| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pralsetinib perturbation in KATO III cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pralsetinib_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.161697 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.143616 |
| DSPP | dentin sialophosphoprotein | 0.115301 |
| LMO7 | LIM domain 7 | 0.105273 |
| MYOF | myoferlin | 0.099911 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0904752 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0898636 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0732683 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0690994 |
| GDA | guanine deaminase | 0.0679612 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.061709 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.057753 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0544193 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0502454 |
| DSTN | destrin (actin depolymerizing factor) | 0.0477677 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0469449 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0458471 |
| RPS12 | ribosomal protein S12 | 0.0404406 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0391983 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0388865 |
| TMC5 | transmembrane channel-like 5 | 0.0388384 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0383356 |
| SMAD3 | SMAD family member 3 | 0.0374889 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | 0.0370405 |
| MGAM2 | maltase-glucoamylase 2 (putative) | 0.0370247 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.036546 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.033632 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0336016 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0333373 |
| ENO1 | enolase 1, (alpha) | 0.0329774 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0326368 |
| GOLGB1 | golgin B1 | 0.0301183 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0298571 |
| TXNRD1 | thioredoxin reductase 1 | 0.0291588 |
| SET | SET nuclear proto-oncogene | 0.0291081 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0289469 |
| B2M | beta-2-microglobulin | 0.0289051 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.02838 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0283073 |
| DST | dystonin | 0.0281984 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0280418 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0269839 |
| CANX | calnexin | 0.0269642 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.0269056 |
| PCBP2 | poly(rC) binding protein 2 | 0.0268026 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0265442 |
| GALNT5 | polypeptide N-acetylgalactosaminyltransferase 5 | 0.0256164 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0255685 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0247552 |
| SH3RF1 | SH3 domain containing ring finger 1 | 0.0246923 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0245072 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0244735 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0244213 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | 0.0244165 |
| TUG1 | taurine up-regulated 1 (non-protein coding) | 0.023969 |
| LURAP1L | leucine rich adaptor protein 1-like | 0.0239082 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0238665 |
| FNIP1 | folliculin interacting protein 1 | 0.0236229 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0230879 |
| RBM47 | RNA binding motif protein 47 | 0.022788 |
| RPS3 | ribosomal protein S3 | 0.0226995 |
| TMF1 | TATA element modulatory factor 1 | 0.0222924 |
| HYOU1 | hypoxia up-regulated 1 | 0.0219367 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0215488 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0214261 |
| TJP1 | tight junction protein 1 | 0.0211024 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0209644 |
| MB21D2 | Mab-21 domain containing 2 | 0.0207887 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0206653 |
| CLMN | calmin (calponin-like, transmembrane) | 0.0201718 |
| AHR | aryl hydrocarbon receptor | 0.0200581 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0196314 |
| ITGB8 | integrin, beta 8 | 0.0193709 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0193457 |
| LCN2 | lipocalin 2 | 0.0190889 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0190778 |
| CENPF | centromere protein F, 350/400kDa | 0.0189163 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0187259 |
| SIK3 | SIK family kinase 3 | 0.0184984 |
| CLTC | clathrin, heavy chain (Hc) | 0.0181423 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.0180687 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0177971 |
| NTN4 | netrin 4 | 0.0175514 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0174694 |
| AGR3 | anterior gradient 3 | 0.0172703 |
| COPG1 | coatomer protein complex, subunit gamma 1 | 0.0172468 |
| UGT1A6 | UDP glucuronosyltransferase 1 family, polypeptide A6 | 0.0172353 |
| HDAC9 | histone deacetylase 9 | 0.017072 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 0.0169491 |
| MT2A | metallothionein 2A | 0.0169365 |
| COBL | cordon-bleu WH2 repeat protein | 0.0168738 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0165924 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0165148 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0164818 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0164362 |
| EGFR | epidermal growth factor receptor | 0.0164083 |
| PCM1 | pericentriolar material 1 | 0.0162304 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0160353 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0159003 |
