Ponatinib_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ponatinib perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ponatinib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.312784
MYH9 myosin, heavy chain 9, non-muscle 0.158737
PABPC1 poly(A) binding protein, cytoplasmic 1 0.125302
POSTN periostin, osteoblast specific factor 0.118684
TGFBI transforming growth factor, beta-induced, 68kDa 0.108891
CALR calreticulin 0.0923736
COL6A3 collagen, type VI, alpha 3 0.0914519
COL1A1 collagen, type I, alpha 1 0.0902841
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0872846
ENO1 enolase 1, (alpha) 0.082641
LDHA lactate dehydrogenase A 0.079003
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0662854
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0623631
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.061928
HLA-B major histocompatibility complex, class I, B 0.061155
STC2 stanniocalcin 2 0.0559345
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0548034
COL3A1 collagen, type III, alpha 1 0.053778
FLNA filamin A, alpha 0.0537488
IGFBP7 insulin-like growth factor binding protein 7 0.0537176
GANAB glucosidase, alpha; neutral AB 0.0534116
B2M beta-2-microglobulin 0.0519592
COL5A1 collagen, type V, alpha 1 0.0516999
EEF2 eukaryotic translation elongation factor 2 0.0509955
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.05085
PSD3 pleckstrin and Sec7 domain containing 3 0.050834
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0495468
RPS8 ribosomal protein S8 0.0434
COL1A2 collagen, type I, alpha 2 0.0433428
RNF220 ring finger protein 220 0.0431648
EEF1G eukaryotic translation elongation factor 1 gamma 0.0430387
COL4A1 collagen, type IV, alpha 1 0.0406024
RPS3 ribosomal protein S3 0.0405972
COL6A1 collagen, type VI, alpha 1 0.0401203
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0401071
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0389037
RPL13A ribosomal protein L13a 0.0383578
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.0373386
PLEC plectin 0.0371662
YBX1 Y box binding protein 1 0.0369592
COL7A1 collagen, type VII, alpha 1 0.0363365
CANX calnexin 0.0358577
PFN1 profilin 1 0.0357863
RPL5 ribosomal protein L5 0.0356551
IFI6 interferon, alpha-inducible protein 6 0.0344276
CFB complement factor B 0.0337182
PDE4D phosphodiesterase 4D, cAMP-specific 0.0331175
PCBP2 poly(rC) binding protein 2 0.0329718
RPL36 ribosomal protein L36 0.032712
ZMIZ1 zinc finger, MIZ-type containing 1 0.032391
TPM2 tropomyosin 2 (beta) 0.0323182
COL4A2 collagen, type IV, alpha 2 0.0322361
VEGFA vascular endothelial growth factor A 0.0316916
RPL26 ribosomal protein L26 0.0314517
ZNF292 zinc finger protein 292 0.0312187
PRELID2 PRELI domain containing 2 0.0310994
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0309733
TMEM59 transmembrane protein 59 0.0307589
NCOR2 nuclear receptor corepressor 2 0.0306528
DPYSL3 dihydropyrimidinase-like 3 0.0304609
ARRDC3 arrestin domain containing 3 0.0304049
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.030039
EGFR epidermal growth factor receptor 0.0296458
COL6A2 collagen, type VI, alpha 2 0.0283242
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.027882
RPS2 ribosomal protein S2 0.0274231
GOLGA4 golgin A4 0.027076
HLA-A major histocompatibility complex, class I, A 0.0268541
OPTN optineurin 0.0266976
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0262122
TAPBP TAP binding protein (tapasin) 0.025311
RPS19 ribosomal protein S19 0.0249783
CYB5R3 cytochrome b5 reductase 3 0.0248896
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0246809
CTSB cathepsin B 0.0245692
LPP LIM domain containing preferred translocation partner in lipoma 0.02454
TNIP1 TNFAIP3 interacting protein 1 0.024529
AHCYL1 adenosylhomocysteinase-like 1 0.0240974
APP amyloid beta (A4) precursor protein 0.0238974
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.023891
RPL6 ribosomal protein L6 0.0236872
TLN1 talin 1 0.0236723
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0236227
LMNA lamin A/C 0.0234723
CD99 CD99 molecule 0.0234366
BRD4 bromodomain containing 4 0.0233446
LOXL2 lysyl oxidase-like 2 0.0229947
ITGA11 integrin, alpha 11 0.0228556
HMGA1 high mobility group AT-hook 1 0.0226642
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0225147
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0222469
FBXL7 F-box and leucine-rich repeat protein 7 0.0219035
RPS12 ribosomal protein S12 0.0218708
PIEZO2 piezo-type mechanosensitive ion channel component 2 0.0218088
VASP vasodilator-stimulated phosphoprotein 0.021597
S100A9 S100 calcium binding protein A9 0.0215182
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0214483
CALU calumenin 0.0213117
ZBTB20 zinc finger and BTB domain containing 20 0.0210519
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0209625

decreased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 -0.319259
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.252906
