Posaconazole_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Posaconazole perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Posaconazole_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.240663
SPTBN1 spectrin, beta, non-erythrocytic 1 0.127283
DSPP dentin sialophosphoprotein 0.100039
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0987012
ENO1 enolase 1, (alpha) 0.0895273
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0875846
FNDC3B fibronectin type III domain containing 3B 0.0782052
AKAP12 A kinase (PRKA) anchor protein 12 0.0731868
DDIT4 DNA-damage-inducible transcript 4 0.0714841
PEG3 paternally expressed 3 0.0604157
SAMD4A sterile alpha motif domain containing 4A 0.058813
ASPH aspartate beta-hydroxylase 0.0570087
KDM3A lysine (K)-specific demethylase 3A 0.0555982
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0487009
BHLHE40 basic helix-loop-helix family, member e40 0.0477616
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0468432
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0458449
DTNA dystrobrevin, alpha 0.0445524
PLIN2 perilipin 2 0.0422416
TNS1 tensin 1 0.0418047
FMNL2 formin-like 2 0.0410217
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0404612
LRMDA leucine rich melanocyte differentiation associated 0.0392963
APOB apolipoprotein B 0.0376275
INSIG2 insulin induced gene 2 0.0374135
GRK3 G protein-coupled receptor kinase 3 0.0367483
KDM7A lysine (K)-specific demethylase 7A 0.0364913
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0361656
WWC2 WW and C2 domain containing 2 0.0361373
GMDS GDP-mannose 4,6-dehydratase 0.0358069
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.035485
KIZ kizuna centrosomal protein 0.0352318
LDHA lactate dehydrogenase A 0.0351138
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.034484
SOD2 superoxide dismutase 2, mitochondrial 0.0328494
RUNX1 runt-related transcription factor 1 0.0322276
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0321367
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0320371
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.031982
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0315307
RAB6A RAB6A, member RAS oncogene family 0.0307757
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0302294
CLIC4 chloride intracellular channel 4 0.0298992
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0297768
CYTH1 cytohesin 1 0.02964
HOOK2 hook microtubule-tethering protein 2 0.0293734
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0286155
AFDN afadin, adherens junction formation factor 0.0285932
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0281694
FAM13A family with sequence similarity 13, member A 0.0281263
MYH9 myosin, heavy chain 9, non-muscle 0.0280614
ELL2 elongation factor, RNA polymerase II, 2 0.0279469
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0277254
ATP10A ATPase, class V, type 10A 0.0275963
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 0.0274687
MACF1 microtubule-actin crosslinking factor 1 0.027266
NGLY1 N-glycanase 1 0.0270485
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0269107
CORO1C coronin, actin binding protein, 1C 0.0267416
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0267229
YEATS2 YEATS domain containing 2 0.0265723
PRELID2 PRELI domain containing 2 0.0260783
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0259493
HELZ helicase with zinc finger 0.0257875
RYBP RING1 and YY1 binding protein 0.0255186
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.025482
STC2 stanniocalcin 2 0.0252106
CAMTA1 calmodulin binding transcription activator 1 0.0250204
KMT2E lysine (K)-specific methyltransferase 2E 0.0247478
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.0244847
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0244429
PIAS2 protein inhibitor of activated STAT, 2 0.0242228
FBXO42 F-box protein 42 0.0241675
UTRN utrophin 0.0236642
ATXN1 ataxin 1 0.0235053
TPD52 tumor protein D52 0.0234247
MSI2 musashi RNA-binding protein 2 0.0232377
GK glycerol kinase 0.0231499
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0229734
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0229223
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.0227545
MAP2K1 mitogen-activated protein kinase kinase 1 0.0227305
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0227012
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0225371
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0222427
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.022193
ZHX2 zinc fingers and homeoboxes 2 0.0221656
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0220419
LPP LIM domain containing preferred translocation partner in lipoma 0.0218415
ARFGEF3 ARFGEF family member 3 0.0217036
TARS1 threonyl-tRNA synthetase 1 0.0216809
PGK1 phosphoglycerate kinase 1 0.0210151
PHF21A PHD finger protein 21A 0.0208072
IGF2 insulin-like growth factor 2 0.0207655
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.0207536
