Posaconazole_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Posaconazole perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Posaconazole_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.326475
FNDC3B fibronectin type III domain containing 3B 0.119836
MYH9 myosin, heavy chain 9, non-muscle 0.106303
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0975249
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0899092
GRB10 growth factor receptor-bound protein 10 0.0848236
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0822244
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.078581
NAV2 neuron navigator 2 0.0748245
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0696252
FAM13A family with sequence similarity 13, member A 0.0673304
MYO6 myosin VI 0.0636417
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0621624
TSC22D2 TSC22 domain family, member 2 0.0613479
LPP LIM domain containing preferred translocation partner in lipoma 0.0608411
TRIO trio Rho guanine nucleotide exchange factor 0.0592446
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.0569564
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0555792
ELL2 elongation factor, RNA polymerase II, 2 0.0513286
MSMO1 methylsterol monooxygenase 1 0.0512231
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.051182
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0506536
ENO1 enolase 1, (alpha) 0.0505918
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0481366
APLP2 amyloid beta (A4) precursor-like protein 2 0.0474349
FHIT fragile histidine triad 0.047035
PTK2 protein tyrosine kinase 2 0.0452589
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0432988
ARRDC3 arrestin domain containing 3 0.0421211
LDHA lactate dehydrogenase A 0.0420812
CALR calreticulin 0.0420632
PLEC plectin 0.0416557
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0414273
UBA6 ubiquitin-like modifier activating enzyme 6 0.0395881
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0393905
EZR ezrin 0.0387279
MACF1 microtubule-actin crosslinking factor 1 0.0385718
SAMD12 sterile alpha motif domain containing 12 0.0382398
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0380705
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0377636
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0371395
MSN moesin 0.0366875
RCOR1 REST corepressor 1 0.0360722
SREBF2 sterol regulatory element binding transcription factor 2 0.0358361
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0354141
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0351051
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0350099
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0342197
NRIP1 nuclear receptor interacting protein 1 0.0342103
SOD2 superoxide dismutase 2, mitochondrial 0.034076
TPM3 tropomyosin 3 0.0334145
FLNB filamin B, beta 0.0333361
CD46 CD46 molecule, complement regulatory protein 0.0331025
UPP1 uridine phosphorylase 1 0.0329678
ZFP36L1 ZFP36 ring finger protein-like 1 0.0329557
CCNL1 cyclin L1 0.0327491
TXNRD1 thioredoxin reductase 1 0.032312
G0S2 G0/G1 switch 2 0.0320497
ICAM1 intercellular adhesion molecule 1 0.0310045
ANXA5 annexin A5 0.029965
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0297086
HOOK2 hook microtubule-tethering protein 2 0.0295793
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0295487
ANLN anillin, actin binding protein 0.0295319
HSPA8 heat shock 70kDa protein 8 0.0293774
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0293361
CCSER1 coiled-coil serine-rich protein 1 0.0291241
IL6ST interleukin 6 signal transducer 0.0289818
ITCH itchy E3 ubiquitin protein ligase 0.028815
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0285332
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0285225
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0285188
FDPS farnesyl diphosphate synthase 0.0283805
RYBP RING1 and YY1 binding protein 0.0283632
ELOVL5 ELOVL fatty acid elongase 5 0.0283167
LIMCH1 LIM and calponin homology domains 1 0.0281116
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0280923
PPARD peroxisome proliferator-activated receptor delta 0.0280804
MKI67 marker of proliferation Ki-67 0.0280292
MSI2 musashi RNA-binding protein 2 0.0279321
MX1 MX dynamin-like GTPase 1 0.0276616
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0272335
SPAG9 sperm associated antigen 9 0.0271581
CLINT1 clathrin interactor 1 0.026936
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0267267
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0264664
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.026379
CORO1C coronin, actin binding protein, 1C 0.0263741
ESRP1 epithelial splicing regulatory protein 1 0.0262454
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0261507
MCL1 myeloid cell leukemia 1 0.0258707
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0256275
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0255403
HPCAL1 hippocalcin-like 1 0.0253593
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0253398
