Ponatinib_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ponatinib perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ponatinib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 0.143214
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.14282
MUC6 mucin 6, oligomeric mucus/gel-forming 0.118846
FAT1 FAT atypical cadherin 1 0.0896339
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0882042
NALF1 NALCN channel auxiliary factor 1 0.0790999
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0760513
CEMIP cell migration inducing protein, hyaluronan binding 0.0712844
GPHN gephyrin 0.0706697
PIGR polymeric immunoglobulin receptor 0.0704432
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0686137
ITGA6 integrin, alpha 6 0.0601482
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0534223
GMDS GDP-mannose 4,6-dehydratase 0.0521404
MYO1E myosin IE 0.0508628
ALCAM activated leukocyte cell adhesion molecule 0.0504401
TRIM2 tripartite motif containing 2 0.0474277
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.0435942
FLNB filamin B, beta 0.0426858
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0421722
DSPP dentin sialophosphoprotein 0.0410104
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0407033
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.0382878
GREB1L growth regulation by estrogen in breast cancer-like 0.0371477
AHNAK AHNAK nucleoprotein 0.0359989
PATJ PATJ crumbs cell polarity complex component 0.0348972
VCL vinculin 0.0342215
ANTXR2 anthrax toxin receptor 2 0.0341176
CTBP2 C-terminal binding protein 2 0.032617
FHIT fragile histidine triad 0.0325878
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0321861
MYH9 myosin, heavy chain 9, non-muscle 0.0315679
PKP2 plakophilin 2 0.0313984
CADPS Ca++-dependent secretion activator 0.0311429
RAD51B RAD51 paralog B 0.0310643
PTPRK protein tyrosine phosphatase, receptor type, K 0.0309455
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.0308444
ENO1 enolase 1, (alpha) 0.0295816
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0293
MLEC malectin 0.0290372
EPHB2 EPH receptor B2 0.0289842
PDLIM5 PDZ and LIM domain 5 0.0289688
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0287425
ABHD2 abhydrolase domain containing 2 0.0282052
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.028079
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0280305
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0279604
NCOR1 nuclear receptor corepressor 1 0.027945
LPP LIM domain containing preferred translocation partner in lipoma 0.0277511
MBNL1 muscleblind-like splicing regulator 1 0.0275629
CCSER1 coiled-coil serine-rich protein 1 0.0269362
MECOM MDS1 and EVI1 complex locus 0.0269296
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0268869
NRXN3 neurexin 3 0.0265894
ARHGAP32 Rho GTPase activating protein 32 0.0263546
RNF217 ring finger protein 217 0.0261537
MAML3 mastermind-like 3 (Drosophila) 0.0259472
ANKRD17 ankyrin repeat domain 17 0.0257082
PDE4D phosphodiesterase 4D, cAMP-specific 0.0253031
CUX1 cut-like homeobox 1 0.0252671
GPA33 glycoprotein A33 (transmembrane) 0.0248965
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0246273
TNS4 tensin 4 0.0245093
PARD3 par-3 family cell polarity regulator 0.0244241
ARHGAP26 Rho GTPase activating protein 26 0.0243553
EZR ezrin 0.0242902
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0240031
LGALS3 lectin, galactoside-binding, soluble, 3 0.0239169
ACTN4 actinin, alpha 4 0.0235727
CALB1 calbindin 1, 28kDa 0.0235035
AFF1 AF4/FMR2 family, member 1 0.0232777
SAMD5 sterile alpha motif domain containing 5 0.0230646
TBC1D5 TBC1 domain family, member 5 0.0230479
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0226246
GTF2IRD1 GTF2I repeat domain containing 1 0.0225221
ETV6 ets variant 6 0.0221052
EXOC4 exocyst complex component 4 0.0216601
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 0.0214589
RHPN2 rhophilin, Rho GTPase binding protein 2 0.0213667
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0212143
RAB10 RAB10, member RAS oncogene family 0.0211434
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.021084
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0208952
PARD3B par-3 family cell polarity regulator beta 0.0207918
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0207814
FOXP1 forkhead box P1 0.0207389
ITGB4 integrin, beta 4 0.02073
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0206942
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0206088
MAML2 mastermind-like 2 (Drosophila) 0.0205644
SPON1 spondin 1, extracellular matrix protein 0.0204898
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.0204456
SBF2 SET binding factor 2 0.0204062
SYNE2 spectrin repeat containing, nuclear envelope 2 0.02033
