| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ponatinib perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ponatinib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.174812 |
| FNDC3B | fibronectin type III domain containing 3B | 0.129947 |
| ATP13A2 | ATPase type 13A2 | 0.127387 |
| ZNF292 | zinc finger protein 292 | 0.124117 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.123212 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.120565 |
| HELZ | helicase with zinc finger | 0.11793 |
| MT2A | metallothionein 2A | 0.106616 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0970514 |
| CARD16 | caspase recruitment domain family, member 16 | 0.0875238 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0763449 |
| RPL26 | ribosomal protein L26 | 0.0738366 |
| SNX9 | sorting nexin 9 | 0.071064 |
| GPC6 | glypican 6 | 0.0679287 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0677395 |
| WDR45B | WD repeat domain 45B | 0.0662507 |
| SBF2 | SET binding factor 2 | 0.0658507 |
| IGF2 | insulin-like growth factor 2 | 0.0650074 |
| RPS8 | ribosomal protein S8 | 0.0637 |
| RPLP1 | ribosomal protein, large, P1 | 0.0593304 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.05832 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.057048 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0569229 |
| RPS16 | ribosomal protein S16 | 0.0541264 |
| WASF2 | WAS protein family, member 2 | 0.0515391 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0511001 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0507322 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.0494372 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.049419 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0490753 |
| RBM25 | RNA binding motif protein 25 | 0.0490263 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0488417 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0475349 |
| SQSTM1 | sequestosome 1 | 0.0466858 |
| UBE2K | ubiquitin-conjugating enzyme E2K | 0.0459714 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0440517 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0440188 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0433728 |
| SP100 | SP100 nuclear antigen | 0.0431081 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0430001 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.0420643 |
| KAT6B | K(lysine) acetyltransferase 6B | 0.0416089 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.040372 |
| CD109 | CD109 molecule | 0.0385061 |
| RPLP2 | ribosomal protein, large, P2 | 0.0380481 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0377248 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0376244 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0369191 |
| SPATA13 | spermatogenesis associated 13 | 0.035437 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.034799 |
| CANX | calnexin | 0.0346864 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0344352 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0343404 |
| SRPK2 | SRSF protein kinase 2 | 0.033953 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0332686 |
| KRT8 | keratin 8, type II | 0.0331845 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.032492 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0323412 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0313925 |
| STAG2 | stromal antigen 2 | 0.0307217 |
| SMYD3 | SET and MYND domain containing 3 | 0.0301242 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0298783 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0295084 |
| NDRG1 | N-myc downstream regulated 1 | 0.029334 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0286544 |
| EGFR | epidermal growth factor receptor | 0.0282147 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0277841 |
| YAP1 | Yes-associated protein 1 | 0.0266755 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0263278 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0255157 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0247215 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0243256 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0242827 |
| MCL1 | myeloid cell leukemia 1 | 0.0230595 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | 0.0230057 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0224942 |
| NAV2 | neuron navigator 2 | 0.0221989 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0216361 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.021582 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0208441 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0203966 |
| FMNL2 | formin-like 2 | 0.0197419 |
| CDC73 | cell division cycle 73 | 0.0190791 |
| RPL23 | ribosomal protein L23 | 0.0188504 |
| MAP4 | microtubule-associated protein 4 | 0.0187976 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0183232 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0181875 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | 0.0166334 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0160722 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0153521 |
| NF1 | neurofibromin 1 | 0.014563 |
| MED13 | mediator complex subunit 13 | 0.0145098 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0143692 |
| RUNX1 | runt-related transcription factor 1 | 0.0140256 |
| LDHA | lactate dehydrogenase A | 0.0135696 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0129344 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.01248 |
| ANXA2 | annexin A2 | 0.0110228 |
| NBAS | neuroblastoma amplified sequence | 0.010791 |
| ENO1 | enolase 1, (alpha) | 0.0103622 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.195696 |
| HMGA2 | high mobility group AT-hook 2 | -0.122954 |
| VIM | vimentin | -0.107605 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.106376 |
| ASPH | aspartate beta-hydroxylase | -0.10343 |
| RPS6 | ribosomal protein S6 | -0.102225 |
| TMSB10 | thymosin beta 10 | -0.0978769 |
| RPL35A | ribosomal protein L35a | -0.097357 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0935883 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0894621 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0851855 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0835971 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0833155 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0818742 |
| CDH13 | cadherin 13 | -0.0769313 |
| TPM4 | tropomyosin 4 | -0.0743455 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0719415 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0716752 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0680865 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0680305 |
| LAMA4 | laminin, alpha 4 | -0.0666583 |
| ACTG1 | actin gamma 1 | -0.065181 |
| GPBP1 | GC-rich promoter binding protein 1 | -0.0638785 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0621919 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0616742 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0594771 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0594354 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0581387 |
| FN1 | fibronectin 1 | -0.0577094 |
| GOLGA4 | golgin A4 | -0.0577065 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0571982 |
| FLNB | filamin B, beta | -0.0553557 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0535028 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0534677 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0523675 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.05183 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0517768 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0513128 |
| SETD5 | SET domain containing 5 | -0.0503166 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0496528 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0493134 |
| PTEN | phosphatase and tensin homolog | -0.0480696 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0473283 |
| TNS3 | tensin 3 | -0.0458958 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0456236 |
| OGA | O-GlcNAcase | -0.0453833 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.0451064 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0441695 |
| ATXN1 | ataxin 1 | -0.0436086 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0433893 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0409192 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0398755 |
| USP34 | ubiquitin specific peptidase 34 | -0.0384434 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0376544 |
| PKM | pyruvate kinase, muscle | -0.037608 |
| PTK2 | protein tyrosine kinase 2 | -0.0371686 |
| PTMA | prothymosin, alpha | -0.0359806 |
| RPL15 | ribosomal protein L15 | -0.0354128 |
| LARP1 | La ribonucleoprotein domain family, member 1 | -0.0324054 |
| MYOF | myoferlin | -0.0322288 |
| FHIT | fragile histidine triad | -0.0319472 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0296131 |
| EGR1 | early growth response 1 | -0.0296068 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0286818 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.028636 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0283864 |
| RPS19 | ribosomal protein S19 | -0.0279912 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.0277188 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0271304 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0269959 |
| ERBIN | erbb2 interacting protein | -0.0255947 |
| EZR | ezrin | -0.0254845 |
| FNIP1 | folliculin interacting protein 1 | -0.0241314 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0237729 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0237592 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0230928 |
| RPL37 | ribosomal protein L37 | -0.0230333 |
| ITGA6 | integrin, alpha 6 | -0.0201899 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0194671 |
| RAD51B | RAD51 paralog B | -0.019297 |
| RPS13 | ribosomal protein S13 | -0.0184262 |
| RPS3 | ribosomal protein S3 | -0.0177476 |
| PPP2R5C | protein phosphatase 2, regulatory subunit B', gamma | -0.0171341 |
| LMO7 | LIM domain 7 | -0.0170223 |
| SLTM | SAFB-like, transcription modulator | -0.0152022 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0145225 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0143711 |
| MYO1E | myosin IE | -0.0121297 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0120605 |
| CDK6 | cyclin-dependent kinase 6 | -0.0105544 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0102914 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.0100898 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.00837133 |
| PRKCA | protein kinase C, alpha | -0.00810567 |
| PGK1 | phosphoglycerate kinase 1 | -0.00781834 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.00759503 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0029183 |
| JMJD1C | jumonji domain containing 1C | -0.0026975 |
| PRELID2 | PRELI domain containing 2 | -0.00167724 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -6.717E-5 |
