Ponatinib_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ponatinib perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Ponatinib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.331011
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.120265
RPS3 ribosomal protein S3 0.0980767
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0881045
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0853885
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0829201
PDE4D phosphodiesterase 4D, cAMP-specific 0.070272
ENO1 enolase 1, (alpha) 0.069187
TBC1D22A TBC1 domain family, member 22A 0.0500503
MT2A metallothionein 2A 0.0499798
FAM13A family with sequence similarity 13, member A 0.0498828
EGR1 early growth response 1 0.0493329
ARRDC3 arrestin domain containing 3 0.048563
AKAP9 A kinase (PRKA) anchor protein 9 0.0485135
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0481225
RPL37A ribosomal protein L37a 0.0470243
RPS8 ribosomal protein S8 0.046689
RPS12 ribosomal protein S12 0.045933
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0408349
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0402088
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0395629
TTC3 tetratricopeptide repeat domain 3 0.0389812
FTH1 ferritin, heavy polypeptide 1 0.0388387
RPL35A ribosomal protein L35a 0.0387576
RAD51B RAD51 paralog B 0.0383164
MCTP1 multiple C2 domains, transmembrane 1 0.0377977
HMGA1 high mobility group AT-hook 1 0.0377021
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.036482
IRS2 insulin receptor substrate 2 0.036394
PCBP2 poly(rC) binding protein 2 0.0351813
RPL5 ribosomal protein L5 0.0343127
RPL11 ribosomal protein L11 0.0341737
TNRC6B trinucleotide repeat containing 6B 0.0339991
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0338839
SEC61G Sec61 gamma subunit 0.0336071
PLEC plectin 0.0331812
PRELID2 PRELI domain containing 2 0.0328315
TPT1 tumor protein, translationally-controlled 1 0.032287
EEF1G eukaryotic translation elongation factor 1 gamma 0.0310268
CALR calreticulin 0.0309555
PTEN phosphatase and tensin homolog 0.0308033
PER2 period circadian clock 2 0.0303024
RPS25 ribosomal protein S25 0.0302421
RPS6 ribosomal protein S6 0.0301652
CD99 CD99 molecule 0.0301644
RPS2 ribosomal protein S2 0.0299918
INTS6 integrator complex subunit 6 0.0298068
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.029329
CPE carboxypeptidase E 0.0286471
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0286022
RPL7 ribosomal protein L7 0.0284394
GPC6 glypican 6 0.0279504
RPS27 ribosomal protein S27 0.0278408
RUNX1 runt-related transcription factor 1 0.0278315
RPS29 ribosomal protein S29 0.0276988
HYOU1 hypoxia up-regulated 1 0.0276642
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0274972
RPL23 ribosomal protein L23 0.0274942
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0272948
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0264134
GOLGB1 golgin B1 0.0263673
FAAH2 fatty acid amide hydrolase 2 0.0262694
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0261236
EEF2 eukaryotic translation elongation factor 2 0.0258063
BPTF bromodomain PHD finger transcription factor 0.0257199
RPL36 ribosomal protein L36 0.0254492
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0248678
MKI67 marker of proliferation Ki-67 0.0247445
RPL13A ribosomal protein L13a 0.0246668
KTN1 kinectin 1 (kinesin receptor) 0.0245375
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0243946
LIMCH1 LIM and calponin homology domains 1 0.0241817
LGALS12 lectin, galactoside-binding, soluble, 12 0.023919
DOCK5 dedicator of cytokinesis 5 0.0236784
TBL1X transducin (beta)-like 1X-linked 0.0236299
TTC39C tetratricopeptide repeat domain 39C 0.0235433
GPHN gephyrin 0.0235039
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0234687
APLP2 amyloid beta (A4) precursor-like protein 2 0.0233374
CNTN1 contactin 1 0.023275
TMCO3 transmembrane and coiled-coil domains 3 0.0230565
NAP1L1 nucleosome assembly protein 1-like 1 0.0230535
ATXN7 ataxin 7 0.0228659
AFF1 AF4/FMR2 family, member 1 0.0225904
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0224982
PRKD1 protein kinase D1 0.0224709
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0222858
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0222848
CIB1 calcium and integrin binding 1 (calmyrin) 0.0220531
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0219901
MBNL2 muscleblind-like splicing regulator 2 0.0218339
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0218277
EYA2 EYA transcriptional coactivator and phosphatase 2 0.0217188
GANAB glucosidase, alpha; neutral AB 0.0216985
PFN1 profilin 1 0.0216867
RACK1 receptor for activated C kinase 1 0.0211839
RPL26 ribosomal protein L26 0.0211654
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0211054
MIDEAS mitotic deacetylase associated SANT domain protein 0.021075
ANKRD11 ankyrin repeat domain 11 0.0210279

decreased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 -0.187346
LMO7 LIM domain 7 -0.185035
THSD4 thrombospondin, type I, domain containing 4 -0.108274
