Ponatinib_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ponatinib perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ponatinib_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4B phosphodiesterase 4B, cAMP-specific 0.159231
PABPC1 poly(A) binding protein, cytoplasmic 1 0.132786
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0964258
TPT1 tumor protein, translationally-controlled 1 0.0902332
LPP LIM domain containing preferred translocation partner in lipoma 0.0867894
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0752768
ZEB1 zinc finger E-box binding homeobox 1 0.0748273
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.07371
LDHA lactate dehydrogenase A 0.0730492
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0726775
ANXA1 annexin A1 0.0692508
HDAC9 histone deacetylase 9 0.0685509
FLNB filamin B, beta 0.0630041
RPL13A ribosomal protein L13a 0.0628381
ENO1 enolase 1, (alpha) 0.0588729
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.0583668
RPS8 ribosomal protein S8 0.0566508
CALR calreticulin 0.0556052
CANX calnexin 0.0543492
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0530656
PDE10A phosphodiesterase 10A 0.0525295
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0498665
NAP1L1 nucleosome assembly protein 1-like 1 0.0497199
GOLGA4 golgin A4 0.0494446
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0466629
ZMIZ1 zinc finger, MIZ-type containing 1 0.0462506
VCL vinculin 0.046088
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0455021
GSE1 Gse1 coiled-coil protein 0.0449513
GLI2 GLI family zinc finger 2 0.0448822
RPL35A ribosomal protein L35a 0.0447471
NAV2 neuron navigator 2 0.0440538
EEF1G eukaryotic translation elongation factor 1 gamma 0.043622
GLI3 GLI family zinc finger 3 0.0433317
CENPF centromere protein F, 350/400kDa 0.0422825
EEF2 eukaryotic translation elongation factor 2 0.0391426
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0391384
TRERF1 transcriptional regulating factor 1 0.0372896
CALU calumenin 0.037114
HSPB1 heat shock 27kDa protein 1 0.0368537
ZNF292 zinc finger protein 292 0.0366036
MKI67 marker of proliferation Ki-67 0.0363534
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0360433
TGFBR3 transforming growth factor, beta receptor III 0.0359843
PFN1 profilin 1 0.0350997
HMGA1 high mobility group AT-hook 1 0.0349444
RPL26 ribosomal protein L26 0.0343022
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.034149
TJP1 tight junction protein 1 0.0340448
FAT1 FAT atypical cadherin 1 0.033988
PCBP2 poly(rC) binding protein 2 0.0338602
CD47 CD47 molecule 0.0332585
FBLN2 fibulin 2 0.0316761
GANAB glucosidase, alpha; neutral AB 0.0315005
AHNAK AHNAK nucleoprotein 0.0313762
CLIP2 CAP-GLY domain containing linker protein 2 0.031087
CUX1 cut-like homeobox 1 0.0307971
FNDC3B fibronectin type III domain containing 3B 0.0307352
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.030725
CTBP2 C-terminal binding protein 2 0.0299443
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0298234
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0294626
RPS3 ribosomal protein S3 0.0292673
TPM4 tropomyosin 4 0.0289776
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0286731
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0285044
UNC13A unc-13 homolog A (C. elegans) 0.0284965
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0283552
RPS13 ribosomal protein S13 0.0281401
ANLN anillin, actin binding protein 0.0278541
FOXP1 forkhead box P1 0.0277632
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.027703
BMP10 bone morphogenetic protein 10 0.0276667
SSBP2 single-stranded DNA binding protein 2 0.0275224
TAC4 tachykinin 4 (hemokinin) 0.0274257
NFIA nuclear factor I/A 0.0272499
RRBP1 ribosome binding protein 1 0.0272274
TPD52 tumor protein D52 0.027168
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.026671
SON SON DNA binding protein 0.0262076
LOXL3 lysyl oxidase-like 3 0.0260843
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0259614
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0259445
VDAC3 voltage-dependent anion channel 3 0.0254116
RPL23 ribosomal protein L23 0.0253633
JUN jun proto-oncogene 0.0249694
DLG1 discs, large homolog 1 (Drosophila) 0.0243747
SEC24D SEC24 family member D 0.0241445
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0238698
RPL7A ribosomal protein L7a 0.0237864
HSPA8 heat shock 70kDa protein 8 0.0237789
MEIS2 Meis homeobox 2 0.0236117
RPS12 ribosomal protein S12 0.0235374
SGMS2 sphingomyelin synthase 2 0.023395
MYO1E myosin IE 0.0233724
UBAP2L ubiquitin associated protein 2-like 0.0231647
ASPH aspartate beta-hydroxylase 0.0229775
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0229239
SET SET nuclear proto-oncogene 0.0226021
FUBP1 far upstream element (FUSE) binding protein 1 0.0225406

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.176625
PKM pyruvate kinase, muscle -0.158055
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0948168
