Posaconazole_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Posaconazole perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Posaconazole_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.210956
SPTBN1 spectrin, beta, non-erythrocytic 1 0.123461
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0829019
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0811705
MBNL2 muscleblind-like splicing regulator 2 0.075015
STK39 serine threonine kinase 39 0.0726977
PADI1 peptidyl arginine deiminase, type I 0.0720516
MACC1 metastasis associated in colon cancer 1 0.0697985
BTBD9 BTB (POZ) domain containing 9 0.0692305
CCNL1 cyclin L1 0.0680554
MUC13 mucin 13, cell surface associated 0.0663043
STK24 serine/threonine kinase 24 0.064255
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0635647
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0616943
PRELID2 PRELI domain containing 2 0.0580473
EZR ezrin 0.0570151
RUNX1 runt-related transcription factor 1 0.0566014
FNDC3B fibronectin type III domain containing 3B 0.0565575
SREBF2 sterol regulatory element binding transcription factor 2 0.0546528
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0544888
ERRFI1 ERBB receptor feedback inhibitor 1 0.0537269
EPS8 epidermal growth factor receptor pathway substrate 8 0.053356
SQSTM1 sequestosome 1 0.0522979
ANXA2 annexin A2 0.0518885
FNDC3A fibronectin type III domain containing 3A 0.0505105
ZNF292 zinc finger protein 292 0.0494243
RBM39 RNA binding motif protein 39 0.0465984
EHF ets homologous factor 0.0465508
SDCBP2 syndecan binding protein (syntenin) 2 0.0456408
NEBL nebulette 0.0452922
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0449441
SORBS1 sorbin and SH3 domain containing 1 0.0447929
MYO1E myosin IE 0.044219
USP54 ubiquitin specific peptidase 54 0.0441743
LMO7 LIM domain 7 0.0438289
FNIP1 folliculin interacting protein 1 0.0436613
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0431358
MYH9 myosin, heavy chain 9, non-muscle 0.0430648
TRIM2 tripartite motif containing 2 0.0426487
FEM1C fem-1 homolog c (C. elegans) 0.0419074
ERBIN erbb2 interacting protein 0.0413004
EFNB2 ephrin-B2 0.0412991
ZMYND8 zinc finger, MYND-type containing 8 0.0407507
RAD51B RAD51 paralog B 0.0399815
NRIP1 nuclear receptor interacting protein 1 0.0397422
PHF3 PHD finger protein 3 0.0396635
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0396464
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0394274
H1-0 H1.0 linker histone 0.0383718
MYO5B myosin VB 0.0382232
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0373652
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0373424
SCARB1 scavenger receptor class B, member 1 0.0360864
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0358069
DSCAML1 Down syndrome cell adhesion molecule like 1 0.035027
MLPH melanophilin 0.0348266
ADIPOR2 adiponectin receptor 2 0.0346285
ITGA6 integrin, alpha 6 0.0339042
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.033752
ABHD2 abhydrolase domain containing 2 0.0335889
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.03347
NDRG1 N-myc downstream regulated 1 0.0332874
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0331167
BCLAF1 BCL2-associated transcription factor 1 0.0330538
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0330425
ATP11A ATPase, class VI, type 11A 0.0327887
ARGLU1 arginine and glutamate rich 1 0.0327521
TC2N tandem C2 domains, nuclear 0.0324464
ARHGAP5 Rho GTPase activating protein 5 0.0319028
KIF16B kinesin family member 16B 0.0318944
UBL3 ubiquitin-like 3 0.0308824
CD46 CD46 molecule, complement regulatory protein 0.0306637
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0302862
GRK3 G protein-coupled receptor kinase 3 0.030103
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 0.0300818
FMN1 formin 1 0.0299297
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0296849
ETNK1 ethanolamine kinase 1 0.0295778
STS steroid sulfatase (microsomal), isozyme S 0.029213
CMIP c-Maf inducing protein 0.0290367
SH3PXD2A SH3 and PX domains 2A 0.0288285
CTNND1 catenin (cadherin-associated protein), delta 1 0.0287155
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0284478
ANXA11 annexin A11 0.0284154
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0283333
FDPS farnesyl diphosphate synthase 0.0281949
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 0.0281202
ATXN1 ataxin 1 0.0280402
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.027752
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0276465
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0275178
RAB6A RAB6A, member RAS oncogene family 0.0274854
CEMIP2 cell migration inducing hyaluronidase 2 0.0274791
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0274579
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0271785
ARHGAP32 Rho GTPase activating protein 32 0.0271287
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0271099
