| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Posaconazole perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Posaconazole_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.155971 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0782422 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0757287 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0755777 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0734864 |
| XPO1 | exportin 1 | 0.0703424 |
| OGA | O-GlcNAcase | 0.0690056 |
| PCBP2 | poly(rC) binding protein 2 | 0.0677654 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0673558 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.066117 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0635339 |
| RAD51B | RAD51 paralog B | 0.0609034 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0608614 |
| RTN4 | reticulon 4 | 0.0608475 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0566412 |
| PGK1 | phosphoglycerate kinase 1 | 0.0552613 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0523226 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0499049 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0495616 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0491742 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0491565 |
| CEP192 | centrosomal protein 192kDa | 0.0484752 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0483635 |
| CCNL1 | cyclin L1 | 0.0483161 |
| PLCB4 | phospholipase C, beta 4 | 0.0476135 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0471685 |
| JMJD1C | jumonji domain containing 1C | 0.0471098 |
| PHIP | pleckstrin homology domain interacting protein | 0.0455673 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0454992 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0448578 |
| RBM39 | RNA binding motif protein 39 | 0.0446323 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0444432 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0441631 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | 0.0440781 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0438986 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0430387 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0424506 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.040643 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0401555 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0393621 |
| ZNF292 | zinc finger protein 292 | 0.0388128 |
| PCNX1 | pecanex 1 | 0.0387347 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0384318 |
| ANLN | anillin, actin binding protein | 0.038256 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0380338 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0367343 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0366841 |
| PRELID2 | PRELI domain containing 2 | 0.0366261 |
| MED13L | mediator complex subunit 13-like | 0.0364849 |
| TPM3 | tropomyosin 3 | 0.0364537 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0359879 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0352947 |
| BBX | bobby sox homolog (Drosophila) | 0.0348068 |
| ENO1 | enolase 1, (alpha) | 0.0347391 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0347242 |
| SMC4 | structural maintenance of chromosomes 4 | 0.034439 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0342626 |
| H1-0 | H1.0 linker histone | 0.0339188 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.0335529 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0333939 |
| RUSC2 | RUN and SH3 domain containing 2 | 0.033314 |
| SPAG9 | sperm associated antigen 9 | 0.0330992 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | 0.0329038 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0328006 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0327119 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0326726 |
| MYOF | myoferlin | 0.032531 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0324288 |
| RPL3 | ribosomal protein L3 | 0.0321416 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0318588 |
| KRT18 | keratin 18, type I | 0.031799 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0316565 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0315158 |
| MKI67 | marker of proliferation Ki-67 | 0.03143 |
| TAB2 | TGF-beta activated kinase 1/MAP3K7 binding protein 2 | 0.0314052 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | 0.0309786 |
| FDPS | farnesyl diphosphate synthase | 0.030829 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0304664 |
| CENPF | centromere protein F, 350/400kDa | 0.0302636 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0298457 |
| RRM2 | ribonucleotide reductase M2 | 0.0290845 |
| TNRC6A | trinucleotide repeat containing 6A | 0.0288977 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0288258 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.0287006 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0286851 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0286103 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0279543 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0279156 |
| ADIPOR2 | adiponectin receptor 2 | 0.0278612 |
| SINHCAF | SIN3-HDAC complex associated factor | 0.027722 |
| NCKAP1 | NCK-associated protein 1 | 0.0274481 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0273159 |
| CEP250 | centrosomal protein 250kDa | 0.027286 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0269934 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0269104 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0268348 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0267813 |
