Ponatinib_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ponatinib perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ponatinib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PABPC1 poly(A) binding protein, cytoplasmic 1 0.142618
VIM vimentin 0.110915
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.109931
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.107743
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0888455
CENPF centromere protein F, 350/400kDa 0.0875313
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0865841
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0761714
PFN1 profilin 1 0.0605914
CALR calreticulin 0.0596008
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0586755
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0564778
MKI67 marker of proliferation Ki-67 0.0562779
RPL35A ribosomal protein L35a 0.0547514
PEG10 paternally expressed 10 0.0512987
YBX1 Y box binding protein 1 0.0499774
RAD21 RAD21 homolog (S. pombe) 0.0472595
GARS1 glycyl-tRNA synthetase 1 0.046965
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0456287
RPL26 ribosomal protein L26 0.0437712
EEF2 eukaryotic translation elongation factor 2 0.0436719
PCBP2 poly(rC) binding protein 2 0.0425792
CKAP5 cytoskeleton associated protein 5 0.0416836
RPS3 ribosomal protein S3 0.0393497
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0390356
TPX2 TPX2, microtubule-associated 0.0382611
RPL23 ribosomal protein L23 0.0381403
TSC22D2 TSC22 domain family, member 2 0.0380631
HMGA1 high mobility group AT-hook 1 0.0378038
TPM3 tropomyosin 3 0.0378005
TMSB10 thymosin beta 10 0.037671
HMGB2 high mobility group box 2 0.037018
CENPE centromere protein E, 312kDa 0.0368278
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0364995
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0364848
ACTG1 actin gamma 1 0.0364347
SMC4 structural maintenance of chromosomes 4 0.0362553
RPS8 ribosomal protein S8 0.0357411
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.0344944
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0340039
ATP5F1B ATP synthase F1 subunit beta 0.0332678
ANLN anillin, actin binding protein 0.0327836
EEF1G eukaryotic translation elongation factor 1 gamma 0.0327735
CANX calnexin 0.032232
RPL6 ribosomal protein L6 0.0316335
NCKAP1 NCK-associated protein 1 0.0315877
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.031455
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0313812
RPL5 ribosomal protein L5 0.0309642
PRRC2C proline-rich coiled-coil 2C 0.0309036
MTF2 metal response element binding transcription factor 2 0.0308731
TMSB4X thymosin beta 4, X-linked 0.0306943
MTDH metadherin 0.0305165
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0304189
OSBPL8 oxysterol binding protein-like 8 0.0303156
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0298331
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0297307
KIF5B kinesin family member 5B 0.02956
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0295378
SRSF11 serine/arginine-rich splicing factor 11 0.0295003
TPR translocated promoter region, nuclear basket protein 0.0294742
RPS12 ribosomal protein S12 0.0292707
PDIA6 protein disulfide isomerase family A, member 6 0.0291928
RPS6 ribosomal protein S6 0.029021
POTEF POTE ankyrin domain family, member F 0.0290201
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0289988
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0283908
PTMA prothymosin, alpha 0.0283277
RPL37A ribosomal protein L37a 0.0282835
ZFR zinc finger RNA binding protein 0.0279342
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0277292
KTN1 kinectin 1 (kinesin receptor) 0.0275508
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0273189
TPT1 tumor protein, translationally-controlled 1 0.0272098
RTN4 reticulon 4 0.0271695
RSRC2 arginine/serine-rich coiled-coil 2 0.0271111
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0269742
H1-0 H1.0 linker histone 0.0269417
KIF4A kinesin family member 4A 0.0267908
MYH9 myosin, heavy chain 9, non-muscle 0.0266221
CKAP2 cytoskeleton associated protein 2 0.0264452
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0262647
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 0.0262168
LDHA lactate dehydrogenase A 0.0261212
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0256472
RPS2 ribosomal protein S2 0.0256318
TRA2A transformer 2 alpha homolog (Drosophila) 0.0255049
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.02547
NACA nascent polypeptide-associated complex alpha subunit 0.0252794
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 0.0248372
KMT2E lysine (K)-specific methyltransferase 2E 0.0242798
NAP1L1 nucleosome assembly protein 1-like 1 0.0242122
SPTSSA serine palmitoyltransferase, small subunit A 0.0234689
CSDE1 cold shock domain containing E1, RNA-binding 0.0233824
HMGB1 high mobility group box 1 0.0232808
ZNF292 zinc finger protein 292 0.0231836
CALU calumenin 0.0230407
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0226784
RPL7 ribosomal protein L7 0.0225746
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0225738

decreased expression

Symbol Name Standardized Value
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.168952
