| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pralsetinib perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Pralsetinib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.356055 |
| VIM | vimentin | 0.196412 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.191943 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0715949 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0701286 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0667483 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0660156 |
| ENO1 | enolase 1, (alpha) | 0.0653374 |
| ASPH | aspartate beta-hydroxylase | 0.0634202 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0624508 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0612074 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0602553 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0600612 |
| LDHA | lactate dehydrogenase A | 0.0590314 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0565038 |
| TPI1 | triosephosphate isomerase 1 | 0.0546779 |
| ANXA1 | annexin A1 | 0.0542009 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0539919 |
| CANX | calnexin | 0.051852 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0510393 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0498529 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0485173 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0430044 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0429126 |
| IPO7 | importin 7 | 0.0423906 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0419781 |
| CLTC | clathrin, heavy chain (Hc) | 0.0412792 |
| CDK6 | cyclin-dependent kinase 6 | 0.0410444 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0401443 |
| PEG10 | paternally expressed 10 | 0.0399756 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0393043 |
| RPLP0 | ribosomal protein, large, P0 | 0.0382681 |
| CALR | calreticulin | 0.0381524 |
| DST | dystonin | 0.036764 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0364385 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0363558 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0359666 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0353846 |
| RRM2 | ribonucleotide reductase M2 | 0.0352575 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0350628 |
| YAP1 | Yes-associated protein 1 | 0.0346362 |
| PGK1 | phosphoglycerate kinase 1 | 0.034556 |
| TXNRD1 | thioredoxin reductase 1 | 0.0341676 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.0341337 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0336128 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0333088 |
| RACK1 | receptor for activated C kinase 1 | 0.0329536 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0326693 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0318697 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.031524 |
| RPL3 | ribosomal protein L3 | 0.0305812 |
| PCBP2 | poly(rC) binding protein 2 | 0.0303534 |
| SQSTM1 | sequestosome 1 | 0.030121 |
| RPS12 | ribosomal protein S12 | 0.0301041 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0299992 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.029816 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.0297464 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0297264 |
| RPL4 | ribosomal protein L4 | 0.0294926 |
| DSPP | dentin sialophosphoprotein | 0.0289692 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0289226 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0286869 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.028556 |
| MYPN | myopalladin | 0.0282157 |
| PCDH9 | protocadherin 9 | 0.0272841 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | 0.0269768 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0268419 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.026565 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0259376 |
| INTS6 | integrator complex subunit 6 | 0.025894 |
| RPS3 | ribosomal protein S3 | 0.0258732 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.025309 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0251594 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.0251431 |
| SET | SET nuclear proto-oncogene | 0.0249921 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0246238 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | 0.0242859 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0242721 |
| CD164 | CD164 molecule, sialomucin | 0.023877 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0230152 |
| AP2M1 | adaptor-related protein complex 2, mu 1 subunit | 0.0229819 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.02292 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0229136 |
| PLK2 | polo-like kinase 2 | 0.0228566 |
| DENND5A | DENN/MADD domain containing 5A | 0.0227752 |
| SPAG9 | sperm associated antigen 9 | 0.0226886 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0226048 |
| CEP350 | centrosomal protein 350kDa | 0.0225153 |
| TPM3 | tropomyosin 3 | 0.0224986 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.022462 |
| RPL7 | ribosomal protein L7 | 0.0221465 |
| TPR | translocated promoter region, nuclear basket protein | 0.0221076 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0221067 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0219971 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0219564 |
| GOLGB1 | golgin B1 | 0.0218912 |
| EPHA6 | EPH receptor A6 | 0.0211944 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0211133 |
