| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ponatinib perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ponatinib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.130903 |
| IGF2 | insulin-like growth factor 2 | 0.112265 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.106073 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0963083 |
| TPM3 | tropomyosin 3 | 0.0657707 |
| HMGA1 | high mobility group AT-hook 1 | 0.0570972 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0507666 |
| CALR | calreticulin | 0.048505 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0438668 |
| RPL23 | ribosomal protein L23 | 0.0411579 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0395291 |
| RPS3 | ribosomal protein S3 | 0.0390783 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0389557 |
| RPL6 | ribosomal protein L6 | 0.0368083 |
| RPS8 | ribosomal protein S8 | 0.0362798 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0358224 |
| YBX1 | Y box binding protein 1 | 0.0343645 |
| TPD52 | tumor protein D52 | 0.0339937 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0332936 |
| RPS2 | ribosomal protein S2 | 0.0330026 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0326873 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0314438 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0301024 |
| PFN1 | profilin 1 | 0.0299583 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0284486 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0281749 |
| RPL13A | ribosomal protein L13a | 0.0278388 |
| ACTG1 | actin gamma 1 | 0.0276772 |
| CANX | calnexin | 0.0270251 |
| RPS21 | ribosomal protein S21 | 0.0262761 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0254745 |
| RPL26 | ribosomal protein L26 | 0.0248108 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0247562 |
| RPL36 | ribosomal protein L36 | 0.0247075 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.023787 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0236575 |
| SRGN | serglycin | 0.0236252 |
| STC2 | stanniocalcin 2 | 0.0234633 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0228357 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0219353 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0217222 |
| RPL37A | ribosomal protein L37a | 0.0215517 |
| POTEF | POTE ankyrin domain family, member F | 0.0214804 |
| TFRC | transferrin receptor | 0.0213284 |
| GADD45B | growth arrest and DNA-damage-inducible, beta | 0.0209096 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0208961 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0206418 |
| RPL18 | ribosomal protein L18 | 0.0206386 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0203952 |
| GANAB | glucosidase, alpha; neutral AB | 0.0200076 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0199265 |
| RPS12 | ribosomal protein S12 | 0.0198446 |
| RPS29 | ribosomal protein S29 | 0.0196787 |
| ZNF292 | zinc finger protein 292 | 0.0195182 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | 0.0190514 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0190369 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0188659 |
| RPL8 | ribosomal protein L8 | 0.018559 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0184484 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0183584 |
| CHN1 | chimerin 1 | 0.0183504 |
| RBM39 | RNA binding motif protein 39 | 0.0181344 |
| B2M | beta-2-microglobulin | 0.0181069 |
| LMNA | lamin A/C | 0.0180314 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.017846 |
| NUP58 | nucleoporin 58 | 0.0177851 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0177363 |
| RPL35A | ribosomal protein L35a | 0.0176163 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0175575 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.0171459 |
| RPL5 | ribosomal protein L5 | 0.0171319 |
| FNBP1L | formin binding protein 1-like | 0.0170858 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0169217 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0166308 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0166245 |
| BZW2 | basic leucine zipper and W2 domains 2 | 0.016404 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0163532 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0161032 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.0160785 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.016026 |
| PLS3 | plastin 3 | 0.0160101 |
| CALU | calumenin | 0.0159561 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0159539 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0158805 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.0156327 |
| COX6A1 | cytochrome c oxidase subunit VIa polypeptide 1 | 0.0156089 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0154737 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0154503 |
| NOP58 | NOP58 ribonucleoprotein | 0.0153784 |
| RLF | rearranged L-myc fusion | 0.0151715 |
| RPL7 | ribosomal protein L7 | 0.0151069 |
| RBM8A | RNA binding motif protein 8A | 0.0150935 |
| SERF2 | small EDRK-rich factor 2 | 0.0150741 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0149014 |
| VGLL4 | vestigial-like family member 4 | 0.014778 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.014737 |
| CYRIB | CYFIP related Rac1 interactor B | 0.0147296 |
| RPS6 | ribosomal protein S6 | 0.0146084 |
| RPS25 | ribosomal protein S25 | 0.0144608 |
