Pralsetinib_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pralsetinib perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pralsetinib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DSPP dentin sialophosphoprotein 0.182393
AKAP12 A kinase (PRKA) anchor protein 12 0.181453
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.167501
ENO1 enolase 1, (alpha) 0.138941
FAM107B family with sequence similarity 107, member B 0.110877
PDLIM5 PDZ and LIM domain 5 0.102947
SAMD4A sterile alpha motif domain containing 4A 0.0934024
TF transferrin 0.0898601
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.082261
ASPH aspartate beta-hydroxylase 0.0792677
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0766189
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0721841
DST dystonin 0.0699417
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.067259
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0641741
EXT1 exostosin glycosyltransferase 1 0.0627757
AHSG alpha-2-HS-glycoprotein 0.0613033
INTS6 integrator complex subunit 6 0.0531519
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.052927
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0528364
EEF2 eukaryotic translation elongation factor 2 0.0508741
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0508567
SVIL supervillin 0.0505117
CANX calnexin 0.0497426
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0495741
LOC112694756 uncharaterized LOC112694756 0.0495195
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0480628
MYH9 myosin, heavy chain 9, non-muscle 0.0479497
DSTN destrin (actin depolymerizing factor) 0.0467008
PAWR PRKC, apoptosis, WT1, regulator 0.046697
MBNL2 muscleblind-like splicing regulator 2 0.0463968
MACF1 microtubule-actin crosslinking factor 1 0.044796
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0440797
KYNU kynureninase 0.0440239
LPP LIM domain containing preferred translocation partner in lipoma 0.0438723
DLC1 DLC1 Rho GTPase activating protein 0.0427892
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0412858
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0412479
NFE2L2 nuclear factor, erythroid 2-like 2 0.0410188
ATXN1 ataxin 1 0.0401216
RPLP0 ribosomal protein, large, P0 0.0400359
MBNL1 muscleblind-like splicing regulator 1 0.0400319
ERRFI1 ERBB receptor feedback inhibitor 1 0.039802
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0381523
LDHA lactate dehydrogenase A 0.0376641
FOXP1 forkhead box P1 0.0373232
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0371616
TRIO trio Rho guanine nucleotide exchange factor 0.0357419
PTMA prothymosin, alpha 0.0357305
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0355143
LMO7 LIM domain 7 0.0352969
UBC ubiquitin C 0.0352652
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0352642
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.034969
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.034744
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0347235
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0344319
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0341587
FERMT2 fermitin family member 2 0.0340574
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0339451
VEGFA vascular endothelial growth factor A 0.0339223
MYO1E myosin IE 0.0338
MYO6 myosin VI 0.0336304
RACK1 receptor for activated C kinase 1 0.0335102
GOLGA4 golgin A4 0.0332947
CLIC4 chloride intracellular channel 4 0.0330661
DIAPH1 diaphanous-related formin 1 0.0329265
ARID5B AT rich interactive domain 5B (MRF1-like) 0.032723
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.031792
PALLD palladin, cytoskeletal associated protein 0.0316049
SIK3 SIK family kinase 3 0.031425
RPL3 ribosomal protein L3 0.0304083
RPS27A ribosomal protein S27a 0.0295362
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0295031
VCL vinculin 0.0293281
ZSWIM6 zinc finger, SWIM-type containing 6 0.0292249
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0292174
NSUN6 NOP2/Sun domain family, member 6 0.0290529
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0287353
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0285885
PTPRK protein tyrosine phosphatase, receptor type, K 0.0284532
SERTAD2 SERTA domain containing 2 0.0282088
KLF6 Kruppel-like factor 6 0.0281023
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0280562
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0279269
PCBP2 poly(rC) binding protein 2 0.0276585
GDI2 GDP dissociation inhibitor 2 0.0276437
LIMS1 LIM and senescent cell antigen-like domains 1 0.0274697
MCU mitochondrial calcium uniporter 0.027385
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0271447
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0269764
CP ceruloplasmin (ferroxidase) 0.0268188
RAD51B RAD51 paralog B 0.0264385
RSL1D1 ribosomal L1 domain containing 1 0.0263802
MYO5B myosin VB 0.0263762
KIF1B kinesin family member 1B 0.0262731
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0261156
AFF1 AF4/FMR2 family, member 1 0.0257255
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0255913
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0255814

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.235441