IFRD1 interferon-related developmental regulator 1 0.0205195
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0204549
AUH AU RNA binding protein/enoyl-CoA hydratase 0.020228
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0201457
WNK1 WNK lysine deficient protein kinase 1 0.0201425

decreased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.303754
TPT1 tumor protein, translationally-controlled 1 -0.123571
C3 complement component 3 -0.0995643
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0969134
GPC3 glypican 3 -0.0905952
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0854436
RPS6 ribosomal protein S6 -0.0800376
MT2A metallothionein 2A -0.0795737
RPL11 ribosomal protein L11 -0.0767294
APOA2 apolipoprotein A-II -0.0668217
RPS24 ribosomal protein S24 -0.060847
RPLP1 ribosomal protein, large, P1 -0.0605826
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0593128
RPS8 ribosomal protein S8 -0.0571245
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0566796
FTL ferritin, light polypeptide -0.0548445
RPLP2 ribosomal protein, large, P2 -0.0512197
SVIL supervillin -0.0476048
RPL9 ribosomal protein L9 -0.0446077
FOXP1 forkhead box P1 -0.0436214
CCL20 chemokine (C-C motif) ligand 20 -0.0433487
RPS27A ribosomal protein S27a -0.0429495
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0424112
RPL26 ribosomal protein L26 -0.0421595
RPL34 ribosomal protein L34 -0.0417413
BCL2L1 BCL2-like 1 -0.0401129
RPL5 ribosomal protein L5 -0.0392174
NKD1 naked cuticle homolog 1 (Drosophila) -0.0390507
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0384213
APOE apolipoprotein E -0.0383072
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0379274
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0375989
RPS21 ribosomal protein S21 -0.035746
GPC6 glypican 6 -0.0354549
RPL35A ribosomal protein L35a -0.0351647
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0348786
RPS19 ribosomal protein S19 -0.0334994
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -0.0334207
JMJD1C jumonji domain containing 1C -0.0332178
AMBP alpha-1-microglobulin/bikunin precursor -0.0330346
RPS14 ribosomal protein S14 -0.0326199
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.0315562
RPLP0 ribosomal protein, large, P0 -0.0311162
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.0309234
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0309171
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0308915
RPL37A ribosomal protein L37a -0.030395
LCN2 lipocalin 2 -0.0302748
PTMA prothymosin, alpha -0.0297118
RPS29 ribosomal protein S29 -0.0295594
RPS13 ribosomal protein S13 -0.028755
IGFBP1 insulin-like growth factor binding protein 1 -0.0286165
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0284031
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0277182
NAP1L1 nucleosome assembly protein 1-like 1 -0.0271575
RPL19 ribosomal protein L19 -0.0269487
FAM135A family with sequence similarity 135, member A -0.0267852
RPL8 ribosomal protein L8 -0.0266259
RPS15 ribosomal protein S15 -0.0265344
RPS23 ribosomal protein S23 -0.0263061
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0262937
SMAD3 SMAD family member 3 -0.0260758
TXNRD1 thioredoxin reductase 1 -0.0260221
APOA1 apolipoprotein A-I -0.0259206
RBM25 RNA binding motif protein 25 -0.0256354
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0255157
EGR1 early growth response 1 -0.0254823
ITGB5 integrin, beta 5 -0.0253835
RPL31 ribosomal protein L31 -0.025309
LOC112694756 uncharaterized LOC112694756 -0.0251676
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 -0.0248199
RAB2A RAB2A, member RAS oncogene family -0.0244358
KIF21A kinesin family member 21A -0.0239526
H3-3B H3.3 histone B -0.0238884
RRBP1 ribosome binding protein 1 -0.0237278
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0236029
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0233142
SDC4 syndecan 4 -0.0233071
NRIP1 nuclear receptor interacting protein 1 -0.0232647
RPL38 ribosomal protein L38 -0.0232556
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0231259
ACTG1 actin gamma 1 -0.0231162
EIF5B eukaryotic translation initiation factor 5B -0.0230412
MIDN midnolin -0.0230335
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0230207
RPS10 ribosomal protein S10 -0.0229919
ARID3A AT rich interactive domain 3A (BRIGHT-like) -0.022965
ENAH enabled homolog (Drosophila) -0.0228812
RPL12 ribosomal protein L12 -0.022867
RPL13A ribosomal protein L13a -0.0225507
IER3 immediate early response 3 -0.0224304
PDGFB platelet-derived growth factor beta polypeptide -0.0224126
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0222987
RTN4 reticulon 4 -0.0220863
GPAM glycerol-3-phosphate acyltransferase, mitochondrial -0.0219758
ZMYND8 zinc finger, MYND-type containing 8 -0.0218524
SOX4 SRY (sex determining region Y)-box 4 -0.0218117
RPL37 ribosomal protein L37 -0.0214345
VCL vinculin -0.0213327
PTBP3 polypyrimidine tract binding protein 3 -0.0212408