Posaconazole_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Posaconazole perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Posaconazole_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FLNB filamin B, beta 0.219942
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.154135
TIMP3 TIMP metallopeptidase inhibitor 3 0.14788
TRIO trio Rho guanine nucleotide exchange factor 0.127475
MEF2A myocyte enhancer factor 2A 0.127384
PODXL podocalyxin-like 0.102574
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0971871
SLC35F3 solute carrier family 35, member F3 0.0969947
GRB10 growth factor receptor-bound protein 10 0.0935619
MYOF myoferlin 0.0917046
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0850602
NDRG1 N-myc downstream regulated 1 0.0841331
NRIP1 nuclear receptor interacting protein 1 0.0827723
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0803875
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0787863
NAV2 neuron navigator 2 0.0781432
RICTOR RPTOR independent companion of MTOR, complex 2 0.0769713
ESYT2 extended synaptotagmin-like protein 2 0.0710951
MTSS1 metastasis suppressor 1 0.0693093
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0690904
H1-0 H1.0 linker histone 0.0670249
LMO7 LIM domain 7 0.0632124
FOXO1 forkhead box O1 0.0618183
PSD3 pleckstrin and Sec7 domain containing 3 0.0600316
PGK1 phosphoglycerate kinase 1 0.0590523
EZR ezrin 0.0586155
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0581936
ZEB1 zinc finger E-box binding homeobox 1 0.0570108
BHLHE40 basic helix-loop-helix family, member e40 0.0568106
LDHA lactate dehydrogenase A 0.0533599
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.052473
BCL2L1 BCL2-like 1 0.0524095
ACTN4 actinin, alpha 4 0.0518605
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0515536
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0506681
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0504671
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0494686
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0494306
DOCK9 dedicator of cytokinesis 9 0.0487457
SULF1 sulfatase 1 0.0485185
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0474542
UBE2H ubiquitin-conjugating enzyme E2H 0.0471316
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0469428
OGA O-GlcNAcase 0.0462171
SREBF2 sterol regulatory element binding transcription factor 2 0.0454377
KIAA1217 KIAA1217 0.0453604
MYO10 myosin X 0.0449698
SQSTM1 sequestosome 1 0.0442924
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0442213
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0430824
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0426384
NCOR2 nuclear receptor corepressor 2 0.0420045
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.04193
TMEM135 transmembrane protein 135 0.0417975
NCOA3 nuclear receptor coactivator 3 0.0417913
RAI14 retinoic acid induced 14 0.0413781
MYH9 myosin, heavy chain 9, non-muscle 0.0407206
FNIP1 folliculin interacting protein 1 0.0404565
ANKRD11 ankyrin repeat domain 11 0.0401787
PLEC plectin 0.0397962
FRMD6 FERM domain containing 6 0.0391535
CEMIP cell migration inducing protein, hyaluronan binding 0.0383707
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0378266
MRPS6 mitochondrial ribosomal protein S6 0.0377361
AKAP13 A kinase (PRKA) anchor protein 13 0.0374292
SAMD9 sterile alpha motif domain containing 9 0.0373944
RUNX1 runt-related transcription factor 1 0.0370634
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.0361552
DST dystonin 0.0361248
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0360809
ANXA11 annexin A11 0.0351322
SOD2 superoxide dismutase 2, mitochondrial 0.0351012
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0349791
PLS3 plastin 3 0.0349295
NPC1 Niemann-Pick disease, type C1 0.0349198
ITGA6 integrin, alpha 6 0.034904
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0342541
ADAM10 ADAM metallopeptidase domain 10 0.0338948
ACSS2 acyl-CoA synthetase short-chain family member 2 0.0338437
SQLE squalene epoxidase 0.03381
KDM7A lysine (K)-specific demethylase 7A 0.0334815
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0334036
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0332578
ITCH itchy E3 ubiquitin protein ligase 0.033092
GPRC5B G protein-coupled receptor, class C, group 5, member B 0.0327618
LDLR low density lipoprotein receptor 0.0325344
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.0325143
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0323434
SLK STE20-like kinase 0.032083
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0319658
IVNS1ABP influenza virus NS1A binding protein 0.0319046
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0315707
ANXA2 annexin A2 0.0311338
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0311117
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0309536
ZMYND8 zinc finger, MYND-type containing 8 0.0304974