| HMGB2 | high mobility group box 2 | 0.0158773 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NPSR1 | neuropeptide S receptor 1 | -0.327737 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.166827 |
| EMP1 | epithelial membrane protein 1 | -0.123971 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.119624 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.112028 |
| TMSB10 | thymosin beta 10 | -0.111066 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0927708 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0924969 |
| FLNB | filamin B, beta | -0.0856039 |
| S100A6 | S100 calcium binding protein A6 | -0.0828509 |
| ANXA2 | annexin A2 | -0.0823335 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0819596 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0781671 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0769028 |
| S100A10 | S100 calcium binding protein A10 | -0.0690186 |
| EHBP1 | EH domain binding protein 1 | -0.0606542 |
| BCL2L1 | BCL2-like 1 | -0.0557452 |
| TNIK | TRAF2 and NCK interacting kinase | -0.055183 |
| AGR2 | anterior gradient 2 | -0.0550887 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0550756 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.05284 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0510657 |
| ITGA6 | integrin, alpha 6 | -0.0504725 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0492729 |
| PTMA | prothymosin, alpha | -0.0490581 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0474044 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0473216 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0467718 |
| ACTN4 | actinin, alpha 4 | -0.0459845 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0450424 |
| KRT7 | keratin 7, type II | -0.0444224 |
| TMEM123 | transmembrane protein 123 | -0.0438631 |
| KRT8 | keratin 8, type II | -0.0436329 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0426268 |
| TPM4 | tropomyosin 4 | -0.0411215 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0406759 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0396706 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.039104 |
| HLA-A | major histocompatibility complex, class I, A | -0.0385942 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0385304 |
| GNAS | GNAS complex locus | -0.0382794 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0372265 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0370131 |
| AUTS2 | autism susceptibility candidate 2 | -0.0368967 |
| CCND1 | cyclin D1 | -0.036229 |
| INSIG1 | insulin induced gene 1 | -0.0361795 |
| RPL35A | ribosomal protein L35a | -0.0359113 |
| ITGB4 | integrin, beta 4 | -0.0358755 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0350968 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0348809 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0348477 |
| TFRC | transferrin receptor | -0.0347289 |
| PRKCA | protein kinase C, alpha | -0.0346198 |
| MSI2 | musashi RNA-binding protein 2 | -0.0345061 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0344036 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0341089 |
| SLC38A1 | solute carrier family 38, member 1 | -0.033778 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0337445 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0332678 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0327377 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0327254 |
| DENND1A | DENN/MADD domain containing 1A | -0.0327162 |
| LLGL2 | lethal giant larvae homolog 2 (Drosophila) | -0.0319555 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -0.0315981 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0314847 |
| KLK10 | kallikrein-related peptidase 10 | -0.0313679 |
| FDPS | farnesyl diphosphate synthase | -0.0313114 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.031277 |
| TMBIM1 | transmembrane BAX inhibitor motif containing 1 | -0.0312009 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | -0.0309693 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0307783 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0306045 |
| PKM | pyruvate kinase, muscle | -0.0304833 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0303588 |
| WDR45B | WD repeat domain 45B | -0.0303445 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0302224 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0300367 |
| GPX2 | glutathione peroxidase 2 | -0.0299228 |
| RPS24 | ribosomal protein S24 | -0.029801 |
| TMPRSS4 | transmembrane protease, serine 4 | -0.0296935 |
| RPL23 | ribosomal protein L23 | -0.0296764 |
| HLA-B | major histocompatibility complex, class I, B | -0.0296706 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0294265 |
| TMCC1 | transmembrane and coiled-coil domain family 1 | -0.0289257 |
| EGR1 | early growth response 1 | -0.0287802 |
| TES | testin LIM domain protein | -0.0285059 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0281079 |
| FBXO11 | F-box protein 11 | -0.027937 |
| RRBP1 | ribosome binding protein 1 | -0.0278852 |
| RPL34 | ribosomal protein L34 | -0.027107 |
| HLA-C | major histocompatibility complex, class I, C | -0.0270822 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0270659 |
| ONECUT3 | one cut homeobox 3 | -0.0268741 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0268107 |
| FOXN2 | forkhead box N2 | -0.026332 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0262951 |
| FASN | fatty acid synthase | -0.0260053 |
| ARHGAP6 | Rho GTPase activating protein 6 | -0.0259559 |
| ANO1 | anoctamin 1, calcium activated chloride channel | -0.0258764 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0256775 |
