| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pralsetinib perturbation in CHP-212 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Pralsetinib_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.203612 |
| VCL | vinculin | 0.149486 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.129063 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.121061 |
| FMN1 | formin 1 | 0.119687 |
| DST | dystonin | 0.104907 |
| TLE4 | transducin-like enhancer of split 4 | 0.101287 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0740586 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0729225 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.0700588 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.069723 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0676792 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0660263 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0652941 |
| PCBP2 | poly(rC) binding protein 2 | 0.0636123 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | 0.0558378 |
| ASPH | aspartate beta-hydroxylase | 0.0542107 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0540324 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0505204 |
| PCDH9 | protocadherin 9 | 0.0488425 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0487232 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0484624 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0465725 |
| MYCN | v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog | 0.0465463 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0462144 |
| MEIS2 | Meis homeobox 2 | 0.0460548 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0448482 |
| PTMA | prothymosin, alpha | 0.04477 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0444943 |
| MYO1E | myosin IE | 0.0436183 |
| ENAH | enabled homolog (Drosophila) | 0.0429714 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0425562 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.042347 |
| PRKCA | protein kinase C, alpha | 0.0412794 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0410166 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0401415 |
| INTS6 | integrator complex subunit 6 | 0.0399377 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0399027 |
| FERMT2 | fermitin family member 2 | 0.0398761 |
| FAM13A | family with sequence similarity 13, member A | 0.0396265 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0394122 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0393606 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0391288 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0381669 |
| CLTC | clathrin, heavy chain (Hc) | 0.038154 |
| ITGA1 | integrin, alpha 1 | 0.0376216 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0375506 |
| SET | SET nuclear proto-oncogene | 0.0371848 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0370942 |
| CENPF | centromere protein F, 350/400kDa | 0.0369676 |
| HOMER1 | homer scaffolding protein 1 | 0.0363487 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0363306 |
| TPM1 | tropomyosin 1 (alpha) | 0.0358774 |
| MEF2A | myocyte enhancer factor 2A | 0.0356413 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.035614 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0355894 |
| RAD51B | RAD51 paralog B | 0.0352561 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0348392 |
| MRTFA | myocardin related transcription factor A | 0.0346056 |
| SMYD3 | SET and MYND domain containing 3 | 0.0344634 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | 0.0340385 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0338252 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0337331 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0335638 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0335158 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0333968 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0332332 |
| TCF12 | transcription factor 12 | 0.0331522 |
| ZNF638 | zinc finger protein 638 | 0.0329696 |
| ATXN1 | ataxin 1 | 0.0329547 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0327392 |
| FAM107B | family with sequence similarity 107, member B | 0.0323588 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.032148 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0320473 |
| UNC5C | unc-5 homolog C (C. elegans) | 0.0319735 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | 0.0319453 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0313803 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0313262 |
| APP | amyloid beta (A4) precursor protein | 0.0311517 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | 0.0310809 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0307211 |
| RPL7 | ribosomal protein L7 | 0.0305702 |
| SEPTIN9 | septin 9 | 0.0305088 |
| B2M | beta-2-microglobulin | 0.0298346 |
| SIK3 | SIK family kinase 3 | 0.0297157 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0291179 |
| FRMD5 | FERM domain containing 5 | 0.0288212 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0287581 |
| LPIN1 | lipin 1 | 0.0286634 |
| GPATCH2L | G patch domain containing 2-like | 0.0286323 |
| RUNX1 | runt-related transcription factor 1 | 0.0285018 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0282381 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.027677 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0276211 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0274902 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0274062 |
| CCDC88A | coiled-coil domain containing 88A | 0.0273901 |
