Posaconazole_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Posaconazole perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Posaconazole_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.231801
PDE4B phosphodiesterase 4B, cAMP-specific 0.153038
HDAC9 histone deacetylase 9 0.120998
SSBP2 single-stranded DNA binding protein 2 0.104501
SOX6 SRY (sex determining region Y)-box 6 0.103731
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0882395
KMT2E lysine (K)-specific methyltransferase 2E 0.0787818
KDM3A lysine (K)-specific demethylase 3A 0.0751822
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0710285
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0681921
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0665223
EEF2 eukaryotic translation elongation factor 2 0.0663505
ECT2 epithelial cell transforming 2 0.0646057
ANKRD11 ankyrin repeat domain 11 0.0641882
ANXA1 annexin A1 0.0638076
PCBP2 poly(rC) binding protein 2 0.0624767
ELOVL5 ELOVL fatty acid elongase 5 0.062089
EPS8 epidermal growth factor receptor pathway substrate 8 0.061624
ZEB1 zinc finger E-box binding homeobox 1 0.0595957
CCNL1 cyclin L1 0.0584456
CPED1 cadherin-like and PC-esterase domain containing 1 0.0563685
UBA6 ubiquitin-like modifier activating enzyme 6 0.0560736
JMJD1C jumonji domain containing 1C 0.0557496
ZNF292 zinc finger protein 292 0.0551977
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0543272
QKI QKI, KH domain containing, RNA binding 0.0538251
SREBF2 sterol regulatory element binding transcription factor 2 0.0531501
FNDC3B fibronectin type III domain containing 3B 0.0531438
PICALM phosphatidylinositol binding clathrin assembly protein 0.0529002
PGK1 phosphoglycerate kinase 1 0.0516313
MKI67 marker of proliferation Ki-67 0.051609
NUP58 nucleoporin 58 0.0514812
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0513209
MYOF myoferlin 0.0502185
LPP LIM domain containing preferred translocation partner in lipoma 0.0493232
NAMPT nicotinamide phosphoribosyltransferase 0.0489895
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0487645
CDC73 cell division cycle 73 0.0484513
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0482547
EIF4A2 eukaryotic translation initiation factor 4A2 0.047698
PDGFC platelet derived growth factor C 0.0462309
ZFAND3 zinc finger, AN1-type domain 3 0.0457019
RAB6A RAB6A, member RAS oncogene family 0.0451016
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.045078
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0447626
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0433562
NCKAP1 NCK-associated protein 1 0.0430643
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0430556
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0426415
XPO1 exportin 1 0.0420684
RPL3 ribosomal protein L3 0.0418143
WSB1 WD repeat and SOCS box containing 1 0.040221
DSCAM Down syndrome cell adhesion molecule 0.0399491
FAT1 FAT atypical cadherin 1 0.0398756
TFG TRK-fused gene 0.0394387
CAMTA1 calmodulin binding transcription activator 1 0.0385519
TXNIP thioredoxin interacting protein 0.0378777
HELZ helicase with zinc finger 0.0373692
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0373666
ENO2 enolase 2 (gamma, neuronal) 0.037081
KDM6A lysine (K)-specific demethylase 6A 0.0368239
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0365799
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0364797
PDIA6 protein disulfide isomerase family A, member 6 0.0362201
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0360856
SESN2 sestrin 2 0.0356209
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0353593
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0353206
BMP10 bone morphogenetic protein 10 0.0349894
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0347972
CLIP1 CAP-GLY domain containing linker protein 1 0.0346542
MSI2 musashi RNA-binding protein 2 0.0340713
RBM39 RNA binding motif protein 39 0.0336774
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0332258
WAC WW domain containing adaptor with coiled-coil 0.0331964
STAG2 stromal antigen 2 0.033185
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0331846
CASC3 cancer susceptibility candidate 3 0.0328845
PDS5B PDS5 cohesin associated factor B 0.0328558
RYBP RING1 and YY1 binding protein 0.0323799
ADAM17 ADAM metallopeptidase domain 17 0.0322842
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0322616
DIAPH3 diaphanous-related formin 3 0.0322395
USP9X ubiquitin specific peptidase 9, X-linked 0.0322351
SRRM2 serine/arginine repetitive matrix 2 0.0320934
PRELID2 PRELI domain containing 2 0.0318542
FAM168A family with sequence similarity 168, member A 0.0311154
CENPF centromere protein F, 350/400kDa 0.030897
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0308528
CALR calreticulin 0.0304787
FDPS farnesyl diphosphate synthase 0.0304371
SET SET nuclear proto-oncogene 0.030344
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0303056
YAP1 Yes-associated protein 1 0.0302457
ANK2 ankyrin 2, neuronal 0.0302272
