Ponatinib_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ponatinib perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ponatinib_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 0.0636746
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0631387
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0473709
ANKRD11 ankyrin repeat domain 11 0.0465773
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0420008
IGF2 insulin-like growth factor 2 0.0418918
B2M beta-2-microglobulin 0.04136
SMYD3 SET and MYND domain containing 3 0.0346639
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0346146
VIM vimentin 0.0342367
POTEF POTE ankyrin domain family, member F 0.0336955
RHOBTB3 Rho-related BTB domain containing 3 0.0332575
ZBTB20 zinc finger and BTB domain containing 20 0.0326663
RPL26 ribosomal protein L26 0.031247
WWOX WW domain containing oxidoreductase 0.0306637
BICD1 bicaudal D homolog 1 (Drosophila) 0.0303698
DST dystonin 0.0300519
N4BP2L2 NEDD4 binding protein 2-like 2 0.0300155
RPL35A ribosomal protein L35a 0.0299178
RPS3 ribosomal protein S3 0.0298437
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0292432
RNF213 ring finger protein 213 0.0289103
ATXN1 ataxin 1 0.0288796
RORA RAR-related orphan receptor A 0.0284113
HMGA2 high mobility group AT-hook 2 0.0278133
DOCK9 dedicator of cytokinesis 9 0.026801
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0267901
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0262075
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0257884
RPS13 ribosomal protein S13 0.0255353
CCDC88A coiled-coil domain containing 88A 0.0250247
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0250016
ATM ATM serine/threonine kinase 0.0249062
LPP LIM domain containing preferred translocation partner in lipoma 0.0242739
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0242475
ZMYND8 zinc finger, MYND-type containing 8 0.0241942
TNRC6B trinucleotide repeat containing 6B 0.0240368
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0239838
ENO1 enolase 1, (alpha) 0.0236466
PTMA prothymosin, alpha 0.0236109
AKAP9 A kinase (PRKA) anchor protein 9 0.023289
RPL37A ribosomal protein L37a 0.0231146
RPS8 ribosomal protein S8 0.0230098
PURA purine-rich element binding protein A 0.0228802
TRIM56 tripartite motif containing 56 0.0227852
LMO7 LIM domain 7 0.0227403
RAD51B RAD51 paralog B 0.0226808
FLNA filamin A, alpha 0.0226776
TPI1 triosephosphate isomerase 1 0.0225379
MPRIP myosin phosphatase Rho interacting protein 0.022445
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.0223234
TTC17 tetratricopeptide repeat domain 17 0.0220469
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0216132
CCDC91 coiled-coil domain containing 91 0.0214416
SEPTIN9 septin 9 0.0214261
PRSS23 protease, serine, 23 0.0213918
HLA-B major histocompatibility complex, class I, B 0.021091
MAP2K5 mitogen-activated protein kinase kinase 5 0.0210283
JAK1 Janus kinase 1 0.0209671
UTRN utrophin 0.0206649
BPTF bromodomain PHD finger transcription factor 0.0206422
SCAPER S-phase cyclin A-associated protein in the ER 0.0202731
RPS29 ribosomal protein S29 0.0202037
SET SET nuclear proto-oncogene 0.0200534
ARHGAP12 Rho GTPase activating protein 12 0.0199037
NCOR1 nuclear receptor corepressor 1 0.0198932
CEP250 centrosomal protein 250kDa 0.01975
PODXL podocalyxin-like 0.0195363
MYO9B myosin IXB 0.0194785
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0193939
SRPK2 SRSF protein kinase 2 0.0193486
CELF1 CUGBP, Elav-like family member 1 0.0192223
ENO2 enolase 2 (gamma, neuronal) 0.018981
UVRAG UV radiation resistance associated 0.0188937
RPL23 ribosomal protein L23 0.0183006
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 0.0181516
IGFBP3 insulin-like growth factor binding protein 3 0.018101
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) 0.017827
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) 0.0176553
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0176488
PARD3B par-3 family cell polarity regulator beta 0.0176466
SLC38A2 solute carrier family 38, member 2 0.017531
SVIL supervillin 0.0175037
P4HB prolyl 4-hydroxylase, beta polypeptide 0.01748
PRKCA protein kinase C, alpha 0.0174613
WARS1 tryptophanyl-tRNA synthetase 1 0.0174241
SYNJ2 synaptojanin 2 0.017405
DPYD dihydropyrimidine dehydrogenase 0.017389
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 0.0173784
LMNA lamin A/C 0.0172802
RPL36 ribosomal protein L36 0.0172379
RIMS2 regulating synaptic membrane exocytosis 2 0.0168319
RBM6 RNA binding motif protein 6 0.0167418
SCAMP1 secretory carrier membrane protein 1 0.0167211
NPAS2 neuronal PAS domain protein 2 0.016661
RPS25 ribosomal protein S25 0.0166164
PDE4D phosphodiesterase 4D, cAMP-specific 0.0164329
AHNAK2 AHNAK nucleoprotein 2 0.0163791
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0163736
CANX calnexin 0.0163508

decreased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0549718
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0510236
CD44 CD44 molecule (Indian blood group) -0.0484238
