| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pralsetinib perturbation in Hs 766T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Pralsetinib_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0727853 |
| ASPH | aspartate beta-hydroxylase | 0.0718668 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0676675 |
| MSN | moesin | 0.0613423 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0574015 |
| ENO1 | enolase 1, (alpha) | 0.052297 |
| B2M | beta-2-microglobulin | 0.0517889 |
| CD44 | CD44 molecule (Indian blood group) | 0.051391 |
| MTSS1 | metastasis suppressor 1 | 0.0511573 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0500178 |
| MYOF | myoferlin | 0.0477145 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0471928 |
| SMAD3 | SMAD family member 3 | 0.0454329 |
| VCL | vinculin | 0.0450856 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0450476 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0436573 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0419725 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.041404 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0406845 |
| INTS6 | integrator complex subunit 6 | 0.0405292 |
| TGM2 | transglutaminase 2 | 0.0385084 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0375232 |
| DST | dystonin | 0.0371189 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0359113 |
| SIK3 | SIK family kinase 3 | 0.0354733 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0328836 |
| ANGPTL4 | angiopoietin-like 4 | 0.0327891 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0326122 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0325955 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0321325 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | 0.0320171 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0317141 |
| LMO7 | LIM domain 7 | 0.0315734 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0311433 |
| BARX2 | BARX homeobox 2 | 0.0310905 |
| TPM3 | tropomyosin 3 | 0.0303348 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0299536 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0296739 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.029636 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0283556 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0277753 |
| ARRDC3 | arrestin domain containing 3 | 0.0277345 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0271774 |
| FUT11 | fucosyltransferase 11 (alpha (1,3) fucosyltransferase) | 0.0270447 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0267138 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0264832 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.026397 |
| SEPTIN9 | septin 9 | 0.0257245 |
| UBC | ubiquitin C | 0.0257222 |
| RPLP1 | ribosomal protein, large, P1 | 0.0253834 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0250295 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0249137 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.024815 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0246217 |
| DOK5 | docking protein 5 | 0.0243117 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.024144 |
| ANKRD28 | ankyrin repeat domain 28 | 0.024122 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0237959 |
| IPO7 | importin 7 | 0.0236327 |
| KIAA1217 | KIAA1217 | 0.0234507 |
| RPS6 | ribosomal protein S6 | 0.0233786 |
| TXNIP | thioredoxin interacting protein | 0.0232175 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0229649 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0228601 |
| JAG1 | jagged 1 | 0.0226988 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.022696 |
| DIAPH1 | diaphanous-related formin 1 | 0.0225993 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0222075 |
| ANO6 | anoctamin 6 | 0.0221516 |
| AOPEP | aminopeptidase O (putative) | 0.022101 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0219882 |
| JMJD1C | jumonji domain containing 1C | 0.0217483 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0217257 |
| LDHA | lactate dehydrogenase A | 0.0215886 |
| IGFBP6 | insulin-like growth factor binding protein 6 | 0.0213322 |
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.0210993 |
| PCBP2 | poly(rC) binding protein 2 | 0.0209438 |
| GOLGB1 | golgin B1 | 0.0209265 |
| SLK | STE20-like kinase | 0.0209023 |
| IFI44L | interferon-induced protein 44-like | 0.0206206 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0205703 |
| CREBBP | CREB binding protein | 0.0204118 |
| RPL37 | ribosomal protein L37 | 0.0202063 |
| RPL35 | ribosomal protein L35 | 0.0201351 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0199189 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0197546 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0197133 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0192502 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0191557 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0188744 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | 0.018769 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0187519 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0186755 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.018604 |
| PDZD8 | PDZ domain containing 8 | 0.0185712 |
| EFNA5 | ephrin-A5 | 0.0185703 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0185573 |
| HLA-E | major histocompatibility complex, class I, E | 0.0185413 |
| BPTF | bromodomain PHD finger transcription factor | 0.0183368 |
