Ponatinib_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ponatinib perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ponatinib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PABPC1 poly(A) binding protein, cytoplasmic 1 0.22221
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.145283
TPM3 tropomyosin 3 0.0850578
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0825177
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0736367
KTN1 kinectin 1 (kinesin receptor) 0.0688426
ZCCHC7 zinc finger, CCHC domain containing 7 0.0638188
COPA coatomer protein complex, subunit alpha 0.0584309
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.057625
IGF2 insulin-like growth factor 2 0.0572994
GOLGA4 golgin A4 0.054023
CANX calnexin 0.0497931
P4HB prolyl 4-hydroxylase, beta polypeptide 0.048674
EGR1 early growth response 1 0.0414865
NUP58 nucleoporin 58 0.0411966
PFN1 profilin 1 0.0409045
HMGA1 high mobility group AT-hook 1 0.0404428
ATXN2 ataxin 2 0.0393324
AKAP9 A kinase (PRKA) anchor protein 9 0.0381477
MKI67 marker of proliferation Ki-67 0.037804
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0368796
TLN1 talin 1 0.0365819
EEF2 eukaryotic translation elongation factor 2 0.036538
GOLGB1 golgin B1 0.0363346
SEC31A SEC31 homolog A (S. cerevisiae) 0.0335575
RAD51B RAD51 paralog B 0.0333977
CCNL1 cyclin L1 0.0331067
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0328095
RPL13A ribosomal protein L13a 0.0326672
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0322559
SYNE2 spectrin repeat containing, nuclear envelope 2 0.031772
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0317595
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0314008
CALU calumenin 0.0312794
EEF1G eukaryotic translation elongation factor 1 gamma 0.031184
CALR calreticulin 0.0308493
ADAR adenosine deaminase, RNA-specific 0.0301847
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0299867
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0298725
HELZ helicase with zinc finger 0.0292477
COPB2 coatomer protein complex, subunit beta 2 (beta prime) 0.0290926
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0289167
PYGL phosphorylase, glycogen, liver 0.0287957
TFG TRK-fused gene 0.0287442
SRP54 signal recognition particle 54kDa 0.0284779
TMEM165 transmembrane protein 165 0.0283598
SMC4 structural maintenance of chromosomes 4 0.0283404
CAMTA1 calmodulin binding transcription activator 1 0.0281167
TNPO3 transportin 3 0.0279662
PDIA4 protein disulfide isomerase family A, member 4 0.0277628
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0273756
PNN pinin, desmosome associated protein 0.0273716
HYOU1 hypoxia up-regulated 1 0.0272228
LMAN1 lectin, mannose-binding, 1 0.0265636
WASF2 WAS protein family, member 2 0.026203
ARF4 ADP-ribosylation factor 4 0.0258287
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0254968
RPS27 ribosomal protein S27 0.0253332
ZNF292 zinc finger protein 292 0.0252311
WSB1 WD repeat and SOCS box containing 1 0.025193
COG6 component of oligomeric golgi complex 6 0.0250935
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 0.0249649
MLF1 myeloid leukemia factor 1 0.0247399
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0245343
MLEC malectin 0.0245084
CEP135 centrosomal protein 135kDa 0.0243229
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0241824
KDM2A lysine (K)-specific demethylase 2A 0.0238885
AHCYL1 adenosylhomocysteinase-like 1 0.0237699
COPB1 coatomer protein complex, subunit beta 1 0.0236922
PGM3 phosphoglucomutase 3 0.0236262
MSH6 mutS homolog 6 0.0236134
KHDC4 KH domain containing 4, pre-mRNA splicing factor 0.0235985
TMEM14B transmembrane protein 14B 0.0235964
PDIA6 protein disulfide isomerase family A, member 6 0.0235097
TMEM39A transmembrane protein 39A 0.0233311
RAB1A RAB1A, member RAS oncogene family 0.022964
TRIO trio Rho guanine nucleotide exchange factor 0.0227892
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.022695
MORF4L2 mortality factor 4 like 2 0.0226715
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0222949
GOLGA2 golgin A2 0.0222288
YAP1 Yes-associated protein 1 0.0221933
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.0220862
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0220519
CSNK1A1 casein kinase 1, alpha 1 0.0220393
MARCHF4 membrane associated ring-CH-type finger 4 0.0219971
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0219087
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0218537
NCOR2 nuclear receptor corepressor 2 0.0216553
GORASP2 golgi reassembly stacking protein 2, 55kDa 0.0216246
WDR43 WD repeat domain 43 0.0216114
PCBP2 poly(rC) binding protein 2 0.021141
TMF1 TATA element modulatory factor 1 0.0210724
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0208511
YBX1 Y box binding protein 1 0.0208423
PDIA3 protein disulfide isomerase family A, member 3 0.0206965
NDRG1 N-myc downstream regulated 1 0.0206037
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0203289
FCHSD2 FCH and double SH3 domains 2 0.0203203

decreased expression

Symbol Name Standardized Value
