Ponatinib_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ponatinib perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ponatinib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.224589
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.217838
TPT1 tumor protein, translationally-controlled 1 0.0931498
CALR calreticulin 0.086002
RPS3 ribosomal protein S3 0.0852793
HMGA1 high mobility group AT-hook 1 0.0778704
RPL35A ribosomal protein L35a 0.0667608
RPS29 ribosomal protein S29 0.0655196
LAMB3 laminin, beta 3 0.0590646
TACSTD2 tumor-associated calcium signal transducer 2 0.0525675
HMGB2 high mobility group box 2 0.051997
EEF1G eukaryotic translation elongation factor 1 gamma 0.0508876
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0505577
RPL13A ribosomal protein L13a 0.0503097
CANX calnexin 0.0487194
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0471904
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0466922
RPL5 ribosomal protein L5 0.0451599
RPL37A ribosomal protein L37a 0.0450468
RPLP2 ribosomal protein, large, P2 0.0450467
RPS8 ribosomal protein S8 0.0438049
ZNF292 zinc finger protein 292 0.0410787
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0406173
RPL23 ribosomal protein L23 0.0401687
MYH9 myosin, heavy chain 9, non-muscle 0.0399654
SLC38A1 solute carrier family 38, member 1 0.0396987
BHLHE40 basic helix-loop-helix family, member e40 0.0388707
RPL6 ribosomal protein L6 0.0382588
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0380429
LMNA lamin A/C 0.0380325
RACK1 receptor for activated C kinase 1 0.0379059
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0374303
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0372866
RPL26 ribosomal protein L26 0.0371778
RPL8 ribosomal protein L8 0.037067
CALU calumenin 0.0368128
RPL18 ribosomal protein L18 0.0363826
LAMC2 laminin, gamma 2 0.0357765
NAP1L1 nucleosome assembly protein 1-like 1 0.0347255
EIF1 eukaryotic translation initiation factor 1 0.034711
RPS19 ribosomal protein S19 0.0342269
RAD21 RAD21 homolog (S. pombe) 0.0329891
RPL36 ribosomal protein L36 0.0324812
NAMPT nicotinamide phosphoribosyltransferase 0.0321694
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0319504
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.030859
P4HB prolyl 4-hydroxylase, beta polypeptide 0.03082
RPL34 ribosomal protein L34 0.0300382
HSPA8 heat shock 70kDa protein 8 0.0297493
STC2 stanniocalcin 2 0.0293271
RPS21 ribosomal protein S21 0.0290075
RPS27 ribosomal protein S27 0.0289323
RPL38 ribosomal protein L38 0.02882
PEG10 paternally expressed 10 0.0286721
ASPH aspartate beta-hydroxylase 0.0282987
RPS13 ribosomal protein S13 0.0282392
FAM13A family with sequence similarity 13, member A 0.0281549
RPL36A ribosomal protein L36a 0.0279837
EPCAM epithelial cell adhesion molecule 0.0275498
KDM3A lysine (K)-specific demethylase 3A 0.0272986
FLNA filamin A, alpha 0.0264326
YBX3 Y box binding protein 3 0.0262224
CTSD cathepsin D 0.0258865
S100A9 S100 calcium binding protein A9 0.0253957
YBX1 Y box binding protein 1 0.0249473
ANLN anillin, actin binding protein 0.0248612
GANAB glucosidase, alpha; neutral AB 0.0245902
RPS10 ribosomal protein S10 0.02455
TMEM59 transmembrane protein 59 0.024359
RPS27A ribosomal protein S27a 0.0243532
RPL37 ribosomal protein L37 0.0241031
KLF6 Kruppel-like factor 6 0.024081
CRABP2 cellular retinoic acid binding protein 2 0.0239995
RLF rearranged L-myc fusion 0.0239969
TMED9 transmembrane emp24 protein transport domain containing 9 0.0239198
TPM3 tropomyosin 3 0.0234236
ENO1 enolase 1, (alpha) 0.0232651
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.023095
GOLGA4 golgin A4 0.0227047
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0225762
RPL7A ribosomal protein L7a 0.0223736
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0219084
NACA nascent polypeptide-associated complex alpha subunit 0.0217829
COX6C cytochrome c oxidase subunit VIc 0.0217278
TFRC transferrin receptor 0.0217278
SDC4 syndecan 4 0.0215674
RPL11 ribosomal protein L11 0.0214277
TMED2 transmembrane emp24 domain trafficking protein 2 0.0212717
DDIT4 DNA-damage-inducible transcript 4 0.0212076
PLEC plectin 0.0210495
HLA-A major histocompatibility complex, class I, A 0.0210446
MACC1 metastasis associated in colon cancer 1 0.0208115
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 0.0207507
LMAN2 lectin, mannose-binding 2 0.0207417
TUFT1 tuftelin 1 0.0205645
HMGB1 high mobility group box 1 0.020495
FLNB filamin B, beta 0.0203676
WSB1 WD repeat and SOCS box containing 1 0.0199789
PTPRF protein tyrosine phosphatase, receptor type, F 0.0196944
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0196349

decreased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.159226
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.142793
ZFP36L1 ZFP36 ring finger protein-like 1 -0.132836
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.112974