| HYOU1 | hypoxia up-regulated 1 | 0.0144541 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.155204 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.134605 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.129644 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.108764 |
| FTL | ferritin, light polypeptide | -0.0977612 |
| TMSB10 | thymosin beta 10 | -0.0969374 |
| TXNRD1 | thioredoxin reductase 1 | -0.0930975 |
| GRAMD1B | GRAM domain containing 1B | -0.0884954 |
| PM20D1 | peptidase M20 domain containing 1 | -0.087356 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0673186 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0556408 |
| IER3 | immediate early response 3 | -0.0488995 |
| RPLP1 | ribosomal protein, large, P1 | -0.0479243 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0440007 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0374402 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0371163 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0352112 |
| WWOX | WW domain containing oxidoreductase | -0.03519 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.033593 |
| USP34 | ubiquitin specific peptidase 34 | -0.031922 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0307578 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0295599 |
| NRG1 | neuregulin 1 | -0.0294327 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | -0.0294262 |
| JMJD1C | jumonji domain containing 1C | -0.0272229 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | -0.0255356 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0254506 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0253777 |
| VIM | vimentin | -0.0252709 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0252099 |
| PKM | pyruvate kinase, muscle | -0.02493 |
| S100A6 | S100 calcium binding protein A6 | -0.0247717 |
| IL6 | interleukin 6 | -0.0246021 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0228344 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0227746 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0227448 |
| STC1 | stanniocalcin 1 | -0.0227361 |
| EXOC6B | exocyst complex component 6B | -0.0220622 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0218742 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0217799 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0213399 |
| GLIS3 | GLIS family zinc finger 3 | -0.0211811 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0205638 |
| TNPO1 | transportin 1 | -0.0205044 |
| RPL4 | ribosomal protein L4 | -0.0198744 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0198086 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | -0.0197233 |
| RPL31 | ribosomal protein L31 | -0.0195862 |
| KYNU | kynureninase | -0.0195331 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0190678 |
| CENPF | centromere protein F, 350/400kDa | -0.0189817 |
| OSMR | oncostatin M receptor | -0.01856 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0184078 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0183127 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0181847 |
| BICC1 | BicC family RNA binding protein 1 | -0.0181093 |
| RAD51B | RAD51 paralog B | -0.0178989 |
| RASAL2 | RAS protein activator like 2 | -0.017722 |
| VMP1 | vacuole membrane protein 1 | -0.0175836 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0175376 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0175118 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0173862 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0173825 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0173368 |
| AFF4 | AF4/FMR2 family, member 4 | -0.017336 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.0173346 |
| RBM25 | RNA binding motif protein 25 | -0.0172595 |
| DST | dystonin | -0.0172226 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0171369 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0170868 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0169937 |
| UBC | ubiquitin C | -0.0165737 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.016565 |
| PSMD7 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 | -0.0164465 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0164228 |
| FHIT | fragile histidine triad | -0.0163432 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0163425 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0163313 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.016329 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0162741 |
| SHTN1 | shootin 1 | -0.0161421 |
| MAP1B | microtubule-associated protein 1B | -0.0157954 |
| PPP2R5C | protein phosphatase 2, regulatory subunit B', gamma | -0.0157581 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0155601 |
| KIAA0319 | KIAA0319 | -0.0155443 |
| PRDX1 | peroxiredoxin 1 | -0.0155431 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0154328 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0153825 |
| NBEAL1 | neurobeachin-like 1 | -0.0153163 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | -0.0153113 |
| ATXN10 | ataxin 10 | -0.0153023 |
| NEMF | nuclear export mediator factor | -0.0152423 |
| PFKP | phosphofructokinase, platelet | -0.0152106 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0151854 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0148637 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.0148462 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.014843 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0148385 |
| NAV3 | neuron navigator 3 | -0.0146517 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0146357 |