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0249558
ESYT2 extended synaptotagmin-like protein 2 0.0247861
KDM6A lysine (K)-specific demethylase 6A 0.0245155
TNIP1 TNFAIP3 interacting protein 1 0.0243296
ATP13A3 ATPase type 13A3 0.0240781

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.148936
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.120314
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0997405
TMSB10 thymosin beta 10 -0.0812088
PTMA prothymosin, alpha -0.0719524
ACTG1 actin gamma 1 -0.0701602
S100A6 S100 calcium binding protein A6 -0.0685512
ALCAM activated leukocyte cell adhesion molecule -0.0646529
FN1 fibronectin 1 -0.0643397
RPL35A ribosomal protein L35a -0.0566977
IGFBP3 insulin-like growth factor binding protein 3 -0.0528265
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0505683
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0483159
POTEF POTE ankyrin domain family, member F -0.0478728
CCND1 cyclin D1 -0.0477585
EIF1 eukaryotic translation initiation factor 1 -0.0441929
RPS3 ribosomal protein S3 -0.0428561
TM4SF1 transmembrane 4 L six family member 1 -0.0420756
RPS8 ribosomal protein S8 -0.0405789
RPL34 ribosomal protein L34 -0.0399608
RACK1 receptor for activated C kinase 1 -0.0398426
RPS6 ribosomal protein S6 -0.0396531
RPL37A ribosomal protein L37a -0.0385765
RPS27A ribosomal protein S27a -0.0385462
RASAL2 RAS protein activator like 2 -0.0366468
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0360138
LMO7 LIM domain 7 -0.0359068
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0335117
RBM25 RNA binding motif protein 25 -0.0333998
SLC38A1 solute carrier family 38, member 1 -0.0332662
RPS13 ribosomal protein S13 -0.0329819
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0326495
MBNL1 muscleblind-like splicing regulator 1 -0.0321296
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0319108
RPLP0 ribosomal protein, large, P0 -0.0316926
EFNA5 ephrin-A5 -0.0315833
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0313428
CAPN2 calpain 2, (m/II) large subunit -0.0312533
RPL19 ribosomal protein L19 -0.0301322
RPL9 ribosomal protein L9 -0.0298841
RPL12 ribosomal protein L12 -0.0296932
RPLP1 ribosomal protein, large, P1 -0.0295109
ERBIN erbb2 interacting protein -0.0294729
ANXA2 annexin A2 -0.0278488
GPBP1 GC-rich promoter binding protein 1 -0.0272387
TPT1 tumor protein, translationally-controlled 1 -0.0271954
KRT7 keratin 7, type II -0.0271498
GNAS GNAS complex locus -0.0271251
RPS14 ribosomal protein S14 -0.026964
RPS19 ribosomal protein S19 -0.0260958
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0251729
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0250899
RPS5 ribosomal protein S5 -0.0250567
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0248267
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0247068
CANX calnexin -0.0245185
LOC112694756 uncharaterized LOC112694756 -0.0243654
RPS16 ribosomal protein S16 -0.024182
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0240794
FBXL2 F-box and leucine-rich repeat protein 2 -0.0236519
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.0235214
DSCAM Down syndrome cell adhesion molecule -0.0234277
TJP1 tight junction protein 1 -0.0232435
FNIP1 folliculin interacting protein 1 -0.0230887
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0229458
ARHGAP20 Rho GTPase activating protein 20 -0.0229435
ARHGAP5 Rho GTPase activating protein 5 -0.0227526
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0227477
RPL27A ribosomal protein L27a -0.0225846
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0225661
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0225278
NF1 neurofibromin 1 -0.022521
RPL5 ribosomal protein L5 -0.0223446
EXT1 exostosin glycosyltransferase 1 -0.0221737
PLAU plasminogen activator, urokinase -0.0219238
RPLP2 ribosomal protein, large, P2 -0.0217612
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0215835
EGFR epidermal growth factor receptor -0.0208857
DTNA dystrobrevin, alpha -0.0208036
RPL26 ribosomal protein L26 -0.0203885
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0203775
TMSB4X thymosin beta 4, X-linked -0.0201098
VGLL3 vestigial-like family member 3 -0.0199246
CERT1 ceramide transporter 1 -0.0197724
RPL8 ribosomal protein L8 -0.0197605
STRN3 striatin, calmodulin binding protein 3 -0.0191292
PGBD5 piggyBac transposable element derived 5 -0.0189711
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0188344
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0188214
RPL37 ribosomal protein L37 -0.018781
VIM vimentin -0.018637
USP15 ubiquitin specific peptidase 15 -0.018617
CDK13 cyclin-dependent kinase 13 -0.0185735
RHOBTB3 Rho-related BTB domain containing 3 -0.0185434
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha -0.0185297
YBX1 Y box binding protein 1 -0.0184798
CCNI cyclin I -0.0184256
SOX4 SRY (sex determining region Y)-box 4 -0.0183428
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 -0.0182484
MAP4 microtubule-associated protein 4 -0.0180907