| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ponatinib perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ponatinib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NLGN1 | neuroligin 1 | 0.197562 |
| DST | dystonin | 0.10575 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0980104 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0920759 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0911998 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0828954 |
| TENM3 | teneurin transmembrane protein 3 | 0.0742527 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0740801 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0686306 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0672523 |
| HSPB1 | heat shock 27kDa protein 1 | 0.0669783 |
| CALR | calreticulin | 0.0669268 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0662528 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.062235 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | 0.0621481 |
| EHBP1 | EH domain binding protein 1 | 0.0617927 |
| ENO1 | enolase 1, (alpha) | 0.0592622 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0580932 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.057472 |
| PEG10 | paternally expressed 10 | 0.0540018 |
| CANX | calnexin | 0.051697 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0507799 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0501958 |
| HMGA1 | high mobility group AT-hook 1 | 0.0490725 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0480513 |
| LDHA | lactate dehydrogenase A | 0.0468618 |
| RPS8 | ribosomal protein S8 | 0.0444642 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0439598 |
| AHNAK | AHNAK nucleoprotein | 0.0431786 |
| RNF213 | ring finger protein 213 | 0.0430515 |
| KLF6 | Kruppel-like factor 6 | 0.0415669 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0406133 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.040086 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0397823 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0392844 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0390834 |
| RPL35A | ribosomal protein L35a | 0.0388149 |
| TPM4 | tropomyosin 4 | 0.0384337 |
| ANXA1 | annexin A1 | 0.0379299 |
| GANAB | glucosidase, alpha; neutral AB | 0.0359311 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0359088 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | 0.0355156 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0354036 |
| PTMA | prothymosin, alpha | 0.0353929 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0353181 |
| RPL26 | ribosomal protein L26 | 0.0348209 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.034209 |
| HDAC9 | histone deacetylase 9 | 0.0338427 |
| TPM3 | tropomyosin 3 | 0.0336625 |
| MAP1B | microtubule-associated protein 1B | 0.0335553 |
| HELB | helicase (DNA) B | 0.0332647 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0330996 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0328567 |
| RPL6 | ribosomal protein L6 | 0.0326079 |
| FSTL5 | follistatin-like 5 | 0.0324708 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.032436 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0322077 |
| ETV6 | ets variant 6 | 0.0320142 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | 0.0319758 |
| BPTF | bromodomain PHD finger transcription factor | 0.0315104 |
| RPL13A | ribosomal protein L13a | 0.0310934 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0306597 |
| RACK1 | receptor for activated C kinase 1 | 0.0304051 |
| VASP | vasodilator-stimulated phosphoprotein | 0.0301313 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0299605 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.0298809 |
| EPHA5 | EPH receptor A5 | 0.0288251 |
| ACTG1 | actin gamma 1 | 0.0287676 |
| RPS27A | ribosomal protein S27a | 0.0287133 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.028594 |
| SPTSSA | serine palmitoyltransferase, small subunit A | 0.0284545 |
| NSD2 | nuclear receptor binding SET domain protein 2 | 0.0281673 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | 0.0279787 |
| NEBL | nebulette | 0.0277199 |
| TPI1 | triosephosphate isomerase 1 | 0.0277082 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0276422 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | 0.0273485 |
| RPS3 | ribosomal protein S3 | 0.0271514 |
| YAP1 | Yes-associated protein 1 | 0.027063 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | 0.0270494 |
| S100A10 | S100 calcium binding protein A10 | 0.0268808 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | 0.0268139 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0268123 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0267644 |
| RPL23 | ribosomal protein L23 | 0.0266893 |
| BCL6 | B-cell CLL/lymphoma 6 | 0.0265573 |
| PCBP2 | poly(rC) binding protein 2 | 0.0265552 |
| KSR2 | kinase suppressor of ras 2 | 0.0264975 |
| GOLGB1 | golgin B1 | 0.0263267 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0260715 |
| MKI67 | marker of proliferation Ki-67 | 0.0255455 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.025401 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.0251425 |
| CARS1 | cysteinyl-tRNA synthetase 1 | 0.025076 |
| ADIPOR2 | adiponectin receptor 2 | 0.0248095 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0244642 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0242271 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.024149 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0240865 |
