Ponatinib_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ponatinib perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ponatinib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.176696
APOB apolipoprotein B 0.16989
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.124092
IGF2 insulin-like growth factor 2 0.0774756
SPTBN1 spectrin, beta, non-erythrocytic 1 0.076255
IGFBP1 insulin-like growth factor binding protein 1 0.0683592
TF transferrin 0.0615522
LRMDA leucine rich melanocyte differentiation associated 0.0594814
DSPP dentin sialophosphoprotein 0.0562961
ENO1 enolase 1, (alpha) 0.0519569
ERRFI1 ERBB receptor feedback inhibitor 1 0.0480901
A2M alpha-2-macroglobulin 0.0474302
CFB complement factor B 0.0439125
AFDN afadin, adherens junction formation factor 0.0434155
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0422061
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0417921
FNDC3B fibronectin type III domain containing 3B 0.0388429
GPC6 glypican 6 0.0382902
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0371502
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0355351
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0324625
GPC3 glypican 3 0.0309761
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0301106
KIAA1217 KIAA1217 0.0300133
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.029527
SVIL supervillin 0.0293047
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0292459
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0288358
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0280963
FBF1 Fas (TNFRSF6) binding factor 1 0.0277971
HMGA1 high mobility group AT-hook 1 0.0274531
PTPRM protein tyrosine phosphatase, receptor type, M 0.0263207
SAMD4A sterile alpha motif domain containing 4A 0.0263035
DOCK4 dedicator of cytokinesis 4 0.0255684
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0241027
CTSB cathepsin B 0.0235278
NKD1 naked cuticle homolog 1 (Drosophila) 0.0231194
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0230536
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 0.0228754
PEG3 paternally expressed 3 0.0227663
TIMP1 TIMP metallopeptidase inhibitor 1 0.0227072
MACF1 microtubule-actin crosslinking factor 1 0.022621
LDHA lactate dehydrogenase A 0.0226012
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0223056
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.0220089
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0215811
CANX calnexin 0.0214913
IGF1R insulin-like growth factor 1 receptor 0.0211887
MYH9 myosin, heavy chain 9, non-muscle 0.021038
EHBP1 EH domain binding protein 1 0.0210018
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0209444
ELL2 elongation factor, RNA polymerase II, 2 0.0207819
ZMYND8 zinc finger, MYND-type containing 8 0.0206944
UTRN utrophin 0.0206209
NFIA nuclear factor I/A 0.0188693
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0188691
MALRD1 MAM and LDL receptor class A domain containing 1 0.018749
SOS1 son of sevenless homolog 1 (Drosophila) 0.0184281
FAT1 FAT atypical cadherin 1 0.0182127
ICAM1 intercellular adhesion molecule 1 0.0178652
MTUS1 microtubule associated tumor suppressor 1 0.017766
FLNB filamin B, beta 0.0174769
ADGRG6 adhesion G protein-coupled receptor G6 0.0173006
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0170224
CALR calreticulin 0.0169874
PTCHD4 patched domain containing 4 0.0169852
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0169246
MAML2 mastermind-like 2 (Drosophila) 0.0168676
TBC1D22A TBC1 domain family, member 22A 0.0163993
SMYD3 SET and MYND domain containing 3 0.0162663
RUNX1 runt-related transcription factor 1 0.0162135
TMEM123 transmembrane protein 123 0.0161531
SOD2 superoxide dismutase 2, mitochondrial 0.0161
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0160159
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.015948
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0157254
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0156576
TMEM45B transmembrane protein 45B 0.0156503
TFRC transferrin receptor 0.0155094
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0154654
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0153686
PRELID2 PRELI domain containing 2 0.0153281
APLP2 amyloid beta (A4) precursor-like protein 2 0.0151251
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0149331
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 0.0147635
HELZ helicase with zinc finger 0.0146808
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0146137
DDIT4 DNA-damage-inducible transcript 4 0.0145181
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0144074
DNAH17 dynein, axonemal, heavy chain 17 0.0139876
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0136659
RPL6 ribosomal protein L6 0.0135832
KRT8 keratin 8, type II 0.0135401
