Posaconazole_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Posaconazole perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Posaconazole_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.127264
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.112669
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.107613
NAMPT nicotinamide phosphoribosyltransferase 0.100419
FNDC3B fibronectin type III domain containing 3B 0.0991197
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0878923
TRIO trio Rho guanine nucleotide exchange factor 0.0791514
CD109 CD109 molecule 0.0759885
FAM13A family with sequence similarity 13, member A 0.066331
ASPH aspartate beta-hydroxylase 0.0654674
AHR aryl hydrocarbon receptor 0.0607528
PRELID2 PRELI domain containing 2 0.0575239
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0551381
MYH9 myosin, heavy chain 9, non-muscle 0.0535627
GLUL glutamate-ammonia ligase 0.0524648
RUNX2 runt-related transcription factor 2 0.0520096
DST dystonin 0.04874
PLIN2 perilipin 2 0.0471461
CENPF centromere protein F, 350/400kDa 0.0464444
TXNRD1 thioredoxin reductase 1 0.0464269
STC2 stanniocalcin 2 0.046049
SEC23A Sec23 homolog A (S. cerevisiae) 0.0456051
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0453796
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0449781
FTH1 ferritin, heavy polypeptide 1 0.0446403
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0444629
RICTOR RPTOR independent companion of MTOR, complex 2 0.0441495
NRIP1 nuclear receptor interacting protein 1 0.0436168
OGA O-GlcNAcase 0.0427737
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0401827
DOCK5 dedicator of cytokinesis 5 0.0400599
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0398435
NRP1 neuropilin 1 0.0389801
KMT2C lysine (K)-specific methyltransferase 2C 0.0385071
ZNF292 zinc finger protein 292 0.0381811
LIFR leukemia inhibitory factor receptor alpha 0.0381342
CTBP2 C-terminal binding protein 2 0.0372016
ESYT2 extended synaptotagmin-like protein 2 0.036992
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0366706
TTC3 tetratricopeptide repeat domain 3 0.0364835
SFTPA2 surfactant protein A2 0.0364574
TPR translocated promoter region, nuclear basket protein 0.0362911
TPM3 tropomyosin 3 0.0361563
GPC6 glypican 6 0.0360852
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0360529
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0354261
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0350223
HMGB3 high mobility group box 3 0.0346811
SMOX spermine oxidase 0.0340239
WAC WW domain containing adaptor with coiled-coil 0.0337517
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0335834
VEGFC vascular endothelial growth factor C 0.0334549
APLP2 amyloid beta (A4) precursor-like protein 2 0.0330129
COPA coatomer protein complex, subunit alpha 0.0329187
AFDN afadin, adherens junction formation factor 0.0328882
ERBIN erbb2 interacting protein 0.0328656
GRB10 growth factor receptor-bound protein 10 0.0325684
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0321384
TBC1D22A TBC1 domain family, member 22A 0.0321337
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0320307
HPCAL1 hippocalcin-like 1 0.0319653
FRYL FRY-like 0.031959
CDC73 cell division cycle 73 0.031738
UBA6 ubiquitin-like modifier activating enzyme 6 0.0316876
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0314354
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0312577
SUCO SUN domain containing ossification factor 0.0311529
NPC1 Niemann-Pick disease, type C1 0.0309568
SLTM SAFB-like, transcription modulator 0.0308009
ELL2 elongation factor, RNA polymerase II, 2 0.0306138
PDIA6 protein disulfide isomerase family A, member 6 0.0304124
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0302802
ITGA1 integrin, alpha 1 0.0302282
ARHGAP35 Rho GTPase activating protein 35 0.0299747
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0299707
BIRC6 baculoviral IAP repeat containing 6 0.0296679
ERRFI1 ERBB receptor feedback inhibitor 1 0.0296327
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0294443
USP9X ubiquitin specific peptidase 9, X-linked 0.0292349
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0292115
MKI67 marker of proliferation Ki-67 0.0291238
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.028508
USP34 ubiquitin specific peptidase 34 0.0284459
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0281654
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0280551
SPRED2 sprouty-related, EVH1 domain containing 2 0.0276712
SRRM2 serine/arginine repetitive matrix 2 0.02758
LDHA lactate dehydrogenase A 0.0275154
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0273782
SOD2 superoxide dismutase 2, mitochondrial 0.0273284
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0272677
YME1L1 YME1-like 1 ATPase 0.0271744
ARRDC3 arrestin domain containing 3 0.0271415