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.122804
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.112405
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0745076
ITGAV integrin, alpha V -0.0724001
HDAC9 histone deacetylase 9 -0.0701779
ADGRL2 adhesion G protein-coupled receptor L2 -0.0700631
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0697784
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0642193
CADM2 cell adhesion molecule 2 -0.0623496
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0604355
TENM3 teneurin transmembrane protein 3 -0.0602194
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0592962
COL11A1 collagen, type XI, alpha 1 -0.0527498
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0498597
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0464133
NCAM2 neural cell adhesion molecule 2 -0.0453246
PCDH9 protocadherin 9 -0.0438364
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0431255
SAMD4A sterile alpha motif domain containing 4A -0.0428167
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0404215
PLPP1 phospholipid phosphatase 1 -0.0387549
TRPS1 trichorhinophalangeal syndrome I -0.0367867
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0356364
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0347139
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0347086
LRRC4C leucine rich repeat containing 4C -0.0334346
SLIT2 slit homolog 2 (Drosophila) -0.0316532
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0315232
ZEB2 zinc finger E-box binding homeobox 2 -0.031295
KCTD16 potassium channel tetramerization domain containing 16 -0.0309958
NTM neurotrimin -0.030957
RASAL2 RAS protein activator like 2 -0.0303926
PCLO piccolo presynaptic cytomatrix protein -0.0291615
NPAS3 neuronal PAS domain protein 3 -0.0282985
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0279856
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0274136
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.026982
JMJD1C jumonji domain containing 1C -0.0261975
SLC38A2 solute carrier family 38, member 2 -0.0253749
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0251345
TNRC6B trinucleotide repeat containing 6B -0.0251195
NHSL1 NHS-like 1 -0.0236066
TRIO trio Rho guanine nucleotide exchange factor -0.0233318
ZNF217 zinc finger protein 217 -0.0224421
MRPS6 mitochondrial ribosomal protein S6 -0.0221692
PGAP1 post-GPI attachment to proteins 1 -0.0221565
ARB2A ARB2 cotranscriptional regulator A -0.0214154
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0212799
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0212655
TRAK1 trafficking protein, kinesin binding 1 -0.0211472
RBM20 RNA binding motif protein 20 -0.0209706
CHD1 chromodomain helicase DNA binding protein 1 -0.0209493
ANK2 ankyrin 2, neuronal -0.0205362
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0203162
ADGRV1 adhesion G protein-coupled receptor V1 -0.0200678
DMD dystrophin -0.019933
LRRN3 leucine rich repeat neuronal 3 -0.0197558
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.019489
HMCN1 hemicentin 1 -0.0194696
LPIN2 lipin 2 -0.0193902
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.0193586
TAS2R14 taste receptor, type 2, member 14 -0.0190803
RERE arginine-glutamic acid dipeptide (RE) repeats -0.018924
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0187944
ZFP30 ZFP30 zinc finger protein -0.0186294
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0185344
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0184657
WWC2 WW and C2 domain containing 2 -0.0183368
COLGALT2 collagen beta(1-O)galactosyltransferase 2 -0.0177295
SLC44A5 solute carrier family 44, member 5 -0.0176975
HS6ST2 heparan sulfate 6-O-sulfotransferase 2 -0.0176795
NEBL nebulette -0.0176652
CAMTA1 calmodulin binding transcription activator 1 -0.017637
PARD3B par-3 family cell polarity regulator beta -0.0175285
CSRNP3 cysteine-serine-rich nuclear protein 3 -0.0175135
SREBF2 sterol regulatory element binding transcription factor 2 -0.0175096
ZC3H12B zinc finger CCCH-type containing 12B -0.0174709
SHROOM3 shroom family member 3 -0.0173182
MAP3K7 mitogen-activated protein kinase kinase kinase 7 -0.0172299
SIK2 salt-inducible kinase 2 -0.0171944
NRG1 neuregulin 1 -0.017049
USP25 ubiquitin specific peptidase 25 -0.0169436
MEF2C myocyte enhancer factor 2C -0.0169262
UBAP2 ubiquitin associated protein 2 -0.0167875
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 -0.0166669
STAG2 stromal antigen 2 -0.0164237
USP9X ubiquitin specific peptidase 9, X-linked -0.01615
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 -0.016141
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0161378
CDK6 cyclin-dependent kinase 6 -0.0160879
CCDC102B coiled-coil domain containing 102B -0.0160172
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0157286
CSMD3 CUB and Sushi multiple domains 3 -0.0156437
UBE3C ubiquitin protein ligase E3C -0.0156372
TUT4 terminal uridylyl transferase 4 -0.0155899
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0155793
CDH19 cadherin 19, type 2 -0.0155113
MTREX Mtr4 exosome RNA helicase -0.0154435
JARID2 jumonji, AT rich interactive domain 2 -0.0154306