| PCM1 | pericentriolar material 1 | 0.020885 |
| UBC | ubiquitin C | 0.0208711 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NLGN1 | neuroligin 1 | -0.178586 |
| TMSB10 | thymosin beta 10 | -0.137835 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.126209 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0721279 |
| EGR1 | early growth response 1 | -0.0716263 |
| NHSL1 | NHS-like 1 | -0.0694794 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0648672 |
| RASAL2 | RAS protein activator like 2 | -0.0563068 |
| AREG | amphiregulin | -0.0516972 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | -0.0508427 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0493897 |
| HMGA1 | high mobility group AT-hook 1 | -0.0468759 |
| RPL35A | ribosomal protein L35a | -0.0468375 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0467769 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0450943 |
| PFN1 | profilin 1 | -0.0448896 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0437673 |
| RPS21 | ribosomal protein S21 | -0.0393753 |
| FTL | ferritin, light polypeptide | -0.0372397 |
| TRA2B | transformer 2 beta homolog (Drosophila) | -0.0370722 |
| RPLP2 | ribosomal protein, large, P2 | -0.0365494 |
| ACTG1 | actin gamma 1 | -0.0363221 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0359307 |
| RPL23 | ribosomal protein L23 | -0.0344654 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0336427 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0329723 |
| RBMX | RNA binding motif protein, X-linked | -0.0326646 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.032514 |
| RPS19 | ribosomal protein S19 | -0.032181 |
| RPS29 | ribosomal protein S29 | -0.0312533 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0304589 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0303696 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0296046 |
| RPL8 | ribosomal protein L8 | -0.0293883 |
| BCHE | butyrylcholinesterase | -0.0292686 |
| EHBP1 | EH domain binding protein 1 | -0.0292003 |
| NABP1 | nucleic acid binding protein 1 | -0.0286491 |
| ZNF804A | zinc finger protein 804A | -0.0285594 |
| SMC4 | structural maintenance of chromosomes 4 | -0.028186 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0281137 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0276182 |
| CMIP | c-Maf inducing protein | -0.0275749 |
| NAV3 | neuron navigator 3 | -0.0267782 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0264516 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0263723 |
| USP34 | ubiquitin specific peptidase 34 | -0.0259648 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0252992 |
| CUX1 | cut-like homeobox 1 | -0.0251536 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0251529 |
| RPS13 | ribosomal protein S13 | -0.0251269 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0249937 |
| RPS15 | ribosomal protein S15 | -0.0249262 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.024495 |
| GNB4 | guanine nucleotide binding protein (G protein), beta polypeptide 4 | -0.0242242 |
| GCG | glucagon | -0.0241158 |
| RSRC1 | arginine/serine-rich coiled-coil 1 | -0.0239535 |
| KIF18B | kinesin family member 18B | -0.0239463 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0236726 |
| RPL34 | ribosomal protein L34 | -0.023316 |
| RPL28 | ribosomal protein L28 | -0.0231939 |
| TGM2 | transglutaminase 2 | -0.0231798 |
| RPL36 | ribosomal protein L36 | -0.0230072 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0225605 |
| RPL38 | ribosomal protein L38 | -0.0223383 |
| TSPAN5 | tetraspanin 5 | -0.022161 |
| PCDH7 | protocadherin 7 | -0.0218636 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0216156 |
| FUS | FUS RNA binding protein | -0.0215948 |
| RPS23 | ribosomal protein S23 | -0.0215352 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0213922 |
| RPS11 | ribosomal protein S11 | -0.0212133 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | -0.0210231 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0210055 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0209163 |
| RTN4 | reticulon 4 | -0.0208202 |
| CCND1 | cyclin D1 | -0.0206853 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.0203635 |
| ATN1 | atrophin 1 | -0.020332 |
| MAP4 | microtubule-associated protein 4 | -0.0201989 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0196945 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0194449 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.0191466 |
| MTCL1 | microtubule crosslinking factor 1 | -0.0190931 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0189252 |
| WDR43 | WD repeat domain 43 | -0.0188659 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0188621 |
| RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | -0.0188216 |
| RPS27 | ribosomal protein S27 | -0.0182684 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0182611 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0182287 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | -0.0179938 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0179866 |
| RPS24 | ribosomal protein S24 | -0.017675 |
| RPL11 | ribosomal protein L11 | -0.0176444 |
| ZFP64 | ZFP64 zinc finger protein | -0.0176353 |
| TMEM41B | transmembrane protein 41B | -0.0173253 |
| RPS14 | ribosomal protein S14 | -0.0170713 |
| YBX3 | Y box binding protein 3 | -0.0169873 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0168333 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0167464 |