MUC5B mucin 5B, oligomeric mucus/gel-forming 0.0202944
SH3D19 SH3 domain containing 19 0.0202771
FTH1 ferritin, heavy polypeptide 1 0.0202729
EHBP1 EH domain binding protein 1 0.0202264
PCBP2 poly(rC) binding protein 2 0.0201676
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0200043

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.21765
RPLP1 ribosomal protein, large, P1 -0.0888756
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0857498
TMSB10 thymosin beta 10 -0.0845891
FTL ferritin, light polypeptide -0.0739941
EIF1 eukaryotic translation initiation factor 1 -0.0632544
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0628936
TPT1 tumor protein, translationally-controlled 1 -0.0600153
RPS19 ribosomal protein S19 -0.0550994
MT2A metallothionein 2A -0.0535028
PTMA prothymosin, alpha -0.0471615
RPL35A ribosomal protein L35a -0.045246
RPL12 ribosomal protein L12 -0.0448669
RPL34 ribosomal protein L34 -0.0445006
S100P S100 calcium binding protein P -0.0438866
RPS6 ribosomal protein S6 -0.0411369
NDRG1 N-myc downstream regulated 1 -0.0406658
RPL36 ribosomal protein L36 -0.0406442
RPS24 ribosomal protein S24 -0.0402901
RPL19 ribosomal protein L19 -0.0390506
RPL31 ribosomal protein L31 -0.0368533
LOC112694756 uncharaterized LOC112694756 -0.0352266
RPL32 ribosomal protein L32 -0.0351985
RPLP2 ribosomal protein, large, P2 -0.0341311
RPLP0 ribosomal protein, large, P0 -0.0334051
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0323099
RPL37A ribosomal protein L37a -0.0314447
RPL9 ribosomal protein L9 -0.0306976
ISG15 ISG15 ubiquitin-like modifier -0.0291594
RPS12 ribosomal protein S12 -0.0279084
RPS8 ribosomal protein S8 -0.0277147
GDF15 growth differentiation factor 15 -0.0274836
RPS20 ribosomal protein S20 -0.0269852
RPL23 ribosomal protein L23 -0.0261395
RPL30 ribosomal protein L30 -0.0254795
AREG amphiregulin -0.0254037
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.025352
RPS23 ribosomal protein S23 -0.0252559
PKM pyruvate kinase, muscle -0.0244075
RPL28 ribosomal protein L28 -0.0244014
RPS13 ribosomal protein S13 -0.024376
MT1X metallothionein 1X -0.0238735
RPL11 ribosomal protein L11 -0.0228783
RPS16 ribosomal protein S16 -0.0227336
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0225019
EREG epiregulin -0.0224957
RPS11 ribosomal protein S11 -0.0221549
RPL37 ribosomal protein L37 -0.021525
RPS29 ribosomal protein S29 -0.0214886
KDM3A lysine (K)-specific demethylase 3A -0.0210111
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0210109
RPS4X ribosomal protein S4, X-linked -0.0207775
VDAC1 voltage-dependent anion channel 1 -0.0204852
PLAUR plasminogen activator, urokinase receptor -0.0203612
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0200572
MKNK2 MAP kinase interacting serine/threonine kinase 2 -0.0199817
RPS5 ribosomal protein S5 -0.0198199
SELENOK selenoprotein K -0.0196451
RPL27A ribosomal protein L27a -0.0195202
RPL26 ribosomal protein L26 -0.0193438
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0193303
RPS27 ribosomal protein S27 -0.0192688
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0190315
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0189127
MT1E metallothionein 1E -0.018601
IER3 immediate early response 3 -0.0176695
RPL27 ribosomal protein L27 -0.0174438
RPS17 ribosomal protein S17 -0.0171927
RRBP1 ribosome binding protein 1 -0.0171597
S100A14 S100 calcium binding protein A14 -0.0170205
RPS21 ribosomal protein S21 -0.0168082
ATF4 activating transcription factor 4 -0.0163296
RPL38 ribosomal protein L38 -0.0162899
KLF5 Kruppel-like factor 5 (intestinal) -0.0161248
ACTG1 actin gamma 1 -0.0160363
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0160176
RPL36AL ribosomal protein L36a-like -0.0156744
RPL7A ribosomal protein L7a -0.0156625
RPL35 ribosomal protein L35 -0.0155844
AGR2 anterior gradient 2 -0.015564
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0155347
BTG1 B-cell translocation gene 1, anti-proliferative -0.0155172
RBM39 RNA binding motif protein 39 -0.014861
RPS15 ribosomal protein S15 -0.0143584
GSTP1 glutathione S-transferase pi 1 -0.0139263
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0138096
OGA O-GlcNAcase -0.0136916
TXNRD1 thioredoxin reductase 1 -0.0136046
RPL14 ribosomal protein L14 -0.0135418
S100A10 S100 calcium binding protein A10 -0.0135196
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0135151
B2M beta-2-microglobulin -0.0134804
RPS14 ribosomal protein S14 -0.0131938
ESYT2 extended synaptotagmin-like protein 2 -0.0131636
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0129231
CCNI cyclin I -0.0128782
RPS25 ribosomal protein S25 -0.0128551
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -0.0127877
ONECUT3 one cut homeobox 3 -0.0127515
PERP PERP, TP53 apoptosis effector -0.0125457