| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pralsetinib perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Pralsetinib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.165473 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.156722 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.136043 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.125448 |
| LMO7 | LIM domain 7 | 0.123798 |
| EXT1 | exostosin glycosyltransferase 1 | 0.109057 |
| DSPP | dentin sialophosphoprotein | 0.0907813 |
| MYO1E | myosin IE | 0.0903476 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.0866942 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0865492 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0822356 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0734056 |
| MUC13 | mucin 13, cell surface associated | 0.0712386 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0706538 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0678338 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0660393 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0631721 |
| CANX | calnexin | 0.0592106 |
| LDHA | lactate dehydrogenase A | 0.05724 |
| RPS12 | ribosomal protein S12 | 0.057016 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0561934 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0555348 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0554084 |
| PDZD8 | PDZ domain containing 8 | 0.054712 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0515752 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0481646 |
| CALR | calreticulin | 0.0480166 |
| FAT1 | FAT atypical cadherin 1 | 0.0470499 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.046973 |
| APP | amyloid beta (A4) precursor protein | 0.0467181 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0444881 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.044041 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0434126 |
| SVIL | supervillin | 0.0426941 |
| NCOA7 | nuclear receptor coactivator 7 | 0.0413203 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0411322 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0402891 |
| LURAP1L | leucine rich adaptor protein 1-like | 0.0399276 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0399132 |
| RPLP0 | ribosomal protein, large, P0 | 0.0398185 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0380871 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0378739 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0376305 |
| MYO5B | myosin VB | 0.0374873 |
| B2M | beta-2-microglobulin | 0.0370156 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0368017 |
| ENO1 | enolase 1, (alpha) | 0.0366822 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0366458 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0356716 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.035644 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0354674 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0353225 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.0352206 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0347077 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0345683 |
| TGFBR3 | transforming growth factor, beta receptor III | 0.0337935 |
| NEBL | nebulette | 0.0331 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0329036 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0324335 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0322971 |
| PIGR | polymeric immunoglobulin receptor | 0.0319332 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0310528 |
| TRPS1 | trichorhinophalangeal syndrome I | 0.0309853 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0309474 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0308434 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0305866 |
| DSTN | destrin (actin depolymerizing factor) | 0.0293745 |
| SQSTM1 | sequestosome 1 | 0.0293666 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0290082 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0285912 |
| SIK3 | SIK family kinase 3 | 0.0283342 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | 0.028091 |
| MED13 | mediator complex subunit 13 | 0.0273909 |
| POF1B | premature ovarian failure, 1B | 0.0273192 |
| ANXA1 | annexin A1 | 0.0271289 |
| FTL | ferritin, light polypeptide | 0.0269095 |
| AHNAK | AHNAK nucleoprotein | 0.0268839 |
| SMAD2 | SMAD family member 2 | 0.0268675 |
| ETV6 | ets variant 6 | 0.0265376 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.026465 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0262831 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | 0.0262285 |
| PGK1 | phosphoglycerate kinase 1 | 0.0261674 |
| RND3 | Rho family GTPase 3 | 0.0260278 |
| ATF3 | activating transcription factor 3 | 0.0259422 |
| UNC13B | unc-13 homolog B (C. elegans) | 0.0258964 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.025775 |
| TJP1 | tight junction protein 1 | 0.0257509 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0257035 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.025585 |
| EPCAM | epithelial cell adhesion molecule | 0.0255801 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0255315 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0254187 |
| CRY1 | cryptochrome circadian clock 1 | 0.0249561 |
| DUSP16 | dual specificity phosphatase 16 | 0.0249311 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0248946 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.0248315 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0248046 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0247856 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | 0.0244794 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NPSR1 | neuropeptide S receptor 1 | -0.200297 |
