Ponatinib_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ponatinib perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ponatinib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.231715
IGF2 insulin-like growth factor 2 0.11422
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0969869
MYH9 myosin, heavy chain 9, non-muscle 0.0869571
VIM vimentin 0.0865228
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0846961
TPD52 tumor protein D52 0.0795063
PTK2 protein tyrosine kinase 2 0.0781634
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0778521
FNIP1 folliculin interacting protein 1 0.0713511
ACTG1 actin gamma 1 0.0705567
GARS1 glycyl-tRNA synthetase 1 0.0704804
RPS6 ribosomal protein S6 0.0704441
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0700849
FAT1 FAT atypical cadherin 1 0.0680621
NCOA3 nuclear receptor coactivator 3 0.0676385
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0635621
MBNL2 muscleblind-like splicing regulator 2 0.0626083
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0617241
SBF2 SET binding factor 2 0.0614901
RPS16 ribosomal protein S16 0.061225
IGFBP3 insulin-like growth factor binding protein 3 0.0604401
USP47 ubiquitin specific peptidase 47 0.0600859
RPS8 ribosomal protein S8 0.0595431
TRIO trio Rho guanine nucleotide exchange factor 0.0587911
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0587206
RAB2A RAB2A, member RAS oncogene family 0.0577346
RAB7A RAB7A, member RAS oncogene family 0.0576196
GPC6 glypican 6 0.0573569
DST dystonin 0.0566434
FOXP1 forkhead box P1 0.0565825
SRPK2 SRSF protein kinase 2 0.0565525
HMGA1 high mobility group AT-hook 1 0.0565443
COG5 component of oligomeric golgi complex 5 0.0554562
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0552001
SLC38A2 solute carrier family 38, member 2 0.0547445
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0539734
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0533252
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0525266
PDE8A phosphodiesterase 8A 0.0511413
ATXN1 ataxin 1 0.0488515
KCMF1 potassium channel modulatory factor 1 0.0485627
CALU calumenin 0.0482025
RPL26 ribosomal protein L26 0.0479452
JMJD1C jumonji domain containing 1C 0.0467718
PDLIM5 PDZ and LIM domain 5 0.0466292
PHF3 PHD finger protein 3 0.0465992
FTH1 ferritin, heavy polypeptide 1 0.0444699
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0444317
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0444144
CTNND1 catenin (cadherin-associated protein), delta 1 0.043755
CCNY cyclin Y 0.0429533
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0428099
LDHA lactate dehydrogenase A 0.0427806
TPM4 tropomyosin 4 0.0427466
TGFBI transforming growth factor, beta-induced, 68kDa 0.0420922
RB1CC1 RB1-inducible coiled-coil 1 0.0419519
COL1A2 collagen, type I, alpha 2 0.0418562
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0406828
EEF1G eukaryotic translation elongation factor 1 gamma 0.0406464
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.040116
NCOR1 nuclear receptor corepressor 1 0.0396002
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0395739
RPS3 ribosomal protein S3 0.0391281
EEF2 eukaryotic translation elongation factor 2 0.039007
NAP1L1 nucleosome assembly protein 1-like 1 0.0386276
PIBF1 progesterone immunomodulatory binding factor 1 0.038593
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0383732
ADAM10 ADAM metallopeptidase domain 10 0.0381636
BRWD1 bromodomain and WD repeat domain containing 1 0.0381546
KDM3A lysine (K)-specific demethylase 3A 0.0378723
ELL2 elongation factor, RNA polymerase II, 2 0.037413
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0370029
RPS12 ribosomal protein S12 0.0368403
PRELID2 PRELI domain containing 2 0.0368109
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0367299
EGFR epidermal growth factor receptor 0.0366989
GLG1 golgi glycoprotein 1 0.0363543
RPL23 ribosomal protein L23 0.0355996
GPBP1 GC-rich promoter binding protein 1 0.0353622
PSD3 pleckstrin and Sec7 domain containing 3 0.0351363
RHOBTB3 Rho-related BTB domain containing 3 0.0346231
AKAP12 A kinase (PRKA) anchor protein 12 0.0344072
KMT2E lysine (K)-specific methyltransferase 2E 0.0336611
MAP4 microtubule-associated protein 4 0.0334563
MARCHF6 membrane associated ring-CH-type finger 6 0.0334529
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0332629
MT2A metallothionein 2A 0.0332517
NBAS neuroblastoma amplified sequence 0.0329693
RPL35A ribosomal protein L35a 0.0328541
TNS3 tensin 3 0.0325287
PUM1 pumilio RNA-binding family member 1 0.0309734
ZFAND3 zinc finger, AN1-type domain 3 0.0307708
FTL ferritin, light polypeptide 0.0306749
ZNF292 zinc finger protein 292 0.0306463
ARB2A ARB2 cotranscriptional regulator A 0.0305337
PTGES2 prostaglandin E synthase 2 0.0304561
RICTOR RPTOR independent companion of MTOR, complex 2 0.0302027
BCLAF1 BCL2-associated transcription factor 1 0.0301174
LPP LIM domain containing preferred translocation partner in lipoma 0.0298712

decreased expression

Symbol Name Standardized Value
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.188778
