| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pralsetinib perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Pralsetinib_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | 0.293777 |
| EXT1 | exostosin glycosyltransferase 1 | 0.149237 |
| SMAD3 | SMAD family member 3 | 0.145311 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.12693 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.114212 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0949403 |
| ASPH | aspartate beta-hydroxylase | 0.0862844 |
| DST | dystonin | 0.0858184 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0838158 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0761334 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0739699 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0590099 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0582333 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0556892 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0530044 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0528165 |
| FAT1 | FAT atypical cadherin 1 | 0.05276 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0523054 |
| ENO1 | enolase 1, (alpha) | 0.0521469 |
| MYO1E | myosin IE | 0.0520007 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.0514831 |
| HKDC1 | hexokinase domain containing 1 | 0.0499475 |
| ZNF292 | zinc finger protein 292 | 0.0497033 |
| ETV6 | ets variant 6 | 0.0486866 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 0.0486746 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0486671 |
| DSPP | dentin sialophosphoprotein | 0.0481684 |
| KYNU | kynureninase | 0.0481463 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0477509 |
| RNF213 | ring finger protein 213 | 0.0473453 |
| SIK3 | SIK family kinase 3 | 0.0473397 |
| CANX | calnexin | 0.0453422 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.044879 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0438632 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0435286 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0431456 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0423199 |
| FNIP2 | folliculin interacting protein 2 | 0.0412243 |
| FNIP1 | folliculin interacting protein 1 | 0.0410189 |
| PDZD8 | PDZ domain containing 8 | 0.0409593 |
| LCN2 | lipocalin 2 | 0.0407976 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0406785 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0393176 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0387309 |
| TJP1 | tight junction protein 1 | 0.0385187 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.0382535 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.0375985 |
| INTS6 | integrator complex subunit 6 | 0.0362924 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0362056 |
| YAP1 | Yes-associated protein 1 | 0.0359795 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0357625 |
| DIAPH1 | diaphanous-related formin 1 | 0.0354129 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0346292 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0345786 |
| MYO5B | myosin VB | 0.0341743 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0340795 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0337648 |
| RBM47 | RNA binding motif protein 47 | 0.0334224 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0333612 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0327075 |
| RAB10 | RAB10, member RAS oncogene family | 0.0327013 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0325802 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0315025 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0314172 |
| EFNB2 | ephrin-B2 | 0.0313729 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0305666 |
| JMJD1C | jumonji domain containing 1C | 0.030314 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0302939 |
| ERBIN | erbb2 interacting protein | 0.0301398 |
| LURAP1L | leucine rich adaptor protein 1-like | 0.0300657 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0299267 |
| MAP7 | microtubule-associated protein 7 | 0.0295931 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0293551 |
| MYOF | myoferlin | 0.0292628 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0290635 |
| DPP4 | dipeptidyl-peptidase 4 | 0.0289228 |
| TMEM65 | transmembrane protein 65 | 0.0288183 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0287535 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0285637 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0283769 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0282953 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0281536 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0278663 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0278317 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0264177 |
| SET | SET nuclear proto-oncogene | 0.0263458 |
| TRIM2 | tripartite motif containing 2 | 0.0263334 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.0262131 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0261747 |
| RPL7L1 | ribosomal protein L7-like 1 | 0.0261523 |
| RPLP0 | ribosomal protein, large, P0 | 0.0261213 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0257606 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0256886 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0249123 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0248588 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0247245 |
| LOC112694756 | uncharaterized LOC112694756 | 0.024463 |
| PPARG | peroxisome proliferator-activated receptor gamma | 0.0243769 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.024276 |