PRKG1 protein kinase, cGMP-dependent, type I 0.0270032
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0269899
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0265824

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.20127
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.106649
EPSTI1 epithelial stromal interaction 1 (breast) -0.102978
PTMA prothymosin, alpha -0.0979538
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0864694
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.072986
LYZ lysozyme -0.0703295
RIGI RNA sensor RIG-I -0.0689599
RNF213 ring finger protein 213 -0.0686683
AHI1 Abelson helper integration site 1 -0.0651029
SP100 SP100 nuclear antigen -0.0645276
HLA-B major histocompatibility complex, class I, B -0.0625609
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0616676
RPL35A ribosomal protein L35a -0.0612165
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0608654
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0606754
LCN2 lipocalin 2 -0.0572534
ACTG1 actin gamma 1 -0.0504876
PERP PERP, TP53 apoptosis effector -0.0480621
INTS6 integrator complex subunit 6 -0.0458305
RPS24 ribosomal protein S24 -0.0448118
RPS6 ribosomal protein S6 -0.0428648
RPL34 ribosomal protein L34 -0.0426408
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.042196
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0418197
EPHB2 EPH receptor B2 -0.0407861
MAP7 microtubule-associated protein 7 -0.0405636
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0396542
MX1 MX dynamin-like GTPase 1 -0.0383777
TM4SF1 transmembrane 4 L six family member 1 -0.0381009
CANX calnexin -0.0376883
PMP22 peripheral myelin protein 22 -0.037574
RPS8 ribosomal protein S8 -0.0372477
B2M beta-2-microglobulin -0.0366708
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0346695
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0340434
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0338418
PIBF1 progesterone immunomodulatory binding factor 1 -0.0336081
IFIH1 interferon induced with helicase C domain 1 -0.0334244
RPL9 ribosomal protein L9 -0.032559
FTL ferritin, light polypeptide -0.0319979
FRMD5 FERM domain containing 5 -0.0312879
PLSCR2 phospholipid scramblase 2 -0.0308615
RPL26 ribosomal protein L26 -0.0305244
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0301309
MX2 MX dynamin-like GTPase 2 -0.0297953
HLA-C major histocompatibility complex, class I, C -0.0296787
RBM25 RNA binding motif protein 25 -0.0295897
XAF1 XIAP associated factor 1 -0.0292161
STAU1 staufen double-stranded RNA binding protein 1 -0.0290379
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0286421
RPL31 ribosomal protein L31 -0.02864
RPL19 ribosomal protein L19 -0.0279775
POTEF POTE ankyrin domain family, member F -0.0275887
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0274026
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0273203
RPS25 ribosomal protein S25 -0.027077
RPL7L1 ribosomal protein L7-like 1 -0.0267977
HM13 histocompatibility (minor) 13 -0.0265591
RPLP0 ribosomal protein, large, P0 -0.0265001
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0264225
GMDS GDP-mannose 4,6-dehydratase -0.0261131
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0255477
RPS21 ribosomal protein S21 -0.0253393
WSB1 WD repeat and SOCS box containing 1 -0.0251733
H3-3B H3.3 histone B -0.0251325
RPL37 ribosomal protein L37 -0.0249911
RPS29 ribosomal protein S29 -0.0249018
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0243257
IGFBP3 insulin-like growth factor binding protein 3 -0.0242201
MPHOSPH8 M-phase phosphoprotein 8 -0.0239054
RPL28 ribosomal protein L28 -0.0238367
UBC ubiquitin C -0.0237973
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0237963
RPL38 ribosomal protein L38 -0.0237253
RPS16 ribosomal protein S16 -0.0237163
RAD21 RAD21 homolog (S. pombe) -0.02308
EXT1 exostosin glycosyltransferase 1 -0.0229509
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0227847
S100A9 S100 calcium binding protein A9 -0.0225342
POU2F2 POU class 2 homeobox 2 -0.022445
RPL36A ribosomal protein L36a -0.0223614
TMSB10 thymosin beta 10 -0.0223436
PKM pyruvate kinase, muscle -0.0222327
RPS23 ribosomal protein S23 -0.0222231
GLG1 golgi glycoprotein 1 -0.0222127
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0219658
APOL6 apolipoprotein L, 6 -0.0217715
IER3 immediate early response 3 -0.0217597
SAMHD1 SAM domain and HD domain 1 -0.0216394
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0215644
VDAC1 voltage-dependent anion channel 1 -0.0215163
THOC2 THO complex 2 -0.0215067
ZNFX1 zinc finger, NFX1-type containing 1 -0.0214977
TMEM87A transmembrane protein 87A -0.0214807
RPS27A ribosomal protein S27a -0.0213436
KPNB1 karyopherin (importin) beta 1 -0.0213383
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0213361
VIM vimentin -0.0205243
ADAR adenosine deaminase, RNA-specific -0.020027