BIRC3 baculoviral IAP repeat containing 3 -0.0463242
ANKRD28 ankyrin repeat domain 28 -0.0449169
FNDC3B fibronectin type III domain containing 3B -0.0417898
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0388506
JMJD1C jumonji domain containing 1C -0.0375346
OSMR oncostatin M receptor -0.0375215
ELL2 elongation factor, RNA polymerase II, 2 -0.0359561
NCEH1 neutral cholesterol ester hydrolase 1 -0.0357191
YBX3 Y box binding protein 3 -0.0348106
BIRC6 baculoviral IAP repeat containing 6 -0.0341036
LOC112694756 uncharaterized LOC112694756 -0.033694
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0331337
ECT2 epithelial cell transforming 2 -0.0315094
STRN3 striatin, calmodulin binding protein 3 -0.0314444
ANLN anillin, actin binding protein -0.0309569
PALM2AKAP2 PALM2 and AKAP2 fusion -0.030641
DSCAM Down syndrome cell adhesion molecule -0.0305156
TRIO trio Rho guanine nucleotide exchange factor -0.0299928
SNX14 sorting nexin 14 -0.0290755
USP12 ubiquitin specific peptidase 12 -0.0290493
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0289273
ATP13A3 ATPase type 13A3 -0.0284691
RPL4 ribosomal protein L4 -0.026818
NAMPT nicotinamide phosphoribosyltransferase -0.0267801
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0262518
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0262152
COPB1 coatomer protein complex, subunit beta 1 -0.0261884
FMNL2 formin-like 2 -0.0259748
GLS2 glutaminase 2 (liver, mitochondrial) -0.025879
ZC3H11A zinc finger CCCH-type containing 11A -0.0257899
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0254319
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0253939
BHLHE40 basic helix-loop-helix family, member e40 -0.025196
EGR1 early growth response 1 -0.0246233
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0245902
BIRC2 baculoviral IAP repeat containing 2 -0.0245358
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0238109
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0237471
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0236056
MIS18BP1 MIS18 binding protein 1 -0.023486
YAP1 Yes-associated protein 1 -0.0230627
TM9SF3 transmembrane 9 superfamily member 3 -0.0225143
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0222416
NIPBL Nipped-B homolog (Drosophila) -0.0215776
IER3 immediate early response 3 -0.0215681
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0214355
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.021379
PDGFA platelet-derived growth factor alpha polypeptide -0.0212915
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0209999
HDLBP high density lipoprotein binding protein -0.0209808
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0208597
SDC4 syndecan 4 -0.0205777
TM4SF1 transmembrane 4 L six family member 1 -0.0204614
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0203512
CRY1 cryptochrome circadian clock 1 -0.0202134
PCNX4 pecanex 4 -0.0199513
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0199356
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -0.0195766
CEP95 centrosomal protein 95kDa -0.0193569
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0191327
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0191216
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) -0.0190286
DGKD diacylglycerol kinase, delta 130kDa -0.0190136
NUP98 nucleoporin 98kDa -0.0190085
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0189562
OXSR1 oxidative stress responsive 1 -0.0189055
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0188679
NABP1 nucleic acid binding protein 1 -0.0188627
BSG basigin (Ok blood group) -0.0188132
SOD2 superoxide dismutase 2, mitochondrial -0.0187752
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.018728
RAB1A RAB1A, member RAS oncogene family -0.0185876
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0184823
COPA coatomer protein complex, subunit alpha -0.0182701
CUL3 cullin 3 -0.0182422
KIAA1328 KIAA1328 -0.0180863
HILPDA hypoxia inducible lipid droplet-associated -0.017887
VMP1 vacuole membrane protein 1 -0.0177927
PBX3 pre-B-cell leukemia homeobox 3 -0.01773
GAS2L3 growth arrest-specific 2 like 3 -0.0176343
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.017489
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.017358
ASPH aspartate beta-hydroxylase -0.0173413
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0173287
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0167734
WDR45B WD repeat domain 45B -0.0166753
KMT2A lysine (K)-specific methyltransferase 2A -0.0165213
CDK5RAP2 CDK5 regulatory subunit associated protein 2 -0.0165133
AKAP8L A kinase (PRKA) anchor protein 8-like -0.0164742
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0164563
HBP1 HMG-box transcription factor 1 -0.0163909
SAFB scaffold attachment factor B -0.016385
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0163476
CEP290 centrosomal protein 290kDa -0.0162263
NAV2 neuron navigator 2 -0.0161396
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0159951
WBP11 WW domain binding protein 11 -0.0159622