| TNS4 | tensin 4 | -0.163845 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | -0.15746 |
| TMSB10 | thymosin beta 10 | -0.123234 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.111106 |
| ANXA2 | annexin A2 | -0.102178 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.100823 |
| FLNB | filamin B, beta | -0.0945676 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | -0.093748 |
| RNF43 | ring finger protein 43 | -0.0827365 |
| NDRG1 | N-myc downstream regulated 1 | -0.0777546 |
| ACTN4 | actinin, alpha 4 | -0.0727688 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0719858 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0714774 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0677305 |
| CALB1 | calbindin 1, 28kDa | -0.0589714 |
| ONECUT3 | one cut homeobox 3 | -0.055489 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0527884 |
| HMGA1 | high mobility group AT-hook 1 | -0.0525429 |
| ITGB4 | integrin, beta 4 | -0.0522264 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0520021 |
| FERMT1 | fermitin family member 1 | -0.051781 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0495162 |
| PKM | pyruvate kinase, muscle | -0.0493026 |
| PRSS3 | protease, serine, 3 | -0.0484146 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.0480132 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0460675 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0455878 |
| RREB1 | ras responsive element binding protein 1 | -0.045079 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0446182 |
| KRT8 | keratin 8, type II | -0.0439396 |
| KLF3 | Kruppel-like factor 3 (basic) | -0.0430251 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | -0.042681 |
| SBF2 | SET binding factor 2 | -0.0421282 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0417068 |
| POTEF | POTE ankyrin domain family, member F | -0.041413 |
| ITGA6 | integrin, alpha 6 | -0.0410588 |
| BCL2L1 | BCL2-like 1 | -0.0408636 |
| GPHN | gephyrin | -0.040311 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0403075 |
| RPL35A | ribosomal protein L35a | -0.040259 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0401693 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | -0.0391617 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0385709 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.03822 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0375311 |
| ABHD2 | abhydrolase domain containing 2 | -0.0375044 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0372955 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0367491 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0364651 |
| S100A6 | S100 calcium binding protein A6 | -0.0364331 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0356817 |
| FOSL1 | FOS-like antigen 1 | -0.0354632 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0350364 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0350267 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0348635 |
| GOLGA4 | golgin A4 | -0.0342097 |
| SETD5 | SET domain containing 5 | -0.0340174 |
| MUC17 | mucin 17, cell surface associated | -0.0336957 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | -0.0330931 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0327065 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0326532 |
| RBM25 | RNA binding motif protein 25 | -0.0319753 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0318513 |
| MAP4 | microtubule-associated protein 4 | -0.0317358 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0316975 |
| EPHA2 | EPH receptor A2 | -0.0316628 |
| PPP2R5C | protein phosphatase 2, regulatory subunit B', gamma | -0.0314421 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0310472 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | -0.0310175 |
| SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | -0.0309724 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0305888 |
| ESRP1 | epithelial splicing regulatory protein 1 | -0.0303839 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0303652 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0300249 |
| TPM4 | tropomyosin 4 | -0.0298885 |
| JUP | junction plakoglobin | -0.0296116 |
| VDR | vitamin D (1,25- dihydroxyvitamin D3) receptor | -0.029546 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0292433 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0291598 |
| PRELID2 | PRELI domain containing 2 | -0.0286371 |
| TMEM45B | transmembrane protein 45B | -0.0280471 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | -0.0279367 |
| ETNK1 | ethanolamine kinase 1 | -0.0278344 |
| PCDHB16 | protocadherin beta 16 | -0.027723 |
| PTPRE | protein tyrosine phosphatase, receptor type, E | -0.0273063 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.0272534 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0271145 |
| RPL23 | ribosomal protein L23 | -0.0264162 |
| EGR1 | early growth response 1 | -0.0263684 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0263437 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0263411 |
| AVL9 | AVL9 homolog (S. cerevisiase) | -0.0263009 |
| THOC2 | THO complex 2 | -0.0262882 |
| PTMA | prothymosin, alpha | -0.0262803 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | -0.0262109 |
| CDCP1 | CUB domain containing protein 1 | -0.0261005 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0253719 |
| VMP1 | vacuole membrane protein 1 | -0.0252689 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0252183 |
