Ponatinib_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ponatinib perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ponatinib_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.25447
NRG1 neuregulin 1 0.218814
HLA-B major histocompatibility complex, class I, B 0.12403
STC2 stanniocalcin 2 0.113402
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.102751
PTMA prothymosin, alpha 0.100271
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0966356
ASPH aspartate beta-hydroxylase 0.0894228
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0851528
ENO1 enolase 1, (alpha) 0.0781206
TPT1 tumor protein, translationally-controlled 1 0.0733665
LMNA lamin A/C 0.0733492
RPL26 ribosomal protein L26 0.0702515
MRPS6 mitochondrial ribosomal protein S6 0.0689289
B2M beta-2-microglobulin 0.0662525
NAMPT nicotinamide phosphoribosyltransferase 0.0547438
CANX calnexin 0.0543817
CALR calreticulin 0.0535567
LIMCH1 LIM and calponin homology domains 1 0.0532759
RAI14 retinoic acid induced 14 0.0523932
HLA-A major histocompatibility complex, class I, A 0.0495216
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0494463
RPL37A ribosomal protein L37a 0.0479346
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0479172
SQSTM1 sequestosome 1 0.04756
RPS27 ribosomal protein S27 0.04755
SOX4 SRY (sex determining region Y)-box 4 0.0466557
RPS3 ribosomal protein S3 0.0459649
TMSB10 thymosin beta 10 0.0457891
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.045682
RPL35A ribosomal protein L35a 0.0451087
ZFP36L1 ZFP36 ring finger protein-like 1 0.0450207
HMGA2 high mobility group AT-hook 2 0.0446962
IFI27 interferon, alpha-inducible protein 27 0.0443105
SFRP1 secreted frizzled-related protein 1 0.0438868
ACTG1 actin gamma 1 0.0437834
DDIT4 DNA-damage-inducible transcript 4 0.0429337
TENM4 teneurin transmembrane protein 4 0.0413467
TMSB4X thymosin beta 4, X-linked 0.0401851
RPL23 ribosomal protein L23 0.0397598
RPS8 ribosomal protein S8 0.0389477
LY6E lymphocyte antigen 6 complex, locus E 0.038855
SFTPA2 surfactant protein A2 0.0386745
GRB10 growth factor receptor-bound protein 10 0.0385745
CTSD cathepsin D 0.0383501
TRIO trio Rho guanine nucleotide exchange factor 0.0383001
RPS12 ribosomal protein S12 0.0375663
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0373434
FAM13A family with sequence similarity 13, member A 0.0368328
MYH9 myosin, heavy chain 9, non-muscle 0.0366309
RPL18 ribosomal protein L18 0.0353923
HMGA1 high mobility group AT-hook 1 0.0348208
RACK1 receptor for activated C kinase 1 0.0344017
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0342403
RPL13A ribosomal protein L13a 0.0341902
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0340791
FLNB filamin B, beta 0.0326035
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0323776
RPS27A ribosomal protein S27a 0.0323473
IGFBP5 insulin-like growth factor binding protein 5 0.0321652
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0314044
LOC102724023 ES1 protein homolog, mitochondrial 0.0306859
CADM1 cell adhesion molecule 1 0.0305429
EEF1G eukaryotic translation elongation factor 1 gamma 0.0304642
RPS29 ribosomal protein S29 0.0300868
TPI1 triosephosphate isomerase 1 0.0297852
VEGFA vascular endothelial growth factor A 0.0293805
DNAH5 dynein, axonemal, heavy chain 5 0.0290994
TPM3 tropomyosin 3 0.0290633
S100A9 S100 calcium binding protein A9 0.0290173
RPL36 ribosomal protein L36 0.028885
HILPDA hypoxia inducible lipid droplet-associated 0.0286165
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0286056
HDGF hepatoma-derived growth factor 0.0281971
RPL8 ribosomal protein L8 0.0275342
AHNAK AHNAK nucleoprotein 0.0274088
CTSB cathepsin B 0.02739
RPS25 ribosomal protein S25 0.027097
RPS21 ribosomal protein S21 0.0267878
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0265582
IRS2 insulin receptor substrate 2 0.0264746
IFRD1 interferon-related developmental regulator 1 0.0264375
MYOF myoferlin 0.0262094
UGCG UDP-glucose ceramide glucosyltransferase 0.0256078
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0255363
IFI6 interferon, alpha-inducible protein 6 0.0255251
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0252443
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0251261
TPD52 tumor protein D52 0.0247473
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0246225
DPYD dihydropyrimidine dehydrogenase 0.0243881
ZNF292 zinc finger protein 292 0.0240848
MCL1 myeloid cell leukemia 1 0.024069
ARL4C ADP-ribosylation factor-like 4C 0.023249
PDIA6 protein disulfide isomerase family A, member 6 0.023137
RPH3AL rabphilin 3A-like (without C2 domains) 0.0230014
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0228078
TMED9 transmembrane emp24 protein transport domain containing 9 0.0226677
RPS11 ribosomal protein S11 0.022586
CALU calumenin 0.0225816

decreased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.265516
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.165349
