Posterior Subcapsular Cataract Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A type of cataract affecting the posterior pole of lens immediately adjacent to ('beneath') the Lens capsule. (Human Phenotype Ontology, HP_0007787)
External Link https://www.disgenet.org/browser/0/1/0/C0858617
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Genes

65 genes associated with the disease Posterior Subcapsular Cataract in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ACAD8 acyl-CoA dehydrogenase family, member 8
ACVR1 activin A receptor, type I
ADAM9 ADAM metallopeptidase domain 9
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
ARID1A AT rich interactive domain 1A (SWI-like)
CASP3 caspase 3, apoptosis-related cysteine peptidase
CD274 CD274 molecule
CD47 CD47 molecule
CFB complement factor B
CHMP4B charged multivesicular body protein 4B
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRYAB crystallin, alpha B
CRYBA1 crystallin, beta A1
CRYBB2 crystallin, beta B2
CXCL8 chemokine (C-X-C motif) ligand 8
DCT dopachrome tautomerase
EPHA2 EPH receptor A2
F3 coagulation factor III (thromboplastin, tissue factor)
FGF19 fibroblast growth factor 19
GJA3 gap junction protein, alpha 3, 46kDa
GJA8 gap junction protein, alpha 8, 50kDa
GRAP2 GRB2-related adaptor protein 2
GSTT1 glutathione S-transferase theta 1
HAMP hepcidin antimicrobial peptide
HLA-DOA major histocompatibility complex, class II, DO alpha
HSF4 heat shock transcription factor 4
IL23A interleukin 23, alpha subunit p19
IL6 interleukin 6
IMPG2 interphotoreceptor matrix proteoglycan 2
LAMA3 laminin, alpha 3
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MET MET proto-oncogene, receptor tyrosine kinase
MIP major intrinsic protein of lens fiber
MME membrane metallo-endopeptidase
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
NFE2L2 nuclear factor, erythroid 2-like 2
NUCB1 nucleobindin 1
OAT ornithine aminotransferase
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PAEP progestagen-associated endometrial protein
PANK4 pantothenate kinase 4
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PITX3 paired-like homeodomain 3
PNPLA3 patatin-like phospholipase domain containing 3
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
PRDX6 peroxiredoxin 6
RBP3 retinol binding protein 3, interstitial
REEP6 receptor accessory protein 6
RLN2 relaxin 2
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
SPRTN SprT-like N-terminal domain
STATH statherin
TM6SF2 transmembrane 6 superfamily member 2
TONSL tonsoku-like, DNA repair protein
TP53 tumor protein p53
TULP1 tubby like protein 1
USH2A Usher syndrome 2A (autosomal recessive, mild)
WRN Werner syndrome, RecQ helicase-like
ZNF408 zinc finger protein 408