| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ponatinib perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ponatinib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.197019 |
| CANX | calnexin | 0.100778 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0970098 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0851211 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0834634 |
| GRAMD1B | GRAM domain containing 1B | 0.0829181 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0815634 |
| FN1 | fibronectin 1 | 0.0808307 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0805352 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0794796 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0789011 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0751322 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0626899 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0579572 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0576844 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0560125 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0533564 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0521077 |
| EPHA4 | EPH receptor A4 | 0.0507841 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0506985 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0491788 |
| LDHA | lactate dehydrogenase A | 0.0484441 |
| RPH3AL | rabphilin 3A-like (without C2 domains) | 0.0471557 |
| LAMA1 | laminin, alpha 1 | 0.0428122 |
| FLNB | filamin B, beta | 0.0411286 |
| TBXT | T-box transcription factor T | 0.0403516 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0400809 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0395122 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.039379 |
| PYGL | phosphorylase, glycogen, liver | 0.0390592 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0379552 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.0376284 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0372241 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0355586 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.0354848 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0351837 |
| CTBP2 | C-terminal binding protein 2 | 0.0350309 |
| FLNA | filamin A, alpha | 0.0349653 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0344779 |
| CUL4A | cullin 4A | 0.0344009 |
| CALU | calumenin | 0.0340331 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0337957 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.0331877 |
| CALR | calreticulin | 0.0321152 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0319309 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0318814 |
| RPL13A | ribosomal protein L13a | 0.0316515 |
| GANAB | glucosidase, alpha; neutral AB | 0.0314539 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | 0.031327 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0309642 |
| ENO1 | enolase 1, (alpha) | 0.0308413 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.030491 |
| EFNA5 | ephrin-A5 | 0.0301257 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.029211 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0289826 |
| STC2 | stanniocalcin 2 | 0.0288515 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0285857 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0284418 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0282464 |
| TPM3 | tropomyosin 3 | 0.0279572 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.0273944 |
| AHNAK | AHNAK nucleoprotein | 0.0273135 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0269592 |
| CD99 | CD99 molecule | 0.0266669 |
| FAM13A | family with sequence similarity 13, member A | 0.026065 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0259025 |
| HDAC4 | histone deacetylase 4 | 0.0258749 |
| OGA | O-GlcNAcase | 0.025826 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0255583 |
| ARRDC3 | arrestin domain containing 3 | 0.0253697 |
| CUL4B | cullin 4B | 0.0249093 |
| APP | amyloid beta (A4) precursor protein | 0.0247472 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0247355 |
| MTR | 5-methyltetrahydrofolate-homocysteine methyltransferase | 0.0246023 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0245153 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0243598 |
| PRELID2 | PRELI domain containing 2 | 0.0239011 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | 0.0237239 |
| MCL1 | myeloid cell leukemia 1 | 0.0233433 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.023309 |
| LAMB1 | laminin, beta 1 | 0.0229555 |
| MAFK | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K | 0.0226718 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0224746 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0224289 |
| CREB5 | cAMP responsive element binding protein 5 | 0.022288 |
| RPL6 | ribosomal protein L6 | 0.0222355 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.0221576 |
| WWC1 | WW and C2 domain containing 1 | 0.022048 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0216573 |
| NFIA | nuclear factor I/A | 0.0213489 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0212305 |
| PCBP2 | poly(rC) binding protein 2 | 0.0211058 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | 0.021086 |
| NBAS | neuroblastoma amplified sequence | 0.0210094 |
| HLA-B | major histocompatibility complex, class I, B | 0.0208401 |
| UBAP2L | ubiquitin associated protein 2-like | 0.0206833 |
| MKI67 | marker of proliferation Ki-67 | 0.0206453 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0205513 |
