Ponatinib_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ponatinib perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ponatinib_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.159907
CLU clusterin 0.132532
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.108313
LDHA lactate dehydrogenase A 0.093721
ENO1 enolase 1, (alpha) 0.0932275
MEF2A myocyte enhancer factor 2A 0.0771472
NAMPT nicotinamide phosphoribosyltransferase 0.0754714
CD44 CD44 molecule (Indian blood group) 0.0741332
EMP1 epithelial membrane protein 1 0.0734386
MBNL2 muscleblind-like splicing regulator 2 0.0732418
ITCH itchy E3 ubiquitin protein ligase 0.0645304
OGA O-GlcNAcase 0.062989
DSTN destrin (actin depolymerizing factor) 0.0625523
ANXA1 annexin A1 0.0620901
PGK1 phosphoglycerate kinase 1 0.0603931
ESYT2 extended synaptotagmin-like protein 2 0.0565219
GOLGA4 golgin A4 0.0558484
KRT17 keratin 17, type I 0.0549215
CANX calnexin 0.0535722
ITGA6 integrin, alpha 6 0.0517118
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0513816
EZR ezrin 0.0510002
ARRDC3 arrestin domain containing 3 0.0489736
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0486414
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0477638
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.04624
RICTOR RPTOR independent companion of MTOR, complex 2 0.044095
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0434382
AKAP9 A kinase (PRKA) anchor protein 9 0.043255
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0424683
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0421861
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0421824
LOC112694756 uncharaterized LOC112694756 0.0418879
CUL4B cullin 4B 0.0410647
SERINC3 serine incorporator 3 0.0406106
ANLN anillin, actin binding protein 0.0397597
KTN1 kinectin 1 (kinesin receptor) 0.0395921
EFHD2 EF-hand domain family, member D2 0.0387845
CD99 CD99 molecule 0.0376701
DLG1 discs, large homolog 1 (Drosophila) 0.0362857
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0362568
NPEPPS aminopeptidase puromycin sensitive 0.0361185
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0358244
FTH1 ferritin, heavy polypeptide 1 0.0357411
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.035512
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0352842
LMNA lamin A/C 0.0352055
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0344966
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0334709
PHF21A PHD finger protein 21A 0.0333797
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0324196
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0321534
CAV1 caveolin 1, caveolae protein, 22kDa 0.0321348
MRPS6 mitochondrial ribosomal protein S6 0.031932
MXI1 MAX interactor 1, dimerization protein 0.0317283
TRIO trio Rho guanine nucleotide exchange factor 0.0309009
GARS1 glycyl-tRNA synthetase 1 0.0308184
KDM7A lysine (K)-specific demethylase 7A 0.0305955
ZNF292 zinc finger protein 292 0.0303082
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0300547
NCOA3 nuclear receptor coactivator 3 0.0299136
RBM39 RNA binding motif protein 39 0.0297785
LMAN1 lectin, mannose-binding, 1 0.0294687
ANXA2 annexin A2 0.0292267
TPM3 tropomyosin 3 0.0291675
FN1 fibronectin 1 0.0291308
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0285289
FNIP1 folliculin interacting protein 1 0.0284998
TMSB4X thymosin beta 4, X-linked 0.028449
SKIC3 SKI3 subunit of superkiller complex 0.0284313
LIFR leukemia inhibitory factor receptor alpha 0.0282337
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0281306
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0280372
PDIA3 protein disulfide isomerase family A, member 3 0.027945
IGF2 insulin-like growth factor 2 0.0278759
TMSB10 thymosin beta 10 0.027814
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 0.0278122
ANKH ANKH inorganic pyrophosphate transport regulator 0.0278047
RAB6A RAB6A, member RAS oncogene family 0.0277755
TXNIP thioredoxin interacting protein 0.0277321
ANKRD33B ankyrin repeat domain 33B 0.0274704
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.026972
KIF16B kinesin family member 16B 0.0269389
SQLE squalene epoxidase 0.0266337
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0266209
RTN4 reticulon 4 0.0263889
CALU calumenin 0.026151
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0261016
GLYAT glycine-N-acyltransferase 0.0259673
EEF2 eukaryotic translation elongation factor 2 0.0259462
KIAA1217 KIAA1217 0.0256092
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0255349
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0254625
YBX3 Y box binding protein 3 0.0254095
KRT6A keratin 6A, type II 0.0251998
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0250798
CSDE1 cold shock domain containing E1, RNA-binding 0.0249046
MARCHF6 membrane associated ring-CH-type finger 6 0.0238026
RIOK3 RIO kinase 3 0.0237946
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0233561

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.178206
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.158947
