| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ponatinib perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ponatinib_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.109085 |
| TXNRD1 | thioredoxin reductase 1 | 0.099441 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0777427 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.076048 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0700972 |
| AHNAK | AHNAK nucleoprotein | 0.0604152 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0567734 |
| CENPF | centromere protein F, 350/400kDa | 0.0508914 |
| CANX | calnexin | 0.0480488 |
| VIM | vimentin | 0.0465672 |
| LDHA | lactate dehydrogenase A | 0.0449905 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0404618 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0384532 |
| CDK19 | cyclin-dependent kinase 19 | 0.0379866 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0375129 |
| RTN4 | reticulon 4 | 0.0367998 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0338636 |
| AARS1 | alanyl-tRNA synthetase 1 | 0.0336867 |
| ERBIN | erbb2 interacting protein | 0.0324792 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0322838 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0322303 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0318557 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0318211 |
| YEATS2 | YEATS domain containing 2 | 0.0316385 |
| TNPO1 | transportin 1 | 0.0313017 |
| GOLGA4 | golgin A4 | 0.0312724 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0312115 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0311507 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0307539 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0303931 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0301291 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0293991 |
| MKI67 | marker of proliferation Ki-67 | 0.0292611 |
| TMEM41B | transmembrane protein 41B | 0.0291313 |
| ZNF292 | zinc finger protein 292 | 0.0283257 |
| TRERF1 | transcriptional regulating factor 1 | 0.0275483 |
| OGA | O-GlcNAcase | 0.0274982 |
| XPO1 | exportin 1 | 0.0267774 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.026698 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0259373 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0255642 |
| CLTC | clathrin, heavy chain (Hc) | 0.0253597 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0252869 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.0250195 |
| GPBP1L1 | GC-rich promoter binding protein 1-like 1 | 0.024437 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0242053 |
| FNIP1 | folliculin interacting protein 1 | 0.0239173 |
| PCBP2 | poly(rC) binding protein 2 | 0.0236594 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.0236056 |
| TCEA1 | transcription elongation factor A (SII), 1 | 0.0234929 |
| ANXA1 | annexin A1 | 0.0234795 |
| XPOT | exportin, tRNA | 0.0234793 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0234104 |
| ANKRD50 | ankyrin repeat domain 50 | 0.0231857 |
| NCKAP1 | NCK-associated protein 1 | 0.0231804 |
| WDR26 | WD repeat domain 26 | 0.0226316 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0225162 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 0.0223671 |
| MAP4 | microtubule-associated protein 4 | 0.0223098 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | 0.0221685 |
| YARS1 | tyrosyl-tRNA synthetase 1 | 0.0221273 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0220295 |
| BPTF | bromodomain PHD finger transcription factor | 0.0219136 |
| CEP170 | centrosomal protein 170kDa | 0.0219126 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0218945 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0218471 |
| UBXN7 | UBX domain protein 7 | 0.0218228 |
| DARS1 | aspartyl-tRNA synthetase 1 | 0.0216799 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0214428 |
| PSAT1 | phosphoserine aminotransferase 1 | 0.0214048 |
| PYGB | phosphorylase, glycogen; brain | 0.021195 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.0211177 |
| CD109 | CD109 molecule | 0.0211149 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0210307 |
| KLHL24 | kelch-like family member 24 | 0.0210039 |
| CUL4B | cullin 4B | 0.0207883 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0206325 |
| GPT2 | glutamic pyruvate transaminase (alanine aminotransferase) 2 | 0.0205588 |
| ZNF148 | zinc finger protein 148 | 0.0205301 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0205107 |
| KIF1B | kinesin family member 1B | 0.0203542 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0198644 |
| SP3 | Sp3 transcription factor | 0.0198643 |
| ANLN | anillin, actin binding protein | 0.0195213 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0195211 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0194446 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0194158 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0194068 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0193416 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0193353 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0191348 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0191343 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0189938 |
| RAI1 | retinoic acid induced 1 | 0.0188513 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0187945 |
| RPRD2 | regulation of nuclear pre-mRNA domain containing 2 | 0.0185758 |
| NUP58 | nucleoporin 58 | 0.0185612 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0185118 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | 0.018495 |