| CEP112 | centrosomal protein 112kDa | 0.0240474 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AREG | amphiregulin | -0.158101 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.101646 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.095418 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0937122 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0838212 |
| TXNRD1 | thioredoxin reductase 1 | -0.0753659 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.068431 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0653186 |
| CCNL1 | cyclin L1 | -0.0644667 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.063145 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0619455 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0595124 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0578006 |
| TMEM41B | transmembrane protein 41B | -0.0544242 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0517876 |
| MGAT4C | MGAT4 family, member C | -0.0502501 |
| RTN4 | reticulon 4 | -0.0496125 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0485037 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0477221 |
| CPOX | coproporphyrinogen oxidase | -0.0450451 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | -0.0445 |
| IPO7 | importin 7 | -0.0442823 |
| JMJD1C | jumonji domain containing 1C | -0.0436595 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0434802 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0432444 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0429779 |
| RPS2 | ribosomal protein S2 | -0.04183 |
| RPLP1 | ribosomal protein, large, P1 | -0.0410637 |
| NEK7 | NIMA-related kinase 7 | -0.0406126 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0398295 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0391327 |
| RBM39 | RNA binding motif protein 39 | -0.0390691 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0380369 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0373886 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0372653 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0372536 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.035617 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0344915 |
| EDN1 | endothelin 1 | -0.0344548 |
| CCN2 | cellular communication network factor 2 | -0.0334139 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0333838 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0331519 |
| RRM2 | ribonucleotide reductase M2 | -0.0331404 |
| WDR43 | WD repeat domain 43 | -0.0328716 |
| CDK17 | cyclin-dependent kinase 17 | -0.0323025 |
| OXR1 | oxidation resistance 1 | -0.0321317 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.032023 |
| MMP12 | matrix metallopeptidase 12 | -0.0315525 |
| GART | phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase | -0.0314001 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.0313978 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.0298037 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0295809 |
| GSK3B | glycogen synthase kinase 3 beta | -0.029474 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0292879 |
| COG5 | component of oligomeric golgi complex 5 | -0.0289381 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.028449 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.028365 |
| MATR3 | matrin 3 | -0.0281911 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0273041 |
| XPO1 | exportin 1 | -0.0270408 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.0265923 |
| FTL | ferritin, light polypeptide | -0.0262899 |
| CARD16 | caspase recruitment domain family, member 16 | -0.026228 |
| DIAPH1 | diaphanous-related formin 1 | -0.0262228 |
| AP3S1 | adaptor-related protein complex 3, sigma 1 subunit | -0.0261623 |
| RAB10 | RAB10, member RAS oncogene family | -0.0260864 |
| RPL4 | ribosomal protein L4 | -0.0260582 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0260382 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0260157 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | -0.0257822 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | -0.0254706 |
| ATAD2B | ATPase family, AAA domain containing 2B | -0.0254325 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0248689 |
| ETNK1 | ethanolamine kinase 1 | -0.0245106 |
| PTMS | parathymosin | -0.0245029 |
| RBM25 | RNA binding motif protein 25 | -0.0243562 |
| ATP11A | ATPase, class VI, type 11A | -0.0242346 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0239157 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0237721 |
| TNPO1 | transportin 1 | -0.0235304 |
| NKTR | natural killer cell triggering receptor | -0.0233012 |
| VMP1 | vacuole membrane protein 1 | -0.0232615 |
| THOC1 | THO complex 1 | -0.023254 |
| CEP192 | centrosomal protein 192kDa | -0.0231443 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0231241 |
| HSPA4 | heat shock 70kDa protein 4 | -0.0224374 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0220182 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.0215689 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0213403 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0213277 |
| THOC2 | THO complex 2 | -0.0213248 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | -0.0208919 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0208716 |
| BTG3 | BTG family, member 3 | -0.0208635 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | -0.0207217 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0207058 |
| GPHN | gephyrin | -0.0206987 |
| PPP4R1 | protein phosphatase 4, regulatory subunit 1 | -0.0205587 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | -0.0202667 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.0202594 |