MTSS1 metastasis suppressor 1 -0.124809
PALM2AKAP2 PALM2 and AKAP2 fusion -0.105988
INTS6 integrator complex subunit 6 -0.0978493
SLC35F3 solute carrier family 35, member F3 -0.0870383
PDLIM5 PDZ and LIM domain 5 -0.0856221
HMGA2 high mobility group AT-hook 2 -0.0826527
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0728859
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0691467
BCAR3 breast cancer anti-estrogen resistance 3 -0.0690409
ANO1 anoctamin 1, calcium activated chloride channel -0.0652615
PDE4D phosphodiesterase 4D, cAMP-specific -0.0626534
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0568199
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.0562066
RIGI RNA sensor RIG-I -0.05595
DPYD dihydropyrimidine dehydrogenase -0.0530942
RASAL2 RAS protein activator like 2 -0.0511011
THSD4 thrombospondin, type I, domain containing 4 -0.0498568
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0465622
EXT1 exostosin glycosyltransferase 1 -0.046465
RCOR1 REST corepressor 1 -0.0461
PALLD palladin, cytoskeletal associated protein -0.0451101
HDAC9 histone deacetylase 9 -0.0446215
ALCAM activated leukocyte cell adhesion molecule -0.0435857
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0425863
SULF2 sulfatase 2 -0.0418409
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0415188
DGKH diacylglycerol kinase, eta -0.0373305
IFI44L interferon-induced protein 44-like -0.0369848
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0369578
VCL vinculin -0.0365711
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0343176
MECOM MDS1 and EVI1 complex locus -0.0337867
PICALM phosphatidylinositol binding clathrin assembly protein -0.0337785
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0331493
CTBP2 C-terminal binding protein 2 -0.0329168
LUZP1 leucine zipper protein 1 -0.0328555
CDK6 cyclin-dependent kinase 6 -0.0324042
EFNA5 ephrin-A5 -0.0323243
CSMD2 CUB and Sushi multiple domains 2 -0.0320384
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0320107
PSD3 pleckstrin and Sec7 domain containing 3 -0.0318056
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0316019
HSPG2 heparan sulfate proteoglycan 2 -0.0307941
LAMC2 laminin, gamma 2 -0.0306267
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0304814
MPRIP myosin phosphatase Rho interacting protein -0.0303295
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0300656
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0297436
SP100 SP100 nuclear antigen -0.0294583
MAML2 mastermind-like 2 (Drosophila) -0.0290012
CORO2A coronin, actin binding protein, 2A -0.0283664
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 -0.0283416
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0282655
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0282171
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0280194
LAMA5 laminin, alpha 5 -0.0277818
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0276754
RAD51B RAD51 paralog B -0.0273246
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0271079
DENND1A DENN/MADD domain containing 1A -0.0270767
RNF217 ring finger protein 217 -0.0269068
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0263684
MTAP methylthioadenosine phosphorylase -0.0263106
MACF1 microtubule-actin crosslinking factor 1 -0.0260442
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0258729
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0258232
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0255107
SETX senataxin -0.0251627
CMIP c-Maf inducing protein -0.0250628
CUX1 cut-like homeobox 1 -0.0246614
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -0.0245311
NRIP1 nuclear receptor interacting protein 1 -0.0244837
PITPNB phosphatidylinositol transfer protein, beta -0.0238529
SOX5 SRY (sex determining region Y)-box 5 -0.0229859
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0229019
SMYD3 SET and MYND domain containing 3 -0.0228749
IFI44 interferon-induced protein 44 -0.0226496
NCKAP5 NCK-associated protein 5 -0.022585
NPAS2 neuronal PAS domain protein 2 -0.0225433
EGFR epidermal growth factor receptor -0.0225204
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0222028
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0221115
CLIC4 chloride intracellular channel 4 -0.0220827
CDK17 cyclin-dependent kinase 17 -0.0220389
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0219656
AKAP13 A kinase (PRKA) anchor protein 13 -0.0219655
KIAA1549L KIAA1549-like -0.0218328
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0216394
ACTN1 actinin, alpha 1 -0.0215905
TNS3 tensin 3 -0.0215199
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 -0.0212867
RHOJ ras homolog family member J -0.0211531
AHRR aryl-hydrocarbon receptor repressor -0.0211092
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0208628
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0208433
ACTN4 actinin, alpha 4 -0.0207222
RAP1B RAP1B, member of RAS oncogene family -0.0206112
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0205038