| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pralsetinib perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pralsetinib_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.208495 |
| DST | dystonin | 0.202095 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.197311 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.120327 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.096669 |
| ENO1 | enolase 1, (alpha) | 0.0863179 |
| CANX | calnexin | 0.0792049 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0791489 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.075008 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0717572 |
| TXNIP | thioredoxin interacting protein | 0.0701958 |
| RPS12 | ribosomal protein S12 | 0.0678965 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0641865 |
| HDAC9 | histone deacetylase 9 | 0.0615139 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0614073 |
| SP100 | SP100 nuclear antigen | 0.0579526 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0575363 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0557504 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0557406 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0551585 |
| PRELID2 | PRELI domain containing 2 | 0.0546462 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0545576 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0533991 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.052925 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0523974 |
| LDHA | lactate dehydrogenase A | 0.0518521 |
| B2M | beta-2-microglobulin | 0.0495653 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0494915 |
| CALR | calreticulin | 0.048669 |
| PLK2 | polo-like kinase 2 | 0.0476793 |
| COL5A2 | collagen, type V, alpha 2 | 0.0450171 |
| SQSTM1 | sequestosome 1 | 0.044768 |
| PTMA | prothymosin, alpha | 0.0445858 |
| MYOF | myoferlin | 0.0445704 |
| PCBP2 | poly(rC) binding protein 2 | 0.0431661 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0425556 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0424698 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0423153 |
| SET | SET nuclear proto-oncogene | 0.0413401 |
| PGK1 | phosphoglycerate kinase 1 | 0.0413109 |
| VCL | vinculin | 0.0407371 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0402914 |
| CAPRIN2 | caprin family member 2 | 0.03973 |
| ASPH | aspartate beta-hydroxylase | 0.0388959 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0379883 |
| TMSB4X | thymosin beta 4, X-linked | 0.037921 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0378814 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0370283 |
| CADM2 | cell adhesion molecule 2 | 0.0364477 |
| FUT11 | fucosyltransferase 11 (alpha (1,3) fucosyltransferase) | 0.036388 |
| TP63 | tumor protein p63 | 0.0359182 |
| ANGPTL4 | angiopoietin-like 4 | 0.0359044 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0358477 |
| RNF213 | ring finger protein 213 | 0.0353181 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.034431 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | 0.0343509 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0343193 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0336557 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0334186 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0332172 |
| SPAG9 | sperm associated antigen 9 | 0.0329694 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0326521 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0324176 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0322903 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0321868 |
| MB21D2 | Mab-21 domain containing 2 | 0.0320776 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0318416 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0313973 |
| RPS6 | ribosomal protein S6 | 0.0310889 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0305876 |
| FMNL2 | formin-like 2 | 0.0298593 |
| SDC4 | syndecan 4 | 0.0297054 |
| RPS18 | ribosomal protein S18 | 0.0296535 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0295915 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0292408 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | 0.0292093 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0291262 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0289776 |
| AEBP2 | AE binding protein 2 | 0.0287546 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0286007 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0278273 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0276138 |
| PLIN2 | perilipin 2 | 0.0273191 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0271818 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0271512 |
| TRIM56 | tripartite motif containing 56 | 0.0271348 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | 0.0270683 |
| HOMER1 | homer scaffolding protein 1 | 0.0267096 |
| BRD2 | bromodomain containing 2 | 0.0265984 |
| INTS6 | integrator complex subunit 6 | 0.0265801 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0263171 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0262825 |
| APP | amyloid beta (A4) precursor protein | 0.0261554 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0260477 |
| EGFR | epidermal growth factor receptor | 0.0259619 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0258432 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0255926 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0254622 |
| LNPEP | leucyl/cystinyl aminopeptidase | 0.0253355 |