MEGF6 multiple EGF-like-domains 6 0.0304662
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.0302809
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0302146
FTH1 ferritin, heavy polypeptide 1 0.0299387

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.143384
RPS6 ribosomal protein S6 -0.0947122
PTMA prothymosin, alpha -0.0886491
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0754937
RPS8 ribosomal protein S8 -0.0733024
RPS21 ribosomal protein S21 -0.0617023
RPLP2 ribosomal protein, large, P2 -0.0582664
MT2A metallothionein 2A -0.0567926
TPT1 tumor protein, translationally-controlled 1 -0.0566214
RPS13 ribosomal protein S13 -0.0565551
B2M beta-2-microglobulin -0.0554592
CLU clusterin -0.0551292
KTN1 kinectin 1 (kinesin receptor) -0.0537707
RPS3 ribosomal protein S3 -0.0496778
LMNA lamin A/C -0.0491121
RPS2 ribosomal protein S2 -0.0483937
RPL11 ribosomal protein L11 -0.0463308
HM13 histocompatibility (minor) 13 -0.045537
HLA-B major histocompatibility complex, class I, B -0.0446369
RPLP1 ribosomal protein, large, P1 -0.0442872
TMSB10 thymosin beta 10 -0.0413513
POTEF POTE ankyrin domain family, member F -0.0408322
DPYD dihydropyrimidine dehydrogenase -0.0402979
PIBF1 progesterone immunomodulatory binding factor 1 -0.0376277
RPL37A ribosomal protein L37a -0.0364084
ACTG1 actin gamma 1 -0.0356684
RPL5 ribosomal protein L5 -0.0346063
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0345364
RPS19 ribosomal protein S19 -0.0337146
CANX calnexin -0.0336035
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.03312
GNAS GNAS complex locus -0.0326582
DSTN destrin (actin depolymerizing factor) -0.0324079
RPS12 ribosomal protein S12 -0.0321978
RPS27A ribosomal protein S27a -0.0319136
RPL19 ribosomal protein L19 -0.0312458
RPL12 ribosomal protein L12 -0.0309306
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0307775
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.030481
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0297067
S100A2 S100 calcium binding protein A2 -0.0294246
IFITM3 interferon induced transmembrane protein 3 -0.029193
RPL26 ribosomal protein L26 -0.0289952
INTS6 integrator complex subunit 6 -0.0286132
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0282245
RPL37 ribosomal protein L37 -0.0278706
CDK6 cyclin-dependent kinase 6 -0.0278186
S100A9 S100 calcium binding protein A9 -0.0272734
COG5 component of oligomeric golgi complex 5 -0.0269989
RPL21 ribosomal protein L21 -0.0266636
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0263244
VDAC1 voltage-dependent anion channel 1 -0.0262534
COG6 component of oligomeric golgi complex 6 -0.0262513
RPL7 ribosomal protein L7 -0.0259243
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0256946
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0249686
RPL34 ribosomal protein L34 -0.0246813
RPS29 ribosomal protein S29 -0.024652
NAP1L1 nucleosome assembly protein 1-like 1 -0.0236365
FTL ferritin, light polypeptide -0.0235648
ZRANB2 zinc finger, RAN-binding domain containing 2 -0.0234929
RPL8 ribosomal protein L8 -0.0234078
SRSF11 serine/arginine-rich splicing factor 11 -0.0233289
EIF1 eukaryotic translation initiation factor 1 -0.0230533
RAB2A RAB2A, member RAS oncogene family -0.0228963
STAU1 staufen double-stranded RNA binding protein 1 -0.0228022
TXNIP thioredoxin interacting protein -0.0227997
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0227524
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0225318
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0223103
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -0.0219967
GOLGB1 golgin B1 -0.0219841
PRRC2C proline-rich coiled-coil 2C -0.0219807
RPL9 ribosomal protein L9 -0.0217719
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0215918
FAF1 Fas (TNFRSF6) associated factor 1 -0.0215697
RPS27 ribosomal protein S27 -0.0211931
RPS25 ribosomal protein S25 -0.0208822
RPS5 ribosomal protein S5 -0.0208311
TRAM1 translocation associated membrane protein 1 -0.0206104
EIF5B eukaryotic translation initiation factor 5B -0.0205842
RSL1D1 ribosomal L1 domain containing 1 -0.0205681
RPL36 ribosomal protein L36 -0.020565
ASTN2 astrotactin 2 -0.0205649
MTDH metadherin -0.0204158
MYO9A myosin IXA -0.0204003
RPS17 ribosomal protein S17 -0.0203887
RPL28 ribosomal protein L28 -0.0203296
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0201763
NKTR natural killer cell triggering receptor -0.0201292
CNRIP1 cannabinoid receptor interacting protein 1 -0.0200954
AKAP9 A kinase (PRKA) anchor protein 9 -0.0200747
RACK1 receptor for activated C kinase 1 -0.0200296
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0199721
RPS23 ribosomal protein S23 -0.0199065
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0198007
RPL32 ribosomal protein L32 -0.019735
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0197012
RPL31 ribosomal protein L31 -0.019464
RPS16 ribosomal protein S16 -0.019343