Pralsetinib_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pralsetinib perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pralsetinib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYOF myoferlin 0.125562
PDE4D phosphodiesterase 4D, cAMP-specific 0.120409
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.114845
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.114813
LOC112694756 uncharaterized LOC112694756 0.104307
EGFR epidermal growth factor receptor 0.104042
PM20D1 peptidase M20 domain containing 1 0.102285
SLTM SAFB-like, transcription modulator 0.10209
ENO1 enolase 1, (alpha) 0.101109
GRAMD1B GRAM domain containing 1B 0.100897
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0870756
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.083404
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0706269
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0667417
THSD4 thrombospondin, type I, domain containing 4 0.0617497
CEMIP cell migration inducing protein, hyaluronan binding 0.0598327
TBC1D22A TBC1 domain family, member 22A 0.0598229
ASPH aspartate beta-hydroxylase 0.0589292
DOCK5 dedicator of cytokinesis 5 0.0584911
RNF213 ring finger protein 213 0.0583507
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0556959
LOC102724023 ES1 protein homolog, mitochondrial 0.055143
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0500129
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0499679
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0493321
HSPA8 heat shock 70kDa protein 8 0.0492213
ELL2 elongation factor, RNA polymerase II, 2 0.0464733
NPAS2 neuronal PAS domain protein 2 0.0463954
CCSER1 coiled-coil serine-rich protein 1 0.0460059
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0459835
NFE2L2 nuclear factor, erythroid 2-like 2 0.0456895
MYH9 myosin, heavy chain 9, non-muscle 0.0453451
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0451797
SMYD3 SET and MYND domain containing 3 0.0451545
LMO7 LIM domain 7 0.0446792
RAD51B RAD51 paralog B 0.0446768
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0440676
INTS6 integrator complex subunit 6 0.0436483
SMAD3 SMAD family member 3 0.0428929
LDHA lactate dehydrogenase A 0.0424376
ZNF638 zinc finger protein 638 0.0423681
DSCAM Down syndrome cell adhesion molecule 0.041858
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0417224
PGK1 phosphoglycerate kinase 1 0.0416935
MYO1E myosin IE 0.0413267
EXT1 exostosin glycosyltransferase 1 0.0395317
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.038622
SIK3 SIK family kinase 3 0.038501
ZSWIM6 zinc finger, SWIM-type containing 6 0.0384383
SAMD4A sterile alpha motif domain containing 4A 0.038372
CXCL8 chemokine (C-X-C motif) ligand 8 0.0379165
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0370685
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0368609
EFNA5 ephrin-A5 0.0365643
SP100 SP100 nuclear antigen 0.0360169
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0352246
FNDC3B fibronectin type III domain containing 3B 0.0351827
DST dystonin 0.0349611
DSPP dentin sialophosphoprotein 0.0346835
GPHN gephyrin 0.034592
PDLIM5 PDZ and LIM domain 5 0.0339152
IRS2 insulin receptor substrate 2 0.0336439
AKAP13 A kinase (PRKA) anchor protein 13 0.032518
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0319562
BMP6 bone morphogenetic protein 6 0.0319063
RPLP0 ribosomal protein, large, P0 0.0314326
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0313812
NSUN6 NOP2/Sun domain family, member 6 0.0313138
TUG1 taurine up-regulated 1 (non-protein coding) 0.0312677
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.0307643
MACF1 microtubule-actin crosslinking factor 1 0.0306941
MAP7 microtubule-associated protein 7 0.0306619
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0306497
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0304674
GPC6 glypican 6 0.0304662
FNDC3A fibronectin type III domain containing 3A 0.0303743
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0303594
HOMER1 homer scaffolding protein 1 0.0300488
B2M beta-2-microglobulin 0.0300248
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0299297
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0295631
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0294896
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0294004
EIF4A2 eukaryotic translation initiation factor 4A2 0.0292038
RPS12 ribosomal protein S12 0.028507
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0284779
RPS3 ribosomal protein S3 0.0284704
JMJD1C jumonji domain containing 1C 0.0282173
KTN1 kinectin 1 (kinesin receptor) 0.0281566
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 0.0281188
CABLES1 Cdk5 and Abl enzyme substrate 1 0.0280255
TXNRD1 thioredoxin reductase 1 0.0280113
NAP1L1 nucleosome assembly protein 1-like 1 0.0279909
ATP11A ATPase, class VI, type 11A 0.0277589
LGALS12 lectin, galactoside-binding, soluble, 12 0.0277014
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0272097
BZW1 basic leucine zipper and W2 domains 1 0.0270937
