| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ponatinib perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ponatinib_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| B2M | beta-2-microglobulin | 0.161892 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.139131 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.136795 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.128093 |
| HLA-B | major histocompatibility complex, class I, B | 0.118205 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0740886 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0717867 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0705439 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | 0.0655519 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0626134 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0603377 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0602766 |
| CALR | calreticulin | 0.060075 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0562286 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0553136 |
| ENO1 | enolase 1, (alpha) | 0.0536308 |
| NDRG1 | N-myc downstream regulated 1 | 0.0479316 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0470176 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0423837 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.0415959 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.0410246 |
| TMSB10 | thymosin beta 10 | 0.040722 |
| RPL35A | ribosomal protein L35a | 0.0403464 |
| MT2A | metallothionein 2A | 0.0397715 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0396659 |
| RPL23 | ribosomal protein L23 | 0.0396398 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0385288 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0382177 |
| TMPRSS4 | transmembrane protease, serine 4 | 0.0373239 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0370307 |
| FTL | ferritin, light polypeptide | 0.0369459 |
| HLA-C | major histocompatibility complex, class I, C | 0.0369316 |
| PPARGC1A | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | 0.0353875 |
| CANX | calnexin | 0.0353685 |
| HLA-A | major histocompatibility complex, class I, A | 0.0352974 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0352186 |
| LDHA | lactate dehydrogenase A | 0.0352055 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0351869 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0350253 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0348138 |
| AHNAK | AHNAK nucleoprotein | 0.0345348 |
| CDHR2 | cadherin-related family member 2 | 0.0344189 |
| TRERF1 | transcriptional regulating factor 1 | 0.0324213 |
| S100A10 | S100 calcium binding protein A10 | 0.0318928 |
| DSTN | destrin (actin depolymerizing factor) | 0.0317492 |
| CSTB | cystatin B (stefin B) | 0.0307112 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | 0.0303651 |
| PER2 | period circadian clock 2 | 0.0303265 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | 0.0299932 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.0299131 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.0299022 |
| MT1X | metallothionein 1X | 0.0290772 |
| HLA-E | major histocompatibility complex, class I, E | 0.0288671 |
| MPHOSPH8 | M-phase phosphoprotein 8 | 0.0285732 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0279084 |
| WDR45B | WD repeat domain 45B | 0.0279004 |
| RUNX1 | runt-related transcription factor 1 | 0.0278669 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0278381 |
| AGR2 | anterior gradient 2 | 0.0273159 |
| ANXA1 | annexin A1 | 0.027303 |
| SCARB1 | scavenger receptor class B, member 1 | 0.0272144 |
| PGK1 | phosphoglycerate kinase 1 | 0.0269937 |
| BPTF | bromodomain PHD finger transcription factor | 0.0267911 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0267401 |
| KLF6 | Kruppel-like factor 6 | 0.026588 |
| CALU | calumenin | 0.0263524 |
| MEIS2 | Meis homeobox 2 | 0.0262324 |
| RPLP1 | ribosomal protein, large, P1 | 0.0259861 |
| KRT19 | keratin 19, type I | 0.0257724 |
| NUCB2 | nucleobindin 2 | 0.0255659 |
| RNF149 | ring finger protein 149 | 0.0253106 |
| NCKAP5 | NCK-associated protein 5 | 0.0252838 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.025283 |
| TPI1 | triosephosphate isomerase 1 | 0.0250248 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0247361 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0246938 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0246693 |
| TMEM59 | transmembrane protein 59 | 0.024593 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | 0.0243363 |
| MKI67 | marker of proliferation Ki-67 | 0.0241437 |
| RPS27 | ribosomal protein S27 | 0.0234251 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0232162 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0231105 |
| AOPEP | aminopeptidase O (putative) | 0.0230408 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0230199 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0229571 |
| ATXN1 | ataxin 1 | 0.0229568 |
| UBC | ubiquitin C | 0.0229473 |
| NEBL | nebulette | 0.0227985 |
| MYO1E | myosin IE | 0.0227804 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0223344 |
| ANXA4 | annexin A4 | 0.0220595 |
| GSE1 | Gse1 coiled-coil protein | 0.0217279 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.021609 |
| CD9 | CD9 molecule | 0.0214054 |
| RPS19 | ribosomal protein S19 | 0.0213905 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0213778 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0212509 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.0212026 |