ANK2 ankyrin 2, neuronal -0.0799016
TXNRD1 thioredoxin reductase 1 -0.0650104
ADAM10 ADAM metallopeptidase domain 10 -0.0645424
RTN4 reticulon 4 -0.0569114
DOCK3 dedicator of cytokinesis 3 -0.0563414
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0550885
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0550306
ZBTB20 zinc finger and BTB domain containing 20 -0.0540198
RBM39 RNA binding motif protein 39 -0.0522726
CCNL1 cyclin L1 -0.0522565
GARS1 glycyl-tRNA synthetase 1 -0.0468606
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0462571
RPLP1 ribosomal protein, large, P1 -0.0427463
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.042345
MEF2A myocyte enhancer factor 2A -0.0416953
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0414588
ZFAND3 zinc finger, AN1-type domain 3 -0.0412591
CCND1 cyclin D1 -0.0409912
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0407292
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0403085
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0396087
S100A6 S100 calcium binding protein A6 -0.0394298
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0385024
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -0.0380579
PRELID2 PRELI domain containing 2 -0.0365494
USP34 ubiquitin specific peptidase 34 -0.0358593
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0348028
RNF145 ring finger protein 145 -0.0341518
QKI QKI, KH domain containing, RNA binding -0.0340533
RPS6 ribosomal protein S6 -0.033792
SRRM2 serine/arginine repetitive matrix 2 -0.0334524
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0334205
MACROD2 MACRO domain containing 2 -0.0330777
IARS1 isoleucyl-tRNA synthetase 1 -0.03281
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0327981
MATR3 matrin 3 -0.0322162
ADAM9 ADAM metallopeptidase domain 9 -0.0320136
JMJD1C jumonji domain containing 1C -0.0314166
CDC73 cell division cycle 73 -0.0310202
ELOVL5 ELOVL fatty acid elongase 5 -0.0297439
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0296059
TSC22D2 TSC22 domain family, member 2 -0.0291759
SOX6 SRY (sex determining region Y)-box 6 -0.0290027
TMEM41B transmembrane protein 41B -0.0288089
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0285967
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0282303
CNOT4 CCR4-NOT transcription complex, subunit 4 -0.0281794
SMYD3 SET and MYND domain containing 3 -0.0280409
GSK3B glycogen synthase kinase 3 beta -0.0279502
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0276673
TBC1D5 TBC1 domain family, member 5 -0.0274897
PTMA prothymosin, alpha -0.0273031
NUP58 nucleoporin 58 -0.0271117
TAS2R14 taste receptor, type 2, member 14 -0.0260805
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0260692
WDR43 WD repeat domain 43 -0.0254763
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0253742
MAN1A2 mannosidase, alpha, class 1A, member 2 -0.025262
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0251507
LOC112694756 uncharaterized LOC112694756 -0.0249725
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0248909
ARL15 ADP-ribosylation factor-like 15 -0.0244018
XRN1 5'-3' exoribonuclease 1 -0.0241996
MIPOL1 mirror-image polydactyly 1 -0.0241931
PSAT1 phosphoserine aminotransferase 1 -0.0238369
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 -0.0236716
BTBD9 BTB (POZ) domain containing 9 -0.0235331
EGFR epidermal growth factor receptor -0.0231532
PARD3B par-3 family cell polarity regulator beta -0.0231113
FBXL17 F-box and leucine-rich repeat protein 17 -0.0230811
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0230544
WAC WW domain containing adaptor with coiled-coil -0.0230358
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0229864
TCERG1 transcription elongation regulator 1 -0.0229289
RHEB Ras homolog enriched in brain -0.0227818
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.022563
OLA1 Obg-like ATPase 1 -0.022557
SPIDR scaffolding protein involved in DNA repair -0.022515
CELF1 CUGBP, Elav-like family member 1 -0.02229
SQSTM1 sequestosome 1 -0.022253
CARD16 caspase recruitment domain family, member 16 -0.0222102
ATP9B ATPase, class II, type 9B -0.0221467
ARB2A ARB2 cotranscriptional regulator A -0.0220767
IFI16 interferon, gamma-inducible protein 16 -0.0220167
ZBTB38 zinc finger and BTB domain containing 38 -0.0219748
SNX13 sorting nexin 13 -0.0219747
RPL14 ribosomal protein L14 -0.0219263
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.021919
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.021836
B2M beta-2-microglobulin -0.0217639
SLC38A2 solute carrier family 38, member 2 -0.0217397
RPL4 ribosomal protein L4 -0.0217009
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 -0.021692
PITPNB phosphatidylinositol transfer protein, beta -0.0216777
CLASP2 cytoplasmic linker associated protein 2 -0.0215843
UHMK1 U2AF homology motif (UHM) kinase 1 -0.0214807
ARL5B ADP-ribosylation factor-like 5B -0.0214448