| MCL1 | myeloid cell leukemia 1 | 0.0271895 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.027187 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0267055 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.448819 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.11804 |
| COL1A1 | collagen, type I, alpha 1 | -0.0874115 |
| NRG1 | neuregulin 1 | -0.0700467 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0517784 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.0493339 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0456695 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0412611 |
| FRMD4A | FERM domain containing 4A | -0.0402554 |
| TMSB10 | thymosin beta 10 | -0.0395427 |
| FTL | ferritin, light polypeptide | -0.0367255 |
| H3-3B | H3.3 histone B | -0.0362721 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0356085 |
| NDRG1 | N-myc downstream regulated 1 | -0.0338401 |
| RPS24 | ribosomal protein S24 | -0.0337267 |
| RPL38 | ribosomal protein L38 | -0.0320343 |
| HAND2 | heart and neural crest derivatives expressed 2 | -0.0296612 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0294369 |
| ANTXR1 | anthrax toxin receptor 1 | -0.0280957 |
| PLAT | plasminogen activator, tissue | -0.0276476 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0271341 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0262886 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0261253 |
| RPL28 | ribosomal protein L28 | -0.0256811 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0254852 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | -0.0254629 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0252745 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0240569 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0235403 |
| RPL9 | ribosomal protein L9 | -0.0232921 |
| CCND1 | cyclin D1 | -0.0232367 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0225774 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0223745 |
| RPS19 | ribosomal protein S19 | -0.0223401 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0216969 |
| KLHL5 | kelch-like family member 5 | -0.0215025 |
| CDC27 | cell division cycle 27 | -0.0211692 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.021125 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.021101 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0209905 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0208387 |
| RPLP1 | ribosomal protein, large, P1 | -0.0206353 |
| ACTG1 | actin gamma 1 | -0.0206073 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0205732 |
| RPS29 | ribosomal protein S29 | -0.0204867 |
| FKBP10 | FK506 binding protein 10, 65 kDa | -0.0203895 |
| USP36 | ubiquitin specific peptidase 36 | -0.0203395 |
| WDR45B | WD repeat domain 45B | -0.0200002 |
| RPL35A | ribosomal protein L35a | -0.0199657 |
| RAB5A | RAB5A, member RAS oncogene family | -0.0196658 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0196141 |
| NME2 | NME/NM23 nucleoside diphosphate kinase 2 | -0.0195246 |
| RPL34 | ribosomal protein L34 | -0.0193163 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.019204 |
| LMNA | lamin A/C | -0.0191966 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0191775 |
| HIP1 | huntingtin interacting protein 1 | -0.0191161 |
| RPS21 | ribosomal protein S21 | -0.0190964 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0189913 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0187962 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0185561 |
| MAP4 | microtubule-associated protein 4 | -0.0185255 |
| CLINT1 | clathrin interactor 1 | -0.0179702 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0177128 |
| COL18A1 | collagen, type XVIII, alpha 1 | -0.0177073 |
| H1-0 | H1.0 linker histone | -0.017634 |
| NPLOC4 | nuclear protein localization 4 homolog (S. cerevisiae) | -0.017575 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0173624 |
| ARF1 | ADP-ribosylation factor 1 | -0.0172548 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0172485 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.017229 |
| RPL7A | ribosomal protein L7a | -0.0172193 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0171918 |
| GNB4 | guanine nucleotide binding protein (G protein), beta polypeptide 4 | -0.0169776 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0169554 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0169445 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | -0.0168698 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0166972 |
| NEK7 | NIMA-related kinase 7 | -0.0166706 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0165976 |
| GAS7 | growth arrest-specific 7 | -0.0165714 |
| RHEB | Ras homolog enriched in brain | -0.0165074 |
| ATXN3 | ataxin 3 | -0.016461 |
| C1ORF21 | chromosome 1 open reading frame 21 | -0.0164516 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0163914 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0163548 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0162673 |
| PARD3 | par-3 family cell polarity regulator | -0.0162193 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.016167 |
| HDLBP | high density lipoprotein binding protein | -0.0161091 |
| FN1 | fibronectin 1 | -0.0161021 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0160099 |
| GDF15 | growth differentiation factor 15 | -0.0159951 |
| TMEM263 | transmembrane protein 263 | -0.0159036 |
| KLHL24 | kelch-like family member 24 | -0.0158795 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0157281 |
| FOXK1 | forkhead box K1 | -0.0157028 |
| FCHSD2 | FCH and double SH3 domains 2 | -0.0156684 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0155529 |
| CLPX | caseinolytic mitochondrial matrix peptidase chaperone subunit | -0.0155447 |