| CLU | clusterin | 0.0183128 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FLNB | filamin B, beta | -0.27928 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.207079 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.206037 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.171397 |
| NDRG1 | N-myc downstream regulated 1 | -0.120142 |
| EMP1 | epithelial membrane protein 1 | -0.096834 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0953076 |
| AHNAK | AHNAK nucleoprotein | -0.0915227 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0906022 |
| SULF1 | sulfatase 1 | -0.0873306 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.077415 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0663707 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0652136 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0602478 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0593016 |
| ITGA6 | integrin, alpha 6 | -0.0583792 |
| RBM39 | RNA binding motif protein 39 | -0.0580656 |
| IGF2 | insulin-like growth factor 2 | -0.0564975 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0559688 |
| MECOM | MDS1 and EVI1 complex locus | -0.0534202 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0524135 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0520674 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.052047 |
| ADAMTS16 | ADAM metallopeptidase with thrombospondin type 1 motif, 16 | -0.0519833 |
| PODXL | podocalyxin-like | -0.0462795 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.045126 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0446962 |
| BCL2L1 | BCL2-like 1 | -0.0434024 |
| ACTN4 | actinin, alpha 4 | -0.0429913 |
| C4BPB | complement component 4 binding protein, beta | -0.0418059 |
| GNAS | GNAS complex locus | -0.0404689 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0403427 |
| COL17A1 | collagen, type XVII, alpha 1 | -0.0401981 |
| EFHD2 | EF-hand domain family, member D2 | -0.0401729 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.0394137 |
| LMNA | lamin A/C | -0.0394081 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.039263 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.0379732 |
| FOXO1 | forkhead box O1 | -0.0374835 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0359279 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0355107 |
| ANKRD33B | ankyrin repeat domain 33B | -0.0354076 |
| ANXA2 | annexin A2 | -0.0350561 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | -0.0346014 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0336819 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 | -0.0328494 |
| EZR | ezrin | -0.0322575 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.0321325 |
| LAMA5 | laminin, alpha 5 | -0.0318211 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.031428 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0312072 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0310178 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0308286 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0299248 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0284903 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | -0.0284057 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.02814 |
| KRT6A | keratin 6A, type II | -0.02785 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0278041 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0274762 |
| OGA | O-GlcNAcase | -0.0271929 |
| PLEC | plectin | -0.026802 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0267623 |
| NAV2 | neuron navigator 2 | -0.0264873 |
| STC1 | stanniocalcin 1 | -0.0263701 |
| TAGLN2 | transgelin 2 | -0.0261598 |
| TMSB10 | thymosin beta 10 | -0.0261565 |
| PALLD | palladin, cytoskeletal associated protein | -0.0259582 |
| OXR1 | oxidation resistance 1 | -0.0259186 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0258186 |
| SPAG9 | sperm associated antigen 9 | -0.0257495 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0255432 |
| WASF2 | WAS protein family, member 2 | -0.0254298 |
| ANLN | anillin, actin binding protein | -0.0253814 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | -0.0251033 |
| CD99 | CD99 molecule | -0.0246575 |
| RPS21 | ribosomal protein S21 | -0.0243346 |
| DOCK9 | dedicator of cytokinesis 9 | -0.0241211 |
| DUSP5 | dual specificity phosphatase 5 | -0.0240003 |
| PTHLH | parathyroid hormone-like hormone | -0.0239291 |
| FSCN1 | fascin actin-bundling protein 1 | -0.0234505 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0234498 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0229076 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0228597 |
| XPR1 | xenotropic and polytropic retrovirus receptor 1 | -0.0227652 |
| HM13 | histocompatibility (minor) 13 | -0.0227248 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.022668 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0224517 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0224291 |
| FSTL1 | follistatin-like 1 | -0.0223957 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0223401 |
| THBD | thrombomodulin | -0.0223188 |
| SYPL1 | synaptophysin-like 1 | -0.022315 |
| ITSN1 | intersectin 1 (SH3 domain protein) | -0.0220861 |
| ERAP2 | endoplasmic reticulum aminopeptidase 2 | -0.0217504 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0216995 |
| SDCBP | syndecan binding protein (syntenin) | -0.0216621 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0215444 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0214928 |
| TMEM165 | transmembrane protein 165 | -0.0214597 |
