Posaconazole_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Posaconazole perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Posaconazole_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.100591
ZNF292 zinc finger protein 292 0.0820308
SPAG9 sperm associated antigen 9 0.0812717
SNX14 sorting nexin 14 0.0742977
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0727807
NUP58 nucleoporin 58 0.0675599
NAP1L1 nucleosome assembly protein 1-like 1 0.0666608
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0609033
MYH9 myosin, heavy chain 9, non-muscle 0.0598344
NAV2 neuron navigator 2 0.0595518
WAC WW domain containing adaptor with coiled-coil 0.0591917
TRA2A transformer 2 alpha homolog (Drosophila) 0.0568461
TNPO1 transportin 1 0.0560334
PRELID2 PRELI domain containing 2 0.0549977
INSIG1 insulin induced gene 1 0.0540803
NDRG1 N-myc downstream regulated 1 0.0540358
TRIO trio Rho guanine nucleotide exchange factor 0.0539247
COG5 component of oligomeric golgi complex 5 0.0536164
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0535266
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0517889
NAMPT nicotinamide phosphoribosyltransferase 0.0515227
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0506259
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.049669
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0487639
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.048746
TXNRD1 thioredoxin reductase 1 0.0475489
SET SET nuclear proto-oncogene 0.047169
RAB6A RAB6A, member RAS oncogene family 0.0459969
PYGL phosphorylase, glycogen, liver 0.0457912
PCBP2 poly(rC) binding protein 2 0.0453868
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0453196
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0434366
PDE4D phosphodiesterase 4D, cAMP-specific 0.0432552
FAM13A family with sequence similarity 13, member A 0.0431616
PIKFYVE phosphoinositide kinase, FYVE finger containing 0.0425457
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0423396
SEC23A Sec23 homolog A (S. cerevisiae) 0.0421505
CAPRIN2 caprin family member 2 0.0418408
INSIG2 insulin induced gene 2 0.0412365
PKM pyruvate kinase, muscle 0.0405972
ASPH aspartate beta-hydroxylase 0.0400522
KMT2E lysine (K)-specific methyltransferase 2E 0.0398645
NHSL1 NHS-like 1 0.0395231
RNF145 ring finger protein 145 0.0394906
MATR3 matrin 3 0.0394274
ANKRD37 ankyrin repeat domain 37 0.039316
RPS12 ribosomal protein S12 0.0392245
ENO1 enolase 1, (alpha) 0.0385818
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0385737
CANX calnexin 0.0385187
NBAS neuroblastoma amplified sequence 0.0381019
OLA1 Obg-like ATPase 1 0.03798
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0378903
YAP1 Yes-associated protein 1 0.0375728
UBE2O ubiquitin-conjugating enzyme E2O 0.0370245
TOP2B topoisomerase (DNA) II beta 180kDa 0.0363603
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0361704
TJP1 tight junction protein 1 0.0356544
LCORL ligand dependent nuclear receptor corepressor-like 0.0356291
PDE8A phosphodiesterase 8A 0.0355749
NR1D2 nuclear receptor subfamily 1, group D, member 2 0.0353444
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0352862
RSRC2 arginine/serine-rich coiled-coil 2 0.0350673
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0348167
CENPF centromere protein F, 350/400kDa 0.0344453
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0344167
TENT2 terminal nucleotidyltransferase 2 0.0343617
DNER delta/notch-like EGF repeat containing 0.0338716
TFG TRK-fused gene 0.0336144
MT2A metallothionein 2A 0.0331438
APLP2 amyloid beta (A4) precursor-like protein 2 0.0328708
UBQLN1 ubiquilin 1 0.0327127
CHD1 chromodomain helicase DNA binding protein 1 0.0316345
ATP13A3 ATPase type 13A3 0.0316218
BHLHE40 basic helix-loop-helix family, member e40 0.0314651
SETD5 SET domain containing 5 0.0314188
ANLN anillin, actin binding protein 0.0312699
CUL4B cullin 4B 0.0312583
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0311515
ITCH itchy E3 ubiquitin protein ligase 0.031125
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0310411
MCL1 myeloid cell leukemia 1 0.0304695
EXOC5 exocyst complex component 5 0.030399
UBA6 ubiquitin-like modifier activating enzyme 6 0.0300509
HOOK2 hook microtubule-tethering protein 2 0.030009
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0298744
RBM26 RNA binding motif protein 26 0.0297436
ESYT2 extended synaptotagmin-like protein 2 0.0297155
MORF4L2 mortality factor 4 like 2 0.0296161
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0295194
RPL7 ribosomal protein L7 0.0293898
KIF5B kinesin family member 5B 0.0289183
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0288937
USP3 ubiquitin specific peptidase 3 0.0288304
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.0287582
CEP250 centrosomal protein 250kDa 0.0287086
ZNF638 zinc finger protein 638 0.0286341
PDS5B PDS5 cohesin associated factor B 0.0286317
CKAP5 cytoskeleton associated protein 5 0.0286101
XPO1 exportin 1 0.0286081

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.31238