ASXL1 additional sex combs like transcriptional regulator 1 0.0301018
RIOK3 RIO kinase 3 0.0299422
ELP2 elongator acetyltransferase complex subunit 2 0.0297872
SFTPA2 surfactant protein A2 0.0287515
LCORL ligand dependent nuclear receptor corepressor-like 0.0287395

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.392257
PKM pyruvate kinase, muscle -0.100868
ACTG1 actin gamma 1 -0.0985698
TPT1 tumor protein, translationally-controlled 1 -0.0841422
VCL vinculin -0.074432
PTMA prothymosin, alpha -0.0741229
AHNAK AHNAK nucleoprotein -0.0702051
EGFR epidermal growth factor receptor -0.0669844
LOC112694756 uncharaterized LOC112694756 -0.0634364
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0630138
PDE4D phosphodiesterase 4D, cAMP-specific -0.0590282
S100A6 S100 calcium binding protein A6 -0.0533291
CCND1 cyclin D1 -0.0501354
TMSB4X thymosin beta 4, X-linked -0.0494244
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0433012
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0432549
NBEA neurobeachin -0.0408745
RPS6 ribosomal protein S6 -0.0397241
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.038599
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0384647
FOXP1 forkhead box P1 -0.0383017
ZBTB20 zinc finger and BTB domain containing 20 -0.0351637
EXT1 exostosin glycosyltransferase 1 -0.0346052
NPAS2 neuronal PAS domain protein 2 -0.0339758
OSMR oncostatin M receptor -0.032233
S100A4 S100 calcium binding protein A4 -0.0321203
ARL4C ADP-ribosylation factor-like 4C -0.0320602
RPL34 ribosomal protein L34 -0.0311206
RPLP0 ribosomal protein, large, P0 -0.0310985
RPL9 ribosomal protein L9 -0.028902
GNAS GNAS complex locus -0.0287269
RPS24 ribosomal protein S24 -0.0281192
RPL11 ribosomal protein L11 -0.0278157
EXOC6B exocyst complex component 6B -0.0269183
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0264736
IFI16 interferon, gamma-inducible protein 16 -0.0260377
TBC1D5 TBC1 domain family, member 5 -0.0256939
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0254869
SQSTM1 sequestosome 1 -0.0252732
HLA-B major histocompatibility complex, class I, B -0.0249018
NCEH1 neutral cholesterol ester hydrolase 1 -0.024746
RPL13A ribosomal protein L13a -0.0247264
RPS27A ribosomal protein S27a -0.0246811
METTL15 methyltransferase like 15 -0.024262
RPL35A ribosomal protein L35a -0.0242299
RPLP1 ribosomal protein, large, P1 -0.0238017
HDLBP high density lipoprotein binding protein -0.0236106
RPLP2 ribosomal protein, large, P2 -0.0231845
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0230151
RPS8 ribosomal protein S8 -0.0229864
POTEF POTE ankyrin domain family, member F -0.0222072
NF1 neurofibromin 1 -0.0216084
RPL28 ribosomal protein L28 -0.0215897
GOLGA4 golgin A4 -0.02154
RPL27A ribosomal protein L27a -0.0215394
ARB2A ARB2 cotranscriptional regulator A -0.0205535
ANKRD17 ankyrin repeat domain 17 -0.0204262
RPS23 ribosomal protein S23 -0.0203867
HM13 histocompatibility (minor) 13 -0.0200948
BBS9 Bardet-Biedl syndrome 9 -0.0199916
EIF5B eukaryotic translation initiation factor 5B -0.0199256
RPL5 ribosomal protein L5 -0.0197265
VDAC1 voltage-dependent anion channel 1 -0.0195626
SPRY4 sprouty homolog 4 (Drosophila) -0.0195575
RPS16 ribosomal protein S16 -0.0195157
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0192408
RPS21 ribosomal protein S21 -0.018914
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0188968
HMGB1 high mobility group box 1 -0.0184111
WDPCP WD repeat containing planar cell polarity effector -0.0181616
FBLN2 fibulin 2 -0.0181459
FKBP10 FK506 binding protein 10, 65 kDa -0.0181113
RPS28 ribosomal protein S28 -0.0179321
ANKRD12 ankyrin repeat domain 12 -0.0176817
ACBD6 acyl-CoA binding domain containing 6 -0.0176199
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -0.0174629
SPIDR scaffolding protein involved in DNA repair -0.0173938
RPL26 ribosomal protein L26 -0.0171596
S100A10 S100 calcium binding protein A10 -0.0171197
TAPBP TAP binding protein (tapasin) -0.0170626
RACK1 receptor for activated C kinase 1 -0.0169577
ATRN attractin -0.0167402
RPS29 ribosomal protein S29 -0.0167143
PIWIL1 piwi-like RNA-mediated gene silencing 1 -0.016574
ZNF248 zinc finger protein 248 -0.0164848
PRKN parkin RBR E3 ubiquitin protein ligase -0.0164827
PRDX2 peroxiredoxin 2 -0.0162116
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0161004
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme -0.0160682
S100A9 S100 calcium binding protein A9 -0.0160209
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0159685
ZNFX1 zinc finger, NFX1-type containing 1 -0.0158813
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0156992
KLF3 Kruppel-like factor 3 (basic) -0.0155885
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0155688
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -0.0154883
GLI2 GLI family zinc finger 2 -0.0154789
TAS2R14 taste receptor, type 2, member 14 -0.0154502
GANAB glucosidase, alpha; neutral AB -0.0152862
FAF2 Fas associated factor family member 2 -0.0152722