| TPM3 | tropomyosin 3 | 0.0253002 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | -0.161227 |
| TMSB10 | thymosin beta 10 | -0.148841 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.11764 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.105969 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.105684 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0816013 |
| EGR1 | early growth response 1 | -0.0797768 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0786872 |
| RPL35A | ribosomal protein L35a | -0.0697401 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0670286 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0663827 |
| VIM | vimentin | -0.0659771 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0649335 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0610991 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0595835 |
| SRGN | serglycin | -0.0586403 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0580365 |
| RTN4 | reticulon 4 | -0.0566079 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0551262 |
| ACTG1 | actin gamma 1 | -0.0546553 |
| RAI1 | retinoic acid induced 1 | -0.0491007 |
| TMEM41B | transmembrane protein 41B | -0.0478329 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0470416 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0435385 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.043244 |
| FLNB | filamin B, beta | -0.0410073 |
| USP34 | ubiquitin specific peptidase 34 | -0.0380604 |
| AHNAK | AHNAK nucleoprotein | -0.0357856 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0354309 |
| FBXO11 | F-box protein 11 | -0.0351134 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0335349 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0327173 |
| CCDC91 | coiled-coil domain containing 91 | -0.030738 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0305742 |
| MT2A | metallothionein 2A | -0.0298865 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0297686 |
| UPP1 | uridine phosphorylase 1 | -0.0297258 |
| YBX3 | Y box binding protein 3 | -0.0296336 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0284223 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0281976 |
| EFNA5 | ephrin-A5 | -0.0280172 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0275956 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0275223 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0272994 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0272652 |
| POM121 | POM121 transmembrane nucleoporin | -0.0270935 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0267833 |
| HMGA1 | high mobility group AT-hook 1 | -0.0262754 |
| SBF2 | SET binding factor 2 | -0.0260359 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0259991 |
| GNAS | GNAS complex locus | -0.0259518 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0256018 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.025552 |
| MT1X | metallothionein 1X | -0.0253296 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0248847 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0248115 |
| RPS13 | ribosomal protein S13 | -0.0247903 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0235536 |
| SEC14L1 | SEC14-like 1 (S. cerevisiae) | -0.0234542 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0232966 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | -0.0232883 |
| CFAP299 | cilia and flagella associated protein 299 | -0.0232131 |
| RPS24 | ribosomal protein S24 | -0.0231904 |
| CEP170 | centrosomal protein 170kDa | -0.023068 |
| NAV2 | neuron navigator 2 | -0.0226495 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -0.0225918 |
| FOXN2 | forkhead box N2 | -0.022181 |
| CDK19 | cyclin-dependent kinase 19 | -0.0221722 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0221463 |
| TRA2B | transformer 2 beta homolog (Drosophila) | -0.0220041 |
| GCLM | glutamate-cysteine ligase, modifier subunit | -0.0219905 |
| RIGI | RNA sensor RIG-I | -0.0219646 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0213138 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.021145 |
| FTL | ferritin, light polypeptide | -0.0210576 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0210478 |
| FUS | FUS RNA binding protein | -0.0210003 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.020871 |
| TMEM123 | transmembrane protein 123 | -0.020746 |
| ALDH7A1 | aldehyde dehydrogenase 7 family, member A1 | -0.0206322 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.020554 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0203853 |
| ZNF217 | zinc finger protein 217 | -0.0203576 |
| MAP4 | microtubule-associated protein 4 | -0.0202696 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.020118 |
| RPL38 | ribosomal protein L38 | -0.0200656 |
| RBM25 | RNA binding motif protein 25 | -0.020058 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0199336 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0198966 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0198928 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0195528 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0194772 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | -0.0194604 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0193685 |
| AVL9 | AVL9 homolog (S. cerevisiase) | -0.0192967 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0192724 |
| EPS15 | epidermal growth factor receptor pathway substrate 15 | -0.0192036 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0191305 |
| RRAS2 | related RAS viral (r-ras) oncogene homolog 2 | -0.0190784 |
| BMERB1 | bMERB domain containing 1 | -0.0190488 |
