Posaconazole_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Posaconazole perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Posaconazole_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.297559
COL6A3 collagen, type VI, alpha 3 0.278567
TRIO trio Rho guanine nucleotide exchange factor 0.184552
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.123129
MYH9 myosin, heavy chain 9, non-muscle 0.10484
FNDC3B fibronectin type III domain containing 3B 0.0928747
CADM1 cell adhesion molecule 1 0.0912702
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0891692
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.086142
ELL2 elongation factor, RNA polymerase II, 2 0.0745452
ATP13A3 ATPase type 13A3 0.0670613
NAV2 neuron navigator 2 0.065631
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0619448
SOD2 superoxide dismutase 2, mitochondrial 0.0605104
LOXL2 lysyl oxidase-like 2 0.0568054
PDE10A phosphodiesterase 10A 0.0552915
JARID2 jumonji, AT rich interactive domain 2 0.052098
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0520238
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.050222
CXCL8 chemokine (C-X-C motif) ligand 8 0.0497506
GRB10 growth factor receptor-bound protein 10 0.0479686
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0470679
SPAG9 sperm associated antigen 9 0.0444094
CDH13 cadherin 13 0.0442827
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0434649
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0431805
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0429008
ADAM17 ADAM metallopeptidase domain 17 0.0428807
MTSS1 metastasis suppressor 1 0.0426274
SQLE squalene epoxidase 0.0422771
LDHA lactate dehydrogenase A 0.0417067
BHLHE40 basic helix-loop-helix family, member e40 0.0412523
ESYT2 extended synaptotagmin-like protein 2 0.0411091
ARRDC3 arrestin domain containing 3 0.0408059
SMAD3 SMAD family member 3 0.0389404
KLF7 Kruppel-like factor 7 (ubiquitous) 0.038839
RND3 Rho family GTPase 3 0.0384101
PRELID2 PRELI domain containing 2 0.0380244
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0363292
CALR calreticulin 0.0361176
FMNL2 formin-like 2 0.0360996
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.035727
PDIA6 protein disulfide isomerase family A, member 6 0.0346386
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0344168
ANXA1 annexin A1 0.0341593
FBXO32 F-box protein 32 0.0341405
ZNF292 zinc finger protein 292 0.0341305
RUNX1 runt-related transcription factor 1 0.033988
VEGFA vascular endothelial growth factor A 0.0338105
CAMTA1 calmodulin binding transcription activator 1 0.033122
TIMP3 TIMP metallopeptidase inhibitor 3 0.0329765
NAMPT nicotinamide phosphoribosyltransferase 0.0324337
SREBF2 sterol regulatory element binding transcription factor 2 0.0324289
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0320217
CD109 CD109 molecule 0.0315183
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0309645
INSIG1 insulin induced gene 1 0.0309066
MACF1 microtubule-actin crosslinking factor 1 0.0309035
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0305111
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0300668
KDM3A lysine (K)-specific demethylase 3A 0.0296462
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0291561
MRTFA myocardin related transcription factor A 0.0288513
COL4A1 collagen, type IV, alpha 1 0.0280847
LPP LIM domain containing preferred translocation partner in lipoma 0.0273757
APP amyloid beta (A4) precursor protein 0.0272497
FLNB filamin B, beta 0.0271982
KMT2C lysine (K)-specific methyltransferase 2C 0.0271124
DLG1 discs, large homolog 1 (Drosophila) 0.0270537
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.0265791
ATXN1 ataxin 1 0.0262269
EGFR epidermal growth factor receptor 0.0261669
BBX bobby sox homolog (Drosophila) 0.0260341
ELOVL5 ELOVL fatty acid elongase 5 0.0260238
RAB6A RAB6A, member RAS oncogene family 0.0259574
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0251834
HOOK2 hook microtubule-tethering protein 2 0.0250485
ENO1 enolase 1, (alpha) 0.0249034
TNS1 tensin 1 0.0246933
TSC22D2 TSC22 domain family, member 2 0.0246775
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0246455
TRAM2 translocation associated membrane protein 2 0.0246312
CCNL1 cyclin L1 0.024449
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0242707
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0239554
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0239475
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.0237583
ZFAND3 zinc finger, AN1-type domain 3 0.0237119
FAM13A family with sequence similarity 13, member A 0.0236538
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.0233236
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0229858
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0229712
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0229377
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0229311