| MTDH | metadherin | 0.0210764 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.154832 |
| RNF213 | ring finger protein 213 | -0.132654 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.124652 |
| INTS6 | integrator complex subunit 6 | -0.123311 |
| VCL | vinculin | -0.117011 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.106995 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | -0.101195 |
| STS | steroid sulfatase (microsomal), isozyme S | -0.100585 |
| SP100 | SP100 nuclear antigen | -0.0968694 |
| MX1 | MX dynamin-like GTPase 1 | -0.0961705 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0956386 |
| RIGI | RNA sensor RIG-I | -0.0950457 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.091598 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0741711 |
| PLSCR2 | phospholipid scramblase 2 | -0.0698581 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0686585 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0672057 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -0.0655411 |
| MAP7 | microtubule-associated protein 7 | -0.0643729 |
| PLSCR1 | phospholipid scramblase 1 | -0.0643186 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0620745 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0619331 |
| MX2 | MX dynamin-like GTPase 2 | -0.0613371 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.060834 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0585683 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0583956 |
| SMAD3 | SMAD family member 3 | -0.0578836 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0555308 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0554156 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0548971 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0548147 |
| LYZ | lysozyme | -0.0524156 |
| AREG | amphiregulin | -0.0507548 |
| ANXA2 | annexin A2 | -0.0503117 |
| TM4SF19 | transmembrane 4 L six family member 19 | -0.050227 |
| VMP1 | vacuole membrane protein 1 | -0.0497212 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0496914 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0495877 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0472227 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0471006 |
| PRKCA | protein kinase C, alpha | -0.0454061 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0448448 |
| XAF1 | XIAP associated factor 1 | -0.0435427 |
| LMO7 | LIM domain 7 | -0.0433173 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.0400575 |
| ETV6 | ets variant 6 | -0.0396778 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0367866 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0362511 |
| ATP10B | ATPase, class V, type 10B | -0.036121 |
| TJP1 | tight junction protein 1 | -0.0356777 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0355784 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0342753 |
| DIAPH1 | diaphanous-related formin 1 | -0.0339363 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0332545 |
| ERBIN | erbb2 interacting protein | -0.0323886 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | -0.0322997 |
| ADAR | adenosine deaminase, RNA-specific | -0.032281 |
| IFNGR1 | interferon gamma receptor 1 | -0.0318884 |
| TNS4 | tensin 4 | -0.0310842 |
| UBAP2 | ubiquitin associated protein 2 | -0.0299503 |
| NPSR1 | neuropeptide S receptor 1 | -0.0292005 |
| NF1 | neurofibromin 1 | -0.0285928 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.028381 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | -0.0280823 |
| SPAG9 | sperm associated antigen 9 | -0.0276582 |
| SSH2 | slingshot protein phosphatase 2 | -0.0274605 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0273919 |
| FBXO39 | F-box protein 39 | -0.0273329 |
| BCL2L1 | BCL2-like 1 | -0.0272542 |
| PMP22 | peripheral myelin protein 22 | -0.0272437 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0272 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0271202 |
| NABP1 | nucleic acid binding protein 1 | -0.0268515 |
| SETX | senataxin | -0.0267333 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0265582 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | -0.0263813 |
| POF1B | premature ovarian failure, 1B | -0.0263497 |
| LAP3 | leucine aminopeptidase 3 | -0.0260383 |
| KIF16B | kinesin family member 16B | -0.0258792 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | -0.0257271 |
| DGKH | diacylglycerol kinase, eta | -0.0250043 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0248504 |
| MCL1 | myeloid cell leukemia 1 | -0.024617 |
| ASPH | aspartate beta-hydroxylase | -0.0244677 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.024421 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0238416 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0238 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | -0.0237827 |
| PRKCE | protein kinase C, epsilon | -0.0236212 |
| MSI2 | musashi RNA-binding protein 2 | -0.023373 |
| NUP98 | nucleoporin 98kDa | -0.0233171 |
| USP53 | ubiquitin specific peptidase 53 | -0.0232596 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0231629 |
| CYRIB | CYFIP related Rac1 interactor B | -0.0231491 |
| RAB10 | RAB10, member RAS oncogene family | -0.0230118 |
| VPS37B | vacuolar protein sorting 37 homolog B (S. cerevisiae) | -0.0230098 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0227317 |
| TUFT1 | tuftelin 1 | -0.0225638 |
| PSPC1 | paraspeckle component 1 | -0.0224233 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0223795 |