POTEF POTE ankyrin domain family, member F -0.105956
ACTG1 actin gamma 1 -0.0857912
MYO6 myosin VI -0.0718968
TOP1 topoisomerase (DNA) I -0.0657692
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0641992
TRIO trio Rho guanine nucleotide exchange factor -0.0618042
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0594516
IFI27 interferon, alpha-inducible protein 27 -0.0584502
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0575552
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0563337
FNDC3B fibronectin type III domain containing 3B -0.0556657
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0553731
ADAM9 ADAM metallopeptidase domain 9 -0.0545286
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0536313
FTL ferritin, light polypeptide -0.0521726
RNF145 ring finger protein 145 -0.050552
S100A6 S100 calcium binding protein A6 -0.0494889
ERBIN erbb2 interacting protein -0.0494409
CD2AP CD2-associated protein -0.0467992
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0466126
NDRG1 N-myc downstream regulated 1 -0.0465998
CCNL1 cyclin L1 -0.0454889
LMO7 LIM domain 7 -0.0443435
GRB10 growth factor receptor-bound protein 10 -0.0441077
SLMAP sarcolemma associated protein -0.0420987
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0408902
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.040866
TSC22D2 TSC22 domain family, member 2 -0.0395456
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0389543
FAM3C family with sequence similarity 3, member C -0.0386419
ZFAND3 zinc finger, AN1-type domain 3 -0.0374107
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0367045
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0366365
NAV2 neuron navigator 2 -0.0365026
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0362284
RPLP1 ribosomal protein, large, P1 -0.0354673
IFI16 interferon, gamma-inducible protein 16 -0.0350521
BZW1 basic leucine zipper and W2 domains 1 -0.0350259
TXNRD1 thioredoxin reductase 1 -0.0344939
PTBP3 polypyrimidine tract binding protein 3 -0.034119
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0327606
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0327143
MAP1B microtubule-associated protein 1B -0.0325117
PTK2 protein tyrosine kinase 2 -0.0321312
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0318031
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0313872
TMSB10 thymosin beta 10 -0.0309727
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0309129
PKM pyruvate kinase, muscle -0.0309098
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0306381
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0302857
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0302429
ITCH itchy E3 ubiquitin protein ligase -0.0298024
ITGAV integrin, alpha V -0.0297574
PDLIM5 PDZ and LIM domain 5 -0.0296676
ZC3H11A zinc finger CCCH-type containing 11A -0.0293731
USP3 ubiquitin specific peptidase 3 -0.0289919
STRN3 striatin, calmodulin binding protein 3 -0.0287923
LIMCH1 LIM and calponin homology domains 1 -0.0286436
CAPN2 calpain 2, (m/II) large subunit -0.0285971
VDAC1 voltage-dependent anion channel 1 -0.0277943
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.027665
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0273171
FHIT fragile histidine triad -0.0272174
MSN moesin -0.0269082
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0267722
RPLP0 ribosomal protein, large, P0 -0.026755
BBX bobby sox homolog (Drosophila) -0.0267221
ARHGAP29 Rho GTPase activating protein 29 -0.0266224
TES testin LIM domain protein -0.0266054
TUBA1B tubulin, alpha 1b -0.0265202
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0263853
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.0261471
COPA coatomer protein complex, subunit alpha -0.0261297
CCND1 cyclin D1 -0.0260678
TMEM165 transmembrane protein 165 -0.0260327
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0258886
NKTR natural killer cell triggering receptor -0.0256712
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.025386
RCOR1 REST corepressor 1 -0.025368
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0246819
LNPEP leucyl/cystinyl aminopeptidase -0.0246537
TRAM1 translocation associated membrane protein 1 -0.0245797
TP53BP2 tumor protein p53 binding protein 2 -0.024566
NF1 neurofibromin 1 -0.0244156
SKAP2 src kinase associated phosphoprotein 2 -0.0244114
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0242018
FNBP1L formin binding protein 1-like -0.0241997
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0241926
FOSL1 FOS-like antigen 1 -0.023953
PERP PERP, TP53 apoptosis effector -0.0237556
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0236821
LPP LIM domain containing preferred translocation partner in lipoma -0.0235864
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0235522
F3 coagulation factor III (thromboplastin, tissue factor) -0.0233462
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B -0.0232509