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.106121
OSMR oncostatin M receptor -0.0901633
LAMC2 laminin, gamma 2 -0.0835231
H1-0 H1.0 linker histone -0.0818882
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0782553
PTPRM protein tyrosine phosphatase, receptor type, M -0.0655193
ERRFI1 ERBB receptor feedback inhibitor 1 -0.064708
AKR1C1 aldo-keto reductase family 1, member C1 -0.0606668
STC1 stanniocalcin 1 -0.0588014
SLTM SAFB-like, transcription modulator -0.0577643
BZW1 basic leucine zipper and W2 domains 1 -0.0573071
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0540026
TES testin LIM domain protein -0.053362
SCEL sciellin -0.0530607
SOD2 superoxide dismutase 2, mitochondrial -0.0521645
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0519123
FTL ferritin, light polypeptide -0.0514638
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0491783
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0480139
FNDC3B fibronectin type III domain containing 3B -0.0464379
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0460414
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0453088
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0452383
ASPH aspartate beta-hydroxylase -0.0445586
NAMPT nicotinamide phosphoribosyltransferase -0.0436895
RAP1B RAP1B, member of RAS oncogene family -0.043126
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0425642
ZC3H11A zinc finger CCCH-type containing 11A -0.0424005
NABP1 nucleic acid binding protein 1 -0.0418419
PDLIM5 PDZ and LIM domain 5 -0.0417156
ELL2 elongation factor, RNA polymerase II, 2 -0.0416065
RAB27B RAB27B, member RAS oncogene family -0.0414731
BTG1 B-cell translocation gene 1, anti-proliferative -0.0412278
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0406921
CDCP1 CUB domain containing protein 1 -0.0406913
USP53 ubiquitin specific peptidase 53 -0.0404381
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0380813
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0378199
TOP1 topoisomerase (DNA) I -0.0376826
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.03768
NF1 neurofibromin 1 -0.0368115
MYO1D myosin ID -0.0361696
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0360034
GSK3B glycogen synthase kinase 3 beta -0.0358313
PATJ PATJ crumbs cell polarity complex component -0.0339396
IER3 immediate early response 3 -0.0336155
BMAL2 basic helix-loop-helix ARNT like 2 -0.0326894
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0313579
ZFC3H1 zinc finger, C3H1-type containing -0.0309292
ATP13A3 ATPase type 13A3 -0.0305408
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0303383
NPC1 Niemann-Pick disease, type C1 -0.0302757
PGK1 phosphoglycerate kinase 1 -0.0302612
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0301319
ACTG1 actin gamma 1 -0.0298382
GM2A GM2 ganglioside activator -0.0292726
TSC22D2 TSC22 domain family, member 2 -0.0292062
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0290846
CEMIP cell migration inducing protein, hyaluronan binding -0.0286415
RAB10 RAB10, member RAS oncogene family -0.0285693
HDLBP high density lipoprotein binding protein -0.0281135
ZFAND3 zinc finger, AN1-type domain 3 -0.0280407
GRAMD1B GRAM domain containing 1B -0.026972
KDM3A lysine (K)-specific demethylase 3A -0.0266888
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0266416
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0262727
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) -0.0260262
RASA2 RAS p21 protein activator 2 -0.0257791
ADGRF1 adhesion G protein-coupled receptor F1 -0.0257248
AKAP12 A kinase (PRKA) anchor protein 12 -0.0249047
AKAP13 A kinase (PRKA) anchor protein 13 -0.0247317
ARHGAP32 Rho GTPase activating protein 32 -0.024705
SEPTIN10 septin 10 -0.0244369
TRIP12 thyroid hormone receptor interactor 12 -0.0241274
STRN3 striatin, calmodulin binding protein 3 -0.023778
SPAG9 sperm associated antigen 9 -0.0237738
NDRG1 N-myc downstream regulated 1 -0.0236061
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0235081
NT5C2 5'-nucleotidase, cytosolic II -0.023464
RTN4 reticulon 4 -0.0233989
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0232319
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0232183
GLS2 glutaminase 2 (liver, mitochondrial) -0.0227625
ADAM17 ADAM metallopeptidase domain 17 -0.0227593
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0226215
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0225789
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.022524
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0223937
SP100 SP100 nuclear antigen -0.0223539
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0222208
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.0221539
FBXO11 F-box protein 11 -0.0217816
SAMD4A sterile alpha motif domain containing 4A -0.0217693
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0216605
NCOA3 nuclear receptor coactivator 3 -0.0215391
SENP5 SUMO1/sentrin specific peptidase 5 -0.021226
USP34 ubiquitin specific peptidase 34 -0.0210634