| ANTXR1 | anthrax toxin receptor 1 | 0.0202457 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0200292 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.136646 |
| COL5A2 | collagen, type V, alpha 2 | -0.125022 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.110286 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.105488 |
| FTL | ferritin, light polypeptide | -0.0934511 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0930313 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.087131 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0808763 |
| PTMA | prothymosin, alpha | -0.0803919 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0787284 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0785047 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.077313 |
| RPLP1 | ribosomal protein, large, P1 | -0.0717335 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0713962 |
| TXNRD1 | thioredoxin reductase 1 | -0.069787 |
| KYNU | kynureninase | -0.0688074 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0652095 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0581826 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0570045 |
| PM20D1 | peptidase M20 domain containing 1 | -0.055978 |
| NEK7 | NIMA-related kinase 7 | -0.0533672 |
| RPS24 | ribosomal protein S24 | -0.0497235 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0495012 |
| RPS6 | ribosomal protein S6 | -0.0489467 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0478474 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0469672 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.045677 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0449699 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0444066 |
| MFF | mitochondrial fission factor | -0.0426941 |
| TMX4 | thioredoxin-related transmembrane protein 4 | -0.0413821 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0398912 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0376339 |
| TENM3 | teneurin transmembrane protein 3 | -0.0369561 |
| RPL31 | ribosomal protein L31 | -0.0367335 |
| RPS23 | ribosomal protein S23 | -0.0354342 |
| IER3 | immediate early response 3 | -0.0334159 |
| PKM | pyruvate kinase, muscle | -0.0329802 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0313733 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0311533 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0307652 |
| LSAMP | limbic system-associated membrane protein | -0.0299105 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0296502 |
| GNAS | GNAS complex locus | -0.0293731 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.0285219 |
| GDA | guanine deaminase | -0.0281452 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0266443 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0261446 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0257363 |
| INHBA | inhibin, beta A | -0.0254006 |
| IL6 | interleukin 6 | -0.025348 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0253172 |
| RTN4 | reticulon 4 | -0.0249632 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0249538 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0242715 |
| PDE1A | phosphodiesterase 1A, calmodulin-dependent | -0.0241217 |
| RPLP0 | ribosomal protein, large, P0 | -0.0237831 |
| TNPO1 | transportin 1 | -0.0235224 |
| CADM2 | cell adhesion molecule 2 | -0.0233969 |
| MAP7 | microtubule-associated protein 7 | -0.023379 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0230557 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0229714 |
| RBM39 | RNA binding motif protein 39 | -0.0227683 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.022536 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0224997 |
| RPL9 | ribosomal protein L9 | -0.0219014 |
| RPL19 | ribosomal protein L19 | -0.0216154 |
| SPAG9 | sperm associated antigen 9 | -0.0214872 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0213728 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.020857 |
| PRDX1 | peroxiredoxin 1 | -0.0204445 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.02043 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0203833 |
| RPS19 | ribosomal protein S19 | -0.0203821 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0202084 |
| TKT | transketolase | -0.0199141 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0199037 |
| RPL34 | ribosomal protein L34 | -0.0198863 |
| RPS17 | ribosomal protein S17 | -0.0197921 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0195914 |
| JMJD1C | jumonji domain containing 1C | -0.0195492 |
| PCDH15 | protocadherin-related 15 | -0.0193404 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.0192157 |
| NRCAM | neuronal cell adhesion molecule | -0.0191209 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0189086 |
| RPL39 | ribosomal protein L39 | -0.0186662 |
| ATAD1 | ATPase family, AAA domain containing 1 | -0.0184976 |
| MGST1 | microsomal glutathione S-transferase 1 | -0.0181971 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0181548 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0181414 |
| NRG1 | neuregulin 1 | -0.0180654 |
| TUBA1B | tubulin, alpha 1b | -0.0179155 |
| DISP1 | dispatched homolog 1 (Drosophila) | -0.0178031 |
| RPS14 | ribosomal protein S14 | -0.017464 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.017388 |
| TXNIP | thioredoxin interacting protein | -0.0167915 |
| EPGN | epithelial mitogen | -0.0167544 |
| RPS20 | ribosomal protein S20 | -0.0166386 |
| RBM25 | RNA binding motif protein 25 | -0.0166145 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0163731 |
