Ponatinib_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ponatinib perturbation in SNU-423 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Ponatinib_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.152662
PABPC1 poly(A) binding protein, cytoplasmic 1 0.120801
HLA-B major histocompatibility complex, class I, B 0.113194
MYH9 myosin, heavy chain 9, non-muscle 0.108497
FN1 fibronectin 1 0.107555
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.105845
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0982645
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0875085
EEF2 eukaryotic translation elongation factor 2 0.0834608
CADM1 cell adhesion molecule 1 0.0814725
ZNF292 zinc finger protein 292 0.0752716
LDHA lactate dehydrogenase A 0.0739023
VIM vimentin 0.0720278
B2M beta-2-microglobulin 0.0703158
RPS6 ribosomal protein S6 0.0691082
UGCG UDP-glucose ceramide glucosyltransferase 0.0684553
GOLGA4 golgin A4 0.0643967
RPS3 ribosomal protein S3 0.0634363
RPL23 ribosomal protein L23 0.0611815
RPS8 ribosomal protein S8 0.0608883
RPS12 ribosomal protein S12 0.0604519
TPT1 tumor protein, translationally-controlled 1 0.0602825
EEF1G eukaryotic translation elongation factor 1 gamma 0.0602659
NAP1L1 nucleosome assembly protein 1-like 1 0.057761
CALR calreticulin 0.0577162
SOD2 superoxide dismutase 2, mitochondrial 0.0575242
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0574887
ENO1 enolase 1, (alpha) 0.0572391
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0568801
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0524243
CANX calnexin 0.0519192
ARRDC3 arrestin domain containing 3 0.0505203
OGA O-GlcNAcase 0.0498491
PTMA prothymosin, alpha 0.0495082
SFTPA2 surfactant protein A2 0.0490148
ADM adrenomedullin 0.0484485
FLNA filamin A, alpha 0.0482449
YBX1 Y box binding protein 1 0.0464435
MXI1 MAX interactor 1, dimerization protein 0.0463677
PCBP2 poly(rC) binding protein 2 0.0461748
ANLN anillin, actin binding protein 0.045659
PGK1 phosphoglycerate kinase 1 0.0453655
RPL26 ribosomal protein L26 0.0443114
HELZ helicase with zinc finger 0.04262
OPTN optineurin 0.0423173
ZMIZ1 zinc finger, MIZ-type containing 1 0.0413273
RPL5 ribosomal protein L5 0.0400577
ANXA2 annexin A2 0.0398348
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0397928
MYOF myoferlin 0.0393692
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0393424
FTL ferritin, light polypeptide 0.0391473
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.03887
RPL36A ribosomal protein L36a 0.0387655
RPL11 ribosomal protein L11 0.0387453
SQSTM1 sequestosome 1 0.0382662
RPLP2 ribosomal protein, large, P2 0.0371253
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0356189
RPL35A ribosomal protein L35a 0.035391
MKI67 marker of proliferation Ki-67 0.0340021
RPS13 ribosomal protein S13 0.0327972
TENT5A terminal nucleotidyltransferase 5A 0.0322155
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0321562
RPL12 ribosomal protein L12 0.0320728
RPL7 ribosomal protein L7 0.0320634
RPL37A ribosomal protein L37a 0.0320247
RPL13A ribosomal protein L13a 0.0317187
DDIT4 DNA-damage-inducible transcript 4 0.0312651
RPL19 ribosomal protein L19 0.0312437
LAMP2 lysosomal-associated membrane protein 2 0.0312389
RACK1 receptor for activated C kinase 1 0.0311958
TGFBI transforming growth factor, beta-induced, 68kDa 0.0309415
WTAP Wilms tumor 1 associated protein 0.0308108
DEK DEK proto-oncogene 0.030711
HMGA1 high mobility group AT-hook 1 0.0299498
NT5C2 5'-nucleotidase, cytosolic II 0.0296255
RPL7A ribosomal protein L7a 0.029594
EIF1 eukaryotic translation initiation factor 1 0.0294906
TMEM123 transmembrane protein 123 0.0293269
RPS19 ribosomal protein S19 0.0289738
RPS23 ribosomal protein S23 0.0287745
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.028718
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.028513
FTH1 ferritin, heavy polypeptide 1 0.0279097
UBC ubiquitin C 0.0277587
PNISR PNN-interacting serine/arginine-rich protein 0.0274323
PRELID2 PRELI domain containing 2 0.0273357
KDM3A lysine (K)-specific demethylase 3A 0.0271935
ICAM1 intercellular adhesion molecule 1 0.0270789
HLA-A major histocompatibility complex, class I, A 0.0270583
STC2 stanniocalcin 2 0.0268488
RPS2 ribosomal protein S2 0.02675
RPS27A ribosomal protein S27a 0.026551
CTSD cathepsin D 0.0263939
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0263729
DSTN destrin (actin depolymerizing factor) 0.026307
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.02595
RPL36 ribosomal protein L36 0.0254759
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0253478
RPL6 ribosomal protein L6 0.0253032

decreased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.147322
GLIS3 GLIS family zinc finger 3 -0.133478
AKAP12 A kinase (PRKA) anchor protein 12 -0.122095
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0878424
