Posaconazole_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Posaconazole perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Posaconazole_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LSAMP limbic system-associated membrane protein 0.191497
FMN1 formin 1 0.142981
DST dystonin 0.108592
MEIS2 Meis homeobox 2 0.105243
NRG1 neuregulin 1 0.0903914
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.085921
SOS1 son of sevenless homolog 1 (Drosophila) 0.0847148
PRKCA protein kinase C, alpha 0.0807686
FAM13A family with sequence similarity 13, member A 0.0786292
TLE4 transducin-like enhancer of split 4 0.0778
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0764197
PTPRD protein tyrosine phosphatase, receptor type, D 0.0745132
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0705507
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0689728
MEF2A myocyte enhancer factor 2A 0.0682626
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0670886
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0634588
NALF1 NALCN channel auxiliary factor 1 0.0565651
LINGO2 leucine rich repeat and Ig domain containing 2 0.0563181
SMYD3 SET and MYND domain containing 3 0.0544024
ZBTB20 zinc finger and BTB domain containing 20 0.0543653
SREBF2 sterol regulatory element binding transcription factor 2 0.0539616
ADARB1 adenosine deaminase, RNA-specific, B1 0.0532732
RNF213 ring finger protein 213 0.0531345
PRKD1 protein kinase D1 0.0525491
HELZ helicase with zinc finger 0.050876
MSI2 musashi RNA-binding protein 2 0.0499729
YEATS2 YEATS domain containing 2 0.0498768
LIMCH1 LIM and calponin homology domains 1 0.0488992
CENPF centromere protein F, 350/400kDa 0.0466544
FNBP1 formin binding protein 1 0.0463346
ITPRID2 ITPR interacting domain containing 2 0.0457294
ANTXR1 anthrax toxin receptor 1 0.0452533
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.0441524
ADGRG6 adhesion G protein-coupled receptor G6 0.0440078
NRIP1 nuclear receptor interacting protein 1 0.0438883
SLITRK6 SLIT and NTRK-like family, member 6 0.0435769
CADM1 cell adhesion molecule 1 0.0428485
DPH6 diphthamine biosynthesis 6 0.042625
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.041795
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0411804
LPIN1 lipin 1 0.0393131
DSCAM Down syndrome cell adhesion molecule 0.0392573
RAD51B RAD51 paralog B 0.0384588
THSD4 thrombospondin, type I, domain containing 4 0.0382084
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0374074
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0373068
VCL vinculin 0.0370693
MAML2 mastermind-like 2 (Drosophila) 0.0366782
PCDH9 protocadherin 9 0.0365034
FNDC3B fibronectin type III domain containing 3B 0.0358091
CHD9 chromodomain helicase DNA binding protein 9 0.0356524
TET2 tet methylcytosine dioxygenase 2 0.0347934
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0347075
PSD3 pleckstrin and Sec7 domain containing 3 0.0343148
AHR aryl hydrocarbon receptor 0.0340656
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0335865
SYT1 synaptotagmin I 0.0331743
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.0328834
ZNF638 zinc finger protein 638 0.0328305
CPED1 cadherin-like and PC-esterase domain containing 1 0.0327109
PTPRM protein tyrosine phosphatase, receptor type, M 0.0326086
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0322829
NAMPT nicotinamide phosphoribosyltransferase 0.0318866
SMAD3 SMAD family member 3 0.0317859
FRMD4A FERM domain containing 4A 0.0317086
EXT1 exostosin glycosyltransferase 1 0.0310051
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0303606
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0297183
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0296442
ARHGAP9 Rho GTPase activating protein 9 0.0289519
PTPRK protein tyrosine phosphatase, receptor type, K 0.028869
ZSWIM6 zinc finger, SWIM-type containing 6 0.0286251
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0283672
KDM4C lysine (K)-specific demethylase 4C 0.0280516
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.0279614
TRIO trio Rho guanine nucleotide exchange factor 0.0275091
NREP neuronal regeneration related protein 0.0274267
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0273445
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0273239
ADGRB3 adhesion G protein-coupled receptor B3 0.0269688
MYO6 myosin VI 0.0266542
MYH9 myosin, heavy chain 9, non-muscle 0.026617
RFX7 regulatory factor X, 7 0.0265324
IGF1R insulin-like growth factor 1 receptor 0.0263614
LPP LIM domain containing preferred translocation partner in lipoma 0.0262515
ESYT2 extended synaptotagmin-like protein 2 0.0262502
AUTS2 autism susceptibility candidate 2 0.0262409
BPTF bromodomain PHD finger transcription factor 0.0261175
PGK1 phosphoglycerate kinase 1 0.0259797
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0259389
COL3A1 collagen, type III, alpha 1 0.0259169
