| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pralsetinib perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Pralsetinib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ENO1 | enolase 1, (alpha) | 0.153804 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.141381 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.133044 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.132988 |
| CANX | calnexin | 0.107856 |
| CALR | calreticulin | 0.103803 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.100638 |
| LDHA | lactate dehydrogenase A | 0.0988484 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0961703 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0877373 |
| CD44 | CD44 molecule (Indian blood group) | 0.0852736 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0778684 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0738918 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0736626 |
| ASPH | aspartate beta-hydroxylase | 0.0603802 |
| APP | amyloid beta (A4) precursor protein | 0.0589759 |
| SP100 | SP100 nuclear antigen | 0.0553148 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0496242 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0493659 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0492494 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0490969 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.048601 |
| B2M | beta-2-microglobulin | 0.0477404 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0470161 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.046359 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0461716 |
| VIM | vimentin | 0.0460474 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0457684 |
| MSN | moesin | 0.0455085 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0436086 |
| VEGFA | vascular endothelial growth factor A | 0.0430416 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.042869 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0419464 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0418743 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0413912 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0406697 |
| KIAA1217 | KIAA1217 | 0.0386032 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | 0.0383726 |
| TMSB4X | thymosin beta 4, X-linked | 0.0382227 |
| DSTN | destrin (actin depolymerizing factor) | 0.0380946 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0375735 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0371776 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0369745 |
| PTMA | prothymosin, alpha | 0.0362413 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0360834 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0351306 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0351164 |
| DST | dystonin | 0.0347812 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0346094 |
| RPL7 | ribosomal protein L7 | 0.0320148 |
| ARRDC3 | arrestin domain containing 3 | 0.0317266 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0295717 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0294928 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0293142 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0292881 |
| FAT1 | FAT atypical cadherin 1 | 0.029132 |
| CALU | calumenin | 0.0289288 |
| VCL | vinculin | 0.0288943 |
| HYOU1 | hypoxia up-regulated 1 | 0.0288471 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0286976 |
| PLSCR1 | phospholipid scramblase 1 | 0.0282006 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0281992 |
| GOLGB1 | golgin B1 | 0.027847 |
| ATXN1 | ataxin 1 | 0.0275594 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0273082 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0271999 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0265431 |
| STC2 | stanniocalcin 2 | 0.0263501 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0262134 |
| CLTC | clathrin, heavy chain (Hc) | 0.0253768 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0253722 |
| FAM107B | family with sequence similarity 107, member B | 0.0250534 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0250364 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0249696 |
| HDAC9 | histone deacetylase 9 | 0.024861 |
| DSPP | dentin sialophosphoprotein | 0.0247911 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0245268 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0237873 |
| HLA-E | major histocompatibility complex, class I, E | 0.0236518 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0232552 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0230275 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0229664 |
| IFI44L | interferon-induced protein 44-like | 0.0229443 |
| SVIL | supervillin | 0.02284 |
| RPS6 | ribosomal protein S6 | 0.0228098 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0227192 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0227026 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.022589 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0224153 |
| RPS12 | ribosomal protein S12 | 0.0222254 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0220787 |
| TMF1 | TATA element modulatory factor 1 | 0.021995 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0215857 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.020904 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0208593 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.0207784 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0205271 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0204468 |
| LNPEP | leucyl/cystinyl aminopeptidase | 0.020333 |
| COL3A1 | collagen, type III, alpha 1 | 0.0201877 |
| Symbol | Name | Standardized Value |
|---|---|---|
| COL1A1 | collagen, type I, alpha 1 | -0.287414 |
| NDRG1 | N-myc downstream regulated 1 | -0.264429 |
| COL1A2 | collagen, type I, alpha 2 | -0.135893 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.115548 |
| ATP13A3 | ATPase type 13A3 | -0.0941628 |
| PDE10A | phosphodiesterase 10A | -0.0682291 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0665915 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0553272 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.051049 |
| COL5A1 | collagen, type V, alpha 1 | -0.0500347 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0497463 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0491223 |
| TMEM165 | transmembrane protein 165 | -0.0489507 |
| CDH13 | cadherin 13 | -0.0477741 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0458885 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0451501 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0433777 |
| FTL | ferritin, light polypeptide | -0.0426575 |
| CADM1 | cell adhesion molecule 1 | -0.0404948 |
| TMSB10 | thymosin beta 10 | -0.0402794 |
| RTN4 | reticulon 4 | -0.0364212 |
| ZNF292 | zinc finger protein 292 | -0.0360944 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0360636 |
| LOX | lysyl oxidase | -0.0343153 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0338416 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0336252 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0335936 |
| ACTG1 | actin gamma 1 | -0.0330651 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0326011 |
| MT2A | metallothionein 2A | -0.0322989 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0322724 |
| TFG | TRK-fused gene | -0.0322502 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0314895 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0313912 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0309546 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0308195 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0291165 |
| TPM2 | tropomyosin 2 (beta) | -0.0289236 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0283201 |
| EGR1 | early growth response 1 | -0.0282561 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0280542 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0279347 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0277717 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0276152 |
| TMEM263 | transmembrane protein 263 | -0.0272853 |
| SPAG9 | sperm associated antigen 9 | -0.0272489 |
| USP3 | ubiquitin specific peptidase 3 | -0.0267962 |
| TRAM1 | translocation associated membrane protein 1 | -0.0267333 |
| CALD1 | caldesmon 1 | -0.0263079 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0262385 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0257266 |
| PRR16 | proline rich 16 | -0.0255625 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.0254506 |
| QKI | QKI, KH domain containing, RNA binding | -0.0254052 |
| ADM | adrenomedullin | -0.0249667 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0248463 |
| RPL35A | ribosomal protein L35a | -0.0246558 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0245773 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0245521 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0241105 |
| ANKRD11 | ankyrin repeat domain 11 | -0.023886 |
| RRBP1 | ribosome binding protein 1 | -0.0238389 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0234724 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0230465 |
| HMGA1 | high mobility group AT-hook 1 | -0.0225858 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0225262 |
| FKBP10 | FK506 binding protein 10, 65 kDa | -0.0224849 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0223767 |
| HMGA2 | high mobility group AT-hook 2 | -0.0211308 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0210456 |
| PDE8A | phosphodiesterase 8A | -0.0206204 |
| BBX | bobby sox homolog (Drosophila) | -0.0205717 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0204998 |
| RBM39 | RNA binding motif protein 39 | -0.0198792 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0198725 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0197381 |
| SBF2 | SET binding factor 2 | -0.0196813 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0195752 |
| TRAM2 | translocation associated membrane protein 2 | -0.0195502 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0193831 |
| AFAP1 | actin filament associated protein 1 | -0.0193654 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0191087 |
| RPL28 | ribosomal protein L28 | -0.0189889 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0188059 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0186848 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.018681 |
| RHEB | Ras homolog enriched in brain | -0.0184441 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0183426 |
| EHD2 | EH-domain containing 2 | -0.0182365 |
| KIF13A | kinesin family member 13A | -0.0179833 |
| GNAS | GNAS complex locus | -0.0179069 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0178282 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0177898 |
| FBXO32 | F-box protein 32 | -0.0177702 |
| AZIN1 | antizyme inhibitor 1 | -0.0177465 |
| SETD5 | SET domain containing 5 | -0.0177065 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0176925 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.0175347 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0174446 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0172426 |