CD44 CD44 molecule (Indian blood group) -0.0833629
HMGA2 high mobility group AT-hook 2 -0.0807145
VCL vinculin -0.072456
BICC1 BicC family RNA binding protein 1 -0.054823
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0540424
VCAN versican -0.0531384
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.051898
ZBTB38 zinc finger and BTB domain containing 38 -0.0514279
IGFBP3 insulin-like growth factor binding protein 3 -0.0497876
NABP1 nucleic acid binding protein 1 -0.0496609
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0472855
EXT1 exostosin glycosyltransferase 1 -0.0466938
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0464211
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0460276
NAV1 neuron navigator 1 -0.0448527
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0445066
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0431065
FNDC3B fibronectin type III domain containing 3B -0.042778
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0413515
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0407793
HDAC9 histone deacetylase 9 -0.0394679
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0383469
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0379126
SMAD3 SMAD family member 3 -0.0375163
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0357747
RAI14 retinoic acid induced 14 -0.0353485
PPARD peroxisome proliferator-activated receptor delta -0.0345464
CDH13 cadherin 13 -0.0345402
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0340191
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0338749
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.033464
OSMR oncostatin M receptor -0.0328461
NAMPT nicotinamide phosphoribosyltransferase -0.0327436
CDCP1 CUB domain containing protein 1 -0.0325277
KYNU kynureninase -0.0319356
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0319216
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0313372
VMP1 vacuole membrane protein 1 -0.0305988
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.030426
COL6A3 collagen, type VI, alpha 3 -0.0300857
EGR1 early growth response 1 -0.0292614
RIGI RNA sensor RIG-I -0.0292042
MSN moesin -0.028362
IER3 immediate early response 3 -0.0277661
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0271427
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0266813
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0265956
EHBP1 EH domain binding protein 1 -0.0264844
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0264375
BTG1 B-cell translocation gene 1, anti-proliferative -0.0261931
EGFR epidermal growth factor receptor -0.0261256
CLMP CXADR-like membrane protein -0.025647
PALLD palladin, cytoskeletal associated protein -0.0250551
MAP1B microtubule-associated protein 1B -0.0249382
ADAM12 ADAM metallopeptidase domain 12 -0.0244173
INHBA inhibin, beta A -0.0243875
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0242777
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0241742
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0240119
EFNA5 ephrin-A5 -0.023806
NT5E 5'-nucleotidase, ecto (CD73) -0.0236653
RTN4 reticulon 4 -0.0232303
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0230877
FRMD4A FERM domain containing 4A -0.0228119
DIAPH2 diaphanous-related formin 2 -0.0227619
STC1 stanniocalcin 1 -0.0227277
GPC6 glypican 6 -0.0223919
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0222551
FAM20C family with sequence similarity 20, member C -0.0219392
SAMD3 sterile alpha motif domain containing 3 -0.0217887
EPAS1 endothelial PAS domain protein 1 -0.0217403
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0217321
NRP1 neuropilin 1 -0.0216061
SLC38A2 solute carrier family 38, member 2 -0.0213648
BCAR3 breast cancer anti-estrogen resistance 3 -0.020958
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0208676
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.0202905
JMJD1C jumonji domain containing 1C -0.0198111
TUT7 terminal uridylyl transferase 7 -0.0197549
TOP1 topoisomerase (DNA) I -0.0197083
ZBTB20 zinc finger and BTB domain containing 20 -0.0196969
IFI16 interferon, gamma-inducible protein 16 -0.019533
LHFPL2 lipoma HMGIC fusion partner-like 2 -0.0195144
TGM2 transglutaminase 2 -0.0188286
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0188043
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0182984
IL1RAP interleukin 1 receptor accessory protein -0.0181531
STK17A serine/threonine kinase 17a -0.0181454
ABTB3 ankyrin repeat and BTB domain containing 3 -0.0178923
PLSCR1 phospholipid scramblase 1 -0.0177108
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0176619
SLC38A1 solute carrier family 38, member 1 -0.0171091
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0169365
MYO9A myosin IXA -0.0169085
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0168168
RGS17 regulator of G-protein signaling 17 -0.0167178