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0259099
PBX1 pre-B-cell leukemia homeobox 1 0.0257853
NCOR2 nuclear receptor corepressor 2 0.0256172
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.0254831
COL4A2 collagen, type IV, alpha 2 0.0252507
NCOA7 nuclear receptor coactivator 7 0.0249789
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0247946
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0247773

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.256813
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.181402
VIM vimentin -0.16634
PTMA prothymosin, alpha -0.13372
RPS6 ribosomal protein S6 -0.115197
IGF2 insulin-like growth factor 2 -0.0936898
ACTG1 actin gamma 1 -0.0875215
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0766687
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0648909
RPLP1 ribosomal protein, large, P1 -0.06364
TPT1 tumor protein, translationally-controlled 1 -0.0619387
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0593052
RPS24 ribosomal protein S24 -0.0555404
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0544877
RPL35A ribosomal protein L35a -0.0508905
FTL ferritin, light polypeptide -0.048497
COL1A1 collagen, type I, alpha 1 -0.0481625
RPL34 ribosomal protein L34 -0.0475145
RPS19 ribosomal protein S19 -0.0457242
RPLP0 ribosomal protein, large, P0 -0.0456422
P4HB prolyl 4-hydroxylase, beta polypeptide -0.045018
RPL28 ribosomal protein L28 -0.0442459
HILPDA hypoxia inducible lipid droplet-associated -0.0434644
RPL11 ribosomal protein L11 -0.0434047
TMSB10 thymosin beta 10 -0.0433706
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0428022
RPS14 ribosomal protein S14 -0.0423566
RPS16 ribosomal protein S16 -0.0420146
RPL38 ribosomal protein L38 -0.0411833
RPL23 ribosomal protein L23 -0.0402302
RPS8 ribosomal protein S8 -0.0393726
POTEF POTE ankyrin domain family, member F -0.0388224
ACBD3 acyl-CoA binding domain containing 3 -0.0376999
RPL19 ribosomal protein L19 -0.0376433
RPS25 ribosomal protein S25 -0.0371306
VDAC1 voltage-dependent anion channel 1 -0.0369472
S100A6 S100 calcium binding protein A6 -0.0367642
IER3 immediate early response 3 -0.0363307
RPS3 ribosomal protein S3 -0.0362117
KTN1 kinectin 1 (kinesin receptor) -0.0362044
GNAS GNAS complex locus -0.0358389
RPL32 ribosomal protein L32 -0.0353853
RPL26 ribosomal protein L26 -0.03538
RPS27 ribosomal protein S27 -0.0350558
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0342094
GOLGA4 golgin A4 -0.0338814
RPL9 ribosomal protein L9 -0.0338161
RPS23 ribosomal protein S23 -0.0337279
ANXA2 annexin A2 -0.0334543
LMNA lamin A/C -0.0332834
RPL12 ribosomal protein L12 -0.0331953
PKM pyruvate kinase, muscle -0.0326241
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.032223
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0321629
EIF5B eukaryotic translation initiation factor 5B -0.0318134
RPS11 ribosomal protein S11 -0.0318037
RPLP2 ribosomal protein, large, P2 -0.0317724
RPL36A ribosomal protein L36a -0.03122
DSTN destrin (actin depolymerizing factor) -0.0309983
RPS29 ribosomal protein S29 -0.0308674
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0307488
RPL31 ribosomal protein L31 -0.0297094
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0294027
CCND1 cyclin D1 -0.0289647
PFN1 profilin 1 -0.0284516
EIF1 eukaryotic translation initiation factor 1 -0.0276543
RPS5 ribosomal protein S5 -0.02762
RPL36 ribosomal protein L36 -0.0276019
RPL13A ribosomal protein L13a -0.0269666
COPA coatomer protein complex, subunit alpha -0.0268682
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0254
S100A10 S100 calcium binding protein A10 -0.02524
HMGA1 high mobility group AT-hook 1 -0.0252266
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0248932
RPL37 ribosomal protein L37 -0.0246887
RACK1 receptor for activated C kinase 1 -0.0246076
GATAD2B GATA zinc finger domain containing 2B -0.0245761
PA2G4 proliferation-associated 2G4, 38kDa -0.0241196
BICD1 bicaudal D homolog 1 (Drosophila) -0.0240536
RBM25 RNA binding motif protein 25 -0.0240141
FTH1 ferritin, heavy polypeptide 1 -0.0236082
S100A9 S100 calcium binding protein A9 -0.0235218
RTN4 reticulon 4 -0.0234655
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0232054
RPS17 ribosomal protein S17 -0.0231884
RPL5 ribosomal protein L5 -0.0230089
LDHB lactate dehydrogenase B -0.0229519
KPNB1 karyopherin (importin) beta 1 -0.0229505
FBL fibrillarin -0.022849
USP3 ubiquitin specific peptidase 3 -0.0227944
RPS13 ribosomal protein S13 -0.0226862
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0226522
LOC102724023 ES1 protein homolog, mitochondrial -0.022553
NAP1L1 nucleosome assembly protein 1-like 1 -0.0225081
ZC3H15 zinc finger CCCH-type containing 15 -0.0222993
H3-3B H3.3 histone B -0.0221231
TOP1 topoisomerase (DNA) I -0.0217124
SLMAP sarcolemma associated protein -0.0215449
RPS12 ribosomal protein S12 -0.0214903
RPL37A ribosomal protein L37a -0.0214017