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0189792 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0188528 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0186315 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.0185451 |
| TCF12 | transcription factor 12 | -0.0185143 |
| OSMR | oncostatin M receptor | -0.0184598 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0183087 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0181415 |
| DCLK2 | doublecortin-like kinase 2 | -0.01809 |
| SLC39A11 | solute carrier family 39, member 11 | -0.017843 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0176434 |
| CEP112 | centrosomal protein 112kDa | -0.0176201 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0175193 |
| PDE1C | phosphodiesterase 1C, calmodulin-dependent 70kDa | -0.0174673 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.017437 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.017405 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0173451 |