| TOX3 | TOX high mobility group box family member 3 | 0.0241119 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TPT1 | tumor protein, translationally-controlled 1 | -0.100194 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0954092 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0815617 |
| XAF1 | XIAP associated factor 1 | -0.0741537 |
| EGR1 | early growth response 1 | -0.0729687 |
| LYZ | lysozyme | -0.0726132 |
| TXNIP | thioredoxin interacting protein | -0.0725403 |
| HLA-B | major histocompatibility complex, class I, B | -0.0633371 |
| NDRG1 | N-myc downstream regulated 1 | -0.0632257 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0502108 |
| ITGA6 | integrin, alpha 6 | -0.0493183 |
| EZR | ezrin | -0.0493033 |
| NPSR1 | neuropeptide S receptor 1 | -0.0487581 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0440757 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0438625 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0423337 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0418828 |
| HLA-C | major histocompatibility complex, class I, C | -0.0409535 |
| NCKAP5 | NCK-associated protein 5 | -0.0404028 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0402106 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0395832 |
| SQSTM1 | sequestosome 1 | -0.0389952 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0383344 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0379012 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0358626 |
| MUC20 | mucin 20, cell surface associated | -0.0353457 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0350222 |
| H1-0 | H1.0 linker histone | -0.0348033 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0347883 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0340183 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.0322294 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0309476 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -0.0301734 |
| STS | steroid sulfatase (microsomal), isozyme S | -0.0296254 |
| TNS4 | tensin 4 | -0.029522 |
| CCNL1 | cyclin L1 | -0.0293433 |
| RNF43 | ring finger protein 43 | -0.0290854 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0289857 |
| FTL | ferritin, light polypeptide | -0.0267688 |
| PRKCA | protein kinase C, alpha | -0.026724 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0266168 |
| TMEM62 | transmembrane protein 62 | -0.0265924 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.025886 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0258331 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0253188 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0248778 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0247426 |
| MECOM | MDS1 and EVI1 complex locus | -0.0247099 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0246114 |
| CSTB | cystatin B (stefin B) | -0.0243539 |
| GNAS | GNAS complex locus | -0.0243015 |
| LLGL2 | lethal giant larvae homolog 2 (Drosophila) | -0.0239549 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0238288 |
| ACTN4 | actinin, alpha 4 | -0.0231879 |
| BICRAL | BICRA like chromatin remodeling complex associated protein | -0.0229651 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0226941 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0226804 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0226522 |
| TMSB10 | thymosin beta 10 | -0.0226323 |
| SDCBP2 | syndecan binding protein (syntenin) 2 | -0.0226319 |
| TFRC | transferrin receptor | -0.0222929 |
| ITPKC | inositol-trisphosphate 3-kinase C | -0.0222439 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) | -0.0222094 |
| DIAPH3 | diaphanous-related formin 3 | -0.0222039 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0220562 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0218285 |
| PCED1B | PC-esterase domain containing 1B | -0.0215747 |
| TPM4 | tropomyosin 4 | -0.0215728 |
| RPL34 | ribosomal protein L34 | -0.0215218 |
| RBM39 | RNA binding motif protein 39 | -0.0213944 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0211108 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0210018 |
| FOXP1 | forkhead box P1 | -0.0208554 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0207818 |
| NECTIN2 | nectin cell adhesion molecule 2 | -0.0206145 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | -0.020425 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.0203281 |
| PLCH1 | phospholipase C, eta 1 | -0.0203001 |
| RPL35A | ribosomal protein L35a | -0.0202144 |
| FOXO3 | forkhead box O3 | -0.0199809 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0199713 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.019898 |
| SPG11 | spastic paraplegia 11 (autosomal recessive) | -0.0198857 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0198002 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0197142 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0195504 |
| MXD1 | MAX dimerization protein 1 | -0.0195024 |
| STAT2 | signal transducer and activator of transcription 2, 113kDa | -0.0194883 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0194681 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0193023 |
| RIGI | RNA sensor RIG-I | -0.0192986 |
| TMEM165 | transmembrane protein 165 | -0.0192774 |
| CLYBL | citrate lyase beta like | -0.019229 |
| TC2N | tandem C2 domains, nuclear | -0.0191779 |
| IFT88 | intraflagellar transport 88 | -0.0191735 |
| JUP | junction plakoglobin | -0.0191397 |
| ZDHHC20 | zinc finger, DHHC-type containing 20 | -0.0190582 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0190211 |
| IRF1 | interferon regulatory factor 1 | -0.0187781 |
| SCARB1 | scavenger receptor class B, member 1 | -0.018595 |