| ZFR | zinc finger RNA binding protein | 0.0184476 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TP63 | tumor protein p63 | -0.214582 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.158413 |
| CD44 | CD44 molecule (Indian blood group) | -0.151482 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.12852 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.123441 |
| PTMA | prothymosin, alpha | -0.116901 |
| DST | dystonin | -0.115109 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.102397 |
| CADM2 | cell adhesion molecule 2 | -0.0997116 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0986908 |
| MT2A | metallothionein 2A | -0.0964342 |
| HLA-B | major histocompatibility complex, class I, B | -0.095559 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0905567 |
| PDE10A | phosphodiesterase 10A | -0.0882666 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.08764 |
| RIGI | RNA sensor RIG-I | -0.0876192 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0854726 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | -0.083133 |
| SP100 | SP100 nuclear antigen | -0.0723591 |
| DNER | delta/notch-like EGF repeat containing | -0.0714384 |
| CFAP299 | cilia and flagella associated protein 299 | -0.0694636 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0686143 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.066819 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0663065 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0646834 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0646558 |
| RNF213 | ring finger protein 213 | -0.0639451 |
| EHBP1 | EH domain binding protein 1 | -0.0622883 |
| FMNL2 | formin-like 2 | -0.0605512 |
| PLSCR1 | phospholipid scramblase 1 | -0.0602431 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0581912 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0557762 |
| VCL | vinculin | -0.0536854 |
| TNS3 | tensin 3 | -0.0534293 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0504738 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0504011 |
| TMSB10 | thymosin beta 10 | -0.0500378 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0492923 |
| TMSB4X | thymosin beta 4, X-linked | -0.0477169 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0449148 |
| RPS8 | ribosomal protein S8 | -0.044641 |
| TGM2 | transglutaminase 2 | -0.0445315 |
| RPL35A | ribosomal protein L35a | -0.0442107 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0431515 |
| ECE1 | endothelin converting enzyme 1 | -0.042776 |
| EPHA4 | EPH receptor A4 | -0.0427707 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0419471 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0412525 |
| RPS19 | ribosomal protein S19 | -0.0405929 |
| CAPRIN2 | caprin family member 2 | -0.0402271 |
| NEK10 | NIMA-related kinase 10 | -0.0398627 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0394395 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0384098 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0380614 |
| MYOF | myoferlin | -0.0374843 |
| EFNA5 | ephrin-A5 | -0.0369341 |
| B2M | beta-2-microglobulin | -0.0366723 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0359157 |
| RPL36 | ribosomal protein L36 | -0.0358272 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0353068 |
| DPH6 | diphthamine biosynthesis 6 | -0.0351401 |
| RPL37A | ribosomal protein L37a | -0.0349516 |
| PMP22 | peripheral myelin protein 22 | -0.0346234 |
| FTL | ferritin, light polypeptide | -0.0342968 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0339488 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0338059 |
| SRGN | serglycin | -0.0336981 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0334547 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.0331274 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0330674 |
| CMIP | c-Maf inducing protein | -0.0329391 |
| INTS6 | integrator complex subunit 6 | -0.0319633 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0319364 |
| PRELID2 | PRELI domain containing 2 | -0.031874 |
| RPLP2 | ribosomal protein, large, P2 | -0.0317368 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0315644 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0308886 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0298546 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0296141 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0292403 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0291607 |
| HDAC9 | histone deacetylase 9 | -0.0287577 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.028609 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | -0.0284481 |
| RPL31 | ribosomal protein L31 | -0.0284341 |
| RUNX1 | runt-related transcription factor 1 | -0.0282859 |
| PTK2 | protein tyrosine kinase 2 | -0.0282176 |
| VMP1 | vacuole membrane protein 1 | -0.0282139 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0282014 |
| RPS24 | ribosomal protein S24 | -0.0279057 |
| CDK6 | cyclin-dependent kinase 6 | -0.0278766 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | -0.0277276 |
| RPS6 | ribosomal protein S6 | -0.0275953 |
| RPL38 | ribosomal protein L38 | -0.0275459 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0272489 |
| RPL12 | ribosomal protein L12 | -0.0271957 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0270488 |
| DENND1A | DENN/MADD domain containing 1A | -0.0269833 |
| PRKCE | protein kinase C, epsilon | -0.0265815 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | -0.0262371 |