APOB apolipoprotein B -0.215067
MT2A metallothionein 2A -0.157453
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0958859
APOA2 apolipoprotein A-II -0.0943004
ELL2 elongation factor, RNA polymerase II, 2 -0.0891418
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0856174
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0761188
GPC3 glypican 3 -0.0686668
FNDC3B fibronectin type III domain containing 3B -0.0686308
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0637213
MAML2 mastermind-like 2 (Drosophila) -0.0636901
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.060402
ZMYND8 zinc finger, MYND-type containing 8 -0.0524428
IGFBP1 insulin-like growth factor binding protein 1 -0.0516845
EML4 echinoderm microtubule associated protein like 4 -0.0497716
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0485495
NKD1 naked cuticle homolog 1 (Drosophila) -0.0462675
OSMR oncostatin M receptor -0.0452053
LRMDA leucine rich melanocyte differentiation associated -0.0447274
NPAS2 neuronal PAS domain protein 2 -0.0419727
A2M alpha-2-macroglobulin -0.0417221
TPT1 tumor protein, translationally-controlled 1 -0.0387071
CRLS1 cardiolipin synthase 1 -0.0376769
GPAM glycerol-3-phosphate acyltransferase, mitochondrial -0.0371745
TM4SF1 transmembrane 4 L six family member 1 -0.0360745
EGR1 early growth response 1 -0.0359565
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0346305
TMEM51 transmembrane protein 51 -0.034088
GPC6 glypican 6 -0.0339994
KDM7A lysine (K)-specific demethylase 7A -0.0330938
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0329577
C3 complement component 3 -0.0327775
MALT1 MALT1 paracaspase -0.0325623
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0306538
PLAC8 placenta-specific 8 -0.0300538
RBM39 RNA binding motif protein 39 -0.0298793
RPLP2 ribosomal protein, large, P2 -0.0291488
ATP10A ATPase, class V, type 10A -0.0290657
RPL35A ribosomal protein L35a -0.0285638
NCOA7 nuclear receptor coactivator 7 -0.0282341
FAM135A family with sequence similarity 135, member A -0.0281924
ICAM1 intercellular adhesion molecule 1 -0.0281403
PTBP3 polypyrimidine tract binding protein 3 -0.0276872
FTL ferritin, light polypeptide -0.0275287
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0272695
CDK19 cyclin-dependent kinase 19 -0.0272457
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0267101
MAPK14 mitogen-activated protein kinase 14 -0.0266914
MBNL3 muscleblind-like splicing regulator 3 -0.026282
RRBP1 ribosome binding protein 1 -0.0262348
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0261606
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0257854
MTUS1 microtubule associated tumor suppressor 1 -0.0254317
PDGFB platelet-derived growth factor beta polypeptide -0.0251861
TGFBI transforming growth factor, beta-induced, 68kDa -0.0249845
ACSS3 acyl-CoA synthetase short-chain family member 3 -0.0247731
IER3 immediate early response 3 -0.0244658
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.0242608
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.0236306
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.023538
RTN4 reticulon 4 -0.0232793
EPAS1 endothelial PAS domain protein 1 -0.0231451
MSI2 musashi RNA-binding protein 2 -0.0230883
ARID3A AT rich interactive domain 3A (BRIGHT-like) -0.0230691
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0226377
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.0222661
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0221708
TLK1 tousled-like kinase 1 -0.0217089
ABTB3 ankyrin repeat and BTB domain containing 3 -0.02151
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0214747
SOX5 SRY (sex determining region Y)-box 5 -0.0212654
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0212145
JMJD1C jumonji domain containing 1C -0.0211861
IFI6 interferon, alpha-inducible protein 6 -0.0210716
HLF hepatic leukemia factor -0.0210443
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0209384
TM9SF3 transmembrane 9 superfamily member 3 -0.0208634
HNRNPLL heterogeneous nuclear ribonucleoprotein L-like -0.020721
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0204591
CFB complement factor B -0.0198093
ISG15 ISG15 ubiquitin-like modifier -0.0196118
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0194939
RPL36 ribosomal protein L36 -0.0194336
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0193829
PTPRF protein tyrosine phosphatase, receptor type, F -0.0192809
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0192578
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 -0.0190625
NPR2 natriuretic peptide receptor 2 -0.0189899
CD2AP CD2-associated protein -0.0189479
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0188751
GNAS GNAS complex locus -0.0186808
FN1 fibronectin 1 -0.018302
IFITM1 interferon induced transmembrane protein 1 -0.0181073
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -0.0176857
RBM25 RNA binding motif protein 25 -0.017597
MRTFA myocardin related transcription factor A -0.0174849
IGF2R insulin-like growth factor 2 receptor -0.017316
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like -0.0173084
RPL38 ribosomal protein L38 -0.0172222