DOCK1 dedicator of cytokinesis 1 0.027029
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0268215
SOD2 superoxide dismutase 2, mitochondrial 0.0268108

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.168617
NDRG1 N-myc downstream regulated 1 -0.0957354
TMSB10 thymosin beta 10 -0.0790607
EGR1 early growth response 1 -0.0669587
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0659208
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0607416
TMEM165 transmembrane protein 165 -0.0584953
PKM pyruvate kinase, muscle -0.0472901
LAMC2 laminin, gamma 2 -0.0465986
RAB1A RAB1A, member RAS oncogene family -0.0373659
CES1 carboxylesterase 1 -0.0346995
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0333255
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0310019
CAMTA1 calmodulin binding transcription activator 1 -0.0307744
ACTG1 actin gamma 1 -0.0306829
HDLBP high density lipoprotein binding protein -0.0299925
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0279309
WASF2 WAS protein family, member 2 -0.0278956
SEC31A SEC31 homolog A (S. cerevisiae) -0.0277145
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0274755
PTPRM protein tyrosine phosphatase, receptor type, M -0.0272372
HMGA1 high mobility group AT-hook 1 -0.0264667
NDE1 nudE neurodevelopment protein 1 -0.0230215
LAMB3 laminin, beta 3 -0.0230135
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0225976
MARF1 meiosis regulator and mRNA stability factor 1 -0.021956
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0217743
CST3 cystatin C -0.0217049
PATJ PATJ crumbs cell polarity complex component -0.0212493
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0210638
AGR2 anterior gradient 2 -0.0210088
WDR45B WD repeat domain 45B -0.020802
ARL5B ADP-ribosylation factor-like 5B -0.0206427
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0197576
KRT7 keratin 7, type II -0.019657
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0196239
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0195183
AKR1C1 aldo-keto reductase family 1, member C1 -0.0194681
GORASP2 golgi reassembly stacking protein 2, 55kDa -0.0188207
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0183789
BLZF1 basic leucine zipper nuclear factor 1 -0.0181541
CDCP1 CUB domain containing protein 1 -0.0180792
S100A10 S100 calcium binding protein A10 -0.0178762
RAP1B RAP1B, member of RAS oncogene family -0.0177129
KCMF1 potassium channel modulatory factor 1 -0.0175005
FLNB filamin B, beta -0.0172215
ADAM17 ADAM metallopeptidase domain 17 -0.0170303
ARF4 ADP-ribosylation factor 4 -0.0169282
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.016922
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.016844
SUCO SUN domain containing ossification factor -0.016599
SRP54 signal recognition particle 54kDa -0.0164461
RNMT RNA (guanine-7-) methyltransferase -0.0163514
AHNAK AHNAK nucleoprotein -0.0158715
SREBF2 sterol regulatory element binding transcription factor 2 -0.0158343
FTL ferritin, light polypeptide -0.0158228
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0156208
DUSP5 dual specificity phosphatase 5 -0.0154901
CCNL1 cyclin L1 -0.0154041
PLEC plectin -0.0151421
SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae) -0.0151354
CCNK cyclin K -0.015087
HILPDA hypoxia inducible lipid droplet-associated -0.0149547
KDM5B lysine (K)-specific demethylase 5B -0.0149411
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0147927
F11R F11 receptor -0.0147909
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0147625
RPL34 ribosomal protein L34 -0.0147259
RAB27B RAB27B, member RAS oncogene family -0.0146379
HOOK2 hook microtubule-tethering protein 2 -0.0146367
KDM2A lysine (K)-specific demethylase 2A -0.0144711
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0142467
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0141002
EMP1 epithelial membrane protein 1 -0.0140829
CCND1 cyclin D1 -0.0140291
MXI1 MAX interactor 1, dimerization protein -0.0140259
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0137819
JUP junction plakoglobin -0.0136271
HM13 histocompatibility (minor) 13 -0.013592
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0135311
TM9SF3 transmembrane 9 superfamily member 3 -0.0133154
CCNI cyclin I -0.0131792
SEC24A SEC24 family member A -0.0130316
ACBD3 acyl-CoA binding domain containing 3 -0.012997
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0128469
TPD52 tumor protein D52 -0.0128148
ATG14 autophagy related 14 -0.0126894
MXD1 MAX dimerization protein 1 -0.012686
CD99 CD99 molecule -0.0126542
PDIA3 protein disulfide isomerase family A, member 3 -0.0126519
NPC1 Niemann-Pick disease, type C1 -0.0125691
SMIM14 small integral membrane protein 14 -0.0125479
SEC24D SEC24 family member D -0.0125447
RCOR1 REST corepressor 1 -0.0123226
ZFC3H1 zinc finger, C3H1-type containing -0.0120293
UVRAG UV radiation resistance associated -0.0120188
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0120063
RPL35A ribosomal protein L35a -0.0119648
PERP PERP, TP53 apoptosis effector -0.0119605
RIOK3 RIO kinase 3 -0.0119567