CLIC4 chloride intracellular channel 4 0.0226677
CCNY cyclin Y 0.0225977
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0225492
ANKRD11 ankyrin repeat domain 11 0.0225128
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0223573
NRIP1 nuclear receptor interacting protein 1 0.0222238

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.203095
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.17706
COL1A1 collagen, type I, alpha 1 -0.164845
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0601066
ACTG1 actin gamma 1 -0.0598923
TMSB10 thymosin beta 10 -0.0589811
COL1A2 collagen, type I, alpha 2 -0.0567873
IGFBP3 insulin-like growth factor binding protein 3 -0.0473828
MT2A metallothionein 2A -0.045542
HMGA2 high mobility group AT-hook 2 -0.0437132
RPS6 ribosomal protein S6 -0.0379224
FBN1 fibrillin 1 -0.0365289
GLIS3 GLIS family zinc finger 3 -0.0357349
PTMA prothymosin, alpha -0.0349546
RPS8 ribosomal protein S8 -0.0341122
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0328313
HLA-B major histocompatibility complex, class I, B -0.0310097
CALD1 caldesmon 1 -0.0294359
RPL35A ribosomal protein L35a -0.0288687
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0284207
ALCAM activated leukocyte cell adhesion molecule -0.0280008
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0277473
FTL ferritin, light polypeptide -0.0276846
IER3 immediate early response 3 -0.0272704
FN1 fibronectin 1 -0.0256155
CAVIN1 caveolae associated protein 1 -0.0244927
EIF1 eukaryotic translation initiation factor 1 -0.0237758
DPYD dihydropyrimidine dehydrogenase -0.0235647
WWTR1 WW domain containing transcription regulator 1 -0.0233083
OSMR oncostatin M receptor -0.0229222
PALLD palladin, cytoskeletal associated protein -0.0228127
S100A9 S100 calcium binding protein A9 -0.0227431
AHNAK AHNAK nucleoprotein -0.0219704
ZBTB20 zinc finger and BTB domain containing 20 -0.0213509
RPL28 ribosomal protein L28 -0.0208957
S100A6 S100 calcium binding protein A6 -0.0208691
TPT1 tumor protein, translationally-controlled 1 -0.0207389
RRBP1 ribosome binding protein 1 -0.0205942
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0204964
TRPS1 trichorhinophalangeal syndrome I -0.0204283
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0202588
RPL5 ribosomal protein L5 -0.0199373
RPL19 ribosomal protein L19 -0.0196694
VDAC1 voltage-dependent anion channel 1 -0.0187445
RPL8 ribosomal protein L8 -0.0187003
RPLP1 ribosomal protein, large, P1 -0.0184494
LOC112694756 uncharaterized LOC112694756 -0.0184004
POTEF POTE ankyrin domain family, member F -0.0183559
RPS19 ribosomal protein S19 -0.0181455
RPLP2 ribosomal protein, large, P2 -0.0174048
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.017253
RPL12 ribosomal protein L12 -0.0171785
RPL26 ribosomal protein L26 -0.0171369
TGFBI transforming growth factor, beta-induced, 68kDa -0.0171221
NREP neuronal regeneration related protein -0.0170584
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0168762
TUBB tubulin, beta class I -0.0168537
LMNA lamin A/C -0.0163521
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0160992
VCL vinculin -0.015984
IL6 interleukin 6 -0.0156749
PFN1 profilin 1 -0.0154649
RPL11 ribosomal protein L11 -0.0151616
ANTXR2 anthrax toxin receptor 2 -0.0151156
RPS27A ribosomal protein S27a -0.0150601
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0149853
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.0146152
TAPBP TAP binding protein (tapasin) -0.0144821
RPS13 ribosomal protein S13 -0.0143961
RPLP0 ribosomal protein, large, P0 -0.0143093
CLMP CXADR-like membrane protein -0.0140268
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0140137
CD44 CD44 molecule (Indian blood group) -0.0138896
CCND1 cyclin D1 -0.0136919
MYADM myeloid-associated differentiation marker -0.013648
CYB5R3 cytochrome b5 reductase 3 -0.0135731
RPS5 ribosomal protein S5 -0.0134013
RACK1 receptor for activated C kinase 1 -0.0132945
RPS3 ribosomal protein S3 -0.0132638
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0132073
RPS21 ribosomal protein S21 -0.012989
RPS14 ribosomal protein S14 -0.0128939
RPL36 ribosomal protein L36 -0.0128842
MTDH metadherin -0.0126078
SRGN serglycin -0.0124321
RPL37A ribosomal protein L37a -0.0123675
DSTN destrin (actin depolymerizing factor) -0.0123572
PRSS23 protease, serine, 23 -0.0122916
RPS15 ribosomal protein S15 -0.0120913
PXDN peroxidasin -0.0120579
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0119909
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0119263
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0118623
RPL37 ribosomal protein L37 -0.0117552
IFITM3 interferon induced transmembrane protein 3 -0.011677
RPS23 ribosomal protein S23 -0.0116524
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0116125
DUSP6 dual specificity phosphatase 6 -0.011604
CAV1 caveolin 1, caveolae protein, 22kDa -0.0115452
NRP1 neuropilin 1 -0.0114887