Ponatinib_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ponatinib perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ponatinib_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.210945
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.176964
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.134256
SDK1 sidekick cell adhesion molecule 1 0.0939816
VIM vimentin 0.0925479
MT2A metallothionein 2A 0.0861977
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0792289
ENO1 enolase 1, (alpha) 0.0715621
PCBP2 poly(rC) binding protein 2 0.0714845
LDHA lactate dehydrogenase A 0.069855
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.067354
HMGA1 high mobility group AT-hook 1 0.06542
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0557597
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0554793
B2M beta-2-microglobulin 0.0538677
ASPH aspartate beta-hydroxylase 0.0519292
CA12 carbonic anhydrase XII 0.0518973
RPS8 ribosomal protein S8 0.0516482
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0501951
PTMA prothymosin, alpha 0.0499001
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0489962
TMSB10 thymosin beta 10 0.0475659
FTL ferritin, light polypeptide 0.0475433
MYH9 myosin, heavy chain 9, non-muscle 0.0472491
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0466614
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0466285
BASP1 brain abundant, membrane attached signal protein 1 0.0456208
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0442845
RPS19 ribosomal protein S19 0.042607
RPS12 ribosomal protein S12 0.0420321
CALR calreticulin 0.0416147
RPL23 ribosomal protein L23 0.041559
FAM13A family with sequence similarity 13, member A 0.041134
CANX calnexin 0.04049
YBX1 Y box binding protein 1 0.0399908
NAP1L1 nucleosome assembly protein 1-like 1 0.0399747
NDRG1 N-myc downstream regulated 1 0.0396027
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0395677
FLNB filamin B, beta 0.0395203
KTN1 kinectin 1 (kinesin receptor) 0.0384998
FN1 fibronectin 1 0.0384552
RPS3 ribosomal protein S3 0.0380405
RPS6 ribosomal protein S6 0.037749
ANGPTL4 angiopoietin-like 4 0.0375722
TPT1 tumor protein, translationally-controlled 1 0.0367624
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0367398
RPL35A ribosomal protein L35a 0.0363431
PDIA4 protein disulfide isomerase family A, member 4 0.0357228
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0355272
PDIA3 protein disulfide isomerase family A, member 3 0.0354937
PARP8 poly (ADP-ribose) polymerase family, member 8 0.03481
RPL13A ribosomal protein L13a 0.0340572
FTH1 ferritin, heavy polypeptide 1 0.0337904
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0333445
SQSTM1 sequestosome 1 0.0325933
RPL36 ribosomal protein L36 0.0323169
RPL37A ribosomal protein L37a 0.0322647
RPL5 ribosomal protein L5 0.0321402
RPS29 ribosomal protein S29 0.032082
NAV2 neuron navigator 2 0.0320597
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0318907
RPLP2 ribosomal protein, large, P2 0.0314302
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0311822
RPL11 ribosomal protein L11 0.0309398
RUNX1 runt-related transcription factor 1 0.0307373
PFN1 profilin 1 0.0303284
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0299665
APLP2 amyloid beta (A4) precursor-like protein 2 0.029845
RPS21 ribosomal protein S21 0.0295352
HLA-B major histocompatibility complex, class I, B 0.0294575
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0291316
EEF2 eukaryotic translation elongation factor 2 0.0290525
ICAM1 intercellular adhesion molecule 1 0.0283521
SMAD3 SMAD family member 3 0.0282419
CALU calumenin 0.0281686
KDM2A lysine (K)-specific demethylase 2A 0.027843
RPL12 ribosomal protein L12 0.027694
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0276147
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0272013
POTEF POTE ankyrin domain family, member F 0.0267669
CLEC1B C-type lectin domain family 1, member B 0.0265705
SOD2 superoxide dismutase 2, mitochondrial 0.0262948
HELZ helicase with zinc finger 0.0260548
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0253866
EZR ezrin 0.0245407
RPL34 ribosomal protein L34 0.0244486
RPS27 ribosomal protein S27 0.0242924
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0242741
RPS13 ribosomal protein S13 0.0241553
ZMIZ1 zinc finger, MIZ-type containing 1 0.0240882
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.0240461
S100A6 S100 calcium binding protein A6 0.0240247
RACK1 receptor for activated C kinase 1 0.0238049
UBE2O ubiquitin-conjugating enzyme E2O 0.0233148
S100A10 S100 calcium binding protein A10 0.0232315
EMP1 epithelial membrane protein 1 0.023163
ECE1 endothelin converting enzyme 1 0.0230247
RPS25 ribosomal protein S25 0.0229016
G0S2 G0/G1 switch 2 0.0226528
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0226524

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.0956513
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0742899