| NUP153 | nucleoporin 153kDa | 0.0263836 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.0261114 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0260322 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.200348 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.155532 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.113496 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0747029 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0731825 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0727346 |
| OSMR | oncostatin M receptor | -0.0660108 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0608271 |
| ACTG1 | actin gamma 1 | -0.0585321 |
| AFF3 | AF4/FMR2 family, member 3 | -0.05549 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0517389 |
| INTS6 | integrator complex subunit 6 | -0.0516204 |
| HMGA2 | high mobility group AT-hook 2 | -0.0512443 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0507666 |
| PTMA | prothymosin, alpha | -0.0503103 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0461554 |
| AEBP2 | AE binding protein 2 | -0.0452412 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0446045 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0440444 |
| VCL | vinculin | -0.0431733 |
| RYR3 | ryanodine receptor 3 | -0.043154 |
| RPS8 | ribosomal protein S8 | -0.0413118 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.0412712 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0407205 |
| FNDC3B | fibronectin type III domain containing 3B | -0.040419 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0377085 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0375661 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0361757 |
| HLA-B | major histocompatibility complex, class I, B | -0.0344683 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.034449 |
| FMNL2 | formin-like 2 | -0.0338438 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0331551 |
| MCL1 | myeloid cell leukemia 1 | -0.0330206 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0322255 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.031673 |
| CANX | calnexin | -0.0301478 |
| NEK10 | NIMA-related kinase 10 | -0.0300342 |
| EGFR | epidermal growth factor receptor | -0.0290538 |
| EGR1 | early growth response 1 | -0.0284117 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.028154 |
| GOLGB1 | golgin B1 | -0.0281445 |
| TPM2 | tropomyosin 2 (beta) | -0.0279327 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0276267 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0273581 |
| R3HDM2 | R3H domain containing 2 | -0.0272916 |
| IER3 | immediate early response 3 | -0.02709 |
| DOCK5 | dedicator of cytokinesis 5 | -0.026658 |
| POTEF | POTE ankyrin domain family, member F | -0.0264752 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0259621 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0253033 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0248831 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | -0.0247851 |
| GRAMD1B | GRAM domain containing 1B | -0.0247381 |
| ATXN1 | ataxin 1 | -0.0243208 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0236538 |
| PDE10A | phosphodiesterase 10A | -0.0234882 |
| TPM4 | tropomyosin 4 | -0.0234781 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0233758 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0227107 |
| CUX1 | cut-like homeobox 1 | -0.0226876 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0225505 |
| CFAP44 | cilia and flagella associated protein 44 | -0.022522 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0224568 |
| RPL37 | ribosomal protein L37 | -0.021894 |
| RPL37A | ribosomal protein L37a | -0.021843 |
| ATG7 | autophagy related 7 | -0.0218389 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0216195 |
| TMSB10 | thymosin beta 10 | -0.0213077 |
| AGO3 | argonaute RISC catalytic component 3 | -0.0210527 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.0206565 |
| TAPBP | TAP binding protein (tapasin) | -0.0204992 |
| HDAC8 | histone deacetylase 8 | -0.02029 |
| TRIM59 | tripartite motif containing 59 | -0.020275 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0202263 |
| DIAPH2 | diaphanous-related formin 2 | -0.0200011 |
| SVIL | supervillin | -0.0199239 |
| RSU1 | Ras suppressor protein 1 | -0.0199092 |
| VIM | vimentin | -0.0195668 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0194617 |
| PCDH7 | protocadherin 7 | -0.0194409 |
| RPL26 | ribosomal protein L26 | -0.0191161 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0191112 |
| CCND1 | cyclin D1 | -0.0189027 |
| S100A6 | S100 calcium binding protein A6 | -0.0188802 |
| RPL9 | ribosomal protein L9 | -0.0188587 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | -0.0187594 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0187116 |
| ARMH4 | armadillo like helical domain containing 4 | -0.0185035 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0184982 |
| RPS27A | ribosomal protein S27a | -0.0182672 |
| RPS21 | ribosomal protein S21 | -0.0182159 |
| ST7L | suppression of tumorigenicity 7 like | -0.0181168 |
| HOMER1 | homer scaffolding protein 1 | -0.0179012 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0177487 |
| DNAH11 | dynein, axonemal, heavy chain 11 | -0.0176534 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0176465 |
| GPATCH8 | G patch domain containing 8 | -0.0176139 |
| PCNX4 | pecanex 4 | -0.0175942 |
| LARP4B | La ribonucleoprotein domain family, member 4B | -0.017427 |
| NTSR1 | neurotensin receptor 1 (high affinity) | -0.0173332 |