GRB10 growth factor receptor-bound protein 10 -0.181789
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.168704
SAMD4A sterile alpha motif domain containing 4A -0.155526
LMO7 LIM domain 7 -0.141193
CEMIP cell migration inducing protein, hyaluronan binding -0.134729
MYO1E myosin IE -0.134425
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.124737
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.120242
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.116064
NPEPPS aminopeptidase puromycin sensitive -0.113084
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0937566
PARD3 par-3 family cell polarity regulator -0.0921526
ATOSA atos homolog A -0.0918895
LAMB3 laminin, beta 3 -0.0910965
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0903012
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0890076
ABHD17C abhydrolase domain containing 17C -0.0836096
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0777713
MUC16 mucin 16, cell surface associated -0.0762345
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.073723
AHNAK AHNAK nucleoprotein -0.0695938
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0693849
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0691333
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0680537
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0648572
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0642121
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0622803
RCOR1 REST corepressor 1 -0.0600829
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0598775
SAMD9 sterile alpha motif domain containing 9 -0.0575693
WARS1 tryptophanyl-tRNA synthetase 1 -0.0568846
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0563767
DOCK5 dedicator of cytokinesis 5 -0.056013
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0554378
DSCAM Down syndrome cell adhesion molecule -0.0542801
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0526745
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0522853
LAMC2 laminin, gamma 2 -0.0519715
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0519138
KIAA1217 KIAA1217 -0.04836
FNDC3A fibronectin type III domain containing 3A -0.0479307
ASPH aspartate beta-hydroxylase -0.0466167
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0458186
RBM39 RNA binding motif protein 39 -0.0454618
PPARD peroxisome proliferator-activated receptor delta -0.0449889
GLS2 glutaminase 2 (liver, mitochondrial) -0.0449762
NIPBL Nipped-B homolog (Drosophila) -0.0449152
SVIL supervillin -0.0444743
MAML2 mastermind-like 2 (Drosophila) -0.0439513
MAML3 mastermind-like 3 (Drosophila) -0.0419094
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0413042
ANKRD12 ankyrin repeat domain 12 -0.0412106
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0408885
PDIA3 protein disulfide isomerase family A, member 3 -0.0407948
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0404357
ANTXR2 anthrax toxin receptor 2 -0.0403955
FNDC3B fibronectin type III domain containing 3B -0.0403658
PLAUR plasminogen activator, urokinase receptor -0.0402383
TMEM87A transmembrane protein 87A -0.0399991
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0398015
WASF2 WAS protein family, member 2 -0.0378476
SHB Src homology 2 domain containing adaptor protein B -0.037786
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0377132
HOOK3 hook microtubule-tethering protein 3 -0.0367971
PKM pyruvate kinase, muscle -0.0365677
RIGI RNA sensor RIG-I -0.0360078
ARHGAP21 Rho GTPase activating protein 21 -0.0357519
INTS6 integrator complex subunit 6 -0.0355441
BZW1 basic leucine zipper and W2 domains 1 -0.0353763
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0346213
IGF1R insulin-like growth factor 1 receptor -0.0346185
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0340766
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.033941
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0333019
DOCK4 dedicator of cytokinesis 4 -0.0331848
OSMR oncostatin M receptor -0.0329557
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0329366
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0318555
ZMYM2 zinc finger, MYM-type 2 -0.0316231
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0311704
AKAP9 A kinase (PRKA) anchor protein 9 -0.0310453
SDC4 syndecan 4 -0.0309107
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0306286
RBM47 RNA binding motif protein 47 -0.0305896
ESYT2 extended synaptotagmin-like protein 2 -0.0305824
AGFG1 ArfGAP with FG repeats 1 -0.0303197
DENND4A DENN/MADD domain containing 4A -0.0300092
TBC1D22A TBC1 domain family, member 22A -0.0299658
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0297636
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0297564
MXD1 MAX dimerization protein 1 -0.0295746
FN1 fibronectin 1 -0.0291766
VMP1 vacuole membrane protein 1 -0.0291177
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0291029
HMBOX1 homeobox containing 1 -0.0286639
TXNIP thioredoxin interacting protein -0.0284776
OGA O-GlcNAcase -0.028473
DTNA dystrobrevin, alpha -0.0284648
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0283498