OSMR oncostatin M receptor -0.096729
SLC38A2 solute carrier family 38, member 2 -0.0772485
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0653528
HMGA2 high mobility group AT-hook 2 -0.0645175
TPT1 tumor protein, translationally-controlled 1 -0.0597669
VCL vinculin -0.059384
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0562584
IGFBP3 insulin-like growth factor binding protein 3 -0.0561186
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0541183
ACTG1 actin gamma 1 -0.0536322
SDC4 syndecan 4 -0.0503488
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0490702
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0469802
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0459216
SAMD4A sterile alpha motif domain containing 4A -0.045332
ATM ATM serine/threonine kinase -0.0428168
LOC112694756 uncharaterized LOC112694756 -0.0418778
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0416918
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0407337
MACF1 microtubule-actin crosslinking factor 1 -0.0397345
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0396254
NALCN sodium leak channel, non selective -0.0390158
INTS6 integrator complex subunit 6 -0.0383812
AHNAK AHNAK nucleoprotein -0.0381401
RNF213 ring finger protein 213 -0.0377865
NCEH1 neutral cholesterol ester hydrolase 1 -0.0369976
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0369697
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0368811
IL1RAP interleukin 1 receptor accessory protein -0.0361944
DPYD dihydropyrimidine dehydrogenase -0.0360877
DST dystonin -0.0356817
VIM vimentin -0.0349045
NF1 neurofibromin 1 -0.0348862
ZBTB20 zinc finger and BTB domain containing 20 -0.0348754
EXOC6B exocyst complex component 6B -0.0343648
ELL2 elongation factor, RNA polymerase II, 2 -0.0340219
RANBP17 RAN binding protein 17 -0.0339941
HLA-C major histocompatibility complex, class I, C -0.0328873
SVIL supervillin -0.0325523
EGR1 early growth response 1 -0.0323542
HDAC9 histone deacetylase 9 -0.0322831
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 -0.0319859
SCAPER S-phase cyclin A-associated protein in the ER -0.0317043
BCAR3 breast cancer anti-estrogen resistance 3 -0.0309667
MBNL1 muscleblind-like splicing regulator 1 -0.0308946
PRH1 proline-rich protein HaeIII subfamily 1 -0.0308501
DOCK4 dedicator of cytokinesis 4 -0.0307276
RIGI RNA sensor RIG-I -0.0302482
STARD13 StAR-related lipid transfer (START) domain containing 13 -0.0302476
SCLT1 sodium channel and clathrin linker 1 -0.0298364
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0295743
TMSB10 thymosin beta 10 -0.0295742
SMYD3 SET and MYND domain containing 3 -0.0293569
EXT1 exostosin glycosyltransferase 1 -0.0292997
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0291319
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0289885
FMN1 formin 1 -0.0288948
BICD1 bicaudal D homolog 1 (Drosophila) -0.0288351
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.028628
PSEN1 presenilin 1 -0.0284115
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0282281
PCED1B PC-esterase domain containing 1B -0.0281781
TRPC1 transient receptor potential cation channel, subfamily C, member 1 -0.0280062
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0275477
GNAS GNAS complex locus -0.0273231
PCNX4 pecanex 4 -0.0269679
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial -0.0267743
CMIP c-Maf inducing protein -0.0267138
MSRB3 methionine sulfoxide reductase B3 -0.0266184
CD44 CD44 molecule (Indian blood group) -0.0265759
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -0.0260284
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0260256
SIK2 salt-inducible kinase 2 -0.025981
TAS2R14 taste receptor, type 2, member 14 -0.0259236
GCC2 GRIP and coiled-coil domain containing 2 -0.0257678
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0253711
BTG1 B-cell translocation gene 1, anti-proliferative -0.025139
TNRC18 trinucleotide repeat containing 18 -0.025125
AHI1 Abelson helper integration site 1 -0.0249744
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0249074
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.02488
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0242576
BPTF bromodomain PHD finger transcription factor -0.0240119
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0239052
TM4SF1 transmembrane 4 L six family member 1 -0.0238227
POTEF POTE ankyrin domain family, member F -0.02373
UBB ubiquitin B -0.0236374
RAB31 RAB31, member RAS oncogene family -0.0233964
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0233401
GOLGB1 golgin B1 -0.0231424
SDCCAG8 serologically defined colon cancer antigen 8 -0.022995
NABP1 nucleic acid binding protein 1 -0.0229947
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0229008
YIPF4 Yip1 domain family, member 4 -0.0229006
PHF14 PHD finger protein 14 -0.0228598
SH3KBP1 SH3-domain kinase binding protein 1 -0.022813
MBD5 methyl-CpG binding domain protein 5 -0.022578
CWF19L2 CWF19-like 2, cell cycle control (S. pombe) -0.0223548
FRS2 fibroblast growth factor receptor substrate 2 -0.0223406