IER3 immediate early response 3 -0.161415
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.150675
STC1 stanniocalcin 1 -0.112845
CDH13 cadherin 13 -0.105047
TM4SF1 transmembrane 4 L six family member 1 -0.0935224
TRIO trio Rho guanine nucleotide exchange factor -0.0916035
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0903212
NDRG1 N-myc downstream regulated 1 -0.0836232
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0809286
HMGA2 high mobility group AT-hook 2 -0.0791693
ELL2 elongation factor, RNA polymerase II, 2 -0.0786389
INHBA inhibin, beta A -0.0708511
F3 coagulation factor III (thromboplastin, tissue factor) -0.0684132
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0624754
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0622851
TMSB10 thymosin beta 10 -0.0620257
ATP13A3 ATPase type 13A3 -0.0591985
CD44 CD44 molecule (Indian blood group) -0.0567487
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0524891
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0523545
VIM vimentin -0.0516805
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0506494
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0502827
IL6 interleukin 6 -0.0492568
FTL ferritin, light polypeptide -0.0480826
IGFBP3 insulin-like growth factor binding protein 3 -0.0473909
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0467885
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0455983
ALCAM activated leukocyte cell adhesion molecule -0.0428851
FNDC3B fibronectin type III domain containing 3B -0.0419129
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0412277
EXT1 exostosin glycosyltransferase 1 -0.0406954
CLIC4 chloride intracellular channel 4 -0.038665
BZW1 basic leucine zipper and W2 domains 1 -0.037978
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0378068
PTMA prothymosin, alpha -0.0369834
JARID2 jumonji, AT rich interactive domain 2 -0.0369277
NAMPT nicotinamide phosphoribosyltransferase -0.0361712
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0355399
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0355036
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0353087
LIMS1 LIM and senescent cell antigen-like domains 1 -0.035031
RPLP1 ribosomal protein, large, P1 -0.0348512
TMEM165 transmembrane protein 165 -0.0343278
BHLHE40 basic helix-loop-helix family, member e40 -0.0343267
CLMP CXADR-like membrane protein -0.0338703
TMSB4X thymosin beta 4, X-linked -0.0337484
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0332748
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0327114
JUN jun proto-oncogene -0.0318873
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0318476
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0309548
MAP1B microtubule-associated protein 1B -0.0308826
PDE10A phosphodiesterase 10A -0.0306495
DOCK5 dedicator of cytokinesis 5 -0.0304104
MTSS1 metastasis suppressor 1 -0.0298154
RPS24 ribosomal protein S24 -0.0288585
RTN4 reticulon 4 -0.0288326
EFNA5 ephrin-A5 -0.0282544
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0278797
ASPH aspartate beta-hydroxylase -0.0274239
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0273943
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.027301
CXCL3 chemokine (C-X-C motif) ligand 3 -0.0267641
USP34 ubiquitin specific peptidase 34 -0.0263202
ZBTB38 zinc finger and BTB domain containing 38 -0.0257959
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0257282
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -0.0256657
IL6ST interleukin 6 signal transducer -0.025593
VDAC1 voltage-dependent anion channel 1 -0.0244431
BTG1 B-cell translocation gene 1, anti-proliferative -0.0243464
KDM7A lysine (K)-specific demethylase 7A -0.0241921
DUSP6 dual specificity phosphatase 6 -0.0235
NUMB numb homolog (Drosophila) -0.0234985
H1-0 H1.0 linker histone -0.0234766
MRTFA myocardin related transcription factor A -0.0233087
PTK2 protein tyrosine kinase 2 -0.0230297
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0230245
RRBP1 ribosome binding protein 1 -0.0229896
ZFAND3 zinc finger, AN1-type domain 3 -0.022734
OSMR oncostatin M receptor -0.0227277
RPS20 ribosomal protein S20 -0.0225286
PGK1 phosphoglycerate kinase 1 -0.0225154
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.022446
DLG1 discs, large homolog 1 (Drosophila) -0.0223994
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0222989
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0221899
AFF4 AF4/FMR2 family, member 4 -0.0221386
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0220003
RND3 Rho family GTPase 3 -0.0218375
NAV1 neuron navigator 1 -0.0216051
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0214295
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0211995
RPLP0 ribosomal protein, large, P0 -0.0211469
NALF1 NALCN channel auxiliary factor 1 -0.0211266
RIPK2 receptor-interacting serine-threonine kinase 2 -0.0206968
LMAN1 lectin, mannose-binding, 1 -0.0205113
RPL14 ribosomal protein L14 -0.0204824