TFPI2 tissue factor pathway inhibitor 2 -0.170118
AKAP12 A kinase (PRKA) anchor protein 12 -0.168222
TMSB10 thymosin beta 10 -0.120686
TM4SF1 transmembrane 4 L six family member 1 -0.111433
PDE4D phosphodiesterase 4D, cAMP-specific -0.0991615
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0989426
VIM vimentin -0.0987499
TXNRD1 thioredoxin reductase 1 -0.0953318
UBC ubiquitin C -0.0819111
PDE10A phosphodiesterase 10A -0.072969
PTMA prothymosin, alpha -0.0696081
RPS27A ribosomal protein S27a -0.0643439
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0625346
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0590576
ACTG1 actin gamma 1 -0.0569687
RPLP1 ribosomal protein, large, P1 -0.0532019
IGF1R insulin-like growth factor 1 receptor -0.053153
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.052654
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0523154
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0522904
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0514035
IFI6 interferon, alpha-inducible protein 6 -0.0510108
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0508293
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.049776
AHNAK AHNAK nucleoprotein -0.0474057
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0465914
HLA-B major histocompatibility complex, class I, B -0.0464185
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.046167
MYL12B myosin, light chain 12B, regulatory -0.0461223
NCOA7 nuclear receptor coactivator 7 -0.0458619
OSMR oncostatin M receptor -0.0448819
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0442141
DNAH14 dynein, axonemal, heavy chain 14 -0.0441509
RPS24 ribosomal protein S24 -0.0438226
IER3 immediate early response 3 -0.043219
CAVIN1 caveolae associated protein 1 -0.0424661
RIMS2 regulating synaptic membrane exocytosis 2 -0.0405223
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0404367
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0381286
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0375606
WWOX WW domain containing oxidoreductase -0.0372136
RPLP0 ribosomal protein, large, P0 -0.0361299
RPS4X ribosomal protein S4, X-linked -0.0359378
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0356518
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0353271
MCL1 myeloid cell leukemia 1 -0.0350508
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0345391
TPI1 triosephosphate isomerase 1 -0.0345126
AEBP2 AE binding protein 2 -0.0338413
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0338357
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0336481
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0323998
BLTP2 bridge-like lipid transfer protein family member 2 -0.0312406
STC1 stanniocalcin 1 -0.030743
MAP7 microtubule-associated protein 7 -0.0304592
RPS21 ribosomal protein S21 -0.0303388
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0303124
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0298285
DENND5B DENN/MADD domain containing 5B -0.0297124
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0294766
S100A10 S100 calcium binding protein A10 -0.0292395
ENO1 enolase 1, (alpha) -0.0290021
RPL19 ribosomal protein L19 -0.028914
SLC38A2 solute carrier family 38, member 2 -0.0287327
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0286897
ZFAND3 zinc finger, AN1-type domain 3 -0.0285908
S100A6 S100 calcium binding protein A6 -0.0283925
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0282574
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 -0.0278827
BZW1 basic leucine zipper and W2 domains 1 -0.0278721
RPL7L1 ribosomal protein L7-like 1 -0.0277473
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0276997
SNAP25 synaptosomal-associated protein, 25kDa -0.0273955
PRH1 proline-rich protein HaeIII subfamily 1 -0.027331
LRP1B low density lipoprotein receptor-related protein 1B -0.0272046
PHF3 PHD finger protein 3 -0.027033
PNRC1 proline-rich nuclear receptor coactivator 1 -0.026902
NIPBL Nipped-B homolog (Drosophila) -0.0265749
GNAS GNAS complex locus -0.0265093
HMGA2 high mobility group AT-hook 2 -0.0264946
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0263919
CDK17 cyclin-dependent kinase 17 -0.0263472
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0261296
PDE4B phosphodiesterase 4B, cAMP-specific -0.0258246
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0255363
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.02505
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0247616
SLC38A1 solute carrier family 38, member 1 -0.0247141
XPOT exportin, tRNA -0.0246133
RPL9 ribosomal protein L9 -0.024403
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.024296
SMYD3 SET and MYND domain containing 3 -0.0241524
RPL34 ribosomal protein L34 -0.0240975
NLGN1 neuroligin 1 -0.0237445
RPL31 ribosomal protein L31 -0.0236996
HDAC8 histone deacetylase 8 -0.0235962
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0235708
ZMYM2 zinc finger, MYM-type 2 -0.023486
ATF6 activating transcription factor 6 -0.0233391
BCAS3 breast carcinoma amplified sequence 3 -0.0229333