USP34 ubiquitin specific peptidase 34 -0.0651262
PSD3 pleckstrin and Sec7 domain containing 3 -0.0621212
OSMR oncostatin M receptor -0.0612678
GLCCI1 glucocorticoid induced 1 -0.0577593
ZEB2 zinc finger E-box binding homeobox 2 -0.0569938
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0559668
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0505464
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0489871
HMGA2 high mobility group AT-hook 2 -0.0485571
NRP1 neuropilin 1 -0.0480388
RBM39 RNA binding motif protein 39 -0.0461308
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0442086
IGFBP3 insulin-like growth factor binding protein 3 -0.0441123
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0439782
FNDC3B fibronectin type III domain containing 3B -0.0439238
KYNU kynureninase -0.0421914
NPC1 Niemann-Pick disease, type C1 -0.0388821
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0382961
DPYD dihydropyrimidine dehydrogenase -0.0360073
ZBTB20 zinc finger and BTB domain containing 20 -0.0355444
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0350139
ETV6 ets variant 6 -0.0340123
VRK2 vaccinia related kinase 2 -0.0335245
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0332443
ZNF804A zinc finger protein 804A -0.0305219
ZFAND3 zinc finger, AN1-type domain 3 -0.0305077
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0304363
NF1 neurofibromin 1 -0.0303591
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0301751
VMP1 vacuole membrane protein 1 -0.0299803
OXSR1 oxidative stress responsive 1 -0.0295475
NTN4 netrin 4 -0.0294937
ZC3H12C zinc finger CCCH-type containing 12C -0.0294087
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0290628
SYT1 synaptotagmin I -0.0290497
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0289839
RAB27B RAB27B, member RAS oncogene family -0.0278782
AKAP13 A kinase (PRKA) anchor protein 13 -0.0277063
MON2 MON2 homolog (S. cerevisiae) -0.0275773
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0270718
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0270452
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0266886
ANTXR2 anthrax toxin receptor 2 -0.0265499
LRRC49 leucine rich repeat containing 49 -0.0262929
RUNX2 runt-related transcription factor 2 -0.0254386
ATM ATM serine/threonine kinase -0.0253045
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0252365
MSRB3 methionine sulfoxide reductase B3 -0.0251003
MYO9A myosin IXA -0.0250746
ZFC3H1 zinc finger, C3H1-type containing -0.0246829
ARHGAP5 Rho GTPase activating protein 5 -0.0245256
MBD5 methyl-CpG binding domain protein 5 -0.023807
TRIO trio Rho guanine nucleotide exchange factor -0.0235774
PID1 phosphotyrosine interaction domain containing 1 -0.0234228
DENND4A DENN/MADD domain containing 4A -0.023416
LHFPL2 lipoma HMGIC fusion partner-like 2 -0.0234047
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0227025
HEG1 heart development protein with EGF-like domains 1 -0.0223203
ATP13A3 ATPase type 13A3 -0.022053
TMEM165 transmembrane protein 165 -0.0219787
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0218147
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0218131
JMJD1C jumonji domain containing 1C -0.0214861
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.0213318
GRB10 growth factor receptor-bound protein 10 -0.0209465
ANKRD17 ankyrin repeat domain 17 -0.0205686
EREG epiregulin -0.0202728
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0199594
STRN3 striatin, calmodulin binding protein 3 -0.0198965
NCOA7 nuclear receptor coactivator 7 -0.0198029
EXOC4 exocyst complex component 4 -0.0193336
LUZP1 leucine zipper protein 1 -0.0192791
SOS2 son of sevenless homolog 2 (Drosophila) -0.0192315
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0192154
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0191415
ZNF407 zinc finger protein 407 -0.0191181
GOLGA3 golgin A3 -0.0189811
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0189217
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0187015
CREB5 cAMP responsive element binding protein 5 -0.0186192
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.0184987
RNF24 ring finger protein 24 -0.0184951
SAMD4A sterile alpha motif domain containing 4A -0.0183524
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0183245
ARHGAP24 Rho GTPase activating protein 24 -0.0180707
RAP1B RAP1B, member of RAS oncogene family -0.0180322
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0179306
DYM dymeclin -0.0179279
EXOC6B exocyst complex component 6B -0.0177858
GRIK5 glutamate receptor, ionotropic, kainate 5 -0.0177487
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0177023
COL12A1 collagen, type XII, alpha 1 -0.017422
EHBP1 EH domain binding protein 1 -0.017154
IL1R1 interleukin 1 receptor, type I -0.017127
TJP1 tight junction protein 1 -0.0169814
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0169509
FRMD5 FERM domain containing 5 -0.0168352
LOX lysyl oxidase -0.0168193