| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pralsetinib perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Pralsetinib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.195399 |
| CANX | calnexin | 0.131822 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.123609 |
| MAP1B | microtubule-associated protein 1B | 0.115653 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.115363 |
| PODXL | podocalyxin-like | 0.109941 |
| DST | dystonin | 0.109794 |
| HDAC9 | histone deacetylase 9 | 0.103268 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0944391 |
| LDHA | lactate dehydrogenase A | 0.0943183 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0940304 |
| CALR | calreticulin | 0.0912485 |
| ASPH | aspartate beta-hydroxylase | 0.0880208 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0871612 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0864925 |
| CDH13 | cadherin 13 | 0.0824359 |
| TMSB4X | thymosin beta 4, X-linked | 0.0783508 |
| MSN | moesin | 0.0761371 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0755394 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0733568 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0698509 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0687214 |
| FSTL1 | follistatin-like 1 | 0.0676755 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0645322 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0636184 |
| ENO1 | enolase 1, (alpha) | 0.0622547 |
| DSPP | dentin sialophosphoprotein | 0.0611774 |
| TPM3 | tropomyosin 3 | 0.0595731 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0577369 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0562617 |
| POTEF | POTE ankyrin domain family, member F | 0.0544348 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0534409 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0527988 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0525154 |
| TPM4 | tropomyosin 4 | 0.0524031 |
| VCL | vinculin | 0.0520474 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0518017 |
| APP | amyloid beta (A4) precursor protein | 0.0511838 |
| COL5A1 | collagen, type V, alpha 1 | 0.0504617 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0503924 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0484513 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0476232 |
| EGFR | epidermal growth factor receptor | 0.0472483 |
| EFNA5 | ephrin-A5 | 0.0471537 |
| MYOF | myoferlin | 0.0459541 |
| FLNA | filamin A, alpha | 0.0451129 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0448657 |
| PGK1 | phosphoglycerate kinase 1 | 0.04473 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0444383 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0440822 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0436227 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0435954 |
| CENPF | centromere protein F, 350/400kDa | 0.0428535 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | 0.0427021 |
| B2M | beta-2-microglobulin | 0.0414769 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0413239 |
| CD44 | CD44 molecule (Indian blood group) | 0.0406261 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0404281 |
| SQSTM1 | sequestosome 1 | 0.0400799 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0389099 |
| AHNAK | AHNAK nucleoprotein | 0.0388854 |
| RIGI | RNA sensor RIG-I | 0.0384949 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0371353 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0367819 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0367355 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0358681 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0351875 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0343605 |
| ANXA1 | annexin A1 | 0.0341039 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0340151 |
| NAV2 | neuron navigator 2 | 0.0334001 |
| OR51B5 | olfactory receptor, family 51, subfamily B, member 5 | 0.0328441 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0327728 |
| LNPEP | leucyl/cystinyl aminopeptidase | 0.0324574 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0320559 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0319679 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.031839 |
| SET | SET nuclear proto-oncogene | 0.0318041 |
| BSG | basigin (Ok blood group) | 0.0316003 |
| SP100 | SP100 nuclear antigen | 0.0312958 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0309463 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0305563 |
| TLE4 | transducin-like enhancer of split 4 | 0.0305152 |
| SEPTIN7 | septin 7 | 0.0304102 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0302896 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0301132 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.030084 |
| CDK6 | cyclin-dependent kinase 6 | 0.0299698 |
| PRRC2C | proline-rich coiled-coil 2C | 0.029767 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0292617 |
| DSG2 | desmoglein 2 | 0.0287303 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0286767 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0285832 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0285588 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 0.0285287 |
| TENM3 | teneurin transmembrane protein 3 | 0.0283941 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0282301 |
| EXT1 | exostosin glycosyltransferase 1 | 0.02767 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0275408 |
