| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Posaconazole perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Posaconazole_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0972463 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.070992 |
| FMNL2 | formin-like 2 | 0.070903 |
| RBM39 | RNA binding motif protein 39 | 0.0701056 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0681779 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.063358 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0627046 |
| MCL1 | myeloid cell leukemia 1 | 0.062581 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0613546 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0589472 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0588129 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0558186 |
| FDPS | farnesyl diphosphate synthase | 0.0548341 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0541244 |
| FNBP1L | formin binding protein 1-like | 0.0526965 |
| TPM3 | tropomyosin 3 | 0.0521545 |
| APP | amyloid beta (A4) precursor protein | 0.05009 |
| RPL23 | ribosomal protein L23 | 0.0500888 |
| PCBP2 | poly(rC) binding protein 2 | 0.0488136 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | 0.0482444 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0481899 |
| ZNF292 | zinc finger protein 292 | 0.0478686 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.047524 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0475224 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0472429 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0455734 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0450693 |
| TMSB10 | thymosin beta 10 | 0.044723 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0446934 |
| CCNL1 | cyclin L1 | 0.0435615 |
| CALR | calreticulin | 0.0428738 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0426732 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0422798 |
| FLNB | filamin B, beta | 0.0414034 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0408019 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0404825 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0398322 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0397742 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0395767 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0389267 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0383886 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.0382003 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0380737 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0380261 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0370545 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0369334 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0368784 |
| TPD52 | tumor protein D52 | 0.0367994 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0361278 |
| NDRG1 | N-myc downstream regulated 1 | 0.0360029 |
| ANXA5 | annexin A5 | 0.0359513 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | 0.0352107 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0351767 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0349993 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0346343 |
| PARD3 | par-3 family cell polarity regulator | 0.0344705 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0342898 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0342599 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0341771 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0337847 |
| CUL3 | cullin 3 | 0.033537 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0333999 |
| CALU | calumenin | 0.0333588 |
| HYOU1 | hypoxia up-regulated 1 | 0.0331126 |
| CDC73 | cell division cycle 73 | 0.0330697 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.032957 |
| MRTFA | myocardin related transcription factor A | 0.0328688 |
| SFTPA2 | surfactant protein A2 | 0.0328512 |
| MATR3 | matrin 3 | 0.0326785 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0326781 |
| ANXA1 | annexin A1 | 0.0326042 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0325846 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0324703 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0324212 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0324091 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0323911 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0322169 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0317224 |
| PRR16 | proline rich 16 | 0.0314586 |
| YME1L1 | YME1-like 1 ATPase | 0.0310939 |
| RPL3 | ribosomal protein L3 | 0.0309116 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0303955 |
| KIF5B | kinesin family member 5B | 0.0302726 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0300421 |
| EWSR1 | EWS RNA-binding protein 1 | 0.0297435 |
| MSMO1 | methylsterol monooxygenase 1 | 0.0293702 |
| CASC3 | cancer susceptibility candidate 3 | 0.0293413 |
| NCKAP1 | NCK-associated protein 1 | 0.0292735 |
| NUP153 | nucleoporin 153kDa | 0.0289674 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0286711 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0284987 |
| YTHDF3 | YTH N(6)-methyladenosine RNA binding protein 3 | 0.0284553 |
| CNOT6L | CCR4-NOT transcription complex, subunit 6-like | 0.0284255 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.028054 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0280455 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.0279728 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0277799 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0277606 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.027697 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0276481 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GRAMD1B | GRAM domain containing 1B | -0.274782 |
| PM20D1 | peptidase M20 domain containing 1 | -0.201721 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.179474 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.155815 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.141267 |
| TXNRD1 | thioredoxin reductase 1 | -0.117005 |
| ACTG1 | actin gamma 1 | -0.101447 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0918664 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0879371 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0807845 |
| KYNU | kynureninase | -0.0801537 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.079445 |
| BICC1 | BicC family RNA binding protein 1 | -0.0781259 |
| VIM | vimentin | -0.0706509 |
| HDAC9 | histone deacetylase 9 | -0.0693746 |
| OSMR | oncostatin M receptor | -0.0691982 |
| MT2A | metallothionein 2A | -0.0679749 |
| SVIL | supervillin | -0.0665429 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0633906 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0616035 |
| POTEF | POTE ankyrin domain family, member F | -0.0491256 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0486801 |
| GLIS3 | GLIS family zinc finger 3 | -0.0476533 |
| CMIP | c-Maf inducing protein | -0.0476218 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0449132 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.0425597 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0425382 |
| NTN4 | netrin 4 | -0.0421418 |
| EFNA5 | ephrin-A5 | -0.039194 |
| IER3 | immediate early response 3 | -0.0391323 |
| EHBP1 | EH domain binding protein 1 | -0.0377794 |
| PTMA | prothymosin, alpha | -0.0371899 |
| ASPH | aspartate beta-hydroxylase | -0.037097 |
| SPIDR | scaffolding protein involved in DNA repair | -0.036873 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0358785 |
| FAM107B | family with sequence similarity 107, member B | -0.0355098 |
| AK1 | adenylate kinase 1 | -0.0354753 |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | -0.0354386 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.03534 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0343246 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0340763 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0338128 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.033361 |
| EXOC6B | exocyst complex component 6B | -0.0326417 |
| DENND4A | DENN/MADD domain containing 4A | -0.0325465 |
| NAV3 | neuron navigator 3 | -0.0324803 |
| TRIP11 | thyroid hormone receptor interactor 11 | -0.0323507 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0319241 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0318763 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0317197 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0312722 |
| USP34 | ubiquitin specific peptidase 34 | -0.0308962 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0297896 |
| EGFR | epidermal growth factor receptor | -0.029429 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.0285496 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0285054 |
| WWOX | WW domain containing oxidoreductase | -0.0282753 |
| KLF6 | Kruppel-like factor 6 | -0.0281926 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0281751 |
| RSPO3 | R-spondin 3 | -0.0281725 |
| RASAL2 | RAS protein activator like 2 | -0.0280239 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0279321 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0277282 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0262347 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0260656 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0258661 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0254842 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0254027 |
| NRG1 | neuregulin 1 | -0.0253679 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0252436 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0250043 |
| MYO9A | myosin IXA | -0.0246444 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | -0.0243953 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0241182 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0241141 |
| PDE10A | phosphodiesterase 10A | -0.0240998 |
| TPM4 | tropomyosin 4 | -0.0240212 |
| PCNX4 | pecanex 4 | -0.0239041 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0236353 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0235748 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.023505 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0232147 |
| BPTF | bromodomain PHD finger transcription factor | -0.0231306 |
| FGB | fibrinogen beta chain | -0.0229387 |
| NEGR1 | neuronal growth regulator 1 | -0.0225512 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0221381 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0220227 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0214685 |
| RNF213 | ring finger protein 213 | -0.0210842 |
| ATM | ATM serine/threonine kinase | -0.020923 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0206668 |
| THBS1 | thrombospondin 1 | -0.0205752 |
| FOXP1 | forkhead box P1 | -0.0205345 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0205014 |
| CDK12 | cyclin-dependent kinase 12 | -0.0205011 |
| NSUN6 | NOP2/Sun domain family, member 6 | -0.0203552 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0202547 |
| MIPOL1 | mirror-image polydactyly 1 | -0.0202395 |
| RPLP1 | ribosomal protein, large, P1 | -0.0201445 |
| TBCA | tubulin folding cofactor A | -0.0201421 |