KDM3A lysine (K)-specific demethylase 3A 0.0134911
CNKSR3 CNKSR family member 3 0.0131829
KIZ kizuna centrosomal protein 0.0131113
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0129656
ATRN attractin 0.0129583
NCOR1 nuclear receptor corepressor 1 0.0128923
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0128437

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.0669676
FTL ferritin, light polypeptide -0.0404274
RPLP1 ribosomal protein, large, P1 -0.0393806
AHSG alpha-2-HS-glycoprotein -0.0369502
TMSB10 thymosin beta 10 -0.0347575
RPS6 ribosomal protein S6 -0.0334777
DTNA dystrobrevin, alpha -0.033318
NDRG1 N-myc downstream regulated 1 -0.0321488
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0312246
PLIN2 perilipin 2 -0.0288906
RPS24 ribosomal protein S24 -0.0267755
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0261393
RPL31 ribosomal protein L31 -0.0246437
RPL37A ribosomal protein L37a -0.0222946
SLC38A2 solute carrier family 38, member 2 -0.0217912
RPL34 ribosomal protein L34 -0.0192361
C3 complement component 3 -0.0173369
GNAS GNAS complex locus -0.0170889
RPL9 ribosomal protein L9 -0.0170268
RPL35A ribosomal protein L35a -0.0169385
PKM pyruvate kinase, muscle -0.0159449
PTMA prothymosin, alpha -0.0158481
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -0.0156484
GK glycerol kinase -0.0152282
RPS14 ribosomal protein S14 -0.0148023
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0146731
RPS17 ribosomal protein S17 -0.0146562
EIF1 eukaryotic translation initiation factor 1 -0.0145661
RPS20 ribosomal protein S20 -0.0140132
FTH1 ferritin, heavy polypeptide 1 -0.0139638
GDF15 growth differentiation factor 15 -0.0138215
RPL28 ribosomal protein L28 -0.0137297
RPS5 ribosomal protein S5 -0.0136802
SRRM2 serine/arginine repetitive matrix 2 -0.0135582
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0132486
RPS16 ribosomal protein S16 -0.0132025
JUN jun proto-oncogene -0.0131172
DLC1 DLC1 Rho GTPase activating protein -0.0126284
ISG15 ISG15 ubiquitin-like modifier -0.0125129
MAP1B microtubule-associated protein 1B -0.0124928
RPS23 ribosomal protein S23 -0.0123604
EGR1 early growth response 1 -0.0123037
CYB5R3 cytochrome b5 reductase 3 -0.0122867
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0118226
SP100 SP100 nuclear antigen -0.0118059
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0115906
B2M beta-2-microglobulin -0.0114148
INTS6 integrator complex subunit 6 -0.011409
EIF5B eukaryotic translation initiation factor 5B -0.0113446
RPL27 ribosomal protein L27 -0.0110108
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0109387
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -0.0108846
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0107737
EXT1 exostosin glycosyltransferase 1 -0.0106711
RPS11 ribosomal protein S11 -0.0106297
PERP PERP, TP53 apoptosis effector -0.0106236
RPS19 ribosomal protein S19 -0.0102591
RPL37 ribosomal protein L37 -0.0100983
RPL30 ribosomal protein L30 -0.00989831
RPS8 ribosomal protein S8 -0.00989491
IL32 interleukin 32 -0.0098628
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.00984947
RPS29 ribosomal protein S29 -0.0097658
RNASEH2A ribonuclease H2, subunit A -0.00975734
RAP1B RAP1B, member of RAS oncogene family -0.0097571
RPS12 ribosomal protein S12 -0.00975391
RPS10 ribosomal protein S10 -0.00969926
MYO6 myosin VI -0.00953842
SOX4 SRY (sex determining region Y)-box 4 -0.00939191
RPS25 ribosomal protein S25 -0.00939183
ENO2 enolase 2 (gamma, neuronal) -0.00933624
RPS21 ribosomal protein S21 -0.00927752
UBE2B ubiquitin-conjugating enzyme E2B -0.00923959
VIM vimentin -0.00922177
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.00916279
ATF4 activating transcription factor 4 -0.00915788
RPS13 ribosomal protein S13 -0.00898123
RPLP0 ribosomal protein, large, P0 -0.00885359
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.00882686
BPIFB2 BPI fold containing family B, member 2 -0.00880155
TUBA1C tubulin, alpha 1c -0.00873617
GMDS GDP-mannose 4,6-dehydratase -0.00867524
PALLD palladin, cytoskeletal associated protein -0.00867164
APOE apolipoprotein E -0.00863608
LYZ lysozyme -0.00853363
ZNF644 zinc finger protein 644 -0.00847999
RPL12 ribosomal protein L12 -0.00845712
RPS4X ribosomal protein S4, X-linked -0.00835938
SFTPA2 surfactant protein A2 -0.00830721
UQCRB ubiquinol-cytochrome c reductase binding protein -0.00820216
RPL19 ribosomal protein L19 -0.00818837
RTN4 reticulon 4 -0.00817051
RPS27 ribosomal protein S27 -0.00808709
SREBF2 sterol regulatory element binding transcription factor 2 -0.00806787
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.00805639
TPM4 tropomyosin 4 -0.00803427
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0079702
JUND jun D proto-oncogene -0.00796265
RPL23 ribosomal protein L23 -0.00789773
S100A6 S100 calcium binding protein A6 -0.00787537