CXCL8 chemokine (C-X-C motif) ligand 8 -0.118491
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0790515
EREG epiregulin -0.0581753
EXT1 exostosin glycosyltransferase 1 -0.0576557
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0573045
TXNIP thioredoxin interacting protein -0.0545469
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0495719
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0487476
OSMR oncostatin M receptor -0.0481486
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0455388
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0438479
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0430412
ZC3H12C zinc finger CCCH-type containing 12C -0.0412419
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0396332
NRIP1 nuclear receptor interacting protein 1 -0.0395862
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0390069
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0389032
IL6ST interleukin 6 signal transducer -0.0365059
SUCO SUN domain containing ossification factor -0.0359987
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0351714
CD44 CD44 molecule (Indian blood group) -0.0350375
FNDC3B fibronectin type III domain containing 3B -0.0348237
SMAD3 SMAD family member 3 -0.0343053
ETNK1 ethanolamine kinase 1 -0.0336993
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0335487
MAP1B microtubule-associated protein 1B -0.0334154
MCTP2 multiple C2 domains, transmembrane 2 -0.0333214
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0331619
RAB31 RAB31, member RAS oncogene family -0.0330662
ZC3H11A zinc finger CCCH-type containing 11A -0.0327811
JMJD1C jumonji domain containing 1C -0.0327746
NRP1 neuropilin 1 -0.0322823
ADD3 adducin 3 (gamma) -0.0322027
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0316814
NFE2L2 nuclear factor, erythroid 2-like 2 -0.031616
SMYD3 SET and MYND domain containing 3 -0.0309563
CAB39 calcium binding protein 39 -0.0301645
PELO pelota homolog (Drosophila) -0.029735
TOP1 topoisomerase (DNA) I -0.02924
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0287683
VCL vinculin -0.0285419
MT2A metallothionein 2A -0.0284882
TM9SF3 transmembrane 9 superfamily member 3 -0.0283205
AHR aryl hydrocarbon receptor -0.028241
ANKRD28 ankyrin repeat domain 28 -0.0280835
FTL ferritin, light polypeptide -0.0280601
ZFC3H1 zinc finger, C3H1-type containing -0.0268834
ERBIN erbb2 interacting protein -0.0267176
NIPBL Nipped-B homolog (Drosophila) -0.0267118
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0266306
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0265964
WDR26 WD repeat domain 26 -0.026474
DNM1L dynamin 1-like -0.0263841
RPLP1 ribosomal protein, large, P1 -0.0259858
NPC1 Niemann-Pick disease, type C1 -0.0256659
FAM3C family with sequence similarity 3, member C -0.0255392
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0253685
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.025129
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0249943
COPA coatomer protein complex, subunit alpha -0.024556
FBXL5 F-box and leucine-rich repeat protein 5 -0.0240402
FAF2 Fas associated factor family member 2 -0.0238218
CD109 CD109 molecule -0.0238029
CDCP1 CUB domain containing protein 1 -0.0236212
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0235948
ZNF217 zinc finger protein 217 -0.0235124
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.023429
OGA O-GlcNAcase -0.0231755
PCNX1 pecanex 1 -0.023036
FBXO28 F-box protein 28 -0.0229697
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0229308
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0224007
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0223937
ITGB5 integrin, beta 5 -0.0221498
FBXW11 F-box and WD repeat domain containing 11 -0.0218495
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0218348
MAP3K9 mitogen-activated protein kinase kinase kinase 9 -0.021828
THBS1 thrombospondin 1 -0.0217543
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0213966
CLTC clathrin, heavy chain (Hc) -0.0211045
PTBP3 polypyrimidine tract binding protein 3 -0.0210743
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0210134
SETD5 SET domain containing 5 -0.0208472
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0206144
RESF1 retroelement silencing factor 1 -0.0204521
RHOBTB3 Rho-related BTB domain containing 3 -0.0202959
BLZF1 basic leucine zipper nuclear factor 1 -0.020234
LCORL ligand dependent nuclear receptor corepressor-like -0.0200788
FOXP1 forkhead box P1 -0.0200275
COG5 component of oligomeric golgi complex 5 -0.0199545
ECT2 epithelial cell transforming 2 -0.0197772
SSH1 slingshot protein phosphatase 1 -0.0197685
FNDC3A fibronectin type III domain containing 3A -0.0195494
GAS2L3 growth arrest-specific 2 like 3 -0.0194661
ARHGAP5 Rho GTPase activating protein 5 -0.0193356
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0193121
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0192738
FTH1 ferritin, heavy polypeptide 1 -0.0190426