NBAS neuroblastoma amplified sequence 0.0270569
ADD3 adducin 3 (gamma) 0.0266689
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0266174
PDE8A phosphodiesterase 8A 0.0266153
WDR26 WD repeat domain 26 0.0265574
HIPK2 homeodomain interacting protein kinase 2 0.0264733
FBXO32 F-box protein 32 0.0263588

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.345792
PTMA prothymosin, alpha -0.114505
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.113433
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.110974
NRG1 neuregulin 1 -0.102956
TPT1 tumor protein, translationally-controlled 1 -0.091038
HLA-B major histocompatibility complex, class I, B -0.0859202
MT2A metallothionein 2A -0.0796274
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.079122
S100A6 S100 calcium binding protein A6 -0.0759976
VIM vimentin -0.0756782
RPS6 ribosomal protein S6 -0.072786
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0722608
IER3 immediate early response 3 -0.0560155
ACTG1 actin gamma 1 -0.0544921
S100A10 S100 calcium binding protein A10 -0.0523535
RPS24 ribosomal protein S24 -0.0512822
TMSB10 thymosin beta 10 -0.0493859
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.046947
RPS8 ribosomal protein S8 -0.0422605
VCL vinculin -0.0421173
RPS29 ribosomal protein S29 -0.039767
RPS19 ribosomal protein S19 -0.0396963
RPL9 ribosomal protein L9 -0.038757
TFPI2 tissue factor pathway inhibitor 2 -0.0379185
RPLP2 ribosomal protein, large, P2 -0.0376272
RPLP1 ribosomal protein, large, P1 -0.0364138
RPL38 ribosomal protein L38 -0.0361849
RPL26 ribosomal protein L26 -0.0361045
RPL28 ribosomal protein L28 -0.0359368
LMNA lamin A/C -0.0357324
B2M beta-2-microglobulin -0.0356605
LOC102724023 ES1 protein homolog, mitochondrial -0.034898
RPL8 ribosomal protein L8 -0.0335855
RPS21 ribosomal protein S21 -0.0335619
TM4SF1 transmembrane 4 L six family member 1 -0.0333206
RPL34 ribosomal protein L34 -0.0330896
RPS25 ribosomal protein S25 -0.0325048
RPL31 ribosomal protein L31 -0.0323411
RPL12 ribosomal protein L12 -0.0323203
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0318094
HMGA2 high mobility group AT-hook 2 -0.0310357
S100A9 S100 calcium binding protein A9 -0.0295035
RPS11 ribosomal protein S11 -0.0291528
FTL ferritin, light polypeptide -0.0288953
RPL37A ribosomal protein L37a -0.0284311
RPS27 ribosomal protein S27 -0.0284208
SOX4 SRY (sex determining region Y)-box 4 -0.0281054
TMSB4X thymosin beta 4, X-linked -0.0278798
RPS16 ribosomal protein S16 -0.0271222
RPL36A ribosomal protein L36a -0.0260487
ASTN2 astrotactin 2 -0.0260046
RPS15 ribosomal protein S15 -0.0260022
POTEF POTE ankyrin domain family, member F -0.0255488
TMEM165 transmembrane protein 165 -0.0253345
RPS27A ribosomal protein S27a -0.0252794
RPL32 ribosomal protein L32 -0.0244182
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0243322
EIF5B eukaryotic translation initiation factor 5B -0.0241971
RBM25 RNA binding motif protein 25 -0.0234485
CD63 CD63 molecule -0.0234123
CTSD cathepsin D -0.0234026
RPL35A ribosomal protein L35a -0.0233723
HMGB1 high mobility group box 1 -0.023262
SEPTIN7 septin 7 -0.0230587
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0226202
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.021868
VDAC1 voltage-dependent anion channel 1 -0.0216052
PALLD palladin, cytoskeletal associated protein -0.0214543
RPL19 ribosomal protein L19 -0.0213147
RPLP0 ribosomal protein, large, P0 -0.0213023
RPL37 ribosomal protein L37 -0.0212869
RPS23 ribosomal protein S23 -0.0212372
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa -0.0211915
AHNAK AHNAK nucleoprotein -0.0206087
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0205204
HM13 histocompatibility (minor) 13 -0.0204691
MX2 MX dynamin-like GTPase 2 -0.0203585
CCND1 cyclin D1 -0.0203323
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0198103
RPS28 ribosomal protein S28 -0.0197416
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0193485
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0190631
FAF2 Fas associated factor family member 2 -0.0190547
CXCL3 chemokine (C-X-C motif) ligand 3 -0.0188081
INTS6 integrator complex subunit 6 -0.0181959
RPS5 ribosomal protein S5 -0.0181926
MTDH metadherin -0.0179465
TMEM263 transmembrane protein 263 -0.017942
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.017932
SDC4 syndecan 4 -0.0178945
LY6E lymphocyte antigen 6 complex, locus E -0.0178861
TMED9 transmembrane emp24 protein transport domain containing 9 -0.0177784
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0176126
DUSP6 dual specificity phosphatase 6 -0.0175999
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0175398
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -0.0175227
EXT1 exostosin glycosyltransferase 1 -0.0172822
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.017147
DSTN destrin (actin depolymerizing factor) -0.0171024