| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ponatinib perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ponatinib_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.112933 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.107676 |
| COL6A3 | collagen, type VI, alpha 3 | 0.08658 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0809431 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0781644 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0765053 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0721427 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.066834 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0656472 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0626494 |
| PRELID2 | PRELI domain containing 2 | 0.0617579 |
| HLA-B | major histocompatibility complex, class I, B | 0.0597068 |
| B2M | beta-2-microglobulin | 0.059399 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0585905 |
| FAM13A | family with sequence similarity 13, member A | 0.0545989 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0533567 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0531562 |
| NDRG1 | N-myc downstream regulated 1 | 0.0486259 |
| SDC4 | syndecan 4 | 0.0470871 |
| ZNF292 | zinc finger protein 292 | 0.0469595 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0456115 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0452732 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.0449472 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0443038 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.043988 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.043109 |
| LOXL2 | lysyl oxidase-like 2 | 0.0423244 |
| CALR | calreticulin | 0.0412084 |
| IGF2 | insulin-like growth factor 2 | 0.0411921 |
| ZNF395 | zinc finger protein 395 | 0.0399466 |
| ARRDC3 | arrestin domain containing 3 | 0.038073 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.037953 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0368774 |
| SUCO | SUN domain containing ossification factor | 0.036825 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0360686 |
| FNIP1 | folliculin interacting protein 1 | 0.036058 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0356676 |
| SKIC3 | SKI3 subunit of superkiller complex | 0.0351333 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0350265 |
| COL5A2 | collagen, type V, alpha 2 | 0.0341676 |
| PLEKHA2 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 | 0.0340178 |
| PRRC1 | proline-rich coiled-coil 1 | 0.0339838 |
| EGFR | epidermal growth factor receptor | 0.0338564 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0337481 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0336005 |
| CANX | calnexin | 0.0326651 |
| HELZ | helicase with zinc finger | 0.0323217 |
| RAB1A | RAB1A, member RAS oncogene family | 0.032025 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | 0.0316781 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0314865 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0314242 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0306765 |
| STK4 | serine/threonine kinase 4 | 0.0304918 |
| COL5A1 | collagen, type V, alpha 1 | 0.0299631 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0297945 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0296938 |
| HDLBP | high density lipoprotein binding protein | 0.0289621 |
| ZZZ3 | zinc finger, ZZ-type containing 3 | 0.0286505 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0276762 |
| PTGES2 | prostaglandin E synthase 2 | 0.0276415 |
| FLNA | filamin A, alpha | 0.027394 |
| COPA | coatomer protein complex, subunit alpha | 0.0272312 |
| DSCAM | Down syndrome cell adhesion molecule | 0.027106 |
| ITM2B | integral membrane protein 2B | 0.0267455 |
| NBAS | neuroblastoma amplified sequence | 0.0267132 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0266252 |
| DNAJC25 | DnaJ (Hsp40) homolog, subfamily C , member 25 | 0.0264849 |
| GANAB | glucosidase, alpha; neutral AB | 0.0264237 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0264159 |
| ZNF160 | zinc finger protein 160 | 0.0263148 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0262922 |
| SEPTIN9 | septin 9 | 0.0260012 |
| PPP1R12B | protein phosphatase 1, regulatory subunit 12B | 0.0259223 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0257197 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0256951 |
| SCARB2 | scavenger receptor class B, member 2 | 0.025679 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0256768 |
| RINT1 | RAD50 interactor 1 | 0.0255749 |
| CD109 | CD109 molecule | 0.0254255 |
| CCNG2 | cyclin G2 | 0.0253749 |
| UMAD1 | UBAP1-MVB12-associated (UMA) domain containing 1 | 0.025336 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | 0.0249856 |
| PHF21A | PHD finger protein 21A | 0.0247287 |
| MTREX | Mtr4 exosome RNA helicase | 0.0245125 |
| AUH | AU RNA binding protein/enoyl-CoA hydratase | 0.0244701 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0243028 |
| DDR2 | discoidin domain receptor tyrosine kinase 2 | 0.0240019 |
| VCAM1 | vascular cell adhesion molecule 1 | 0.0239738 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0239157 |
| SEC24A | SEC24 family member A | 0.0238965 |
| NME7 | NME/NM23 family member 7 | 0.0237725 |
| RNASE3 | ribonuclease, RNase A family, 3 | 0.0236725 |
| NRXN3 | neurexin 3 | 0.0235959 |
| USP37 | ubiquitin specific peptidase 37 | 0.0234628 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0234552 |
| CD47 | CD47 molecule | 0.0234549 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0234443 |