| ANKRD11 | ankyrin repeat domain 11 | 0.027339 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.138691 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.117138 |
| FBN1 | fibrillin 1 | -0.114017 |
| MT2A | metallothionein 2A | -0.110159 |
| PLAT | plasminogen activator, tissue | -0.100393 |
| UBC | ubiquitin C | -0.0800026 |
| COL1A2 | collagen, type I, alpha 2 | -0.0775228 |
| LOX | lysyl oxidase | -0.06633 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0570458 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0547404 |
| NDRG1 | N-myc downstream regulated 1 | -0.0510574 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0494748 |
| LOXL2 | lysyl oxidase-like 2 | -0.0484553 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0473273 |
| HLA-B | major histocompatibility complex, class I, B | -0.0471421 |
| AUTS2 | autism susceptibility candidate 2 | -0.0429426 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0390359 |
| CD99 | CD99 molecule | -0.0388258 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0385372 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0363873 |
| STC1 | stanniocalcin 1 | -0.0350067 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0337951 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0330649 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0319911 |
| SBF2 | SET binding factor 2 | -0.0306611 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0305502 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0298717 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0298696 |
| OGA | O-GlcNAcase | -0.0295147 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0294055 |
| HLA-C | major histocompatibility complex, class I, C | -0.0286333 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0284034 |
| TMOD1 | tropomodulin 1 | -0.027548 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0273359 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0271884 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0269887 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0262087 |
| FTL | ferritin, light polypeptide | -0.0257371 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.0256208 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0254518 |
| MT1X | metallothionein 1X | -0.0250745 |
| HIP1 | huntingtin interacting protein 1 | -0.0243993 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.024134 |
| ATP13A3 | ATPase type 13A3 | -0.0240088 |
| RPL28 | ribosomal protein L28 | -0.0239563 |
| MAP4 | microtubule-associated protein 4 | -0.0235528 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0233248 |
| KIFAP3 | kinesin-associated protein 3 | -0.023181 |
| RPL35A | ribosomal protein L35a | -0.0229989 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0224431 |
| LAMA5 | laminin, alpha 5 | -0.0223425 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0222798 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0214561 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | -0.0214275 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0213812 |
| KLHL24 | kelch-like family member 24 | -0.0213344 |
| MRC2 | mannose receptor, C type 2 | -0.0211973 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0210912 |
| DENND5A | DENN/MADD domain containing 5A | -0.0209181 |
| FLNB | filamin B, beta | -0.0208855 |
| RPL34 | ribosomal protein L34 | -0.0208645 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0206527 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | -0.0203313 |
| WTAP | Wilms tumor 1 associated protein | -0.019853 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0195135 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0194341 |
| PXDN | peroxidasin | -0.0192484 |
| ARL15 | ADP-ribosylation factor-like 15 | -0.0191424 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0189779 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0188863 |
| MYADM | myeloid-associated differentiation marker | -0.0185925 |
| SVIL | supervillin | -0.0185521 |
| NKTR | natural killer cell triggering receptor | -0.0180784 |
| RPS11 | ribosomal protein S11 | -0.0180308 |
| GPC6 | glypican 6 | -0.0178664 |
| MYO9B | myosin IXB | -0.0176587 |
| SUCNR1 | succinate receptor 1 | -0.0175388 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0175304 |
| DPYSL2 | dihydropyrimidinase-like 2 | -0.0174417 |
| RPS24 | ribosomal protein S24 | -0.0173602 |
| RPL23 | ribosomal protein L23 | -0.0172141 |
| PML | promyelocytic leukemia | -0.0171819 |
| MTSS1 | metastasis suppressor 1 | -0.0171741 |
| COL18A1 | collagen, type XVIII, alpha 1 | -0.0171549 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0171168 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.0170642 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0170164 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0169729 |
| GNB4 | guanine nucleotide binding protein (G protein), beta polypeptide 4 | -0.016823 |
| FNBP1 | formin binding protein 1 | -0.016656 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0165847 |
| PIAS1 | protein inhibitor of activated STAT, 1 | -0.0165837 |
| IQSEC1 | IQ motif and Sec7 domain 1 | -0.0164774 |
| LRRC49 | leucine rich repeat containing 49 | -0.0164437 |
| ATP11B | ATPase, class VI, type 11B | -0.0164199 |
| SLC22A23 | solute carrier family 22, member 23 | -0.016307 |
| LENG8 | leukocyte receptor cluster (LRC) member 8 | -0.0161775 |
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) | -0.016035 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0160266 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0159421 |