| PIK3C3 | phosphatidylinositol 3-kinase, catalytic subunit type 3 | 0.0231781 |
| TFG | TRK-fused gene | 0.0231742 |
| HLA-C | major histocompatibility complex, class I, C | 0.0230699 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.233544 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.152771 |
| VIM | vimentin | -0.151668 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.131295 |
| TMSB10 | thymosin beta 10 | -0.123126 |
| EXT1 | exostosin glycosyltransferase 1 | -0.113277 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.109587 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.101983 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.09519 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0947371 |
| COL1A1 | collagen, type I, alpha 1 | -0.0941272 |
| FN1 | fibronectin 1 | -0.0872106 |
| GLIS3 | GLIS family zinc finger 3 | -0.0829981 |
| PTMA | prothymosin, alpha | -0.0808439 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0754734 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0753503 |
| CALD1 | caldesmon 1 | -0.0750095 |
| PRSS23 | protease, serine, 23 | -0.0726147 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0712897 |
| STC1 | stanniocalcin 1 | -0.0703083 |
| CD44 | CD44 molecule (Indian blood group) | -0.0688892 |
| CDK6 | cyclin-dependent kinase 6 | -0.0683651 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0650156 |
| RRBP1 | ribosome binding protein 1 | -0.0641807 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0621253 |
| HMGA2 | high mobility group AT-hook 2 | -0.0616223 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.0614415 |
| MAP1B | microtubule-associated protein 1B | -0.0612943 |
| FTL | ferritin, light polypeptide | -0.0606002 |
| EFNA5 | ephrin-A5 | -0.0599994 |
| MT1X | metallothionein 1X | -0.0595647 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0572406 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0564565 |
| VCL | vinculin | -0.0554065 |
| POTEF | POTE ankyrin domain family, member F | -0.0531878 |
| MED13L | mediator complex subunit 13-like | -0.0525198 |
| SEPTIN7 | septin 7 | -0.0518645 |
| CALU | calumenin | -0.0513708 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0501371 |
| ENO1 | enolase 1, (alpha) | -0.0497144 |
| TUBB | tubulin, beta class I | -0.0496257 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0493174 |
| TPM4 | tropomyosin 4 | -0.0480875 |
| RTN4 | reticulon 4 | -0.0454037 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0448033 |
| PTK2 | protein tyrosine kinase 2 | -0.0445797 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0441529 |
| AHNAK | AHNAK nucleoprotein | -0.0441016 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0436667 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0429002 |
| PDE10A | phosphodiesterase 10A | -0.0424856 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0416175 |
| RPLP1 | ribosomal protein, large, P1 | -0.0412919 |
| TXNRD1 | thioredoxin reductase 1 | -0.0408482 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0406352 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0402624 |
| CBX3 | chromobox homolog 3 | -0.0398962 |
| RPL37A | ribosomal protein L37a | -0.0398915 |
| CDH13 | cadherin 13 | -0.0392334 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0390475 |
| ASPH | aspartate beta-hydroxylase | -0.0386965 |
| PKM | pyruvate kinase, muscle | -0.0380331 |
| NAV1 | neuron navigator 1 | -0.0375502 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.0373028 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.037281 |
| H3-3B | H3.3 histone B | -0.0366813 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0365838 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.0365668 |
| KAZN | kazrin, periplakin interacting protein | -0.0357773 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0354412 |
| TPI1 | triosephosphate isomerase 1 | -0.0348235 |
| TMEM165 | transmembrane protein 165 | -0.0338238 |
| FBXO11 | F-box protein 11 | -0.0331286 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.032999 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0322568 |
| RPS24 | ribosomal protein S24 | -0.0322102 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0321472 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0320861 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0320781 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0320721 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0320328 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0316324 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0315298 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0314474 |
| WNK1 | WNK lysine deficient protein kinase 1 | -0.0310816 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0310543 |
| MEF2A | myocyte enhancer factor 2A | -0.0309917 |
| ACTG1 | actin gamma 1 | -0.0305819 |
| GNAS | GNAS complex locus | -0.0304108 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0302471 |
| WDR26 | WD repeat domain 26 | -0.030089 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0300327 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0299716 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0299195 |
| HIP1 | huntingtin interacting protein 1 | -0.0296649 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.029608 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0293911 |
| FRMD4A | FERM domain containing 4A | -0.0291536 |
| RAB31 | RAB31, member RAS oncogene family | -0.0290216 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0285759 |
